Documento #214

Processato

Contenuto Testuale

Influence of some dopaminergic agents on antinociception produced by quinine in mice.
1. The analgesic effect of quinine and the influence of some dopaminergic agents on it were studied in mice. 2. Quinine (25-130mg/kg, ip) effectively elicited antinociceptive effect in a dose related manner. 3. D-Amphetamine (2.5-4mg/kg, ip), L-dopa (25mg/kg, sc), L-dopa (25mg/kg, sc) plus benserazide (12.5mg/kg, sc), alpha-methyl-p-tyrosine (50mg/kg, ip) plus L-dopa (25mg/kg, sc) and pargyline (50mg/kg, ip) significantly attenuated the antinociceptive effect of quinine (50mg/kg, ip), while DOPS (4mg/kg, ip) did not affect quinine antinociception. 4. Pimozide (4mg/kg, ip), L-sulpiride (40mg/kg, ip), SCH 23390 (0.2mg/kg, sc) and alpha-methyl-p-tyrosine (50mg/kg, ip) effectively potentiated the antinociceptive effects of quinine (50mg/kg, ip). 5. Pimozide (4mg/kg, ip) also antagonised the antagonistic effect of d-amphetamine (4mg/kg, ip) on the antinociceptive effect of quinine (50mg/kg, ip). 6. These data indicate that quinine elicited antinociception dose dependently. Furthermore, the influence of pimozide, L-sulpiride and SCH 23390 on quinine antinociception suggests the involvement of dopaminergic mechanisms.

Vettore Embedding

[-0.000853343, 0.0136958165, 0.0019888924, 0.04266992, -0.06734563, ... ]

Dimensioni 768 dim
Creato il 31/03/2026 15:19
Model

[-0.000853343, 0.0136958165, 0.0019888924, 0.04266992, -0.06734563, -0.013776187, -0.013821073, 0.0065805614, 0.02532435, -0.020776736, 0.0022541175, -0.0571228, 0.055283435, 0.04583426, 0.0058293045, 0.018223066, 0.07499648, 0.05231115, 0.009616915, -0.034186922, 0.021595089, 0.047892887, 0.0270898, 0.045414973, 0.0031940895, 0.033073932, 0.02011139, 0.0505903, -0.017316757, -0.06174507, -0.020870296, -0.045623403, 0.06902863, -0.008867936, -0.02970317, 0.049892474, 0.08023329, -0.002326871, 0.07138207, -0.07188654, 0.022681827, 0.0029717174, 0.005628144, 0.038018152, 0.021389019, -0.055111922, -0.024078427, -0.013221342, -0.033932354, -0.015357511, -0.034627832, -0.035208505, 0.011065627, 0.03039178, -0.038073752, 0.04302446, -0.0051099905, 0.044834726, -0.008782981, 0.0047906036, 0.02889904, -0.018561354, -0.030012242, 0.01754112, 0.06899924, -0.030189032, -0.032874558, -0.032096144, 0.063189, 0.07891685, -0.03838803, -0.055009324, -0.012491955, -0.0105932895, 0.12478883, -0.071183614, -0.017985387, 0.01255395, 0.004841097, 0.036825836, 0.017557867, 0.04171743, -0.011836091, -0.05916917, 0.086932175, -0.033125736, -0.021225085, 0.020235285, 0.011267831, -0.07460674, 0.01188946, 0.049238935, 0.0062006256, -0.031664416, -0.059534375, -0.004129361, 0.057662617, 0.020014768, -0.039127488, 0.069408946, 0.03795814, -0.056452416, -0.000554603, 0.04736108, -0.033557493, -0.045100566, 0.019916793, -0.048289392, -0.007979441, 0.04042647, -0.008919677, 0.00635721, 0.014877698, -0.01829762, 0.014438096, -0.014282079, 0.04231848, 0.032349817, -0.0039022912, -0.03284735, 0.022958511, 0.060969148, -0.0058462094, -0.019128194, -0.017960887, 0.021509476, -0.02966272, 0.0433851, -0.03190531, -0.08276297, 0.017924387, 0.00023799382, 0.039383907, 0.02421001, -0.10323538, 0.046670362, 0.02634566, -0.018578129, 0.037715323, 0.0060106097, 0.023005418, -0.0095825875, -0.00072169123, -0.048559625, 0.05535395, -0.0015543717, -0.03567507, -0.047440454, 0.026400747, 0.05810308, 0.0016562592, 0.036380768, 0.016041212, -0.0023270634, -0.016764574, 0.059132878, 0.0038292676, 0.031038871, -0.014262441, -0.0064894822, 0.024270415, -0.009241796, -0.016081223, -0.023038302, -0.03337167, 0.039189912, -0.010233777, 0.026135836, 0.011043751, 0.035216436, 0.026917057, -0.055357974, -0.01342391, 0.002085726, 0.024743218, -0.04951164, 0.050085977, -0.0014467456, -0.0098376395, 0.07384388, -0.039022878, -0.013584117, 0.009492439, 0.027708005, -0.06368588, 0.021289915, -0.04761272, 0.01824962, -0.1026523, -0.048680417, -0.00569836, 0.022739567, -0.012197659, 0.07693998, 0.015887596, -0.002051701, 0.03922065, -0.04288077, -0.0049605155, 0.083650924, -0.009830182, 0.042437263, -0.019433264, -0.0032607187, -0.04902493, -0.059761655, -0.07226198, -0.03008656, -0.028267235, -0.019845016, -0.033706825, -0.0031608245, -0.038071573, 0.0085655805, -0.0028801204, -0.03662982, -0.052474827, 0.03640041, -0.032103706, 0.032578915, -0.00722178, -0.02130703, 0.0064960653, 0.018545268, -0.0160026, 0.0017570397, -0.0008878735, 0.060896248, 0.052342564, -0.049264822, -0.009605176, -0.02791656, 0.06361191, 0.009236147, -0.04278929, -0.0024720968, -0.017477896, 0.0279197, -0.03863672, -0.014248333, 0.01843256, 0.032061376, -0.067144856, 0.08134148, 0.07567201, 0.029864082, 0.021169484, -0.037542548, -0.0070231273, 0.025417704, -0.06561257, 0.03147827, 0.045080002, 0.029473156, -0.004542719, 0.053089608, 0.0272319, 0.016897231, -0.027026204, -0.042859286, -0.03438932, -0.034686916, -0.010243137, 0.01153088, 0.032307584, 0.018088473, 0.046340935, -0.0024614036, 0.027020765, 0.021751506, 0.021728447, 0.01582053, 0.014589267, 0.023711136, 0.017741123, 0.023643501, 0.05569332, -0.041354325, 0.036945496, 0.026061503, 0.0072999345, 0.03474487, -0.031206295, 0.017106324, 0.02687692, 0.03258177, -0.035925597, -0.0036428673, -0.037959784, 0.07005543, 0.0054089585, 0.008565718, 0.02742912, 0.020808855, 0.013746296, 0.007944447, -0.03317109, -0.010847127, -0.023682714, 0.028402057, 0.025786754, -0.028236859, 0.04083963, -0.024187248, 0.026497263, 0.0019004922, -0.062473014, 0.045770276, -0.04826976, -0.001271351, 0.012467927, 0.02509881, -0.048866924, 0.06862483, 0.012635751, -0.017552877, 0.016958479, -0.0027581293, -0.007987562, 0.010579267, 0.023144051, 0.008880749, 0.040896434, 0.013889029, -0.009714843, -0.0064548086, 0.056049872, 0.010135723, -0.014095902, 0.004396244, 0.014536789, -0.048783492, 0.052585725, 0.06233432, -0.050079715, -0.038825646, -0.0056452123, -0.023688933, 0.047646567, 0.0029497717, 0.0107241655, -0.01743527, 0.0056713894, 0.039978094, -0.059223343, -0.040436585, 0.033105627, 0.010819613, 0.0003283501, 0.00563403, 0.013231812, -0.023114778, 0.04824852, -0.008383082, -0.0453927, -0.025991894, 0.055175826, 0.028589528, -0.032362036, 0.042200204, 0.012995218, 0.023171626, 0.04466436, -0.02541624, 0.0040177526, 0.0031886208, 0.03856216, 0.043822262, -0.03600536, 0.026551513, -0.0025080221, 0.0016477412, 0.020042134, 0.018408675, 0.008805481, 0.004896819, -0.018667435, -0.018244514, 0.0393526, 0.006628304, 0.025784224, 0.003260409, 0.027931524, -0.0073435223, -0.006643952, 0.000641666, 0.00481229, 0.041665517, -0.02156327, 0.008498648, -0.016769672, 0.0030070406, 0.006971763, -0.008642916, -0.0019764947, 0.0064847013, -0.017973531, -0.025147142, 0.021827387, 0.019905128, 0.013276196, -0.0002786296, -0.03645717, 0.035994124, 0.017688235, -0.030039389, 1.8253624e-05, -0.037181646, -0.04728708, 0.007862163, 0.013412165, 0.033527214, -0.03278475, 0.022756621, -0.0026392832, -0.057069015, 0.0307834, 0.07156854, -0.015209267, 0.025578022, 0.03369392, -0.013114453, -0.041556634, -0.019939972, -0.001366391, -0.017629666, -0.030231085, -0.06970826, -0.07883387, -0.037432827, -0.022356577, 0.017253734, 0.054570515, -0.011498855, -0.03157248, -0.07978567, -0.041086014, -0.00856295, -0.0029890966, -0.009906524, -0.02464186, -0.045737453, -0.044837106, -0.039503057, 0.022386763, -0.014535851, 0.007950471, -0.022051776, -0.057387415, 0.05474756, 0.040781587, -0.004828739, -0.017178118, 0.0032399795, 0.06483048, -0.009237578, -0.017072357, -0.0007889062, -0.01902731, 0.0018520878, 0.0100683635, 0.04384669, 0.019732757, 0.07736782, -0.018800085, -0.034976866, 0.011256347, -0.028902374, 0.016028576, 0.08372411, 0.0049908687, 0.033947293, -0.003051973, -0.048970584, -0.022811126, -0.021125745, 0.049089894, 0.04542329, -0.03310668, 0.030248934, -0.04340985, -0.0065533496, -0.01905873, 0.027663508, -0.0666635, 0.08003387, 0.008363389, 0.0028010858, -0.04328065, -0.004310226, -0.004027647, 0.03951293, -0.039501563, -0.0014933503, 0.015322816, -0.061274324, 0.0414682, 0.024785092, -0.04404132, -0.06786197, -0.010000001, 0.014505204, 0.09024079, 0.031160064, -0.0059596235, -0.030893926, 0.046042316, -0.013987331, 0.021604227, 0.032437127, -0.036840025, -0.024511375, 0.010367373, -0.0595635, 0.06815626, 0.050487056, -0.013577099, 0.0059278277, -0.025364079, 0.05515189, -0.02192112, -0.04975068, 0.072109275, 0.030616354, 0.05198927, -0.012727988, -0.022832239, 0.06884948, 0.0103702275, -0.00084629713, -0.049392447, -0.016699659, 0.02456356, 0.03949004, -0.053308766, -0.06435771, 0.017304951, -0.04210193, -0.025393112, -0.05445809, -0.029269058, -0.024609549, -0.029817583, 0.0076786554, 0.059804175, -0.03583839, 0.010710313, 0.0042116437, -0.026878774, 0.033759564, 0.09572759, 0.14277363, 0.03133012, -0.06779373, -0.015876135, 0.011644681, 0.013370625, -0.013348611, -0.060166944, 0.015603038, 0.058691587, -0.0060058087, -0.01216114, -0.06456626, 0.075462386, -0.0018776513, 0.013743196, -0.0018845879, 0.048335347, 0.0015389994, -0.0039019783, 0.03544489, -0.03941037, -0.05057573, 0.049616218, 0.0023648618, -0.025860308, -0.022578217, -0.056198757, 0.075225726, 0.0104567595, -0.02180726, -0.044233944, 0.0043403185, -0.040656887, -0.014291525, 0.041498464, 0.06485882, -0.025193788, -0.04150921, -0.008434786, 0.025763154, -0.010094457, 0.001718277, -0.07003611, -0.0039451434, -0.01450706, 0.010358947, -0.012400294, 0.008585251, 0.027496425, 0.031140814, -0.015506007, 0.011430967, 0.010034961, 0.034142226, -0.026214698, -0.020952715, -0.032935742, 0.059414838, 0.00061233697, 0.018270243, 0.0005080293, -0.003963602, -0.03560037, 0.0002649888, -0.027215108, 0.0075505264, -0.06984579, -0.05560698, 0.04300893, 0.0151808355, -0.0257557, 0.027775591, 0.0015920093, 0.0144742355, -0.031386882, 0.042348627, 0.004059998, -0.015978154, -0.008131669, 0.0074663744, 0.02687306, -0.03651606, 0.011869593, 0.023967907, -0.025055634, -0.03358669, -0.032704927, 0.036263127, 0.0060565765, 0.00080946356, 0.008990172, 0.008585109, 0.040154874, 0.02598047, -0.0149542745, 0.010577819, 0.038232177, 0.030428639, 0.03367098, 0.030815383, -0.007110595, -0.0015389806, -0.009292962, 0.048340265, 0.008636335, -0.023958905, 0.044205125, -0.003028496, 0.020996798, -0.04502571, -0.0038068236, 0.045229133, 0.030956572, 0.038661364, 0.041966017, 0.05312359, 0.015805772, -0.042061053, 0.017628338, 0.0015450964, -0.037633978, -0.018881945, -0.012417289, 0.00540105, -0.01973057, -0.003612785, 0.0029308004, -0.024027802, 0.030122748, 0.054364573, 0.026031349, 0.0021730864, 0.06851567, -0.022999652, 0.04808301, -0.029203031, 0.02459085, 0.021927146, -0.020040832, 0.021682795, 0.03202989, -0.07570148, 0.03884541, -0.04221541, 0.009632789, -0.014643605, -0.024823453, -0.012482289, 0.08824098, 0.06048691, 0.045455772, -0.04720226, -0.016613454, 0.04848723, 0.023625074, 0.037659366, -0.003345284, 0.01403016, -0.0037131968, 0.037093863, -0.0061469795, 0.087048575, 0.017736318, 0.05807176, 0.035760228, 0.0073174727, -0.059368536, -0.034427382, -0.029897416, 0.011592017, -0.014903963, 0.045371138, 0.06360942, -0.018631479, -0.0036648943, 0.031663265, -0.050131094, 0.03279752, -0.023949541, -0.0013161612, 0.040145863, -0.0029441505, 0.01886683, 0.07724021, -0.057375956, 0.03663406, 0.009903486, -0.028973484, -0.023732848, -0.05091061, -0.009820561, 0.07317198, -0.00031283847, -0.0027137022, 0.017548218, 0.07434759, 4.2627078e-05, -0.0032413218, -0.058330853, -0.023843827, 0.014208715, 0.014254868, 0.008757291, 0.022147259, -0.016833723, 0.012642856, -0.067045085, -0.031853344, -0.008803717, -0.100390404, -0.04458532, 0.021510156, -0.04183662, 0.044865288, 0.0032497467, 0.037648145]