Documento #370

Processato

Contenuto Testuale

Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2.
Highly potent CCR3 antagonists have been developed from a previously reported series of phenylalanine ester-based leads. Solution-phase, parallel synthesis optimization was utilized to identify highly potent, functional CCR3 antagonists.

Vettore Embedding

[-0.06823753, 0.06429794, -0.014038884, 0.014836404, -0.033298615, ... ]

Dimensioni 768 dim
Creato il 31/03/2026 15:19
Model

[-0.06823753, 0.06429794, -0.014038884, 0.014836404, -0.033298615, 0.011971644, -0.04040491, 0.013433348, 0.027942188, -0.05523733, -0.05120547, -0.041366737, -0.05846843, -0.024646236, -0.05039856, -0.0069996607, 0.07401801, 0.06626267, 0.036693305, 0.0062241503, 0.033511825, -0.018419502, 0.04355927, 0.0025706247, -0.018154064, 0.027502581, 0.075291865, -0.0188016, -0.0143098375, -0.016721075, 0.021900028, -0.022425469, 0.06698582, -0.008438225, 0.018348325, -0.006352767, -0.009099194, 0.04406792, 0.05751362, -0.050784595, -0.046134148, 0.011664502, 0.018525394, 0.000832156, 0.06306486, -0.017552376, -0.008439877, -0.018013082, -0.034225132, -0.008837375, 0.0038398195, -0.030878382, -0.03144796, 0.012017422, -0.012664154, 0.022145085, -0.0843247, 0.032339364, 0.0038473334, 0.020547923, -0.051503636, -0.02974891, -0.077194594, -0.05790272, 0.050915904, 0.06290332, -0.053626925, 0.021757098, -0.00833571, 0.1461854, 0.006417382, -0.07161217, -0.043317944, -0.035845187, 0.10692805, -0.019665929, -0.026338067, 0.039546728, -0.0312806, 0.042381026, -0.026544986, 0.058015767, 0.01905902, 0.04265787, 0.06181235, -0.032868244, -0.021235602, 0.04064188, 0.015108688, -0.0066187256, 0.04497174, 0.047126815, -0.044190515, 0.0015760907, -0.041303717, 0.005226056, -0.001558929, -0.044439685, 0.02144727, 0.00787361, -0.0027934425, -0.057836533, 0.0077947704, 0.07956169, -0.03930945, 0.010240783, 0.05447143, 0.012481264, 0.03127273, -0.013330086, 0.018534543, 0.041303333, 0.02290932, -0.040429037, 0.009043418, 0.030598706, 0.02242669, 0.04989509, 0.029360857, 0.025386246, 0.05098895, 0.01024518, 0.012919769, 0.009350155, -0.0045793983, -0.003306611, 0.039024174, -0.031488154, 0.016031187, -0.07490613, 0.016420538, -0.007916776, 0.008162598, -0.021300396, -0.10060402, -0.036611777, 0.016625665, 0.016354866, 0.021614786, 0.02295751, 0.0490156, -0.028144212, 0.014036529, -0.07202551, 0.045681857, 0.012864028, -0.069509216, -0.049562067, -0.0011207821, 0.02572015, -0.037000913, 0.00914523, 0.0041565876, -0.029921573, -0.047956377, -0.011656421, 0.025282996, -0.035792667, 0.04563166, 0.018596824, 0.011526206, 0.00063430093, 0.04102231, 0.01502063, 0.0031241623, 0.062978536, 0.0056174793, 0.06785582, 0.030272268, 0.041025266, 0.0045134504, -0.053802285, -0.050819036, 0.012482749, -0.042759754, -0.033050567, 0.029848024, -0.0037538973, -0.015424871, -0.0039948444, -0.038137514, 0.03350926, -0.012162481, -0.0066648433, -0.054996178, 0.023699718, -0.043990966, 0.031482894, 0.055916537, 0.02697546, 0.059241876, -0.0014211801, 0.021333728, -0.009663793, 0.062025562, 0.025327599, 0.06017656, -0.02613303, -0.023513133, -0.00825522, -0.03876296, 0.034588885, -0.029968176, 0.013504869, 0.015398294, 0.006270608, -0.019800147, 0.008692031, -0.044955757, 0.018640636, -0.007986783, -0.047449328, -0.05177839, 0.022635832, 0.039494842, 0.0041893143, -0.008723245, 0.052931443, -0.044181205, 0.031857647, 0.008936561, 0.047949284, -0.042696133, -0.018350618, 0.03235029, 0.038608458, -0.022487605, 0.008716322, 0.03678133, 0.04037046, -0.021201149, 0.022488633, 0.0014771906, 0.025589284, -0.029060295, 0.054031767, -0.022811167, -0.007828572, -0.0032981671, 0.02604159, 0.0126337735, -0.036693502, 0.017831415, 0.048973158, 0.001349806, 0.02541239, 0.043171354, -0.006908357, 0.0072118747, 0.04971211, -0.05851381, -0.0025912984, 0.074239865, -0.040522303, 0.054786127, 0.02018798, 0.01752909, -0.030435568, 0.05042543, -0.029986922, 0.013999476, -0.034932718, -0.016628042, -0.036447734, 0.030154187, -0.019011658, -0.029624451, 0.060659714, 0.062617995, 0.04668277, 0.017901598, 0.02306865, -0.023765812, 0.032545418, 0.006614931, 0.05664919, -0.0022603467, 0.025223808, 0.071439594, 0.0034838568, 0.02718187, 0.020479461, -0.0558691, 0.027579619, 0.011833773, 0.013968804, -0.021051737, 0.044946685, -0.020590387, 0.060058374, 0.05650077, -0.0077483947, 0.05395187, 0.032804366, -0.010718134, 0.0047890167, -0.06918742, 0.03180835, -0.034281988, 0.045999277, 0.084362544, -0.08002765, 0.0015232754, -0.0684388, -0.006234194, -0.0009132883, -0.017067568, 0.0036569855, -0.026255015, 0.025832636, 0.0010999981, -0.004813775, -0.025765285, -0.018919667, 0.035318747, -0.029600494, 0.04377301, -0.014398252, 0.012878354, -0.00043540585, 0.02594939, -0.004110295, -0.0640374, -0.01891886, 0.013602089, -0.05600781, 0.055675883, 0.012495771, 0.010874629, -0.02404415, 0.023529174, 0.0006292698, 0.05832465, 0.05211946, 0.06707074, 0.025594749, 0.031367246, 0.058187045, -0.025295354, -0.007311867, -0.025205975, -0.008602587, 0.01966424, -0.02268146, -0.012210403, -0.011468418, 0.021768106, -0.014603875, -0.0021878122, 0.049886547, 0.004174531, 0.0016247223, -0.036124893, 0.017324997, -0.10122066, -0.025134021, -0.013097128, -0.008267116, 0.008388631, 0.012208477, 0.005423531, -0.03422898, 0.038609706, 0.031783734, 0.023303824, -0.030160401, 0.0075426004, -0.010846506, -0.029004011, -0.011538058, 0.018762982, 0.08228651, 0.033327162, 0.0002965277, 0.0021238686, -0.010582268, -0.044520747, -0.04580245, 0.007884915, -0.00953295, 0.028475538, -0.013230331, 0.022593463, 0.0119680185, 0.02793675, -0.0015504063, -0.023705106, 0.06647735, 0.040896926, 0.053341016, -0.021773791, 0.035628546, 0.036602154, -0.06176293, -0.05067135, 0.025549028, 0.005704875, 0.005312471, -0.025184125, -0.022516713, 0.007718889, -0.025093826, -0.028494412, 0.021995097, 0.029091489, -0.021814028, 0.007995534, -0.011378959, 0.020967023, 0.028231833, 0.08026649, -0.040622834, -0.046088737, -0.07367845, -0.0020090144, -0.076467864, -0.018153416, -0.009633319, -0.0677136, 0.028073315, 0.05534645, 0.018344464, 0.028873617, -0.038793497, -0.0352522, -0.037008036, -0.009683073, -0.0035661997, -0.03369948, -0.0585532, 0.024372663, 0.027168702, 0.012636267, 0.03191299, -0.019293852, -0.04700567, -0.053746823, 0.08191594, 0.015357349, -0.01260266, -0.008985179, -0.050066672, 0.00014464959, 0.033172213, 0.02151622, -0.04531539, -0.028525252, -0.012966283, -0.02071821, 0.031842366, 0.015398664, -0.01475461, -0.059860427, 0.042631224, 0.026464105, 0.02548312, 0.03854137, 0.0054884963, -0.054955404, -0.013400701, -0.0055757295, -0.0051385835, 0.0114669325, -0.039295517, -0.04403906, 0.03052234, 0.044672117, -0.046542704, -0.009847581, 0.0112208, -0.043127883, 0.01862828, 0.017614579, -0.011743023, 0.02082364, 0.035096005, 0.04628516, -0.025877273, -0.0030320121, 0.0032628651, -0.05535928, 0.092820175, 0.008751604, -0.015567051, -0.047455713, 0.06492217, -0.022635648, 0.028393125, -0.034851193, -0.024762679, 0.01685661, 0.01649656, -0.036954235, -0.014847283, 0.029136978, -0.0357551, 0.03205124, -0.05224857, -0.036920514, -0.07463531, -0.008276968, -0.014087149, 0.058482476, 0.010045644, -0.0189413, -0.04255417, 0.03919016, -0.014316847, -0.054370504, 0.032968476, 0.029462228, -0.00015662567, 0.02099429, -0.0063054147, 0.000523748, 0.06985497, -0.033662073, -0.07758551, 0.020839054, -0.04527904, -0.04131767, -0.013658189, -0.022459239, -0.0069956216, 0.023796085, -0.02101696, 0.0064599277, 0.027949791, 0.0076016793, -0.002189364, 0.0028707464, 0.003460844, 0.024413234, 0.020877443, -0.0035867947, -0.061138228, 0.036205813, -0.039132047, 0.013902612, 0.013142298, -0.007799735, -0.01732106, -0.00170957, 0.0036199016, 0.010772183, -0.049771376, 0.0024543954, 0.022628402, -0.028077127, -0.04598793, 0.064647965, 0.060603235, 0.061774693, 0.01848951, -0.06456851, 0.032484192, 0.017380504, 0.034925353, -0.03423801, -0.04727798, 0.08140385, -0.06882183, -0.013543909, 0.0005564912, 0.07342735, 0.012586175, 0.0022189245, 0.009265633, 0.027231846, 0.040897, 0.0044776895, 0.007038779, 0.02931051, 0.00928778, -0.0014677726, 0.045686588, -0.0855645, -0.09625912, 0.018579083, -0.013104801, -0.031194465, -0.042328004, 0.024228536, -0.020363025, -0.018499523, -0.045840934, 0.0013861374, 0.018899588, -0.013796835, 0.04083714, -0.049326465, -0.0073637664, -0.038500756, -0.012956062, -0.0091943145, -0.006360742, 0.047068372, -0.004518304, -0.014511938, 0.0010744932, 0.036522225, 0.0052902936, 0.050667394, 0.04427554, 0.030482996, -0.027397199, 0.06724443, -0.061559867, -0.0194571, 0.0028193293, 0.024838002, -0.026745899, 0.027355367, -0.07099832, -0.016696535, 0.028792951, -0.03907272, -0.02933024, -0.00035378683, 0.030547082, 0.039076887, 0.001789402, 0.026942516, 0.03264957, -0.0038915304, -0.043330006, 0.02086053, 0.0004954968, -0.021030853, 0.029365825, 0.011761199, 0.03125372, -0.015344023, 0.002189903, 0.033059686, -0.01100388, -0.0077128885, -0.052160285, -0.018422805, -0.00958473, 0.0011489533, -0.004149018, -0.03302186, -0.046531986, -0.03545888, -0.015891658, -0.004510263, -0.04547181, -0.029073726, 0.06478221, -0.046621237, 0.030508848, -0.01700964, -0.022908702, -0.052696783, 0.023096254, 0.018517291, 0.031207927, 0.06698548, 0.02104984, 0.01706494, 0.008882032, 0.020949969, 0.06810172, 0.051075686, 0.022507353, -0.028431108, -0.049780715, -0.026353136, -0.08816739, -0.04824614, -0.010090825, -0.0052620037, -0.0081299655, -0.020806175, 0.01340777, -0.015916945, 0.021479791, -0.030611126, -0.03938452, -0.026112571, 0.042827558, 0.013128395, 0.03787562, 0.023598531, 0.058553983, -0.000653969, -0.0073355115, 0.03535424, 0.0268607, -0.029833745, 0.018043403, 0.06496634, -0.055047378, 0.009692152, 0.017251233, 0.0014524275, -0.052481774, 0.05696626, 0.0031809907, -0.015921451, -0.004037503, 0.020047873, 0.04780067, 0.012393716, 0.051977903, 0.010376908, -0.008695868, 0.024997715, 0.031260718, -0.049027666, 0.052234106, -0.017588358, 0.07110544, 0.0013454645, 0.027034856, 0.06989074, -0.0538049, -0.03748613, -0.039303828, -0.05777993, 0.05692341, 0.06138138, 0.0041600717, 0.042633615, -0.0029898472, -0.012116822, 0.018161977, -0.10389814, -0.04023196, -0.012367159, -0.017708303, -0.0112289125, -0.026494127, -0.0075601055, 0.023381092, -0.0434296, -0.011908836, 0.015611662, -0.061683793, -0.018162647, -0.013584201, 0.026866073, 0.05012946, 0.022668064, -0.029230116, -0.05004519, 0.018830648, -0.015557681, -0.04103626, -0.022381302, 0.00917512, -0.011436475, 0.044479422, -0.018198363, 0.010152737, -0.016894888, -0.051457003, 0.011606794, -0.04320643, 0.017592298, -0.044473927, 0.03862513, 0.012118288, -0.011712837, 0.011021323, -0.03799823, -0.012890322]