Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1517

MIN ACTIVATION

0.0

Details List

#2023 Feature 2023

#1328 Feature 1328

#2338 Feature 2338

#2085 Feature 2085

#2528 Feature 2528

#2903 Feature 2903

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#2414 Feature 2414

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#1233 Feature 1233

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#1606 Feature 1606

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#1388 Feature 1388

#1815 Feature 1815

#1203 Feature 1203

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#2292 Feature 2292

#1181 Feature 1181

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#1709 Feature 1709

#2285 Feature 2285

#3052 Feature 3052

#365 Feature 365

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#2279 Feature 2279

#1792 Metastatic Cancer

#1996 Feature 1996

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#1096 Feature 1096

#1337 Feature 1337

#260 Feature 260

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#2134 Feature 2134

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#3028 Feature 3028

#1834 Feature 1834

#2059 Feature 2059

#1763 Feature 1763

#1694 Feature 1694

#708 Drug Resistance Mechanisms in Cancer

#1383 Feature 1383

#1860 Feature 1860

#2635 Feature 2635

#495 Feature 495

#2340 Feature 2340

#1011 Feature 1011

#2581 Feature 2581

#1069 Feature 1069

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#2500 Feature 2500

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#1858 Feature 1858

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#404 Interactions and Mechanisms

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#1506 Justification/Rationale for Actions

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#1430 Feature 1430

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#1716 Feature 1716

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#2045 Feature 2045

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#2250 Feature 2250

#2171 Molecular and Cellular Biological Processes

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#968 Feature 968

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#1805 Feature 1805

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#2209 Feature 2209

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#2620 Feature 2620

#2988 Feature 2988

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#2254 Feature 2254

#474 Surgical Procedures & Gastrointestinal Issues

#180 Feature 180

#1756 Feature 1756

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#2033 Feature 2033

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#3070 Spiritual and Holistic Care in Healthcare

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#1244 Feature 1244

#1580 Feature 1580

#3064 Surgical Complications and Physiological Stress

#2368 Feature 2368

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#1220 Feature 1220

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#929 Feature 929

#936 Feature 936

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Document Content

Cathepsin S, a new pruritus biomarker in clinical dandruff/seborrhoeic dermatitis evaluation.
Dandruff/seborrhoeic dermatitis (D/SD) is characterized by Malassezia colonization, impaired barrier function with subsequent inflammation, resulting in dandruff and itching. Histamine is one of the biomarkers of pruritus now widely used in treatment efficacy trials. The exact mechanism leading to histamine release and pruritus is not yet clear. However, it could involve cathepsin S, an activator of proteinase-activated receptor 2 (PAR2). The purpose of this study was to evaluate the levels of cathepsin S, PAR2 and histamine in patients with D/SD compared with healthy subjects through non-invasive sampling of the scalp and to correlate those markers with D/SD clinical parameters. A significant increase in the three biological markers was observed in the D/SD group versus healthy subjects, and those markers were correlated with clinical parameters. In conclusion, cathepsin S could be a potential marker of pruritus in D/SD and could help assessing the effect of treatments.

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