Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1494

MIN ACTIVATION

0.0

Details List

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#708 Drug Resistance Mechanisms in Cancer

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#2171 Molecular and Cellular Biological Processes

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#23 Neuronal Circuitry and Cellular Processes

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#351 Nanomaterial Synthesis and Properties

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#2260 Historical Context & Development

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#374 Medical Imaging and Oncology

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Document Content

Cisplatin inhibits in vitro translation by preventing the formation of complete initiation complex.
We previously reported that mRNA loses the ability to direct in vitro peptide synthesis after incubation with cisplatin. The present study was designed to determine the step in translation that is affected. The rates of translation reactions inhibited by cisplatin were biphasic, having an initial rate comparable to that of the uninhibited reaction before decreasing. Analysis of cisplatin-inhibited reactions in sucrose density gradients showed a decrease in polyribosome formation. These results are consistent with an inhibition of the initiation step of protein synthesis. Individual steps in initiation were tested by analyzing the formation of ribosomal subunits in sucrose gradients that resolve the incomplete complexes. Cisplatin caused an accumulation of 48 S particles accompanied by a decreased amount of completed 80 S initiation complexes. Similar results were obtained in experiments utilizing radiolabeled methionine or mRNA. We conclude that cisplatin blocks the initiation of translation by preventing the joining of the 60 S ribosomal subunit to the 48 S preinitiation subunit.

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