Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1546

MIN ACTIVATION

0.0

Details List

#359 Feature 359

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#318 Feature 318

#831 Feature 831

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#2377 Feature 2377

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#1460 Feature 1460

#1369 Feature 1369

#3064 Surgical Complications and Physiological Stress

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#714 Feature 714

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#673 Feature 673

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#1792 Metastatic Cancer

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#1581 Feature 1581

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#1565 Feature 1565

#357 Feature 357

#351 Nanomaterial Synthesis and Properties

#160 Feature 160

#803 Feature 803

#1050 Feature 1050

#2545 Feature 2545

#1821 Feature 1821

#2929 Feature 2929

#474 Surgical Procedures & Gastrointestinal Issues

#2303 Feature 2303

#2614 Feature #2614

#2117 Feature 2117

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#2713 Feature 2713

#3020 Feature 3020

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#1456 Feature 1456

#166 Feature 166

#1405 Feature 1405

#2221 Feature 2221

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#1116 Feature 1116

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#1219 Feature 1219

#2444 Feature 2444

#992 Feature 992

#2605 Feature 2605

#2108 Feature 2108

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#1315 Feature 1315

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#305 Feature 305

#3026 Feature 3026

#1293 Feature 1293

#2223 Feature 2223

#1740 Feature 1740

#852 Feature 852

#229 Feature 229

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#2513 Feature 2513

#1202 Feature 1202

#1397 Feature 1397

#2871 Feature 2871

#1881 Feature 1881

#923 Feature 923

#1779 Feature 1779

#932 Feature 932

#892 Feature 892

#2836 Feature 2836

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Document Content

Is exocrine pancreatic insufficiency in adult coeliac disease a cause of persisting symptoms?
Patients with coeliac disease may have diarrhoea despite being on a gluten-free diet. To assess whether exocrine pancreatic insufficiency causes persisting symptoms compared with controls, we determined whether pancreatic enzyme supplementation provided symptomatic benefit in coeliac patients with chronic diarrhoea. Patients (n = 259) were subdivided into four groups: (a) new coeliac disease (n = 57), (b) coeliac disease patients on a gluten-free diet without gastrointestinal symptoms (n = 86), (c) coeliac disease patients on a gluten-free diet with chronic diarrhoea (n = 66) and (d) patients with chronic diarrhoea without coeliac disease (n = 50). Stool frequency and weight, before and after treatment with pancreatic enzyme supplementation were recorded. The prevalence of a low faecal elastase-1 within the groups was: group (A) six of 57 (11%), group (B) five of 86 (6%), group (C) 20 of 66 (30%) and group (D) two of 50 (4%). Low faecal elastase-1 was more frequent in coeliac disease patients with chronic diarrhoea vs. other subgroups of coeliac disease (P < or = 0.0001) and controls (P < or = 0.0003). In 18 of 20 stool frequency reduced following pancreatic enzyme supplementation from four per day to one (P < or = 0.001). No weight increase (P = 0.3) was observed. Low faecal elastase is common in patients with coeliac disease and chronic diarrhoea, suggesting exocrine pancreatic insufficiency. In this group of patients, pancreatic enzyme supplementation may provide symptomatic benefit.

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