Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1555

MIN ACTIVATION

0.0

Details List

#1541 Feature 1541

#244 Feature 244

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#2343 Feature 2343

#306 Feature 306

#2331 Feature 2331

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#2232 Medical Case Reports & Cancer Research

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#1503 Feature 1503

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#2027 Feature 2027

#2266 Feature 2266

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#3064 Surgical Complications and Physiological Stress

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#1506 Justification/Rationale for Actions

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#2524 Feature 2524

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#830 Feature 830

#2752 Feature 2752

#1020 Feature 1020

#1576 Feature 1576

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Document Content

Lipid metabolism in the inflammatory lesion of a mouse model of delayed type hypersensitivity. I. Increased acylCoA:cholesterol acyltransferase activity as an integral component of the inflammatory response.
Lipid metabolism was studied in a normal model of delayed type hypersensitivity to methylated bovine serum albumin (MBSA). Following initial sensitization to a single injection of MBSA, MBSA-soaked millipore filter disks (10 mm diam) were implanted in subcutaneous pockets and the course of development and the resolution of the inflammatory lesions were followed biochemically for 35 days. Of particular interest were our observations that the activity of the cholesterol esterifying enzyme, which is attributed to acyl-CoA:cholesterol acyltransferase (ACAT; EC 2.3.1.26) was increased up to 38-fold in the developing inflammatory lesion and represented the single most dramatic alteration in lipid metabolism to occur. As the lesions began to show histological evidence of resolving (between 21 and 35 days), ACAT activity declined toward basal levels. The data suggest the possibility that the ACAT reaction is an important component of the inflammatory response and, as such, offers the possibility of a novel approach to controlling the inflammatory process through ACAT inhibition.

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