Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1501

MIN ACTIVATION

0.0

Details List

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#708 Drug Resistance Mechanisms in Cancer

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#1506 Justification/Rationale for Actions

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#655 Feature 655

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#2232 Medical Case Reports & Cancer Research

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#474 Surgical Procedures & Gastrointestinal Issues

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#1311 Molecular Mechanisms and Biological Processes

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#2924 Feature 2924

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#2016 Feature 2016

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#3016 Feature 3016

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#3011 Feature 3011

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#2170 Feature 2170

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#1745 Feature 1745

#725 Feature 725

#842 Feature 842

#1095 Feature 1095

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Document Content

Catechin-loaded Eudragit microparticles for the management of diabetes: formulation, characterization and in vivo evaluation of antidiabetic efficacy.
Catechin (CT) is natural molecule proved for antidiabetic activity. Clinical application of CT is highly restricted because of its low bioavailability and ineffectiveness in in vivo conditions. Therefore, the main objective of the present investigation was to formulate CT-loaded Eudragit RS 100 microparticles and evaluated for its potential against diabetes. CT microparticles showing highest entrapment efficiency of 92.3 ± 6.5% and higher percentage yield of 63.46 ± 4.3% was selected as optimised formulation. CT microparticles treated rats showed significantly lower blood glucose, cholesterol, LDL, free fatty acid and triglyceride concentrations in comparison to pristine CT-treated rats. The glucose and lipid profiles of microparticle formulation were akin to normal rats. Moreover, CT microparticles did not produce obesity even after 60 days which is a comment side effect of antidiabetic drugs. These results indicate that the CT microparticles can be applied as potential and safe carrier for the treatment of diabetes.

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