Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1555

MIN ACTIVATION

0.0

Details List

#819 Feature 819

#1043 Feature 1043

#1340 Feature 1340

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#2780 Feature 2780

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#2614 Feature #2614

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#2280 Feature 2280

#2133 Feature 2133

#280 Feature 280

#2863 Feature 2863

#619 Feature 619

#1508 Feature 1508

#1423 Feature 1423

#374 Medical Imaging and Oncology

#1501 Feature 1501

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#2298 Feature 2298

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#273 Feature 273

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#1798 Feature 1798

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#2018 Feature 2018

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#1549 Feature 1549

#392 Feature 392

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#406 Feature 406

#527 Feature 527

#1118 Feature 1118

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#518 Feature 518

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#1739 Feature 1739

#2556 Feature 2556

#704 Feature 704

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#2493 Feature 2493

#675 Feature 675

#1497 Feature 1497

#669 Feature 669

#2437 Feature 2437

#1770 Feature 1770

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#2250 Feature 2250

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#2220 Feature 2220

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#2115 Feature 2115

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#2443 Feature 2443

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#2232 Medical Case Reports & Cancer Research

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#2840 Feature 2840

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#1217 Feature 1217

#708 Drug Resistance Mechanisms in Cancer

#2020 Feature 2020

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#724 Feature 724

#2264 Feature 2264

#2061 Feature 2061

#3064 Surgical Complications and Physiological Stress

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#1902 Feature 1902

#455 Feature 455

#602 Feature 602

#1883 Feature 1883

#2526 Feature 2526

#1452 Feature 1452

#261 Feature 261

#954 Feature 954

#238 Feature 238

#404 Interactions and Mechanisms

#290 Feature 290

#1567 Feature 1567

#3070 Spiritual and Holistic Care in Healthcare

#2647 Feature 2647

#586 Feature 586

#2827 Feature 2827

#879 Feature 879

#2816 Feature 2816

#3037 Feature 3037

#2514 Feature 2514

#385 Feature 385

#1737 Feature 1737

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#629 Feature 629

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#1624 Feature 1624

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#2999 Feature 2999

#2168 Feature 2168

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#2961 Feature 2961

#321 Feature 321

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#2511 Feature 2511

#556 Feature 556

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#780 Feature 780

#843 Feature 843

#903 Feature 903

#1826 Feature 1826

#634 Feature 634

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Document Content

Altered bile acid metabolism in primary biliary cirrhosis.
Selected aspects of bile acid metabolism were assessed in six women with primary biliary cirrhosis and varying degrees of cholestasis. Urinary bile acid excretion was markedly increased and correlated highly with serum levels. In three patients in whom urinary bile acids were separated by chromatography, the majority of urinary bile acids were monosulfated (34%, 42%, 32%) or polysulfated and/or glucuronidated (30%, 20%, 38%). The monosulfates of chenodeoxycholic acid were conjugated at either the 3 position (67%, 68%, 73%) or the 7 position (33%, 32%, 27%); similarly, the monosulfates of cholic acid were conjugated at the 3 position (65%, 58%, 68%) or the 7 position (35%, 42%, 32%). The position of sulfation was not markedly influenced by the mode of amidation with glycine or taurine. Chenodeoxycholic exchangeable pool size, turnover rate, and synthesis were measured by isotope dilution and found to be well within normal limits, despite the cholestasis. The fraction of chenodeoxycholic acid synthesis excreted in urine ranged from 9 to 48%; 4--38% of chenodeoxycholic acid synthesis was sulfated. These data indicate that the major abnormalities in bile acid metabolism in patients with cholestasis secondary to primary biliary cirrhosis are formation of sulfated bile acids in greatly increased amounts, elevation of blood levels of primary bile acids, and a shift to renal excretion as a major mechanism for bile acid elimination. Chenodeoxycholic acid synthesis continues at its usual rate despite cholestasis. Whether these changes, including the formation of 7-monosulfated bile acids, occur in other forms of cholestasis and whether either the persistance of unchanged chenodeoxycholic acid synthesis or the formation of such novel conjugates has any pathophysiological significance remain to be investigated.

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