Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1474

MIN ACTIVATION

0.0

Details List

#1802 Feature 1802

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#3064 Surgical Complications and Physiological Stress

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#675 Feature 675

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#149 Feature 149

#1663 Feature 1663

#2907 Feature 2907

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#475 Feature 475

#2250 Feature 2250

#2232 Medical Case Reports & Cancer Research

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#374 Medical Imaging and Oncology

#813 Feature 813

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#2700 Feature 2700

#2508 Feature 2508

#2572 Feature 2572

#1835 Feature 1835

#2819 Feature 2819

#739 Feature 739

#2048 Feature 2048

#708 Drug Resistance Mechanisms in Cancer

#923 Feature 923

#2968 Feature 2968

#1836 Feature 1836

#1322 Feature 1322

#2559 Feature 2559

#1534 Feature 1534

#1528 Feature 1528

#2130 Feature 2130

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#476 Feature 476

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#2282 Feature 2282

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#2589 Feature 2589

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#2073 Feature 2073

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#2059 Feature 2059

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#2956 Feature 2956

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#865 Feature 865

#1311 Molecular Mechanisms and Biological Processes

#1518 Feature 1518

#1393 Feature 1393

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#2469 Feature 2469

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#2675 Feature 2675

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#2270 Feature 2270

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#1612 Feature 1612

#289 Feature 289

#690 Feature 690

#2443 Feature 2443

#2343 Feature 2343

#2535 Feature 2535

#2676 Feature 2676

#1792 Metastatic Cancer

#1799 Feature 1799

#107 Feature 107

#254 Feature 254

#2523 Feature 2523

#1246 Feature 1246

#1028 Feature 1028

#2091 Feature 2091

#2997 Feature 2997

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#2007 Developmental Disparities & Intervention

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Document Content

Effect of ultraviolet (UV) A, UVB or ionizing radiation on the cell cycle of human melanoma cells.
One important component of the cellular response to irradiation is the activation of cell cycle checkpoints. It is known that both ultraviolet (UV) radiation and ionizing radiation (IR) can activate checkpoints at transitions from G(1) to S phase, from G(2) phase to mitosis and during DNA replication. To evaluate the effects of irradiation with different wavelengths on cell cycle alterations. p53-deficient IPC-298 melanoma cells were irradiated with 10 J cm(-2) UVA, 40 mJ cm(-2) UVB, or with 7.5 Gy IR. Cell cycle effects were then determined by DNA/5-bromodeoxyuridine dual-parameter flow cytometry. IPC-298 cells irradiated in G(1) with UVA were not arrested at the G(1)/S transition, but at the G(2)/M transition. Despite p53 deficiency, the cells showed a G(1) arrest after UVB exposure. Furthermore, IR did not affect G(1) or S phase, but induced G(2) phase arrest. Hence, the effects of UVA, but not of UVB, on the cell cycle in p53-deficient melanoma cells are comparable with those of IR. UVA and IR induce radical-mediated strand breaks and DNA lesions, and UVB essentially induces thymine dimers that lead to excision repair-related strand breaks. Different cell cycle effects may be a consequence of different types of DNA damage. The results showed that UVB-irradiated p53-deficient cells are arrested in G(1). Irradiation with the solar radiation component UVB can therefore result in a beneficial retardation of tumour promotion in human skin carrying p53-mutated cell clones.

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