Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1538

MIN ACTIVATION

0.0

Details List

#2706 Feature 2706

#1550 Feature 1550

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#23 Neuronal Circuitry and Cellular Processes

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#467 Feature 467

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#474 Surgical Procedures & Gastrointestinal Issues

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#2265 Feature 2265

#708 Drug Resistance Mechanisms in Cancer

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#2778 Hippocampal Memory and Cognitive Function

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Document Content

Drug interaction between valproic acid and meropenem: a case report.
Valproic acid and meropenam is commonly co-administrated in neurosurgical patients. Meropenem potentially decreases the valproic acid level, which may cause perioperative seizure. There has been no previous report of drug interaction between valproic acid and meropenem in Thailand. The authors report a patient who faced uncontrolled seizure after co-administrated valproic acid and meropenem. The level of valproic acid was assessed in different times after the administration of meropenem. Rapid decrease of valproic level was detected. However due to the administration of other antiepileptic agents, seizure did not develop. It is important for the physicians to recognize drug interaction between valproic acid and meropenem. Avoiding co-administration of both agents, valproic acid level monitoring and additive of other antiepileptic agents seem to be the appropriate solution.

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