Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1518

MIN ACTIVATION

0.0

Details List

#254 Feature 254

#270 Feature 270

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#2095 Feature 2095

#2400 Feature 2400

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#534 Feature 534

#865 Feature 865

#2007 Developmental Disparities & Intervention

#1607 Feature 1607

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#2260 Historical Context & Development

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#1338 Feature 1338

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#1792 Metastatic Cancer

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#2036 Feature 2036

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#905 Feature 905

#2247 Feature 2247

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#2161 Medical/Scientific Discourse with Ethical/Social Implications

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#1474 Feature 1474

#2932 Feature 2932

#2069 Feature 2069

#932 Feature 932

#1707 Feature 1707

#737 Feature 737

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Document Content

Modeling ebola virus disease transmissions with reservoir in a complex virus life ecology.
We propose a new deterministic mathematical model for the transmission dynamics of Ebola Virus Disease (EVD) in a complex Ebola virus life ecology. Our model captures as much as possible the features and patterns of the disease evolution as a three cycle transmission process in the two ways below. Firstly it involves the synergy between the epizootic phase (during which the disease circulates periodically amongst non-human primates populations and decimates them), the enzootic phase (during which the disease always remains in fruit bats population) and the epidemic phase (during which the EVD threatens and decimates human populations). Secondly it takes into account the well-known, the probable/suspected and the hypothetical transmission mechanisms (including direct and indirect routes of contamination) between and within the three different types of populations consisting of humans, animals and fruit bats. The reproduction number R0 for the full model with the environmental contamination is derived and the global asymptotic stability of the disease free equilibrium is established when R0andlt;1. It is conjectured that there exists a unique globally asymptotically stable endemic equilibrium for the full model when R0andgt;1. The role of a contaminated environment is assessed by comparing the human infected component for the sub-model without the environment with that of the full model. Similarly, the sub-model without animals on the one hand and the sub-model without bats on the other hand are studied. It is shown that bats influence more the dynamics of EVD than the animals. Global sensitivity analysis shows that the effective contact rate between humans and fruit bats and the mortality rate for bats are the most influential parameters on the latent and infected human individuals. Numerical simulations, apart from supporting the theoretical results and the existence of a unique globally asymptotically stable endemic equilibrium for the full model, suggest further that: (1) fruit bats are more important in the transmission processes and the endemicity level of EVD than animals. This is in line with biological findings which identified bats as reservoir of Ebola viruses; (2) the indirect environmental contamination is detrimental to human beings, while it is almost insignificant for the transmission in bats.

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