Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1496

MIN ACTIVATION

0.0

Details List

#997 Feature 997

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#23 Neuronal Circuitry and Cellular Processes

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#2250 Feature 2250

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#2161 Medical/Scientific Discourse with Ethical/Social Implications

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#2972 Sensory-Motor Integration

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#3070 Spiritual and Holistic Care in Healthcare

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#1391 Feature 1391

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#831 Feature 831

#1904 Feature 1904

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#2197 Feature 2197

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#1925 Feature 1925

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#2260 Historical Context & Development

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#2356 Feature 2356

#1895 Feature 1895

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Document Content

Epidermal growth factor receptor mutations in small cell lung cancer: a brief report.
Knowledge about the current status of the epidermal growth factor receptor (EGFR) has resulted in an improvement in the treatment of non-small cell lung cancer. In contrast, small cell lung cancer (SCLC) continues to frustrate clinicians with its tendency toward early metastasis and chemotherapy resistance. Recent studies have reported the EGFR mutation and its response to gefitinib treatment in SCLC. We would like to share our experience of EGFR studies on SCLC patients. Between 2004 and 2009, we prospectively collected 76 specimens from patients with SCLC at the National Taiwan University Hospital, Taiwan. These specimens included 10 computed tomography-guided biopsy specimens, 17 echo-guided aspiration specimens, 37 echo-guided biopsy specimens, 1 surgical lobectomy specimen, and 11 malignant pleural effusion specimens. Molecular genetic analysis of the specimens was conducted to detect the EGFR mutation. Among the 76 SCLC specimens we examined, 2 (2.6%) tested positive for the EGFR mutation and both were deletions in exon 19. One patient was administered gefitinib after several lines of chemotherapy but showed no treatment response. To date, only 11 EGFR mutant-positive SCLC patients, including our 2 patients, have been reported. Most of these patients were never smokers. The SCLC harboring EGFR mutation were more likely to be combined with adenocarcinoma compared with the whole SCLC population. The EGFR mutation is rare in SCLC patients. Despite the presence of the EGFR mutation, gefitinib may not be effective in treating SCLC patients.

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