Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1538

MIN ACTIVATION

0.0

Details List

#2551 Feature 2551

#1794 Feature 1794

#2823 Feature 2823

#2752 Feature 2752

#281 Feature 281

#1526 Feature 1526

#506 Feature 506

#823 Feature 823

#872 Feature 872

#1546 Feature 1546

#2423 Feature 2423

#217 Feature 217

#2825 Feature 2825

#1067 Feature 1067

#1230 Feature 1230

#1250 Feature 1250

#1707 Feature 1707

#1531 Feature 1531

#682 Feature 682

#1180 Feature 1180

#1834 Feature 1834

#2549 Feature 2549

#2374 Feature 2374

#2608 Feature 2608

#743 Feature 743

#2022 Feature 2022

#1573 Feature 1573

#858 Feature 858

#1597 Feature 1597

#1949 Feature 1949

#2175 Feature 2175

#159 Feature 159

#2333 Feature 2333

#1280 Feature 1280

#1457 Feature 1457

#1419 Feature 1419

#886 Feature 886

#1549 Feature 1549

#2735 Feature 2735

#2738 Feature 2738

#1611 Feature 1611

#2416 Feature 2416

#1339 Feature 1339

#1950 Feature 1950

#1418 Feature 1418

#500 Feature 500

#1034 Feature 1034

#2297 Feature 2297

#194 Feature 194

#3052 Feature 3052

#1903 Feature 1903

#162 Feature 162

#709 Feature 709

#2977 Feature 2977

#716 Feature 716

#2808 Feature 2808

#2188 Feature 2188

#517 Feature 517

#1085 Feature 1085

#939 Feature 939

#2714 Feature 2714

#2446 Feature 2446

#414 Feature 414

#1170 Feature 1170

#1843 Feature 1843

#2631 Feature 2631

#1115 Feature 1115

#1782 Feature 1782

#1466 Feature 1466

#2533 Feature 2533

#2414 Feature 2414

#1698 Feature 1698

#2859 Feature 2859

#1605 Feature 1605

#501 Feature 501

#491 Feature 491

#1010 Feature 1010

#576 Feature 576

#2331 Feature 2331

#2281 Feature 2281

#1143 Feature 1143

#2836 Feature 2836

#907 Feature 907

#1260 Feature 1260

#901 Feature 901

#1411 Feature 1411

#1954 Feature 1954

#251 Feature 251

#1837 Feature 1837

#600 Feature 600

#1801 Feature 1801

#1352 Feature 1352

#2437 Feature 2437

#848 Feature 848

#113 Feature 113

#2862 Feature 2862

#944 Feature 944

#2961 Feature 2961

#739 Feature 739

#2118 Feature 2118

#352 Feature 352

#591 Feature 591

#1188 Feature 1188

#896 Feature 896

#1208 Feature 1208

#2005 Feature 2005

#826 Feature 826

#222 Feature 222

#2178 Feature 2178

#1153 Feature 1153

#1743 Feature 1743

#2167 Feature 2167

#2949 Feature 2949

#1356 Feature 1356

#705 Feature 705

#498 Feature 498

#2555 Feature 2555

#270 Feature 270

#1039 Feature 1039

#965 Feature 965

#808 Feature 808

#2431 Feature 2431

#340 Feature 340

#2231 Feature 2231

#2858 Feature 2858

#803 Feature 803

#2869 Feature 2869

#2214 Feature 2214

#1021 Feature 1021

#1159 Feature 1159

#2030 Feature 2030

#1807 Feature 1807

#490 Feature 490

#957 Feature 957

#1095 Feature 1095

#2569 Feature 2569

#2908 Feature 2908

#1069 Feature 1069

#1370 Feature 1370

#2758 Feature 2758

#1680 Feature 1680

#420 Feature 420

#1259 Feature 1259

#1878 Feature 1878

#2824 Feature 2824

#524 Feature 524

#2105 Feature 2105

#1651 Feature 1651

#681 Feature 681

#1873 Feature 1873

#1369 Feature 1369

#1997 Feature 1997

#1038 Feature 1038

#241 Feature 241

#264 Feature 264

#1592 Feature 1592

#1990 Feature 1990

#2279 Feature 2279

#2006 Feature 2006

#1293 Feature 1293

#1530 Feature 1530

#1216 Feature 1216

#1964 Feature 1964

#1285 Feature 1285

#2781 Feature 2781

#945 Feature 945

#1909 Feature 1909

#1383 Feature 1383

#2294 Feature 2294

#2979 Feature 2979

#1669 Feature 1669

#326 Feature 326

#1746 Feature 1746

#1348 Feature 1348

#1995 Feature 1995

#1015 Feature 1015

#1102 Feature 1102

#2270 Feature 2270

#2732 Feature 2732

#1290 Feature 1290

#2927 Feature 2927

#1355 Feature 1355

#728 Feature 728

#2591 Feature 2591

#2676 Feature 2676

#1953 Feature 1953

#977 Feature 977

#2247 Feature 2247

#371 Feature 371

#224 Feature 224

#2335 Feature 2335

#587 Feature 587

#837 Feature 837

#1242 Feature 1242

#989 Feature 989

#3028 Feature 3028

#178 Feature 178

#1846 Feature 1846

#2457 Feature 2457

#2539 Feature 2539

#1570 Feature 1570

#928 Feature 928

#1316 Feature 1316

#2746 Feature 2746

#1522 Feature 1522

#775 Feature 775

#2525 Feature 2525

#2972 Sensory-Motor Integration

#2302 Feature 2302

#3021 Feature 3021

#730 Feature 730

#898 Feature 898

#1687 Feature 1687

#2410 Feature 2410

#2248 Feature 2248

#900 Feature 900

#1602 Feature 1602

#768 Feature 768

#2391 Feature 2391

#2319 Feature 2319

#1030 Feature 1030

#1539 Feature 1539

#201 Feature 201

#1776 Feature 1776

#2740 Feature 2740

#2309 Feature 2309

#1413 Feature 1413

#648 Feature 648

#2795 Feature 2795

#2421 Feature 2421

#2290 Feature 2290

#1865 Feature 1865

#2663 Feature 2663

#3047 Feature 3047

#3039 Feature 3039

#2012 Feature 2012

#2046 Feature 2046

#2137 Feature 2137

#1337 Feature 1337

#798 Feature 798

#188 Feature 188

#2873 Feature 2873

#1518 Feature 1518

#1959 Feature 1959

#1494 Feature 1494

#2192 Feature 2192

#132 Feature 132

#1065 Feature 1065

#1346 Feature 1346

#799 Feature 799

#811 Feature 811

#2874 Feature 2874

#2412 Feature 2412

#712 Feature 712

#2164 Feature 2164

#483 Feature 483

#1425 Feature 1425

#1414 Feature 1414

#158 Feature 158

#1140 Feature 1140

#2605 Feature 2605

#1591 Feature 1591

#1933 Feature 1933

#2235 Feature 2235

#2427 Feature 2427

#1371 Feature 1371

#2729 Feature 2729

#2128 Feature 2128

#973 Feature 973

#1554 Feature 1554

#750 Feature 750

#2458 Feature 2458

#1600 Feature 1600

#2896 Feature 2896

#1517 Feature 1517

#868 Feature 868

#2766 Feature 2766

#2396 Feature 2396

#1700 Feature 1700

#2409 Feature 2409

#1374 Feature 1374

#1818 Feature 1818

#307 Feature 307

#2286 Feature 2286

#913 Feature 913

#1096 Feature 1096

#668 Feature 668

#2850 Feature 2850

#795 Feature 795

#2080 Feature 2080

#1435 Feature 1435

#2571 Feature 2571

#436 Feature 436

#1461 Feature 1461

#2618 Feature 2618

#319 Feature 319

#1849 Feature 1849

#2610 Feature 2610

#1084 Feature 1084

#1199 Feature 1199

#755 Feature 755

#256 Feature 256

#1867 Feature 1867

#2183 Feature 2183

#639 Feature 639

#261 Feature 261

#2723 Feature 2723

#2193 Feature 2193

#2954 Feature 2954

#329 Feature 329

#1682 Feature 1682

#2182 Feature 2182

#2151 Feature 2151

#2521 Feature 2521

#480 Feature 480

#2304 Feature 2304

#131 Feature 131

#116 Feature 116

#175 Feature 175

#1886 Feature 1886

#1816 Feature 1816

#1971 Feature 1971

#2100 Feature 2100

#1309 Feature 1309

#2847 Feature 2847

#168 Feature 168

#1755 Feature 1755

#3040 Feature 3040

#2240 Feature 2240

#1567 Feature 1567

#801 Feature 801

#2415 Feature 2415

#664 Feature 664

#2048 Feature 2048

#548 Feature 548

#1683 Feature 1683

#1940 Feature 1940

#1550 Feature 1550

#287 Feature 287

#1585 Feature 1585

#2198 Feature 2198

#2685 Feature 2685

#1812 Feature 1812

#1253 Feature 1253

#983 Feature 983

#1409 Feature 1409

#1256 Feature 1256

#3043 Feature 3043

#1608 Feature 1608

#584 Feature 584

#2538 Feature 2538

#1436 Feature 1436

#185 Feature 185

#2524 Feature 2524

#2171 Molecular and Cellular Biological Processes

#1401 Feature 1401

#183 Feature 183

#538 Feature 538

#2401 Feature 2401

#1023 Feature 1023

#2780 Feature 2780

#1994 Feature 1994

#1896 Feature 1896

#1870 Feature 1870

#1925 Feature 1925

#1179 Feature 1179

#1516 Feature 1516

#2140 Feature 2140

#2083 Feature 2083

#1229 Feature 1229

#1028 Feature 1028

#1331 Feature 1331

#192 Feature 192

#1809 Feature 1809

#107 Feature 107

#2753 Feature 2753

#2201 Feature 2201

#1634 Feature 1634

#1758 Feature 1758

#700 Feature 700

#773 Feature 773

#2964 Feature 2964

#1630 Feature 1630

#767 Feature 767

#1773 Feature 1773

#864 Feature 864

#401 Feature 401

#1302 Sensing and Detection Technologies

#602 Feature 602

#2483 Feature 2483

#2567 Feature 2567

#205 Feature 205

#190 Feature 190

#1408 Feature 1408

#2189 Feature 2189

#1343 Feature 1343

#1747 Feature 1747

#1427 Feature 1427

#1417 Feature 1417

#1277 Feature 1277

#1677 Feature 1677

#1364 Feature 1364

#533 Feature 533

#2590 Feature 2590

#1674 Feature 1674

#1722 Feature 1722

#1728 Feature 1728

#2914 Feature 2914

#1930 Feature 1930

#3069 Feature 3069

#1941 Feature 1941

#649 Feature 649

#563 Feature 563

#1660 Feature 1660

#980 Feature 980

#1421 Feature 1421

#1952 Feature 1952

#2532 Feature 2532

#304 Feature 304

#526 Feature 526

#2637 Feature 2637

#1788 Feature 1788

#2102 Feature 2102

#406 Feature 406

#2272 Feature 2272

#2406 Feature 2406

#2377 Feature 2377

#1135 Feature 1135

#1863 Feature 1863

#2529 Feature 2529

#405 Feature 405

#1350 Feature 1350

#527 Feature 527

#1031 Feature 1031

#1070 Feature 1070

#1472 Feature 1472

#1093 Feature 1093

#937 Feature 937

#2690 Feature 2690

#1044 Feature 1044

#2936 Feature 2936

#1228 Feature 1228

#2575 Feature 2575

#2472 Feature 2472

#2944 Feature 2944

#1659 Feature 1659

#1222 Feature 1222

#759 Feature 759

#2485 Feature 2485

#686 Feature 686

#2064 Feature 2064

#2123 Feature 2123

#1641 Feature 1641

#770 Feature 770

#962 Feature 962

#2038 Feature 2038

#1507 Feature 1507

#1238 Feature 1238

#458 Feature 458

#2513 Feature 2513

#1328 Feature 1328

#1176 Feature 1176

#462 Feature 462

#2682 Feature 2682

#415 Feature 415

#1879 Feature 1879

#2216 Feature 2216

#2804 Feature 2804

#875 Feature 875

#360 Feature 360

#1181 Feature 1181

#629 Feature 629

#1329 Feature 1329

#133 Feature 133

#1626 Feature 1626

#1307 Feature 1307

#1617 Feature 1617

#2701 Feature 2701

#473 Feature 473

#828 Feature 828

#1162 Feature 1162

#1951 Feature 1951

#1685 Feature 1685

#314 Feature 314

#2796 Feature 2796

#1214 Feature 1214

#531 Feature 531

#1344 Feature 1344

#2131 Feature 2131

#910 Feature 910

#2821 Feature 2821

#1921 Feature 1921

#2785 Feature 2785

#1555 Feature 1555

#564 Feature 564

#2885 Feature 2885

#581 Feature 581

#2925 Feature 2925

#2461 Feature 2461

#1332 Feature 1332

#621 Feature 621

#1146 Feature 1146

#413 Feature 413

#1638 Feature 1638

#1681 Feature 1681

#698 Feature 698

#1100 Feature 1100

#1540 Feature 1540

#2078 Feature 2078

#2515 Feature 2515

#3020 Feature 3020

#1390 Feature 1390

#289 Feature 289

#2208 Feature 2208

#669 Feature 669

#101 Feature 101

#1960 Feature 1960

#1268 Feature 1268

#456 Feature 456

#2872 Feature 2872

#276 Feature 276

#2650 Feature 2650

#1232 Feature 1232

#1928 Feature 1928

#1673 Feature 1673

#1434 Feature 1434

#3035 Feature 3035

#2346 Feature 2346

#2667 Feature 2667

#1781 Feature 1781

#1943 Feature 1943

#2960 Feature 2960

#772 Feature 772

#2998 Feature 2998

#2879 Feature 2879

#1810 Feature 1810

#1101 Feature 1101

#1185 Feature 1185

#2296 Feature 2296

#2159 Feature 2159

#442 Feature 442

#3022 Feature 3022

#2450 Feature 2450

#1043 Feature 1043

#577 Feature 577

#2828 Feature 2828

#2462 Feature 2462

#472 Feature 472

#1325 Feature 1325

#1197 Feature 1197

#1969 Feature 1969

#1632 Feature 1632

#2392 Feature 2392

#435 Feature 435

#2180 Feature 2180

#266 Feature 266

#1693 Feature 1693

#1656 Feature 1656

#268 Feature 268

#1261 Feature 1261

#1839 Feature 1839

#569 Feature 569

#2757 Feature 2757

#487 Feature 487

#1336 Feature 1336

#1358 Feature 1358

#1918 Feature 1918

#1027 Feature 1027

#2629 Feature 2629

#138 Feature 138

#2942 Feature 2942

#687 Feature 687

#2806 Feature 2806

#1351 Feature 1351

#1402 Feature 1402

#1762 Feature 1762

#1568 Feature 1568

#1976 Feature 1976

#146 Feature 146

#1714 Feature 1714

#653 Feature 653

#1109 Feature 1109

#2092 Feature 2092

#1730 Feature 1730

#1072 Feature 1072

#2496 Feature 2496

#2677 Feature 2677

#3015 Feature 3015

#1579 Feature 1579

#1927 Feature 1927

#2047 Feature 2047

#1469 Feature 1469

#1345 Feature 1345

#2359 Feature 2359

#2069 Feature 2069

#1078 Feature 1078

#1936 Feature 1936

#1360 Feature 1360

#364 Feature 364

#2531 Feature 2531

#1974 Feature 1974

#1588 Feature 1588

#2698 Feature 2698

#245 Feature 245

#903 Feature 903

#2600 Feature 2600

#2020 Feature 2020

#998 Feature 998

#294 Feature 294

#2325 Feature 2325

#3010 Feature 3010

#1916 Feature 1916

#2556 Feature 2556

#2956 Feature 2956

#761 Feature 761

#2066 Feature 2066

#2467 Feature 2467

#1970 Feature 1970

#2688 Feature #2688

#2481 Feature 2481

#2477 Feature 2477

#1387 Feature 1387

#2597 Feature 2597

#735 Feature 735

#1929 Feature 1929

#2526 Feature 2526

#2505 Feature 2505

#1266 Feature 1266

#2646 Feature 2646

#247 Feature 247

#139 Feature 139

#2241 Feature 2241

#565 Feature 565

#892 Feature 892

#2403 Feature 2403

#1514 Feature 1514

#3027 Feature 3027

#1946 Feature 1946

#106 Feature 106

#2464 Feature 2464

#1868 Feature 1868

#1854 Feature 1854

#496 Feature 496

#2855 Feature 2855

#457 Feature 457

#334 Feature 334

#593 Feature 593

#154 Feature 154

#1221 Feature 1221

#193 Feature 193

#855 Feature 855

#785 Feature 785

#2814 Feature 2814

#583 Feature 583

#2230 Feature 2230

#2074 Feature 2074

#269 Feature 269

#1501 Feature 1501

#2323 Feature 2323

#1395 Feature 1395

#422 Feature 422

#198 Feature 198

#186 Feature 186

#2371 Feature 2371

#2068 Feature 2068

#1595 Feature 1595

#152 Feature 152

#2642 Feature 2642

#1054 Feature 1054

#1996 Feature 1996

#259 Feature 259

#2655 Feature 2655

#2029 Feature 2029

#958 Feature 958

#378 Feature 378

#2489 Feature 2489

#733 Feature 733

#1171 Feature 1171

#2939 Feature 2939

#1624 Feature 1624

#1988 Feature 1988

#2475 Feature 2475

#525 Feature 525

#1139 Feature 1139

#1475 Feature 1475

#104 Feature 104

#856 Feature 856

#919 Feature 919

#2364 Feature 2364

#847 Feature 847

#3045 Feature 3045

#2113 Feature 2113

#1844 Feature 1844

#2867 Feature 2867

#465 Feature 465

#1751 Feature 1751

#1559 Feature 1559

#1572 Feature 1572

#706 Feature 706

#293 Feature 293

#2337 Feature 2337

#1092 Feature 1092

#2973 Feature 2973

#2691 Feature 2691

#2379 Feature 2379

#1875 Feature 1875

#2487 Feature 2487

#2577 Feature 2577

#2799 Feature 2799

#850 Feature 850

#1904 Feature 1904

#1552 Feature 1552

#967 Feature 967

#846 Feature 846

#520 Feature 520

#151 Feature 151

#813 Feature 813

#3063 Feature 3063

#1089 Feature 1089

#244 Feature 244

#3034 Feature 3034

#2491 Feature 2491

#299 Feature 299

#1590 Feature 1590

#2581 Feature 2581

#1769 Feature 1769

#662 Feature 662

#2953 Feature 2953

#969 Feature 969

#1806 Feature 1806

#960 Feature 960

#448 Feature 448

#1684 Feature 1684

#2344 Feature 2344

#387 Feature 387

#310 Feature 310

#1759 Feature 1759

#368 Feature 368

#562 Feature 562

#878 Feature 878

#2301 Feature 2301

#184 Feature 184

#2678 Feature 2678

#1227 Feature 1227

#2948 Feature 2948

#911 Feature 911

#1009 Feature 1009

#389 Feature 389

#645 Feature 645

#560 Feature 560

#2640 Feature 2640

#1312 Feature 1312

#2762 Feature 2762

#2909 Feature 2909

#2507 Feature 2507

#386 Feature 386

#1124 Feature 1124

#1891 Feature 1891

#2000 Feature 2000

#1091 Feature 1091

#2602 Feature 2602

#2660 Feature 2660

#2661 Feature 2661

#929 Feature 929

#200 Feature 200

#2378 Feature 2378

#978 Feature 978

#235 Feature 235

#966 Feature 966

#2455 Feature 2455

#873 Feature 873

#1749 Feature 1749

#2647 Feature 2647

#2303 Feature 2303

#2220 Feature 2220

#1859 Feature 1859

#2238 Feature 2238

#1455 Feature 1455

#2471 Feature 2471

#1207 Feature 1207

#2996 Feature 2996

#2976 Feature 2976

#2754 Feature 2754

#678 Feature 678

#515 Feature 515

#463 Feature 463

#877 Feature 877

#2103 Feature 2103

#922 Feature 922

#2417 Feature 2417

#948 Feature 948

#954 Feature 954

#2479 Feature 2479

#2703 Feature 2703

#1926 Feature 1926

#2541 Feature 2541

#1657 Feature 1657

#160 Feature 160

#2347 Feature 2347

#2109 Feature 2109

#1465 Feature 1465

#2843 Feature 2843

#1011 Feature 1011

#2273 Feature 2273

#1947 Feature 1947

#812 Feature 812

#981 Feature 981

#3001 Feature 3001

#1016 Feature 1016

#1300 Feature 1300

#2338 Feature 2338

#2868 Feature 2868

#692 Feature 692

#484 Feature 484

#2913 Feature 2913

#2352 Feature 2352

#2905 Feature 2905

#845 Feature 845

#592 Feature 592

#2067 Feature 2067

#809 Feature 809

#277 Feature 277

#1690 Feature 1690

#380 Feature 380

#1538 Feature 1538

#2025 Feature 2025

#1066 Feature 1066

#1666 Feature 1666

#1017 Feature 1017

#738 Feature 738

#2144 Feature 2144

#2490 Feature 2490

#1454 Feature 1454

#722 Feature 722

#2888 Feature 2888

#2686 Feature 2686

#2033 Feature 2033

#2438 Feature 2438

#2442 Feature 2442

#1368 Feature 1368

#881 Feature 881

#2381 Feature 2381

#1226 Feature 1226

#171 Feature 171

#1613 Feature 1613

#1975 Feature 1975

#327 Feature 327

#3051 Feature 3051

#778 Feature 778

#693 Feature 693

#1945 Feature 1945

#663 Feature 663

#467 Feature 467

#751 Feature 751

#1254 Feature 1254

#2926 Feature 2926

#1712 Feature 1712

#818 Feature 818

#1195 Feature 1195

#1071 Feature 1071

#1901 Feature 1901

#552 Feature 552

#636 Feature 636

#2801 Feature 2801

#2257 Feature 2257

#2434 Feature 2434

#1764 Feature 1764

#2707 Feature 2707

#1255 Feature 1255

#2574 Feature 2574

#641 Feature 641

#2398 Feature 2398

#1375 Feature 1375

#2654 Feature 2654

#1271 Feature 1271

#625 Feature 625

#1726 Feature 1726

#166 Feature 166

#1057 Feature 1057

#1914 Feature 1914

#291 Feature 291

#1225 Feature 1225

#118 Feature 118

#1729 Feature 1729

#260 Feature 260

#1142 Feature 1142

#2536 Feature 2536

#2545 Feature 2545

#961 Feature 961

#909 Feature 909

#2116 Feature 2116

#791 Feature 791

#2420 Feature 2420

#2748 Feature 2748

#394 Feature 394

#279 Feature 279

#2119 Feature 2119

#701 Feature 701

#598 Feature 598

#831 Feature 831

#1596 Feature 1596

#2764 Feature 2764

#1241 Feature 1241

#1386 Feature 1386

#494 Feature 494

#272 Feature 272

#1621 Feature 1621

#1349 Feature 1349

#923 Feature 923

#1639 Feature 1639

#1445 Feature 1445

#2330 Feature 2330

#932 Feature 932

#303 Feature 303

#1710 Feature 1710

#1006 Feature 1006

#956 Feature 956

#180 Feature 180

#502 Feature 502

#1210 Feature 1210

#1262 Feature 1262

#1720 Feature 1720

#2968 Feature 2968

#2322 Feature 2322

#2156 Feature 2156

#2550 Feature 2550

#3071 Feature 3071

#1318 Feature 1318

#1593 Feature 1593

#2969 Feature 2969

#1215 Feature 1215

#1029 Feature 1029

#2564 Feature 2564

#519 Feature 519

#1606 Feature 1606

#434 Feature 434

#1442 Feature 1442

#708 Drug Resistance Mechanisms in Cancer

#2955 Feature 2955

#637 Feature 637

#2399 Feature 2399

#2897 Feature 2897

#1167 Feature 1167

#2354 Feature 2354

#1381 Feature 1381

#1556 Feature 1556

#2370 Feature 2370

#150 Feature 150

#1598 Feature 1598

#1504 Feature 1504

#842 Feature 842

#1486 Feature 1486

#1467 Feature 1467

#1149 Feature 1149

#906 Feature 906

#243 Feature 243

#1784 Feature 1784

#644 Feature 644

#2184 Feature 2184

#1113 Feature 1113

#1855 Feature 1855

#792 Feature 792

#495 Feature 495

#1515 Feature 1515

#724 Feature 724

#2334 Feature 2334

#924 Feature 924

#2737 Feature 2737

#2805 Feature 2805

#824 Feature 824

#1727 Feature 1727

#119 Feature 119

#348 Feature 348

#2852 Feature 2852

#690 Feature 690

#2797 Feature 2797

#1163 Feature 1163

#1036 Feature 1036

#297 Feature 297

#2984 Feature 2984

#2842 Feature 2842

#889 Feature 889

#3005 Feature 3005

#2349 Feature 2349

#347 Feature 347

#1297 Feature 1297

#2054 Feature 2054

#2384 Feature 2384

#764 Feature 764

#273 Feature 273

#1574 Feature 1574

#2266 Feature 2266

#2099 Feature 2099

#1777 Feature 1777

#2278 Feature 2278

#838 Feature 838

#902 Feature 902

#1410 Feature 1410

#1186 Feature 1186

#2375 Feature 2375

#1127 Feature 1127

#238 Feature 238

#2731 Feature 2731

#725 Feature 725

#2833 Feature 2833

#2376 Feature 2376

#3024 Feature 3024

#2777 Feature 2777

#1399 Feature 1399

#2357 Feature 2357

#780 Feature 780

#2251 Feature 2251

#547 Feature 547

#2256 Feature 2256

#1123 Feature 1123

#2165 Feature 2165

#2568 Feature 2568

#1618 Feature 1618

#1248 Feature 1248

#285 Feature 285

#282 Feature 282

#2965 Feature 2965

#2668 Feature 2668

#424 Feature 424

#776 Feature 776

#2237 Feature 2237

#225 Feature 225

#1224 Feature 1224

#940 Feature 940

#2081 Feature 2081

#1731 Feature 1731

#125 Feature 125

#2508 Feature 2508

#372 Feature 372

#1145 Feature 1145

#1116 Feature 1116

#489 Feature 489

#2749 Feature 2749

#336 Feature 336

#810 Feature 810

#1492 Feature 1492

#2049 Feature 2049

#1537 Feature 1537

#732 Feature 732

#1311 Molecular Mechanisms and Biological Processes

#2666 Feature 2666

#221 Feature 221

#726 Feature 726

#2863 Feature 2863

#3003 Feature 3003

#284 Feature 284

#2910 Feature 2910

#707 Feature 707

#2841 Feature 2841

#2918 Feature 2918

#2596 Feature 2596

#2122 Feature 2122

#727 Feature 727

#1083 Feature 1083

#374 Medical Imaging and Oncology

#2878 Feature 2878

#2252 Feature 2252

#2191 Feature 2191

#2520 Feature 2520

#3065 Feature 3065

#174 Feature 174

#254 Feature 254

#2494 Feature 2494

#1155 Feature 1155

#985 Feature 985

#345 Feature 345

#2166 Feature 2166

#1378 Feature 1378

#2317 Feature 2317

#918 Feature 918

#1487 Feature 1487

#2148 Feature 2148

#2328 Feature 2328

#2355 Feature 2355

#440 Feature 440

#774 Feature 774

#167 Feature 167

#1077 Feature 1077

#1955 Feature 1955

#1212 Feature 1212

#320 Feature 320

#2978 Feature 2978

#599 Feature 599

#522 Feature 522

#1525 Feature 1525

#2901 Feature 2901

#2658 Feature 2658

#1898 Feature 1898

#2324 Feature 2324

#2217 Feature 2217

#2436 Feature 2436

#1750 Feature 1750

#806 Feature 806

#354 Feature 354

#1840 Feature 1840

#529 Feature 529

#2903 Feature 2903

#574 Feature 574

#388 Feature 388

#2336 Feature 2336

#1097 Feature 1097

#1305 Feature 1305

#2866 Feature 2866

#1373 Feature 1373

#1803 Feature 1803

#936 Feature 936

#505 Feature 505

#2587 Feature 2587

#2009 Feature 2009

#1609 Feature 1609

#1541 Feature 1541

#1523 Feature 1523

#23 Neuronal Circuitry and Cellular Processes

#2134 Feature 2134

#2439 Feature 2439

#640 Feature 640

#549 Feature 549

#2848 Feature 2848

#710 Feature 710

#1361 Feature 1361

#147 Feature 147

#2578 Feature 2578

#1851 Feature 1851

#2934 Feature 2934

#2007 Developmental Disparities & Intervention

#3042 Feature 3042

#2627 Feature 2627

#979 Feature 979

#1278 Feature 1278

#793 Feature 793

#163 Feature 163

#642 Feature 642

#2607 Feature 2607

#403 Feature 403

#3046 Feature 3046

#535 Feature 535

#852 Feature 852

#3054 Feature 3054

#1440 Feature 1440

#2163 Feature 2163

#825 Feature 825

#673 Feature 673

#1291 Feature 1291

#2474 Feature 2474

#2519 Feature 2519

#1601 Feature 1601

#2894 Feature 2894

#2570 Feature 2570

#894 Feature 894

#1353 Feature 1353

#946 Feature 946

#840 Feature 840

#1439 Feature 1439

#1911 Feature 1911

#1141 Feature 1141

#1774 Feature 1774

#758 Feature 758

#1392 Feature 1392

#1047 Feature 1047

#543 Feature 543

#1968 Feature 1968

#1106 Feature 1106

#1168 Feature 1168

#1860 Feature 1860

#1088 Feature 1088

#635 Feature 635

#2320 Feature 2320

#2405 Feature 2405

#376 Feature 376

#252 Feature 252

#2674 Feature 2674

#1391 Feature 1391

#2592 Feature 2592

#994 Feature 994

#1459 Feature 1459

#596 Feature 596

#2486 Feature 2486

#691 Feature 691

#1902 Feature 1902

#2197 Feature 2197

#209 Feature 209

#1797 Feature 1797

#1763 Feature 1763

#1732 Feature 1732

#854 Feature 854

#1804 Feature 1804

#1838 Feature 1838

#2860 Feature 2860

#2713 Feature 2713

#2787 Feature 2787

#2634 Feature 2634

#844 Feature 844

#916 Feature 916

#2314 Feature 2314

#446 Feature 446

#1907 Feature 1907

#2902 Feature 2902

#213 Feature 213

#393 Feature 393

#2152 Feature 2152

#2728 Feature 2728

#1192 Feature 1192

#2394 Feature 2394

#2484 Feature 2484

#1614 Feature 1614

#2798 Feature 2798

#2400 Feature 2400

#882 Feature 882

#2985 Feature 2985

#2271 Feature 2271

#2530 Feature 2530

#1068 Feature 1068

#2899 Feature 2899

#784 Feature 784

#1828 Feature 1828

#450 Feature 450

#2811 Feature 2811

#237 Feature 237

#1724 Feature 1724

#271 Feature 271

#433 Feature 433

#253 Feature 253

#3066 Feature 3066

#1551 Feature 1551

#1423 Feature 1423

#1299 Feature 1299

#2611 Feature 2611

#1090 Feature 1090

#947 Feature 947

#2224 Feature 2224

#771 Feature 771

#990 Feature 990

#2966 Feature 2966

#628 Feature 628

#1813 Feature 1813

#1741 Feature 1741

#1129 Feature 1129

#1404 Feature 1404

#631 Feature 631

#1431 Feature 1431

#736 Feature 736

#2673 Feature 2673

#2117 Feature 2117

#1420 Feature 1420

#2517 Feature 2517

#888 Feature 888

#2623 Feature 2623

#609 Feature 609

#1956 Feature 1956

#2742 Feature 2742

#1338 Feature 1338

#590 Feature 590

#2395 Feature 2395

#431 Feature 431

#2088 Feature 2088

#1571 Feature 1571

#1320 Feature 1320

#1948 Feature 1948

#575 Feature 575

#1814 Feature 1814

#857 Feature 857

#2229 Feature 2229

#2652 Feature 2652

#2705 Feature 2705

#2366 Feature 2366

#2759 Feature 2759

#2710 Feature 2710

#1793 Feature 1793

#1599 Feature 1599

#2651 Feature 2651

#2829 Feature 2829

#589 Feature 589

#2839 Feature 2839

#1787 Feature 1787

#843 Feature 843

#862 Feature 862

#615 Feature 615

#2837 Feature 2837

#955 Feature 955

#2004 Feature 2004

#2176 Feature 2176

#2008 Feature 2008

#100 Feature 100

#619 Feature 619

#2360 Feature 2360

#2756 Feature 2756

#2790 Feature 2790

#1449 Feature 1449

#1473 Feature 1473

#2950 Feature 2950

#2194 Feature 2194

#2499 Feature 2499

#2372 Feature 2372

#2840 Feature 2840

#1003 Feature 1003

#830 Feature 830

#861 Feature 861

#3026 Feature 3026

#1450 Feature 1450

#1503 Feature 1503

#2452 Feature 2452

#1388 Feature 1388

#1292 Feature 1292

#2242 Feature 2242

#161 Feature 161

#1432 Feature 1432

#2043 Feature 2043

#2114 Feature 2114

#1327 Feature 1327

#2212 Feature 2212

#1052 Feature 1052

#2886 Feature 2886

#1942 Feature 1942

#1429 Feature 1429

#1040 Feature 1040

#1415 Feature 1415

#381 Feature 381

#1074 Feature 1074

#124 Feature 124

#2062 Feature 2062

#1580 Feature 1580

#262 Feature 262

#963 Feature 963

#130 Feature 130

#1304 Feature 1304

#746 Feature 746

#2635 Feature 2635

#187 Feature 187

#2528 Feature 2528

#464 Feature 464

#2503 Feature 2503

#879 Feature 879

#2245 Feature 2245

#2928 Feature 2928

#3019 Feature 3019

#2846 Feature 2846

#1001 Feature 1001

#2218 Feature 2218

#1938 Feature 1938

#1165 Feature 1165

#1934 Feature 1934

#1416 Feature 1416

#1853 Feature 1853

#510 Feature 510

#2019 Feature 2019

#351 Nanomaterial Synthesis and Properties

#1512 Feature 1512

#1775 Feature 1775

#2177 Feature 2177

#366 Feature 366

#2267 Feature 2267

#874 Feature 874

#2351 Feature 2351

#995 Feature 995

#1498 Feature 1498

#2565 Feature 2565

#481 Feature 481

#2408 Feature 2408

#2207 Feature 2207

#2298 Feature 2298

#3004 Feature 3004

#215 Feature 215

#2441 Feature 2441

#443 Feature 443

#749 Feature 749

#2300 Feature 2300

#2308 Feature 2308

#1087 Feature 1087

#410 Feature 410

#942 Feature 942

#417 Feature 417

#2865 Feature 2865

#1246 Feature 1246

#2709 Feature 2709

#1446 Feature 1446

#1424 Feature 1424

#2127 Feature 2127

#2495 Feature 2495

#2253 Feature 2253

#1900 Feature 1900

#1462 Feature 1462

#370 Feature 370

#1308 Feature 1308

#539 Feature 539

#1529 Feature 1529

#883 Feature 883

#1819 Feature 1819

#1935 Feature 1935

#521 Feature 521

#2179 Feature 2179

#1652 Feature 1652

#2288 Feature 2288

#499 Feature 499

#2898 Feature 2898

#2226 Feature 2226

#2221 Feature 2221

#1237 Feature 1237

#1607 Feature 1607

#594 Feature 594

#2557 Feature 2557

#2812 Feature 2812

#1744 Feature 1744

#2870 Feature 2870

#899 Feature 899

#1668 Feature 1668

#1042 Feature 1042

#1564 Feature 1564

#2940 Feature 2940

#1981 Feature 1981

#753 Feature 753

#155 Feature 155

#2782 Feature 2782

#814 Feature 814

#679 Feature 679

#2579 Feature 2579

#3023 Feature 3023

#612 Feature 612

#1966 Feature 1966

#2813 Feature 2813

#580 Feature 580

#1313 Feature 1313

#120 Feature 120

#2665 Feature 2665

#2260 Historical Context & Development

#1858 Feature 1858

#2329 Feature 2329

#2468 Feature 2468

#1372 Feature 1372

#1961 Feature 1961

#1190 Feature 1190

#2500 Feature 2500

#2980 Feature 2980

#1852 Feature 1852

#987 Feature 987

#2345 Feature 2345

#1211 Feature 1211

#638 Feature 638

#1111 Feature 1111

#145 Feature 145

#544 Feature 544

#2449 Feature 2449

#754 Feature 754

#1049 Feature 1049

#1708 Feature 1708

#734 Feature 734

#1403 Feature 1403

#802 Feature 802

#140 Feature 140

#762 Feature 762

#1919 Feature 1919

#2784 Feature 2784

#1748 Feature 1748

#1303 Feature 1303

#3018 Feature 3018

#1594 Feature 1594

#2044 Feature 2044

#2418 Feature 2418

#1322 Feature 1322

#1734 Feature 1734

#1282 Feature 1282

#2739 Feature 2739

#1963 Feature 1963

#1992 Feature 1992

#1711 Feature 1711

#2476 Feature 2476

#2831 Feature 2831

#2986 Feature 2986

#643 Feature 643

#513 Feature 513

#1120 Feature 1120

#2055 Feature 2055

#369 Feature 369

#1508 Feature 1508

#349 Feature 349

#493 Feature 493

#741 Feature 741

#1236 Feature 1236

#2844 Feature 2844

#915 Feature 915

#1094 Feature 1094

#2348 Feature 2348

#1283 Feature 1283

#1783 Feature 1783

#2001 Feature 2001

#656 Feature 656

#1631 Feature 1631

#703 Feature 703

#2115 Feature 2115

#2580 Feature 2580

Document Content

Crystal structure of the mosquito-larvicidal toxin Cry4Ba and its biological implications.
Cry4Ba, isolated from Bacillus thuringiensis subsp. israelensis, is specifically toxic to the larvae of Aedes and Anopheles mosquitoes. The structure of activated Cry4Ba toxin has been determined by multiple isomorphous replacement with anomalous scattering and refined to R(cryst) = 20.5% and R(free)= 21.8% at 1.75 Angstroms resolution. It resembles previously reported Cry toxin structures but shows the following distinctions. In domain I the helix bundle contains only the long and amphipathic helices alpha3-alpha7. The N-terminal helices alpha1-alpha2b, absent due to proteolysis during crystallisation, appear inessential to toxicity. In domain II the beta-sheet prism presents short apical loops without the beta-ribbon extension of inner strands, thus placing the receptor combining sites close to the sheets. In domain III the beta-sandwich contains a helical extension from the C-terminal strand beta23, which interacts with a beta-hairpin excursion from the edge of the outer sheet. The structure provides a rational explanation of recent mutagenesis and biophysical data on this toxin. Furthermore, added to earlier structures from the Cry toxin family, Cry4Ba completes a minimal structural database covering the Coleoptera, Lepidoptera, Diptera and Lepidoptera/Diptera specificity classes. A multiple structure alignment found that the Diptera-specific Cry4Ba is structurally more closely similar to the Lepidoptera-specific Cry1Aa than the Coleoptera-specific Cry3Aa, but most distantly related to Lepidoptera/Diptera-specific Cry2Aa. The structures are most divergent in domain II, supporting the suggestion that this domain has a major role in specificity determination. They are most similar in the alpha3-alpha7 major fragment of domain I, which contains the alpha4-alpha5 hairpin crucial to pore formation. The collective knowledge of Cry toxin structure and mutagenesis data will lead to a more critical understanding of the structural basis for receptor binding and pore formation, as well as allowing the scope of diversity to be better appreciated.

Similar Documents