Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1514

MIN ACTIVATION

0.0

Details List

#1878 Feature 1878

#1774 Feature 1774

#2824 Feature 2824

#2490 Feature 2490

#648 Feature 648

#2633 Feature 2633

#1710 Feature 1710

#947 Feature 947

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#705 Feature 705

#2197 Feature 2197

#712 Feature 712

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#2067 Feature 2067

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#2212 Feature 2212

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#2160 Feature 2160

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#272 Feature 272

#2335 Feature 2335

#1511 Feature 1511

#2804 Feature 2804

#1359 Feature 1359

#896 Feature 896

#404 Interactions and Mechanisms

#2285 Feature 2285

#1370 Feature 1370

#2823 Feature 2823

#2020 Feature 2020

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#1390 Feature 1390

#1976 Feature 1976

#384 Feature 384

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#732 Feature 732

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#315 Feature 315

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#1641 Feature 1641

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#2936 Feature 2936

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#1712 Feature 1712

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#434 Feature 434

#2069 Feature 2069

#1974 Feature 1974

#1171 Feature 1171

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#273 Feature 273

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#2333 Feature 2333

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#300 Feature 300

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#1271 Feature 1271

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#320 Feature 320

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#2602 Feature 2602

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#1854 Feature 1854

#3004 Feature 3004

#1494 Feature 1494

#346 Feature 346

#455 Feature 455

#669 Feature 669

#2232 Medical Case Reports & Cancer Research

#2849 Feature 2849

#2148 Feature 2148

#1756 Feature 1756

#2456 Feature 2456

#877 Feature 877

#1846 Feature 1846

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#2240 Feature 2240

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#2518 Feature 2518

#2308 Feature 2308

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#1560 Feature 1560

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#2141 Feature 2141

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#2201 Feature 2201

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#1324 Feature 1324

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#2937 Feature 2937

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#1940 Feature 1940

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#3018 Feature 3018

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#1530 Feature 1530

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#1229 Feature 1229

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#2992 Feature 2992

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#103 Feature 103

#1333 Feature 1333

#3070 Spiritual and Holistic Care in Healthcare

#1275 Feature 1275

#2609 Feature 2609

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#227 Feature 227

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#2002 Feature 2002

#1555 Feature 1555

#631 Feature 631

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#415 Feature 415

#708 Drug Resistance Mechanisms in Cancer

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#521 Feature 521

#523 Feature 523

#2765 Feature 2765

#2009 Feature 2009

#2617 Feature 2617

#474 Surgical Procedures & Gastrointestinal Issues

#2717 Feature 2717

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#750 Feature 750

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#333 Feature 333

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#141 Feature 141

#2111 Feature 2111

#2815 Feature 2815

#1864 Feature 1864

#206 Feature 206

#2564 Feature 2564

#3024 Feature 3024

#1491 Feature 1491

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Document Content

Effect of Bacoside A on growth and biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa.
The goal of this study was to evaluate the antibiofilm and antimicrobial activities of Bacoside A, a formulation of phytochemicals from Bacopa monnieri, against Staphylococcus aureus and Pseudomonas aeruginosa, which are known to form biofilms as one of their virulence traits. The antimicrobial effects of Bacoside A were tested using the minimum inhibitory concentration and minimum bactericidal concentration assays. A cell membrane disruption assay was performed to find its possible target site. MTT assay, crystal violet assay, and microscopic studies were performed to assess the antibiofilm activity. Bacoside A showed antimicrobial activity against both test organisms in their planktonic and biofilm states. At a subminimum inhibitory concentration of 200 μg·mL-1, Bacoside A significantly removed ∼88%-93% of bacterial biofilm developed on microtiter plates. Biochemical and microscopic studies suggested that the eradication of biofilm might be due to the loss of extracellular polymeric substances and to a change in cell membrane integrity of the selected bacterial strains treated with Bacoside A. These results indicate that Bacoside A might be considered as an antimicrobial having the ability to disrupt biofilms. Thus, either alone or in combination with other therapeutics, Bacoside A could be useful to treat biofilm-related infections caused by opportunistic bacterial pathogens.

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