Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1513

MIN ACTIVATION

0.0

Details List

#1728 Feature 1728

#1604 Feature 1604

#186 Feature 186

#2425 Feature 2425

#2086 Feature 2086

#2797 Feature 2797

#357 Feature 357

#495 Feature 495

#2373 Feature 2373

#1148 Feature 1148

#2623 Feature 2623

#2802 Feature 2802

#874 Feature 874

#237 Feature 237

#1097 Feature 1097

#1639 Feature 1639

#2092 Feature 2092

#389 Feature 389

#2977 Feature 2977

#1925 Feature 1925

#967 Feature 967

#2792 Feature 2792

#148 Feature 148

#783 Feature 783

#887 Feature 887

#1205 Feature 1205

#2540 Feature 2540

#1245 Feature 1245

#672 Feature 672

#2585 Feature 2585

#681 Feature 681

#1994 Feature 1994

#1391 Feature 1391

#1588 Feature 1588

#476 Feature 476

#1308 Feature 1308

#2857 Feature 2857

#1548 Feature 1548

#2951 Feature 2951

#402 Feature 402

#2138 Feature 2138

#2992 Feature 2992

#350 Feature 350

#990 Feature 990

#2715 Feature 2715

#2415 Feature 2415

#2758 Feature 2758

#2555 Feature 2555

#354 Feature 354

#973 Feature 973

#2340 Feature 2340

#2815 Feature 2815

#322 Feature 322

#1901 Feature 1901

#1804 Feature 1804

#1121 Feature 1121

#2787 Feature 2787

#2146 Feature 2146

#2946 Feature 2946

#2419 Feature 2419

#2846 Feature 2846

#669 Feature 669

#700 Feature 700

#2866 Feature 2866

#2913 Feature 2913

#1805 Feature 1805

#1431 Feature 1431

#511 Feature 511

#2795 Feature 2795

#1087 Feature 1087

#2961 Feature 2961

#1523 Feature 1523

#2668 Feature 2668

#1383 Feature 1383

#896 Feature 896

#110 Feature 110

#787 Feature 787

#1749 Feature 1749

#980 Feature 980

#3008 Feature 3008

#130 Feature 130

#708 Drug Resistance Mechanisms in Cancer

#1928 Feature 1928

#292 Feature 292

#403 Feature 403

#897 Feature 897

#1056 Feature 1056

#821 Feature 821

#1598 Feature 1598

#891 Feature 891

#218 Feature 218

#2737 Feature 2737

#2059 Feature 2059

#2185 Feature 2185

#1684 Feature 1684

#2883 Feature 2883

#848 Feature 848

#2048 Feature 2048

#2079 Feature 2079

#1243 Feature 1243

#2494 Feature 2494

#979 Feature 979

#936 Feature 936

#2109 Feature 2109

#144 Feature 144

#2030 Feature 2030

#1195 Feature 1195

#2121 Feature 2121

#2259 Feature 2259

#1493 Feature 1493

#1750 Feature 1750

#2564 Feature 2564

#566 Feature 566

#877 Feature 877

#895 Feature 895

#633 Feature 633

#1834 Feature 1834

#2545 Feature 2545

#913 Feature 913

#1233 Feature 1233

#1971 Feature 1971

#1063 Feature 1063

#1538 Feature 1538

#431 Feature 431

#2682 Feature 2682

#3063 Feature 3063

#3019 Feature 3019

#2108 Feature 2108

#342 Feature 342

#2385 Feature 2385

#2252 Feature 2252

#475 Feature 475

#582 Feature 582

#1198 Feature 1198

#2068 Feature 2068

#1355 Feature 1355

#2251 Feature 2251

#2210 Feature 2210

#649 Feature 649

#961 Feature 961

#733 Feature 733

#2338 Feature 2338

#3067 Feature 3067

#1627 Feature 1627

#1714 Feature 1714

#2809 Feature 2809

#1338 Feature 1338

#804 Feature 804

#2354 Feature 2354

#2455 Feature 2455

#2816 Feature 2816

#1821 Feature 1821

#1896 Feature 1896

#2104 Feature 2104

#2583 Feature 2583

#1263 Feature 1263

#2221 Feature 2221

#1190 Feature 1190

#579 Feature 579

#120 Feature 120

#548 Feature 548

#138 Feature 138

#1535 Feature 1535

#771 Feature 771

#653 Feature 653

#1537 Feature 1537

#1307 Feature 1307

#900 Feature 900

#2905 Feature 2905

#2790 Feature 2790

#503 Feature 503

#285 Feature 285

#965 Feature 965

#1870 Feature 1870

#610 Feature 610

#2279 Feature 2279

#2039 Feature 2039

#188 Feature 188

#157 Feature 157

#1792 Metastatic Cancer

#1470 Feature 1470

#1578 Feature 1578

#2414 Feature 2414

#2621 Feature 2621

#393 Feature 393

#1822 Feature 1822

#1197 Feature 1197

#573 Feature 573

#1809 Feature 1809

#2627 Feature 2627

#2165 Feature 2165

#284 Feature 284

#687 Feature 687

#675 Feature 675

#243 Feature 243

#1255 Feature 1255

#1325 Feature 1325

#386 Feature 386

#231 Feature 231

#3054 Feature 3054

#1504 Feature 1504

#3065 Feature 3065

#2671 Feature 2671

#3005 Feature 3005

#1960 Feature 1960

#2160 Feature 2160

#2439 Feature 2439

#1993 Feature 1993

#2005 Feature 2005

#2246 Feature 2246

#3015 Feature 3015

#2934 Feature 2934

#698 Feature 698

#370 Feature 370

#168 Feature 168

#2041 Feature 2041

#1799 Feature 1799

#945 Feature 945

#483 Feature 483

#1762 Feature 1762

#1775 Feature 1775

#2260 Historical Context & Development

#2922 Feature 2922

#2698 Feature 2698

#1123 Feature 1123

#2710 Feature 2710

#123 Feature 123

#2991 Feature 2991

#2520 Feature 2520

#1299 Feature #1299

#3007 Feature 3007

#2025 Feature 2025

#638 Feature 638

#199 Feature 199

#735 Feature 735

#1139 Feature 1139

#166 Feature 166

#219 Feature 219

#2028 Feature 2028

#2113 Feature 2113

#1028 Feature 1028

#1575 Feature 1575

#245 Feature 245

#183 Feature 183

#2212 Feature 2212

#1788 Feature 1788

#436 Feature 436

#2535 Feature 2535

#1006 Feature 1006

#155 Feature 155

#978 Feature 978

#2245 Feature 2245

#3057 Feature 3057

#158 Feature 158

#1701 Feature 1701

#956 Feature 956

#221 Feature 221

#1732 Feature 1732

#1868 Feature 1868

#963 Feature 963

#661 Feature 661

#2163 Feature 2163

#1165 Feature 1165

#1473 Feature 1473

#1958 Feature 1958

#1540 Feature 1540

#2090 Feature 2090

#2444 Feature 2444

#1751 Feature 1751

#1846 Feature 1846

#295 Feature 295

#2481 Feature 2481

#2370 Feature 2370

#625 Feature 625

#876 Feature 876

#1840 Feature 1840

#1202 Feature 1202

#257 Feature 257

#2365 Feature 2365

#1736 Feature 1736

#533 Feature 533

#462 Feature 462

#3071 Feature 3071

#1496 Feature 1496

#971 Feature 971

#1657 Feature 1657

#1013 Feature 1013

#2447 Feature 2447

#2459 Feature 2459

#560 Feature 560

#2291 Feature 2291

#792 Feature 792

#3066 Feature 3066

#1448 Feature 1448

#2788 Feature 2788

#2453 Feature 2453

#860 Feature 860

#1240 Feature 1240

#1968 Feature 1968

#2971 Feature 2971

#1738 Feature 1738

#129 Feature 129

#1956 Feature 1956

#1975 Feature 1975

#375 Feature 375

#704 Feature 704

#1677 Feature 1677

#2174 Feature 2174

#1855 Feature 1855

#923 Feature 923

#1987 Feature 1987

#2625 Feature 2625

#2348 Feature 2348

#299 Feature 299

#1372 Feature 1372

#1389 Feature 1389

#2662 Feature 2662

#2410 Feature 2410

#1404 Feature 1404

#1484 Feature 1484

#2553 Feature 2553

#813 Feature 813

#2213 Feature 2213

#812 Feature 812

#2200 Feature 2200

#693 Feature 693

#994 Feature 994

#2085 Feature 2085

#553 Feature 553

#1175 Feature 1175

#1892 Feature 1892

#2467 Feature 2467

#2640 Feature 2640

#3064 Surgical Complications and Physiological Stress

#1774 Feature 1774

#2598 Feature 2598

#2909 Feature 2909

#1285 Feature 1285

#2097 Feature 2097

#437 Feature 437

#741 Feature 741

#1130 Feature 1130

#1653 Feature 1653

#1660 Feature 1660

#679 Feature 679

#811 Feature 811

#968 Feature 968

#159 Feature 159

#2950 Feature 2950

#1401 Feature 1401

#1387 Feature 1387

#1114 Feature 1114

#302 Feature 302

#944 Feature 944

#983 Feature 983

#570 Feature 570

#1138 Feature 1138

#499 Feature 499

#889 Feature 889

#1452 Feature 1452

#411 Feature 411

#2294 Feature 2294

#2953 Feature 2953

#1665 Feature 1665

#1793 Feature 1793

#1406 Feature 1406

#2401 Feature 2401

#149 Feature 149

#906 Feature 906

#215 Feature 215

#1218 Feature 1218

#2803 Feature 2803

#868 Feature 868

#1694 Feature 1694

#615 Feature 615

#1989 Feature 1989

#1582 Feature 1582

#2235 Feature 2235

#2052 Feature 2052

#362 Feature 362

#2918 Feature 2918

#1134 Feature 1134

#761 Feature 761

#2292 Feature 2292

#838 Feature 838

#1418 Feature 1418

#1257 Feature 1257

#947 Feature 947

#452 Feature 452

#1678 Feature 1678

#2277 Feature 2277

#1280 Feature 1280

#1276 Feature 1276

#191 Feature 191

#2474 Feature 2474

#427 Feature 427

#928 Feature 928

#2026 Feature 2026

#595 Feature 595

#2821 Feature 2821

#1861 Feature 1861

#2284 Feature 2284

#2708 Feature 2708

#115 Feature 115

#1348 Feature 1348

#201 Feature 201

#2436 Feature 2436

#904 Feature 904

#380 Feature 380

#145 Feature 145

#1277 Feature 1277

#2503 Feature 2503

#660 Feature 660

#2021 Feature 2021

#2770 Feature 2770

#2630 Feature 2630

#1157 Feature 1157

#2275 Feature 2275

#251 Feature 251

#1992 Feature 1992

#480 Feature 480

#1619 Feature 1619

#2199 Feature 2199

#3060 Feature 3060

#1664 Feature 1664

#2002 Feature 2002

#1154 Feature 1154

#1137 Feature 1137

#2749 Feature 2749

#1912 Feature 1912

#1346 Feature 1346

#2451 Feature #2451

#491 Feature 491

#416 Feature 416

#2369 Feature 2369

#1882 Feature 1882

#2673 Feature 2673

#1969 Feature 1969

#1413 Feature 1413

#523 Feature 523

#726 Feature 726

#1160 Feature 1160

#2101 Feature 2101

#359 Feature 359

#2636 Feature 2636

#3034 Feature 3034

#2734 Feature 2734

#3042 Feature 3042

#517 Feature 517

#104 Feature 104

#832 Feature 832

#2720 Feature 2720

#2103 Feature 2103

#2917 Feature 2917

#1831 Feature 1831

#1609 Feature 1609

#1791 Feature 1791

#1463 Feature 1463

#2675 Feature 2675

#273 Feature 273

#2438 Feature 2438

#1976 Feature 1976

#1465 Feature 1465

#1965 Feature 1965

#801 Feature 801

#1512 Feature 1512

#1573 Feature 1573

#819 Feature 819

#338 Feature 338

#820 Feature 820

#1407 Feature 1407

#636 Feature 636

#2900 Feature 2900

#422 Feature 422

#2767 Feature 2767

#2042 Feature 2042

#1498 Feature 1498

#1193 Feature 1193

#1378 Feature 1378

#1347 Feature 1347

#1696 Feature 1696

#907 Feature 907

#648 Feature 648

#2853 Feature 2853

#972 Feature 972

#2189 Feature 2189

#1570 Feature 1570

#835 Feature 835

#2864 Feature 2864

#2589 Feature 2589

#2830 Feature 2830

#2781 Feature 2781

#2884 Feature 2884

#2073 Feature 2073

#1605 Feature 1605

#1673 Feature 1673

#689 Feature 689

#1542 Feature 1542

#1539 Feature 1539

#800 Feature 800

#1946 Feature 1946

#1125 Feature 1125

#2601 Feature 2601

#1437 Feature 1437

#518 Feature 518

#736 Feature 736

#464 Feature 464

#1650 Feature 1650

#3070 Spiritual and Holistic Care in Healthcare

#2391 Feature 2391

#600 Feature 600

#2619 Feature 2619

#2311 Feature 2311

#703 Feature 703

#2690 Feature 2690

#1514 Feature 1514

#634 Feature 634

#2017 Feature 2017

#1524 Feature 1524

#2014 Feature 2014

#1251 Feature 1251

#2505 Feature 2505

#118 Feature 118

#2190 Feature 2190

#456 Feature 456

#205 Feature 205

#1632 Feature 1632

#601 Feature 601

#1062 Feature 1062

#1779 Feature 1779

#547 Feature 547

#1873 Feature 1873

#826 Feature 826

#2561 Feature 2561

#2289 Feature 2289

#2629 Feature 2629

#2667 Feature 2667

#2140 Feature 2140

#1231 Feature 1231

#1516 Feature 1516

#2595 Feature 2595

#2417 Feature 2417

#2988 Feature 2988

#1020 Feature 1020

#2408 Feature 2408

#2679 Feature 2679

#2772 Feature 2772

#2548 Feature 2548

#387 Feature 387

#2780 Feature 2780

#1267 Feature 1267

#1560 Feature 1560

#2609 Feature 2609

#326 Feature 326

#2959 Feature 2959

#1229 Feature 1229

#1410 Feature 1410

#739 Feature 739

#1279 Feature 1279

#2232 Medical Case Reports & Cancer Research

#2582 Feature 2582

#303 Feature 303

#2559 Feature 2559

#2016 Feature 2016

#203 Feature 203

#2358 Feature 2358

#737 Feature 737

#921 Feature 921

#2255 Feature 2255

#884 Feature 884

#162 Feature 162

#2652 Feature 2652

#1016 Feature 1016

#1049 Feature 1049

#2477 Feature 2477

#1972 Feature 1972

#2231 Feature 2231

#2006 Feature 2006

#1984 Feature 1984

#1551 Feature 1551

#1836 Feature 1836

#2304 Feature 2304

#712 Feature 712

#1128 Feature 1128

#1464 Feature 1464

#2965 Feature 2965

#211 Feature 211

#1932 Feature 1932

#100 Feature 100

#1083 Feature 1083

#594 Feature 594

#1615 Feature 1615

#756 Feature 756

#1885 Feature 1885

#1502 Feature 1502

#2250 Feature 2250

#1692 Feature 1692

#583 Feature 583

#2820 Feature 2820

#400 Feature 400

#1625 Feature 1625

#1864 Feature 1864

#1303 Feature 1303

#2533 Feature 2533

#1919 Feature 1919

#176 Feature 176

#2300 Feature 2300

#2877 Feature 2877

#3056 Feature 3056

#349 Feature 349

#140 Feature 140

#241 Feature 241

#1813 Feature 1813

#472 Feature 472

#2895 Feature 2895

#2658 Feature 2658

#2789 Feature 2789

#1487 Feature 1487

#112 Feature 112

#3010 Feature 3010

#1412 Feature 1412

#2618 Feature 2618

#2631 Feature 2631

#777 Feature 777

#409 Feature 409

#283 Feature 283

#170 Feature 170

#878 Feature 878

#2437 Feature 2437

#1815 Feature 1815

#1776 Feature 1776

#796 Feature 796

#2695 Feature 2695

#2839 Feature 2839

#3039 Feature 3039

#1704 Feature 1704

#2188 Feature 2188

#2760 Feature 2760

#2870 Feature 2870

#1377 Feature 1377

#1688 Feature 1688

#2736 Feature 2736

#294 Feature 294

#1866 Feature 1866

#645 Feature 645

#2485 Feature 2485

#955 Feature 955

#2285 Feature 2285

#1334 Feature 1334

#276 Feature 276

#1189 Feature 1189

#1854 Feature 1854

#198 Feature 198

#1435 Feature 1435

#1990 Feature 1990

#626 Feature 626

#2382 Feature 2382

#1695 Feature 1695

#690 Feature 690

#2110 Feature 2110

#1436 Feature 1436

#1030 Feature 1030

#941 Feature 941

#2351 Feature 2351

#1631 Feature 1631

#1080 Feature 1080

#2962 Feature 2962

#1547 Feature 1547

#974 Feature 974

#1286 Feature 1286

#1136 Feature 1136

#2343 Feature 2343

#1360 Feature 1360

#2916 Feature 2916

#2220 Feature 2220

#2217 Feature 2217

#2001 Feature 2001

#377 Feature 377

#2980 Feature 2980

#1921 Feature 1921

#305 Feature 305

#2626 Feature 2626

#2465 Feature 2465

#1907 Feature 1907

#1384 Feature 1384

#1934 Feature 1934

#161 Feature 161

#1159 Feature 1159

#1699 Feature 1699

#958 Feature 958

#2335 Feature 2335

#2919 Feature 2919

#714 Feature 714

#151 Feature 151

#1294 Feature 1294

#1670 Feature 1670

#2130 Feature 2130

#2051 Feature 2051

#1662 Feature 1662

#1645 Feature 1645

#603 Feature 603

#886 Feature 886

#1478 Feature 1478

#311 Feature 311

#738 Feature 738

#2716 Feature 2716

#2302 Feature 2302

#575 Feature 575

#3037 Feature 3037

#2331 Feature 2331

#2906 Feature 2906

#2599 Feature 2599

#1859 Feature 1859

#1913 Feature 1913

#1543 Feature 1543

#1158 Feature 1158

#265 Feature 265

#1142 Feature 1142

#2979 Feature 2979

#229 Feature 229

#2888 Feature 2888

#2774 Feature 2774

#2077 Feature 2077

#1237 Feature 1237

#537 Feature 537

#916 Feature 916

#2847 Feature 2847

#1611 Feature 1611

#1530 Feature 1530

#861 Feature 861

#1687 Feature 1687

#347 Feature 347

#1497 Feature 1497

#2711 Feature 2711

#2552 Feature 2552

#1698 Feature 1698

#1337 Feature 1337

#2931 Feature 2931

#1895 Feature 1895

#2978 Feature 2978

#2013 Feature 2013

#1744 Feature 1744

#1024 Feature 1024

#1979 Feature 1979

#1479 Feature 1479

#663 Feature 663

#2244 Feature 2244

#1546 Feature 1546

#1852 Feature 1852

#2458 Feature 2458

#696 Feature 696

#2879 Feature 2879

#160 Feature 160

#163 Feature 163

#319 Feature 319

#119 Feature 119

#2666 Feature 2666

#2227 Feature 2227

#1096 Feature 1096

#228 Feature 228

#1985 Feature 1985

#2973 Feature 2973

#395 Feature 395

#2306 Feature 2306

#493 Feature 493

#2035 Feature 2035

#2744 Feature 2744

#2166 Feature 2166

#969 Feature 969

#1753 Feature 1753

#1398 Feature 1398

#1739 Feature 1739

#2936 Feature 2936

#2394 Feature 2394

#1293 Feature 1293

#2738 Feature 2738

#2786 Feature 2786

#1035 Feature 1035

#2383 Feature 2383

#767 Feature 767

#316 Feature 316

#1342 Feature 1342

#502 Feature 502

#2637 Feature 2637

#2374 Feature 2374

#705 Feature 705

#3044 Feature 3044

#1556 Feature 1556

#2779 Feature 2779

#2731 Feature 2731

#2837 Feature 2837

#1078 Feature 1078

#2869 Feature 2869

#2688 Feature #2688

#815 Feature 815

#1867 Feature 1867

#2805 Feature 2805

#2421 Feature 2421

#2785 Feature 2785

#797 Feature 797

#585 Feature 585

#1302 Sensing and Detection Technologies

#234 Feature 234

#1583 Feature 1583

#252 Feature 252

#2361 Feature 2361

#2628 Feature 2628

#1702 Feature 1702

#1760 Feature 1760

#259 Feature 259

#1613 Feature 1613

#2500 Feature 2500

#2741 Feature 2741

#2243 Feature 2243

#2694 Feature 2694

#2908 Feature 2908

#171 Feature 171

#619 Feature 619

#1922 Feature 1922

#2003 Feature 2003

#2214 Feature 2214

#613 Feature 613

#2994 Feature 2994

#1997 Feature 1997

#2510 Feature 2510

#1039 Feature 1039

#2800 Feature 2800

#2133 Feature 2133

#390 Feature 390

#1060 Feature 1060

#1889 Feature 1889

#686 Feature 686

#1150 Feature 1150

#872 Feature 872

#2495 Feature 2495

#2397 Feature 2397

#2811 Feature 2811

#1438 Feature 1438

#307 Feature 307

#1881 Feature 1881

#2192 Feature 2192

#2124 Feature 2124

#2966 Feature 2966

#1629 Feature 1629

#1141 Feature 1141

#1477 Feature 1477

#953 Feature 953

#331 Feature 331

#2036 Feature 2036

#497 Feature 497

#1184 Feature 1184

#391 Feature 391

#1771 Feature 1771

#1247 Feature 1247

#1002 Feature 1002

#2303 Feature 2303

#850 Feature 850

#2693 Feature 2693

#987 Feature 987

#1215 Feature 1215

#1271 Feature 1271

#1244 Feature 1244

#911 Feature 911

#720 Feature 720

#309 Feature 309

#2942 Feature 2942

#433 Feature 433

#1819 Feature 1819

#2960 Feature 2960

#1550 Feature 1550

#2317 Feature 2317

#558 Feature 558

#2049 Feature 2049

#816 Feature 816

#1092 Feature 1092

#2976 Feature 2976

#1876 Feature 1876

#1844 Feature 1844

#808 Feature 808

#2723 Feature 2723

#1210 Feature 1210

#399 Feature 399

#725 Feature 725

#2480 Feature 2480

#142 Feature 142

#1492 Feature 1492

#2022 Feature 2022

#1890 Feature 1890

#340 Feature 340

#278 Feature 278

#1066 Feature 1066

#1287 Feature 1287

#2986 Feature 2986

#2223 Feature 2223

#1426 Feature 1426

#1747 Feature 1747

#630 Feature 630

#2183 Feature 2183

#2602 Feature 2602

#2759 Feature 2759

#2887 Feature 2887

#1380 Feature 1380

#214 Feature 214

#2848 Feature 2848

#167 Feature 167

#1858 Feature 1858

#2055 Feature 2055

#894 Feature 894

#2762 Feature 2762

#2529 Feature 2529

#1903 Feature 1903

#773 Feature 773

#866 Feature 866

#1973 Feature 1973

#2729 Feature 2729

#1725 Feature 1725

#790 Feature 790

#1169 Feature 1169

#2230 Feature 2230

#2742 Feature 2742

#2282 Feature 2282

#768 Feature 768

#763 Feature 763

#1324 Feature 1324

#2705 Feature 2705

#1170 Feature 1170

#3021 Feature 3021

#1486 Feature 1486

#883 Feature 883

#1037 Feature 1037

#339 Feature 339

#1306 Feature 1306

#2526 Feature 2526

#1415 Feature 1415

#807 Feature 807

#1297 Feature 1297

#770 Feature 770

#2162 Feature 2162

#1077 Feature 1077

#1113 Feature 1113

#515 Feature 515

#1321 Feature 1321

#366 Feature 366

#2381 Feature 2381

#1869 Feature 1869

#2757 Feature 2757

#2015 Feature 2015

#1332 Feature 1332

#2490 Feature 2490

#1909 Feature 1909

#1503 Feature 1503

#590 Feature 590

#289 Feature 289

#791 Feature 791

#504 Feature 504

#2956 Feature 2956

#190 Feature 190

#1655 Feature 1655

#180 Feature 180

#611 Feature 611

#1414 Feature 1414

#1361 Feature 1361

#1962 Feature 1962

#2482 Feature 2482

#711 Feature 711

#2083 Feature 2083

#1085 Feature 1085

#1213 Feature 1213

#2664 Feature 2664

#174 Feature 174

#2752 Feature 2752

#667 Feature 667

#670 Feature 670

#1357 Feature 1357

#1261 Feature 1261

#2642 Feature 2642

#379 Feature 379

#2840 Feature 2840

#1520 Feature 1520

#290 Feature 290

#1658 Feature 1658

#1602 Feature 1602

#127 Feature 127

#1920 Feature 1920

#1161 Feature 1161

#1811 Feature 1811

#1835 Feature 1835

#584 Feature 584

#2632 Feature 2632

#1823 Feature 1823

#2824 Feature 2824

#1880 Feature 1880

#665 Feature 665

#2132 Feature 2132

#940 Feature 940

#758 Feature 758

#2339 Feature 2339

#2390 Feature 2390

#2334 Feature 2334

#1527 Feature 1527

#358 Feature 358

#1682 Feature 1682

#1828 Feature 1828

#709 Feature 709

#524 Feature 524

#1421 Feature 1421

#2886 Feature 2886

#487 Feature 487

#1126 Feature 1126

#1203 Feature 1203

#995 Feature 995

#2856 Feature 2856

#175 Feature 175

#2134 Feature 2134

#628 Feature 628

#569 Feature 569

#2672 Feature 2672

#802 Feature 802

#1428 Feature 1428

#871 Feature 871

#2948 Feature 2948

#823 Feature 823

#1482 Feature 1482

#1094 Feature 1094

#2516 Feature 2516

#2067 Feature 2067

#336 Feature 336

#2712 Feature 2712

#368 Feature 368

#2333 Feature 2333

#688 Feature 688

#780 Feature 780

#258 Feature 258

#1310 Feature 1310

#2761 Feature 2761

#1155 Feature 1155

#2594 Feature 2594

#238 Feature 238

#2732 Feature 2732

#2949 Feature 2949

#1059 Feature 1059

#1608 Feature 1608

#2872 Feature 2872

#1345 Feature 1345

#1628 Feature 1628

#2301 Feature 2301

#2660 Feature 2660

#1351 Feature 1351

#1034 Feature 1034

#1612 Feature 1612

#1099 Feature 1099

#1248 Feature 1248

#1705 Feature 1705

#2050 Feature 2050

#1494 Feature 1494

#1076 Feature 1076

#1164 Feature 1164

#2431 Feature 2431

#2921 Feature 2921

#455 Feature 455

#1370 Feature 1370

#2620 Feature 2620

#2148 Feature 2148

#1074 Feature 1074

#2593 Feature 2593

#1333 Feature 1333

#150 Feature 150

#470 Feature 470

#559 Feature 559

#2471 Feature 2471

#1298 Feature 1298

#468 Feature 468

#1185 Feature 1185

#2903 Feature 2903

#535 Feature 535

#1949 Feature 1949

#2377 Feature 2377

#2321 Feature 2321

#2649 Feature 2649

#447 Feature 447

#639 Feature 639

#859 Feature 859

#396 Feature 396

#2178 Feature 2178

#1812 Feature 1812

#2087 Feature 2087

#2336 Feature 2336

#1174 Feature 1174

#2460 Feature 2460

#2990 Feature 2990

#182 Feature 182

#1117 Feature 1117

#2591 Feature 2591

#1817 Feature 1817

#754 Feature 754

#724 Feature 724

#2567 Feature 2567

#2128 Feature 2128

#3024 Feature 3024

#1797 Feature 1797

#444 Feature 444

#697 Feature 697

#1674 Feature 1674

#2646 Feature 2646

#2320 Feature 2320

#782 Feature 782

#2560 Feature 2560

#905 Feature 905

#1447 Feature 1447

#2357 Feature 2357

#753 Feature 753

#1623 Feature 1623

#2078 Feature 2078

#1772 Feature 1772

#448 Feature 448

#516 Feature 516

#1857 Feature 1857

#1196 Feature 1196

#544 Feature 544

#2782 Feature 2782

#847 Feature 847

#1309 Feature 1309

#1200 Feature 1200

#2069 Feature 2069

#562 Feature 562

#543 Feature 543

#2209 Feature 2209

#212 Feature 212

#1359 Feature 1359

#371 Feature 371

#597 Feature 597

#442 Feature 442

#1318 Feature 1318

#317 Feature 317

#128 Feature 128

#1856 Feature 1856

#3025 Feature 3025

#2661 Feature 2661

#2525 Feature 2525

#2933 Feature 2933

#785 Feature 785

#1480 Feature 1480

#960 Feature 960

#1101 Feature 1101

#2435 Feature 2435

#301 Feature 301

#351 Nanomaterial Synthesis and Properties

#1998 Feature 1998

#879 Feature 879

#1888 Feature 1888

#2730 Feature 2730

#1053 Feature 1053

#757 Feature 757

#1690 Feature 1690

#880 Feature 880

#997 Feature 997

#1409 Feature 1409

#577 Feature 577

#1933 Feature 1933

#1517 Feature 1517

#2376 Feature 2376

#1980 Feature 1980

#1038 Feature 1038

#2845 Feature 2845

#2644 Feature 2644

#239 Feature 239

#1301 Feature 1301

#1177 Feature 1177

#1425 Feature 1425

#2276 Feature 2276

#270 Feature 270

#1505 Feature 1505

#2580 Feature 2580

#828 Feature 828

#197 Feature 197

#1802 Feature 1802

#598 Feature 598

#177 Feature 177

#1182 Feature 1182

#1191 Feature 1191

#1742 Feature 1742

#1290 Feature 1290

#2098 Feature 2098

#1754 Feature 1754

#555 Feature 555

#2057 Feature 2057

#2740 Feature 2740

#2061 Feature 2061

#296 Feature 296

#2364 Feature 2364

#2440 Feature 2440

#406 Feature 406

#2657 Feature 2657

#1460 Feature 1460

#2844 Feature 2844

#2932 Feature 2932

#1032 Feature 1032

#2725 Feature 2725

#2491 Feature 2491

#2296 Feature 2296

#934 Feature 934

#1358 Feature 1358

#3002 Feature 3002

#991 Feature 991

#253 Feature 253

#1433 Feature 1433

#1322 Feature 1322

#885 Feature 885

#224 Feature 224

#2676 Feature 2676

#405 Feature 405

#2523 Feature 2523

#1525 Feature 1525

#825 Feature 825

#1001 Feature 1001

#1679 Feature 1679

#2911 Feature 2911

#440 Feature 440

#2167 Feature 2167

#1806 Feature 1806

#1388 Feature 1388

#2047 Feature 2047

#2355 Feature 2355

#501 Feature 501

#2091 Feature 2091

#952 Feature 952

#1356 Feature 1356

#2111 Feature 2111

#1506 Justification/Rationale for Actions

#732 Feature 732

#1082 Feature 1082

#2187 Feature 2187

#699 Feature 699

#1235 Feature 1235

#623 Feature 623

#1399 Feature 1399

#1914 Feature 1914

#528 Feature 528

#1860 Feature 1860

#1718 Feature 1718

#2290 Feature 2290

#3055 Feature 3055

#2257 Feature 2257

#2684 Feature 2684

#2995 Feature 2995

#1227 Feature 1227

#2617 Feature 2617

#2833 Feature 2833

#1105 Feature 1105

#2975 Feature 2975

#627 Feature 627

#1300 Feature 1300

#2544 Feature 2544

#1007 Feature 1007

#864 Feature 864

#1010 Feature 1010

#1029 Feature 1029

#1710 Feature 1710

#1509 Feature 1509

#2216 Feature 2216

#2443 Feature 2443

#510 Feature 510

#2799 Feature 2799

#1941 Feature 1941

#2829 Feature 2829

#1017 Feature 1017

#1644 Feature 1644

#2389 Feature 2389

#2387 Feature 2387

#463 Feature 463

#1833 Feature 1833

#1429 Feature 1429

#1827 Feature 1827

#345 Feature 345

#730 Feature 730

#2665 Feature 2665

#2718 Feature 2718

#3029 Feature 3029

#1459 Feature 1459

#1955 Feature 1955

#2910 Feature 2910

#2517 Feature 2517

#1706 Feature 1706

#1186 Feature 1186

#2983 Feature 2983

#2606 Feature 2606

#2897 Feature 2897

#1591 Feature 1591

#2958 Feature 2958

#2392 Feature 2392

#352 Feature 352

#1638 Feature 1638

#2388 Feature 2388

#185 Feature 185

#587 Feature 587

#122 Feature 122

#2084 Feature 2084

#2634 Feature 2634

#2920 Feature 2920

#612 Feature 612

#1476 Feature 1476

#2205 Feature 2205

#2256 Feature 2256

#2943 Feature 2943

#2912 Feature 2912

#2156 Feature 2156

#931 Feature 931

#1904 Feature 1904

#2378 Feature 2378

#1331 Feature 1331

#2769 Feature 2769

#1508 Feature 1508

#2219 Feature 2219

#951 Feature 951

#2842 Feature 2842

#107 Feature 107

#2876 Feature 2876

#786 Feature 786

#1770 Feature 1770

#1254 Feature 1254

#2195 Feature 2195

#659 Feature 659

#1044 Feature 1044

#3001 Feature 3001

#1680 Feature 1680

#413 Feature 413

#662 Feature 662

#1606 Feature 1606

#2539 Feature 2539

#2487 Feature 2487

#1481 Feature 1481

#1456 Feature 1456

#2566 Feature 2566

#2032 Feature 2032

#1284 Feature 1284

#1328 Feature 1328

#474 Surgical Procedures & Gastrointestinal Issues

#113 Feature 113

#506 Feature 506

#2925 Feature 2925

#2607 Feature 2607

#989 Feature 989

#2579 Feature 2579

#321 Feature 321

#2297 Feature 2297

#2653 Feature 2653

#2835 Feature 2835

#376 Feature 376

#384 Feature 384

#3028 Feature 3028

#1637 Feature 1637

#917 Feature 917

#521 Feature 521

#999 Feature 999

#2158 Feature 2158

#281 Feature 281

#2987 Feature 2987

#1369 Feature 1369

#1112 Feature 1112

#2722 Feature 2722

#2929 Feature 2929

#3032 Feature 3032

#2858 Feature 2858

#1531 Feature 1531

#2641 Feature 2641

#1439 Feature 1439

#488 Feature 488

#2004 Feature 2004

#646 Feature 646

#269 Feature 269

#1730 Feature 1730

#2271 Feature 2271

#525 Feature 525

#2972 Sensory-Motor Integration

#1906 Feature 1906

#344 Feature 344

#2964 Feature 2964

#1640 Feature 1640

#1991 Feature 1991

#420 Feature 420

#1528 Feature 1528

#2590 Feature 2590

#2763 Feature 2763

#1845 Feature 1845

#893 Feature 893

#1995 Feature 1995

#1691 Feature 1691

#1140 Feature 1140

#2648 Feature 2648

#1974 Feature 1974

#2554 Feature 2554

#1571 Feature 1571

#457 Feature 457

#310 Feature 310

#179 Feature 179

#2592 Feature 2592

#2696 Feature 2696

#822 Feature 822

#2056 Feature 2056

#1475 Feature 1475

#1490 Feature 1490

#1211 Feature 1211

#2796 Feature 2796

#2519 Feature 2519

#2330 Feature 2330

#2298 Feature 2298

#2428 Feature 2428

#492 Feature 492

#2935 Feature 2935

#2063 Feature 2063

#2687 Feature 2687

#2384 Feature 2384

#1748 Feature 1748

#578 Feature 578

#1385 Feature 1385

#1176 Feature 1176

#2603 Instructional/Educational Content

#2208 Feature 2208

#2945 Feature 2945

#2313 Feature 2313

#2253 Feature 2253

#539 Feature 539

#1743 Feature 1743

#2745 Feature 2745

#734 Feature 734

#818 Feature 818

#1824 Feature 1824

#494 Feature 494

#2353 Feature 2353

#551 Feature 551

#248 Feature 248

#1292 Feature 1292

#765 Feature 765

#1848 Feature 1848

#204 Feature 204

#3000 Feature 3000

#1278 Feature 1278

#622 Feature 622

#814 Feature 814

#964 Feature 964

#124 Feature 124

#2372 Feature 2372

#3022 Feature 3022

#2565 Feature 2565

#2947 Feature 2947

#2860 Feature 2860

#147 Feature 147

#2704 Feature 2704

#2342 Feature 2342

#2692 Feature 2692

#759 Feature 759

#1451 Feature 1451

#2563 Feature 2563

#892 Feature 892

#1427 Feature 1427

#461 Feature 461

#1533 Feature 1533

#762 Feature 762

#899 Feature 899

#2114 Feature 2114

#206 Feature 206

#1849 Feature 1849

#2751 Feature 2751

Document Content

Enhancement of the complement activating capacity of 17-1A mAb to overcome the effect of membrane-bound complement regulatory proteins on colorectal carcinoma.
Adjuvant immunotherapy with 17-1A mAb directed against colorectal carcinoma is found to be effective in patients. However, 52 % of the patients treated with mAb 17-1A showed recurrence within 7 years. This high recurrence rate might be due to inhibition of complement activation by membrane-bound complement regulatory proteins (mCRP). The effect of these complement regulatory proteins might be reduced by blocking mCRP, or be overcome by activating more complement at the tumor cell membrane. In this study the complement-activating capacity of the 17-1A mAb was enlarged by conjugating it to cobra venom factor (CVF) or C3b. The most important C3 regulatory protein, CD55, was blocked using a bispecific mAb directed against the 17-1A / Ep-CAM antigen and CD55. Up to a 13-fold increase in C3 deposition was observed due to 17-1A-CVF and 17-1A-C3b, as compared to 17-1A. CD55 was shown to partly inhibit complement activation by these conjugates. The effect of the bispecific anti-17-1A / Ep-CAM*anti-CD55 mAb was compared with 17-1A conjugates with CVF or C3, and bispecific mAb were shown to be equally or more efficient in complement activation than the 17-1A-CVF or 17-1A-C3b conjugates. Therefore, 17-1A conjugates and anti-17-1A / EpCAM*anti-CD55 bispecific mAb may be promising immunotherapeutic agents for patients with colorectal cancer.

Similar Documents