Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1517

MIN ACTIVATION

0.0

Details List

#1476 Feature 1476

#1152 Feature 1152

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#1924 Feature 1924

#1192 Feature 1192

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#2914 Feature 2914

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#2440 Feature 2440

#317 Feature 317

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#1683 Feature 1683

#1762 Feature 1762

#1671 Feature 1671

#1695 Feature 1695

#1425 Feature 1425

#158 Feature 158

#708 Drug Resistance Mechanisms in Cancer

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#115 Feature 115

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#1020 Feature 1020

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#1262 Feature 1262

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#185 Feature 185

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#1879 Feature 1879

#2631 Feature 2631

#547 Feature 547

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#168 Feature 168

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#2688 Feature #2688

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#2311 Feature 2311

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#1726 Feature 1726

#2566 Feature 2566

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#180 Feature 180

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#325 Feature 325

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#2433 Feature 2433

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#112 Feature 112

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#186 Feature 186

#2048 Feature 2048

#1722 Feature 1722

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#2662 Feature 2662

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#2316 Feature 2316

#2767 Feature 2767

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#3006 Feature 3006

#223 Feature 223

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#1311 Molecular Mechanisms and Biological Processes

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#474 Surgical Procedures & Gastrointestinal Issues

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#2232 Medical Case Reports & Cancer Research

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Document Content

Genotoxicity of phenacetin in the kidney and liver of Sprague-Dawley gpt delta transgenic rats in 26-week and 52-week repeated-dose studies.
Transgenic rat mutation assays can be used to assess genotoxic properties of chemicals in target organs for carcinogenicity. Mutations in transgenes are genetically neutral and accumulate during a treatment period; thus, assays are suitable for assessing the genotoxic risk of chemicals using a repeated-dose treatment paradigm. However, only a limited number of such studies have been conducted. To examine the utility of transgenic rat assays in repeated-dose studies, we fed male and female Sprague-Dawley gpt delta rats with a 0.5% phenacetin-containing diet for 26 and 52 weeks. A long-term feeding of phenacetin is known to induce renal cancer in rats. Phenacetin administration for 52 weeks in males significantly increased gpt (point mutations) mutant frequency (MF) in the kidney, the target organ of carcinogenesis. In the liver, the nontarget organ of carcinogenesis, gpt MFs were significantly elevated in phenacetin treatment groups of both genders during 26- and 52-week treatments. Furthermore, sensitive to P2 interference (Spi(-)deletions) MF increased in the liver of both genders following 52-week treatment. MFs were higher after treatment for 52 weeks than after treatment for 26 weeks. Frequencies of phenacetin-induced mutations were higher in the liver than in the kidney, suggesting that the intensity of genotoxicity does not necessarily correlate with the induction of tumor formation. Results from gpt delta rat assays of repeated-dose treatments are extremely useful to elucidate the relationship between gene mutations and carcinogenesis in the target organ induced by cancer-causing agents.

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