Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1511

MIN ACTIVATION

0.0

Details List

#2066 Feature 2066

#23 Neuronal Circuitry and Cellular Processes

#2358 Feature 2358

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#1295 Feature 1295

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#1002 Feature 1002

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#1944 Feature 1944

#2470 Feature 2470

#2196 Feature 2196

#2559 Feature 2559

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#740 Feature 740

#164 Feature 164

#1917 Feature 1917

#1349 Feature 1349

#114 Feature 114

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#476 Feature 476

#1106 Feature 1106

#316 Feature 316

#1311 Molecular Mechanisms and Biological Processes

#2199 Feature 2199

#2033 Feature 2033

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#2876 Feature 2876

#374 Medical Imaging and Oncology

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#1082 Feature 1082

#2891 Feature 2891

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#1037 Feature 1037

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#2062 Feature 2062

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#2183 Feature 2183

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#1162 Feature 1162

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#2603 Instructional/Educational Content

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#674 Feature 674

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#1420 Feature 1420

#335 Feature 335

#171 Feature 171

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#524 Feature 524

#112 Feature 112

#2261 Feature 2261

#2188 Feature 2188

#708 Drug Resistance Mechanisms in Cancer

#828 Feature 828

#2805 Feature 2805

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#1529 Feature 1529

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#1924 Feature 1924

#550 Feature 550

#770 Feature 770

#1445 Feature 1445

#2230 Feature 2230

#100 Feature 100

#2531 Feature 2531

#2676 Feature 2676

#1567 Feature 1567

#2161 Medical/Scientific Discourse with Ethical/Social Implications

#2868 Feature 2868

#2562 Feature 2562

#2954 Feature 2954

#2045 Feature 2045

#2442 Feature 2442

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#441 Feature 441

#1439 Feature 1439

#2224 Feature 2224

#1315 Feature 1315

#3002 Feature 3002

#1160 Feature 1160

#1615 Feature 1615

#2778 Hippocampal Memory and Cognitive Function

#456 Feature 456

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#2747 Feature 2747

#132 Feature 132

#2241 Feature 2241

#1859 Feature 1859

#2502 Feature 2502

#2589 Feature 2589

#882 Feature 882

#2972 Sensory-Motor Integration

#2721 Feature 2721

#2917 Feature 2917

#3026 Feature 3026

#696 Feature 696

#983 Feature 983

#2541 Feature 2541

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#2527 Feature 2527

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#3001 Feature 3001

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#1801 Feature 1801

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#2569 Feature 2569

#352 Feature 352

#2154 Feature 2154

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Document Content

LncRNA-TP53TG1 Participated in the Stress Response Under Glucose Deprivation in Glioma.
Gliomas are the most common brain tumors of the center nervous system. And long non-coding RNAs (lncRNAs) are non-protein coding transcripts, which have been considered as one type of gene expression regulator for cancer development. In this study, we investigated the role of lncRNA-TP53TG1 in response to glucose deprivation in human gliomas. The expression levels of TP53TG1 in glioma tissues and cells were analyzed by qRT-PCR. In addition, the influence of TP53TG1 on glucose metabolism related genes at the mRNA level during both high and low glucose treatment was detected by qRT-PCR. MTT, clonogenicity assays, and flow cytometry were performed to detect the cell proliferation and cell apoptosis. Furthermore, the migration of glioma cells was examined by Transwell assays. The expression of TP53TG1 was significantly higher in human glioma tissues or cell lines compared with normal brain tissue or NHA. Moreover, TP53TG1 and some tumor glucose metabolism related genes, such as GRP78, LDHA, and IDH1 were up-regulated significantly in U87 and LN18 cells under glucose deprivation. In addition, knockdown of TP53TG1 decreased cell proliferation and migration and down-regulated GRP78 and IDH1 expression levels and up-regulated PKM2 levels in U87 cells under glucose deprivation. However, over-expression of TP53TG1 showed the opposite tendency. Moreover, the effects of TP53TG1 were more remarkable in low glucose than that in high glucose. Our data showed that TP53TG1 under glucose deprivation may promote cell proliferation and migration by influencing the expression of glucose metabolism related genes in glioma. J. Cell. Biochem. 118: 4897-4904, 2017. © 2017 Wiley Periodicals, Inc.

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