Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1551

MIN ACTIVATION

0.0

Details List

#672 Feature 672

#2076 Feature 2076

#559 Feature 559

#2806 Feature 2806

#729 Feature 729

#2372 Feature 2372

#1628 Feature 1628

#2533 Feature 2533

#1425 Feature 1425

#2151 Feature 2151

#253 Feature 253

#1262 Feature 1262

#1333 Feature 1333

#1964 Feature 1964

#1237 Feature 1237

#1537 Feature 1537

#1404 Feature 1404

#2134 Feature 2134

#952 Feature 952

#1611 Feature 1611

#2292 Feature 2292

#374 Medical Imaging and Oncology

#642 Feature 642

#1487 Feature 1487

#2033 Feature 2033

#2977 Feature 2977

#2467 Feature 2467

#3037 Feature 3037

#1229 Feature 1229

#2381 Feature 2381

#931 Feature 931

#2790 Feature 2790

#1099 Feature 1099

#845 Feature 845

#159 Feature 159

#2599 Feature 2599

#990 Feature 990

#1625 Feature 1625

#892 Feature 892

#2803 Feature 2803

#1516 Feature 1516

#997 Feature 997

#3007 Feature 3007

#868 Feature 868

#1140 Feature 1140

#1844 Feature 1844

#2401 Feature 2401

#267 Feature 267

#581 Feature 581

#2358 Feature 2358

#2182 Feature 2182

#884 Feature 884

#1526 Feature 1526

#1342 Feature 1342

#2251 Feature 2251

#2300 Feature 2300

#708 Drug Resistance Mechanisms in Cancer

#1556 Feature 1556

#558 Feature 558

#759 Feature 759

#1238 Feature 1238

#543 Feature 543

#2635 Feature 2635

#973 Feature 973

#505 Feature 505

#241 Feature 241

#552 Feature 552

#548 Feature 548

#977 Feature 977

#2674 Feature 2674

#664 Feature 664

#1345 Feature 1345

#1722 Feature 1722

#2856 Feature 2856

#2213 Feature 2213

#1179 Feature 1179

#1393 Feature 1393

#2944 Feature 2944

#1629 Feature 1629

#981 Feature 981

#2435 Feature 2435

#510 Feature 510

#1351 Feature 1351

#506 Feature 506

#2229 Feature 2229

#368 Feature 368

#2427 Feature 2427

#2516 Feature 2516

#1549 Feature 1549

#337 Feature 337

#2752 Feature 2752

#1452 Feature 1452

#1131 Feature 1131

#150 Feature 150

#1009 Feature 1009

#1713 Feature 1713

#2549 Feature 2549

#2877 Feature 2877

#2777 Feature 2777

#2880 Feature 2880

#2256 Feature 2256

#1350 Feature 1350

#1332 Feature 1332

#2309 Feature 2309

#951 Feature 951

#1276 Feature 1276

#492 Feature 492

#1641 Feature 1641

#3023 Feature 3023

#1946 Feature 1946

#2572 Feature 2572

#446 Feature 446

#1695 Feature 1695

#2732 Feature 2732

#407 Feature 407

#2858 Feature 2858

#1242 Feature 1242

#1820 Feature 1820

#2982 Feature 2982

#2338 Feature 2338

#580 Feature 580

#597 Feature 597

#958 Feature 958

#519 Feature 519

#780 Feature 780

#957 Feature 957

#2589 Feature 2589

#1976 Feature 1976

#143 Feature 143

#1385 Feature 1385

#2794 Feature 2794

#578 Feature 578

#1464 Feature 1464

#2288 Feature 2288

#2029 Feature 2029

#662 Feature 662

#1610 Feature 1610

#1000 Feature 1000

#1365 Feature 1365

#1853 Feature 1853

#166 Feature 166

#815 Feature 815

#1216 Feature 1216

#1307 Feature 1307

#618 Feature 618

#2767 Feature 2767

#2759 Feature 2759

#2475 Feature 2475

#405 Feature 405

#1600 Feature 1600

#1422 Feature 1422

#890 Feature 890

#251 Feature 251

#2146 Feature 2146

#1419 Feature 1419

#1697 Feature 1697

#329 Feature 329

#1066 Feature 1066

#283 Feature 283

#1953 Feature 1953

#894 Feature 894

#191 Feature 191

#2106 Feature 2106

#1080 Feature 1080

#1352 Feature 1352

#2006 Feature 2006

#1592 Feature 1592

#2869 Feature 2869

#183 Feature 183

#1082 Feature 1082

#2534 Feature 2534

#2571 Feature 2571

#2254 Feature 2254

#1337 Feature 1337

#437 Feature 437

#1805 Feature 1805

#1867 Feature 1867

#2261 Feature 2261

#2498 Feature 2498

#1012 Feature 1012

#1200 Feature 1200

#459 Feature 459

#2126 Feature 2126

#934 Feature 934

#1928 Feature 1928

#701 Feature 701

#2135 Feature 2135

#2823 Feature 2823

#2280 Feature 2280

#1311 Molecular Mechanisms and Biological Processes

#2473 Feature 2473

#2824 Feature 2824

#2440 Feature 2440

#700 Feature 700

#3047 Feature 3047

#2913 Feature 2913

#2990 Feature 2990

#1738 Feature 1738

#2066 Feature 2066

#876 Feature 876

#2985 Feature 2985

#1954 Feature 1954

#221 Feature 221

#1205 Feature 1205

#1017 Feature 1017

#1756 Feature 1756

#774 Feature 774

#2370 Feature 2370

#838 Feature 838

#831 Feature 831

#435 Feature 435

#1119 Feature 1119

#712 Feature 712

#176 Feature 176

#885 Feature 885

#1086 Feature 1086

#2160 Feature 2160

#683 Feature 683

#1016 Feature 1016

#306 Feature 306

#389 Feature 389

#2138 Feature 2138

#324 Feature 324

#307 Feature 307

#1246 Feature 1246

#1807 Feature 1807

#776 Feature 776

#460 Feature 460

#859 Feature 859

#165 Feature 165

#2509 Feature 2509

#865 Feature 865

#1339 Feature 1339

#1467 Feature 1467

#2593 Feature 2593

#1214 Feature 1214

#2781 Feature 2781

#2507 Feature 2507

#2446 Feature 2446

#238 Feature 238

#233 Feature 233

#2003 Feature 2003

#1660 Feature 1660

#1866 Feature 1866

#522 Feature 522

#1435 Feature 1435

#1664 Feature 1664

#666 Feature 666

#365 Feature 365

#1130 Feature 1130

#582 Feature 582

#2742 Feature 2742

#261 Feature 261

#740 Feature 740

#2664 Feature 2664

#1700 Feature 1700

#1283 Feature 1283

#2419 Feature 2419

#360 Feature 360

#2573 Feature 2573

#883 Feature 883

#1256 Feature 1256

#541 Feature 541

#215 Feature 215

#1885 Feature 1885

#1043 Feature 1043

#1967 Feature 1967

#1671 Feature 1671

#2800 Feature 2800

#738 Feature 738

#808 Feature 808

#2132 Feature 2132

#2686 Feature 2686

#1107 Feature 1107

#358 Feature 358

#1846 Feature 1846

#2963 Feature 2963

#1052 Feature 1052

#1147 Feature 1147

#1171 Feature 1171

#1793 Feature 1793

#2612 Feature 2612

#653 Feature 653

#2147 Feature 2147

#2638 Feature 2638

#1809 Feature 1809

#566 Feature 566

#363 Feature 363

#3009 Feature 3009

#2230 Feature 2230

#198 Feature 198

#452 Feature 452

#1297 Feature 1297

#2227 Feature 2227

#1709 Feature 1709

#1381 Feature 1381

#1069 Feature 1069

#174 Feature 174

#2749 Feature 2749

#1730 Feature 1730

#920 Feature 920

#1998 Feature 1998

#1265 Feature 1265

#832 Feature 832

#1539 Feature 1539

#535 Feature 535

#2354 Feature 2354

#1938 Feature 1938

#2540 Feature 2540

#1087 Feature 1087

#252 Feature 252

#1797 Feature 1797

#1515 Feature 1515

#433 Feature 433

#2380 Feature 2380

#2765 Feature 2765

#2568 Feature 2568

#960 Feature 960

#609 Feature 609

#1114 Feature 1114

#1829 Feature 1829

#2477 Feature 2477

#2086 Feature 2086

#2597 Feature 2597

#1601 Feature 1601

#381 Feature 381

#2499 Feature 2499

#1597 Feature 1597

#1542 Feature 1542

#1056 Feature 1056

#2956 Feature 2956

#357 Feature 357

#2980 Feature 2980

#1770 Feature 1770

#2640 Feature 2640

#1124 Feature 1124

#3032 Feature 3032

#841 Feature 841

#2355 Feature 2355

#1244 Feature 1244

#496 Feature 496

#2244 Feature 2244

#493 Feature 493

#3065 Feature 3065

#315 Feature 315

#2992 Feature 2992

#219 Feature 219

#2523 Feature 2523

#917 Feature 917

#1187 Feature 1187

#699 Feature 699

#627 Feature 627

#524 Feature 524

#1065 Feature 1065

#356 Feature 356

#2297 Feature 2297

#2283 Feature 2283

#601 Feature 601

#1962 Feature 1962

#1290 Feature 1290

#2340 Feature 2340

#2399 Feature 2399

#621 Feature 621

#1439 Feature 1439

#2940 Feature 2940

#1810 Feature 1810

#2623 Feature 2623

#1193 Feature 1193

#604 Feature 604

#1203 Feature 1203

#1167 Feature 1167

#243 Feature 243

#1341 Feature 1341

#1753 Feature 1753

#1398 Feature 1398

#746 Feature 746

#1436 Feature 1436

#518 Feature 518

#2030 Feature 2030

#806 Feature 806

#1762 Feature 1762

#2953 Feature 2953

#410 Feature 410

#207 Feature 207

#730 Feature 730

#1816 Feature 1816

#355 Feature 355

#1386 Feature 1386

#1295 Feature 1295

#479 Feature 479

#2676 Feature 2676

#1218 Feature 1218

#1190 Feature 1190

#860 Feature 860

#638 Feature 638

#648 Feature 648

#275 Feature 275

#120 Feature 120

#186 Feature 186

#1004 Feature 1004

#757 Feature 757

#1903 Feature 1903

#2769 Feature 2769

#1758 Feature 1758

#2142 Feature 2142

#2529 Feature 2529

#107 Feature 107

#190 Feature 190

#1831 Feature 1831

#295 Feature 295

#641 Feature 641

#417 Feature 417

#1201 Feature 1201

#1523 Feature 1523

#549 Feature 549

#1901 Feature 1901

#2510 Feature 2510

#1127 Feature 1127

#1732 Feature 1732

#824 Feature 824

#2057 Feature 2057

#2331 Feature 2331

#2337 Feature 2337

#872 Feature 872

#314 Feature 314

#157 Feature 157

#1144 Feature 1144

#1445 Feature 1445

#2265 Feature 2265

#2582 Feature 2582

#1582 Feature 1582

#886 Feature 886

#2190 Feature 2190

#351 Nanomaterial Synthesis and Properties

#1269 Feature 1269

#1544 Feature 1544

#2873 Feature 2873

#792 Feature 792

#1676 Feature 1676

#1304 Feature 1304

#1483 Feature 1483

#2055 Feature 2055

#2010 Feature 2010

#2663 Feature 2663

#1792 Metastatic Cancer

#2567 Feature 2567

#2348 Feature 2348

#1428 Feature 1428

#563 Feature 563

#1550 Feature 1550

#1005 Feature 1005

#1870 Feature 1870

#2788 Feature 2788

#2917 Feature 2917

#1896 Feature 1896

#1652 Feature 1652

#854 Feature 854

#2027 Feature 2027

#302 Feature 302

#1289 Feature 1289

#1446 Feature 1446

#1215 Feature 1215

#1360 Feature 1360

#1417 Feature 1417

#2633 Feature 2633

#2291 Feature 2291

#2675 Feature 2675

#898 Feature 898

#196 Feature 196

#1492 Feature 1492

#2882 Feature 2882

#2905 Feature 2905

#323 Feature 323

#2409 Feature 2409

#1434 Feature 1434

#1316 Feature 1316

#2870 Feature 2870

#2020 Feature 2020

#1196 Feature 1196

#1618 Feature 1618

#1329 Feature 1329

#2319 Feature 2319

#2376 Feature 2376

#2918 Feature 2918

#1670 Feature 1670

#1572 Feature 1572

#2336 Feature 2336

#805 Feature 805

#2548 Feature 2548

#502 Feature 502

#1280 Feature 1280

#414 Feature 414

#2636 Feature 2636

#1604 Feature 1604

#2237 Feature 2237

#1279 Feature 1279

#1063 Feature 1063

#1939 Feature 1939

#1576 Feature 1576

#2083 Feature 2083

#1039 Feature 1039

#2935 Feature 2935

#2671 Feature 2671

#1380 Feature 1380

#2333 Feature 2333

#1525 Feature 1525

#227 Feature 227

#2465 Feature 2465

#1152 Feature 1152

#2900 Feature 2900

#2301 Feature 2301

#1100 Feature 1100

#373 Feature 373

#185 Feature 185

#2601 Feature 2601

#2174 Feature 2174

#1524 Feature 1524

#1977 Feature 1977

#2025 Feature 2025

#794 Feature 794

#1997 Feature 1997

#1106 Feature 1106

#2865 Feature 2865

#319 Feature 319

#793 Feature 793

#1972 Feature 1972

#231 Feature 231

#1645 Feature 1645

#1545 Feature 1545

#1042 Feature 1042

#1759 Feature 1759

#2976 Feature 2976

#1720 Feature 1720

#816 Feature 816

#568 Feature 568

#2402 Feature 2402

#2559 Feature 2559

#2728 Feature 2728

#1842 Feature 1842

#2551 Feature 2551

#1413 Feature 1413

#2350 Feature 2350

#574 Feature 574

#3040 Feature 3040

#1498 Feature 1498

#795 Feature 795

#2648 Feature 2648

#1166 Feature 1166

#1394 Feature 1394

#1157 Feature 1157

#2768 Feature 2768

#2460 Feature 2460

#1469 Feature 1469

#2220 Feature 2220

#1109 Feature 1109

#2425 Feature 2425

#1993 Feature 1993

#983 Feature 983

#1527 Feature 1527

#2329 Feature 2329

#2417 Feature 2417

#2629 Feature 2629

#217 Feature 217

#1331 Feature 1331

#404 Interactions and Mechanisms

#1731 Feature 1731

#614 Feature 614

#2631 Feature 2631

#2552 Feature 2552

#915 Feature 915

#2792 Feature 2792

#1560 Feature 1560

#1733 Feature 1733

#2323 Feature 2323

#383 Feature 383

#448 Feature 448

#2604 Feature 2604

#2647 Feature 2647

#1691 Feature 1691

#2924 Feature 2924

#576 Feature 576

#456 Feature 456

#1936 Feature 1936

#2833 Feature 2833

#723 Feature 723

#2090 Feature 2090

#1596 Feature 1596

#2136 Feature 2136

#353 Feature 353

#1230 Feature 1230

#1802 Feature 1802

#2895 Feature 2895

#1891 Feature 1891

#2180 Feature 2180

#2784 Feature 2784

#2285 Feature 2285

#1913 Feature 1913

#168 Feature 168

#2936 Feature 2936

#1020 Feature 1020

#2958 Feature 2958

#399 Feature 399

#2316 Feature 2316

#2214 Feature 2214

#1116 Feature 1116

#2576 Feature 2576

#955 Feature 955

#2039 Feature 2039

#711 Feature 711

#1919 Feature 1919

#2764 Feature 2764

#187 Feature 187

#889 Feature 889

#2797 Feature 2797

#2930 Feature 2930

#1914 Feature 1914

#2171 Molecular and Cellular Biological Processes

#2349 Feature 2349

#1325 Feature 1325

#1051 Feature 1051

#1755 Feature 1755

#1633 Feature 1633

#2884 Feature 2884

#2089 Feature 2089

#707 Feature 707

#203 Feature 203

#1859 Feature 1859

#2456 Feature 2456

#2683 Feature 2683

#1821 Feature 1821

#2531 Feature 2531

#557 Feature 557

#376 Feature 376

#2100 Feature 2100

#2934 Feature 2934

#847 Feature 847

#348 Feature 348

#1848 Feature 1848

#2592 Feature 2592

#1811 Feature 1811

#436 Feature 436

#1424 Feature 1424

#2247 Feature 2247

#521 Feature 521

#2879 Feature 2879

#350 Feature 350

#1840 Feature 1840

#2503 Feature 2503

#1680 Feature 1680

#807 Feature 807

#1698 Feature 1698

#633 Feature 633

#1788 Feature 1788

#862 Feature 862

#472 Feature 472

#927 Feature 927

#2455 Feature 2455

#2303 Feature 2303

#317 Feature 317

#799 Feature 799

#1013 Feature 1013

#2720 Feature 2720

#129 Feature 129

#803 Feature 803

#1158 Feature 1158

#547 Feature 547

#668 Feature 668

#3060 Feature 3060

#2395 Feature 2395

#1098 Feature 1098

#2687 Feature 2687

#1465 Feature 1465

#583 Feature 583

#1852 Feature 1852

#1548 Feature 1548

#224 Feature 224

#144 Feature 144

#2179 Feature 2179

#1995 Feature 1995

#2903 Feature 2903

#2555 Feature 2555

#2621 Feature 2621

#1430 Feature 1430

#1370 Feature 1370

#938 Feature 938

#2535 Feature 2535

#1278 Feature 1278

#2266 Feature 2266

#1137 Feature 1137

#2615 Feature 2615

#1667 Feature 1667

#650 Feature 650

#2068 Feature 2068

#1949 Feature 1949

#612 Feature 612

#443 Feature 443

#290 Feature 290

#273 Feature 273

#2375 Feature 2375

#1648 Feature 1648

#1726 Feature 1726

#1093 Feature 1093

#1097 Feature 1097

#1588 Feature 1588

#2852 Feature 2852

#943 Feature 943

#2496 Feature 2496

#2816 Feature 2816

#3045 Feature 3045

#225 Feature 225

#235 Feature 235

#153 Feature 153

#2175 Feature 2175

#1067 Feature 1067

#986 Feature 986

#853 Feature 853

#858 Feature 858

#1395 Feature 1395

#1476 Feature 1476

#1590 Feature 1590

#2562 Feature 2562

#1354 Feature 1354

#1880 Feature 1880

#254 Feature 254

#2047 Feature 2047

#1318 Feature 1318

#636 Feature 636

#2524 Feature 2524

#1905 Feature 1905

#564 Feature 564

#517 Feature 517

#940 Feature 940

#2360 Feature 2360

#2112 Feature 2112

#1375 Feature 1375

#1441 Feature 1441

#1650 Feature 1650

#1551 Feature 1551

#909 Feature 909

#1126 Feature 1126

#1014 Feature 1014

#1929 Feature 1929

#2844 Feature 2844

#979 Feature 979

#2911 Feature 2911

#741 Feature 741

#939 Feature 939

#2377 Feature 2377

#657 Feature 657

#277 Feature 277

#1115 Feature 1115

#1883 Feature 1883

#362 Feature 362

#3056 Feature 3056

#1577 Feature 1577

#2191 Feature 2191

#1985 Feature 1985

#2957 Feature 2957

#2271 Feature 2271

#2394 Feature 2394

#1103 Feature 1103

#151 Feature 151

#249 Feature 249

#929 Feature 929

#677 Feature 677

#1442 Feature 1442

#1561 Feature 1561

#610 Feature 610

#1568 Feature 1568

#1113 Feature 1113

#2335 Feature 2335

#1965 Feature 1965

#2457 Feature 2457

#1227 Feature 1227

#649 Feature 649

#2205 Feature 2205

#982 Feature 982

#2082 Feature 2082

#322 Feature 322

#2351 Feature 2351

#2802 Feature 2802

#949 Feature 949

#937 Feature 937

#2232 Medical Case Reports & Cancer Research

#2899 Feature 2899

#1647 Feature 1647

#2073 Feature 2073

#1518 Feature 1518

#1134 Feature 1134

#1948 Feature 1948

#646 Feature 646

#1254 Feature 1254

#1570 Feature 1570

#735 Feature 735

#1789 Feature 1789

#1459 Feature 1459

#432 Feature 432

#1274 Feature 1274

#753 Feature 753

#1161 Feature 1161

#758 Feature 758

#836 Feature 836

#2997 Feature 2997

#397 Feature 397

#2613 Feature 2613

#2737 Feature 2737

#1894 Feature 1894

#1359 Feature 1359

#2225 Feature 2225

#2181 Feature 2181

#1202 Feature 1202

#1263 Feature 1263

#201 Feature 201

#1895 Feature 1895

#364 Feature 364

#1429 Feature 1429

#258 Feature 258

#313 Feature 313

#347 Feature 347

#230 Feature 230

#255 Feature 255

#1689 Feature 1689

#2563 Feature 2563

#2091 Feature 2091

#1924 Feature 1924

#733 Feature 733

#2658 Feature 2658

#2163 Feature 2163

#1555 Feature 1555

#2408 Feature 2408

#284 Feature 284

#770 Feature 770

#2281 Feature 2281

#2241 Feature 2241

#1358 Feature 1358

#2243 Feature 2243

#2462 Feature #2462

#1378 Feature 1378

#615 Feature 615

#532 Feature 532

#1264 Feature 1264

#2755 Feature 2755

#2282 Feature 2282

#1911 Feature 1911

#1008 Feature 1008

#2881 Feature 2881

#2564 Feature 2564

#2805 Feature 2805

#1367 Feature 1367

#3053 Feature 3053

#2023 Feature 2023

#2461 Feature 2461

#1346 Feature 1346

#1522 Feature 1522

#2064 Feature 2064

#2616 Feature 2616

#1799 Feature 1799

#117 Feature 117

#291 Feature 291

#1028 Feature 1028

#1818 Feature 1818

#1204 Feature 1204

#857 Feature 857

#1101 Feature 1101

#2004 Feature 2004

#1182 Feature 1182

#1575 Feature 1575

#1528 Feature 1528

#1776 Feature 1776

#1293 Feature 1293

#1186 Feature 1186

#1044 Feature 1044

#286 Feature 286

#2920 Feature 2920

#2081 Feature 2081

#1581 Feature 1581

#2964 Feature 2964

#595 Feature 595

#2014 Feature 2014

#1565 Feature 1565

#695 Feature 695

#1971 Feature 1971

#2838 Feature 2838

#1892 Feature 1892

#2965 Feature 2965

#2804 Feature 2804

#1908 Feature 1908

#1857 Feature 1857

#690 Feature 690

#2079 Feature 2079

#1153 Feature 1153

#1988 Feature 1988

#2069 Feature 2069

#1418 Feature 1418

#1330 Feature 1330

#123 Feature 123

#2831 Feature 2831

#2745 Feature 2745

#1497 Feature 1497

#429 Feature 429

#2208 Feature 2208

#1219 Feature 1219

#2758 Feature 2758

#525 Feature 525

#798 Feature 798

#1085 Feature 1085

#2184 Feature 2184

#1231 Feature 1231

#1952 Feature 1952

#2841 Feature 2841

#2885 Feature 2885

#2577 Feature 2577

#1245 Feature 1245

#1569 Feature 1569

#2436 Feature 2436

#629 Feature 629

#110 Feature 110

#2149 Feature 2149

#1374 Feature 1374

#2711 Feature 2711

#1707 Feature 1707

#1974 Feature 1974

#1890 Feature 1890

#2063 Feature 2063

#2681 Feature 2681

#2497 Feature 2497

#2590 Feature 2590

#2259 Feature 2259

#457 Feature 457

#667 Feature 667

#223 Feature 223

#218 Feature 218

#2385 Feature 2385

#515 Feature 515

#2575 Feature 2575

#743 Feature 743

#1372 Feature 1372

#2828 Feature 2828

#1584 Feature 1584

#533 Feature 533

#1495 Feature 1495

#1175 Feature 1175

#2453 Feature 2453

#2789 Feature 2789

#1160 Feature 1160

#2979 Feature 2979

#244 Feature 244

#877 Feature 877

#301 Feature 301

#2505 Feature 2505

#2483 Feature 2483

#2359 Feature 2359

#771 Feature 771

#1760 Feature 1760

#2888 Feature 2888

#1338 Feature 1338

#2464 Feature 2464

#1889 Feature 1889

#703 Feature 703

#2669 Feature 2669

#1357 Feature 1357

#256 Feature 256

#1786 Feature 1786

#2423 Feature 2423

#1757 Feature 1757

#2070 Feature 2070

#3069 Feature 3069

#2989 Feature 2989

#2545 Feature 2545

#750 Feature 750

#3036 Feature 3036

#2487 Feature 2487

#2709 Feature 2709

#1414 Feature 1414

#2046 Feature 2046

#162 Feature 162

#2127 Feature 2127

#1185 Feature 1185

#2866 Feature 2866

#947 Feature 947

#941 Feature 941

#1930 Feature 1930

#1817 Feature 1817

#2702 Feature 2702

#1486 Feature 1486

#2766 Feature 2766

#1369 Feature 1369

#1071 Feature 1071

#2627 Feature 2627

#1578 Feature 1578

#1406 Feature 1406

#205 Feature 205

#461 Feature 461

#3024 Feature 3024

#2971 Feature 2971

#2140 Feature 2140

#837 Feature 837

#511 Feature 511

#1854 Feature 1854

#2236 Feature 2236

#1552 Feature 1552

#870 Feature 870

#269 Feature 269

#1785 Feature 1785

#923 Feature 923

#1944 Feature 1944

#2050 Feature 2050

#416 Feature 416

#1763 Feature 1763

#1045 Feature 1045

#2383 Feature 2383

#170 Feature 170

#2107 Feature 2107

#1557 Feature 1557

#2111 Feature 2111

#3030 Feature 3030

#2470 Feature 2470

#1197 Feature 1197

#1388 Feature 1388

#1138 Feature 1138

#276 Feature 276

#326 Feature 326

#1206 Feature 1206

#3064 Surgical Complications and Physiological Stress

#528 Feature 528

#922 Feature 922

#1007 Feature 1007

#3048 Feature 3048

#1658 Feature 1658

#1711 Feature 1711

#262 Feature 262

#2474 Feature 2474

#116 Feature 116

#689 Feature 689

#887 Feature 887

#338 Feature 338

#2198 Feature 2198

#985 Feature 985

#2242 Feature 2242

#2373 Feature 2373

#1125 Feature 1125

#1328 Feature 1328

#2818 Feature 2818

#2109 Feature 2109

#2485 Feature 2485

#401 Feature 401

#379 Feature 379

#882 Feature 882

#2273 Feature 2273

#158 Feature 158

#849 Feature 849

#775 Feature 775

#2637 Feature 2637

#1460 Feature 1460

#2528 Feature 2528

#2624 Feature 2624

#409 Feature 409

#1415 Feature 1415

#1081 Feature 1081

#761 Feature 761

#114 Feature 114

#2108 Feature 2108

#2813 Feature 2813

#2845 Feature 2845

#1909 Feature 1909

#1448 Feature 1448

#1945 Feature 1945

#2539 Feature 2539

#1112 Feature 1112

#2164 Feature 2164

#572 Feature 572

#1474 Feature 1474

#2426 Feature 2426

#2260 Historical Context & Development

#1794 Feature 1794

#152 Feature 152

#279 Feature 279

#421 Feature 421

#2646 Feature 2646

#911 Feature 911

#2270 Feature 2270

#3000 Feature 3000

#2829 Feature 2829

#3003 Feature 3003

#1878 Feature 1878

#1198 Feature 1198

#200 Feature 200

#2125 Feature 2125

#1317 Feature 1317

#1966 Feature 1966

#352 Feature 352

#1485 Feature 1485

#867 Feature 867

#2587 Feature 2587

#715 Feature 715

#2791 Feature 2791

#2908 Feature 2908

#768 Feature 768

#570 Feature 570

#1910 Feature 1910

#1343 Feature 1343

#966 Feature 966

#468 Feature 468

#1639 Feature 1639

#2744 Feature 2744

#1620 Feature 1620

#133 Feature 133

#1509 Feature 1509

#2154 Feature 2154

#2506 Feature 2506

#2007 Developmental Disparities & Intervention

#1178 Feature 1178

#1554 Feature 1554

#1058 Feature 1058

#2418 Feature 2418

#1390 Feature 1390

#546 Feature 546

#126 Feature 126

#950 Feature 950

#3050 Feature 3050

#297 Feature 297

#2863 Feature 2863

#268 Feature 268

#430 Feature 430

#2343 Feature 2343

#1250 Feature 1250

#1834 Feature 1834

#1739 Feature 1739

#380 Feature 380

#993 Feature 993

#1463 Feature 1463

#1427 Feature 1427

#1440 Feature 1440

#2172 Feature 2172

#1188 Feature 1188

#945 Feature 945

#1431 Feature 1431

#2871 Feature 2871

#280 Feature 280

#651 Feature 651

#811 Feature 811

#113 Feature 113

#1102 Feature 1102

#2099 Feature 2099

#1195 Feature 1195

#1050 Feature 1050

#1466 Feature 1466

#1861 Feature 1861

#961 Feature 961

#300 Feature 300

#1749 Feature 1749

#2772 Feature 2772

#2644 Feature 2644

#1396 Feature 1396

#1796 Feature 1796

#463 Feature 463

#1632 Feature 1632

#1858 Feature 1858

#835 Feature 835

#2947 Feature 2947

#2812 Feature 2812

#2304 Feature 2304

#2665 Feature 2665

#179 Feature 179

#1800 Feature 1800

#136 Feature 136

#359 Feature 359

#693 Feature 693

#1266 Feature 1266

#2983 Feature 2983

#2984 Feature 2984

#2835 Feature 2835

#562 Feature 562

#148 Feature 148

#2404 Feature 2404

#1609 Feature 1609

#2034 Feature 2034

#2173 Feature 2173

#1055 Feature 1055

#994 Feature 994

#2234 Feature 2234

#172 Feature 172

#2159 Feature 2159

#1699 Feature 1699

#462 Feature 462

#1675 Feature 1675

#2411 Feature 2411

#1261 Feature 1261

#1746 Feature 1746

#2356 Feature 2356

#334 Feature 334

#2223 Feature 2223

#2012 Feature 2012

#2969 Feature 2969

#1302 Sensing and Detection Technologies

#643 Feature 643

#1362 Feature 1362

#2476 Feature 2476

#2087 Feature 2087

#1183 Feature 1183

#2274 Feature 2274

#1108 Feature 1108

#863 Feature 863

#1705 Feature 1705

#893 Feature 893

#427 Feature 427

#2771 Feature 2771

#1534 Feature 1534

#2071 Feature 2071

#1348 Feature 1348

#3059 Feature 3059

#705 Feature 705

#2026 Feature 2026

#411 Feature 411

#128 Feature 128

#1627 Feature 1627

#875 Feature 875

#2431 Feature 2431

#122 Feature 122

#1011 Feature 1011

#1917 Feature 1917

#2197 Feature 2197

#1054 Feature 1054

#2479 Feature 2479

#1165 Feature 1165

#2398 Feature 2398

#408 Feature 408

#936 Feature 936

#2320 Feature 2320

#2605 Feature 2605

#1180 Feature 1180

#3049 Feature 3049

#474 Surgical Procedures & Gastrointestinal Issues

#2955 Feature 2955

#1887 Feature 1887

#3058 Feature 3058

#2945 Feature 2945

#2672 Feature 2672

#736 Feature 736

#1798 Feature 1798

#2502 Feature 2502

#1855 Feature 1855

#354 Feature 354

#1176 Feature 1176

#899 Feature 899

#631 Feature 631

#2607 Feature 2607

#1479 Feature 1479

#3061 Feature 3061

#1510 Feature 1510

#1025 Feature 1025

#1003 Feature 1003

#1253 Feature 1253

#340 Feature 340

#828 Feature 828

#1851 Feature 1851

#1663 Feature 1663

#2278 Feature 2278

#1941 Feature 1941

#2553 Feature 2553

#3014 Feature 3014

#1026 Feature 1026

#469 Feature 469

#2189 Feature 2189

#303 Feature 303

#1579 Feature 1579

#2876 Feature 2876

#783 Feature 783

#590 Feature 590

#588 Feature 588

#964 Feature 964

#1864 Feature 1864

#1210 Feature 1210

#288 Feature 288

#1221 Feature 1221

#3042 Feature 3042

#1048 Feature 1048

#2919 Feature 2919

#2000 Feature 2000

#2178 Feature 2178

#2434 Feature 2434

#2318 Feature 2318

#3066 Feature 3066

#1869 Feature 1869

#569 Feature 569

#2119 Feature 2119

#1747 Feature 1747

#760 Feature 760

#2078 Feature 2078

#1717 Feature 1717

#661 Feature 661

#1088 Feature 1088

#2714 Feature 2714

#731 Feature 731

#1243 Feature 1243

#2910 Feature 2910

#2662 Feature 2662

#2250 Feature 2250

#1241 Feature 1241

#2515 Feature 2515

#531 Feature 531

#1064 Feature 1064

#596 Feature 596

#483 Feature 483

#777 Feature 777

#1701 Feature 1701

#971 Feature 971

#287 Feature 287

#1468 Feature 1468

#2432 Feature 2432

#1979 Feature 1979

#1767 Feature 1767

#1868 Feature 1868

#1994 Feature 1994

#751 Feature 751

#1292 Feature 1292

#843 Feature 843

#1002 Feature 1002

#1040 Feature 1040

#2011 Feature 2011

#644 Feature 644

#331 Feature 331

#1399 Feature 1399

#1860 Feature 1860

#2949 Feature 2949

#1684 Feature 1684

#2166 Feature 2166

#2782 Feature 2782

#327 Feature 327

#1149 Feature 1149

#1506 Justification/Rationale for Actions

#2855 Feature 2855

#593 Feature 593

#686 Feature 686

#1248 Feature 1248

#2269 Feature 2269

#542 Feature 542

#2780 Feature 2780

#2379 Feature 2379

#2952 Feature 2952

#1255 Feature 1255

#1791 Feature 1791

#1926 Feature 1926

#1703 Feature 1703

#2312 Feature 2312

#1267 Feature 1267

#2118 Feature 2118

#924 Feature 924

#2133 Feature 2133

#2859 Feature 2859

#1148 Feature 1148

#1603 Feature 1603

#544 Feature 544

#1819 Feature 1819

#2275 Feature 2275

#1447 Feature 1447

#2437 Feature 2437

#932 Feature 932

#246 Feature 246

#2822 Feature 2822

#970 Feature 970

#692 Feature 692

#728 Feature 728

#801 Feature 801

#2942 Feature 2942

#2585 Feature 2585

#1336 Feature 1336

#2406 Feature 2406

#2268 Feature 2268

#412 Feature 412

#2584 Feature 2584

#2088 Feature 2088

#1482 Feature 1482

#2139 Feature 2139

#2677 Feature 2677

#1104 Feature 1104

#874 Feature 874

#2489 Feature 2489

#829 Feature 829

#1461 Feature 1461

#2290 Feature 2290

#2193 Feature 2193

#1940 Feature 1940

#2267 Feature 2267

#214 Feature 214

#2103 Feature 2103

#2650 Feature 2650

#2729 Feature 2729

#2471 Feature 2471

#1511 Feature 1511

#2469 Feature 2469

#1888 Feature 1888

#1091 Feature 1091

#2848 Feature 2848

#2295 Feature 2295

#1780 Feature 1780

#1457 Feature 1457

#1690 Feature 1690

#2915 Feature 2915

#871 Feature 871

#902 Feature 902

#386 Feature 386

#1774 Feature 1774

#737 Feature 737

#2926 Feature 2926

#2062 Feature 2062

#2199 Feature 2199

#2710 Feature 2710

#3063 Feature 3063

#1083 Feature 1083

#2286 Feature 2286

#193 Feature 193

#2708 Feature 2708

#880 Feature 880

#1143 Feature 1143

#1640 Feature 1640

#1992 Feature 1992

#272 Feature 272

#814 Feature 814

#3012 Feature 3012

#2187 Feature 2187

#800 Feature 800

#1566 Feature 1566

#3031 Feature 3031

#247 Feature 247

#2666 Feature 2666

#2757 Feature 2757

#250 Feature 250

#1583 Feature 1583

#1876 Feature 1876

#1211 Feature 1211

#561 Feature 561

#756 Feature 756

#2393 Feature 2393

#2566 Feature 2566

#1323 Feature 1323

#1225 Feature 1225

#2028 Feature 2028

#1508 Feature 1508

#987 Feature 987

#127 Feature 127

#1207 Feature 1207

#2162 Feature 2162

#2878 Feature 2878

#2310 Feature 2310

#418 Feature 418

#2991 Feature 2991

#1925 Feature 1925

#242 Feature 242

#1915 Feature 1915

#846 Feature 846

#2954 Feature 2954

#1782 Feature 1782

#848 Feature 848

#2420 Feature 2420

#2480 Feature 2480

#1958 Feature 1958

#23 Neuronal Circuitry and Cellular Processes

#1613 Feature 1613

#495 Feature 495

#727 Feature 727

#1983 Feature 1983

#1164 Feature 1164

#504 Feature 504

#674 Feature 674

#2287 Feature 2287

#2155 Feature 2155

#431 Feature 431

#2894 Feature 2894

#1540 Feature 1540

#1606 Feature 1606

#1666 Feature 1666

#2904 Feature 2904

#2131 Feature 2131

#659 Feature 659

#786 Feature 786

#2129 Feature 2129

#2410 Feature 2410

#2324 Feature 2324

#1823 Feature 1823

#2384 Feature 2384

#1677 Feature 1677

#2176 Feature 2176

#2202 Feature 2202

#2653 Feature 2653

#1146 Feature 1146

#1270 Feature 1270

#2810 Feature 2810

#490 Feature 490

#1546 Feature 1546

#2609 Feature 2609

#630 Feature 630

#2594 Feature 2594

#106 Feature 106

#1240 Feature 1240

#2987 Feature 2987

#2262 Feature 2262

#895 Feature 895

#2481 Feature 2481

#1801 Feature 1801

Document Content

Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration.
We demonstrated previously that rat ascites hepatoma MM1 cells require both lysophosphatidic acid (LPA) and fibronectin (FN) for phagokinetic motility and transcellular migration and that these events are regulated through the RhoA-ROCK pathway. It remains to be elucidated, however, how the signals from both LPA and FN are integrated into cell migration. To examine this, total cellular lysates after stimulation with LPA or FN were subjected to time-course immunoblot analysis with anti-phosphotyrosine antibodies (Abs). Consequently, tyrosine-phosphorylation of paxillin was obviously persistent after stimulation with FN + LPA as compared to after stimulation with either alone. Tyrosine-phosphorylated paxillin comprised 2 components; slowly and fast migrating ones. Immunoblotting of anti-paxillin immunoprecipitates with phosphorylation site-specific Abs revealed the following: tyrosine-phosphorylation was enhanced preferentially on a slowly migrating component after stimulation with FN + LPA; this component contained phosphorylation at both tyrosine residue (Y) 31 and Y118; and phosphorylation of paxillin at Y181 was constitutive and not augmented by stimulation with either FN or LPA. Amiloride, an inhibitor of the Na+/H+ antiporter downstream of ROCK, suppressed cell motility and correspondingly paxillin tyrosine-phosphorylation at both Y31 and Y118. Paxillin phosphorylation weakly induced by FN alone, insufficient for cell migration, was not inhibited by amiloride. These results demonstrate that LPA collaborates with FN for persistent tyrosine phosphorylation of paxillin at both Y31 and Y118, regulated by the Na+/H+ antiporter downstream of ROCK and that this phosphorylated paxillin is essential for MM1 cancer cell migration.

Similar Documents