Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1486

MIN ACTIVATION

0.0

Details List

#2153 Feature 2153

#2993 Feature 2993

#23 Neuronal Circuitry and Cellular Processes

#1565 Feature 1565

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#2007 Developmental Disparities & Intervention

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#2119 Feature 2119

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#2697 Feature 2697

#3028 Feature 3028

#719 Feature 719

#2972 Sensory-Motor Integration

#500 Feature 500

#110 Feature 110

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#621 Feature 621

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#1061 Feature 1061

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#1716 Feature 1716

#263 Feature 263

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#2966 Feature 2966

#2778 Hippocampal Memory and Cognitive Function

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#1422 Feature 1422

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#2260 Historical Context & Development

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#1335 Feature 1335

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#2318 Feature 2318

#3064 Surgical Complications and Physiological Stress

#1978 Feature 1978

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#1311 Molecular Mechanisms and Biological Processes

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#2022 Feature 2022

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#1269 Feature 1269

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Document Content

Type II Diabetes Mellitus Accelerates Age-Dependent Aβ Pathology in Cynomolgus Monkey Brain.
Accumulating evidence suggests that diabetes mellitus (DM) is one of the strongest risk factors for developing Alzheimer's disease (AD). However, it remains unclear how DM accelerates AD pathology in the brain. Cynomolgus monkey (Macaca fascicularis) is one of the nonhuman primates used for biomedical research, and we can observe spontaneous formation of AD pathology, such as senile plaques (SPs) and neurofibrillary tangles (NFTs), with the advance of aging. Furthermore, obesity is occasionally observed and frequently leads to development of type II DM (T2DM) in laboratory-housed cynomolgus monkeys. These findings suggest that cynomolgus monkey is a useful species to study the relationship between T2DM and AD pathology. In T2DM-affected monkey brains, SPs were observed in frontal and temporal lobe cortices almost 5 years earlier than healthy control monkeys. Moreover, age-related endocytic pathology, such as intraneuronal accumulation of enlarged endosomes, was exacerbated in T2DM-affected monkey brains. Since accumulating evidences suggest that endocytic dysfunction is involved in Aβ pathology, T2DM may aggravate age-related endocytic dysfunction, leading to the acceleration of Aβ pathology.

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