Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1486

MIN ACTIVATION

0.0

Details List

#708 Drug Resistance Mechanisms in Cancer

#672 Feature 672

#1805 Feature 1805

#2803 Feature 2803

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#2174 Feature 2174

#187 Feature 187

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#1604 Feature 1604

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#1844 Feature 1844

#2931 Feature 2931

#389 Feature 389

#463 Feature 463

#1130 Feature 1130

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#2792 Feature 2792

#627 Feature 627

#766 Feature 766

#641 Feature 641

#2160 Feature 2160

#2340 Feature 2340

#1834 Feature 1834

#218 Feature 218

#2090 Feature 2090

#2758 Feature 2758

#997 Feature 997

#887 Feature 887

#746 Feature 746

#1994 Feature 1994

#2848 Feature 2848

#2086 Feature 2086

#437 Feature 437

#2592 Feature 2592

#1216 Feature 1216

#3060 Feature 3060

#2845 Feature 2845

#1965 Feature 1965

#838 Feature 838

#1695 Feature 1695

#757 Feature 757

#405 Feature 405

#1792 Metastatic Cancer

#979 Feature 979

#1483 Feature 1483

#363 Feature 363

#952 Feature 952

#2916 Feature 2916

#2354 Feature 2354

#990 Feature 990

#2350 Feature 2350

#2309 Feature 2309

#634 Feature 634

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#3007 Feature 3007

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#2276 Feature 2276

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#2401 Feature 2401

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#334 Feature 334

#2070 Feature 2070

#2280 Feature 2280

#740 Feature 740

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#2250 Feature 2250

#890 Feature 890

#2657 Feature 2657

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#698 Feature 698

#967 Feature 967

#1946 Feature 1946

#1949 Feature 1949

#2004 Feature 2004

#1099 Feature 1099

#929 Feature 929

#2138 Feature 2138

#1610 Feature 1610

#1304 Feature 1304

#575 Feature 575

#1753 Feature 1753

#2797 Feature 2797

#2589 Feature 2589

#1486 Feature 1486

#1407 Feature 1407

#941 Feature 941

#2665 Feature 2665

#2013 Feature 2013

#1243 Feature 1243

#2844 Feature 2844

#152 Feature 152

#1420 Feature 1420

#283 Feature 283

#2647 Feature 2647

#815 Feature 815

#1116 Feature 1116

#350 Feature 350

#265 Feature 265

#411 Feature 411

#1404 Feature 1404

#1025 Feature 1025

#673 Feature 673

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#511 Feature 511

#816 Feature 816

#115 Feature 115

#1441 Feature 1441

#1085 Feature 1085

#1582 Feature 1582

#1492 Feature 1492

#2206 Feature 2206

#2977 Feature 2977

#1556 Feature 1556

#1606 Feature 1606

#1484 Feature 1484

#1203 Feature 1203

#317 Feature 317

#868 Feature 868

#973 Feature 973

#2133 Feature 2133

#2213 Feature 2213

#2738 Feature 2738

#451 Feature 451

#2599 Feature 2599

#422 Feature 422

#379 Feature 379

#2696 Feature 2696

#1262 Feature 1262

#1297 Feature 1297

#1786 Feature 1786

#1967 Feature 1967

#792 Feature 792

#2702 Feature 2702

#375 Feature 375

#550 Feature 550

#1584 Feature 1584

#916 Feature 916

#188 Feature 188

#1386 Feature 1386

#2857 Feature 2857

#227 Feature 227

#1042 Feature 1042

#558 Feature 558

#2525 Feature 2525

#1991 Feature 1991

#1704 Feature 1704

#2025 Feature 2025

#2109 Feature 2109

#899 Feature 899

#1815 Feature 1815

#1431 Feature 1431

#2039 Feature 2039

#767 Feature 767

#1244 Feature 1244

#2822 Feature 2822

#2288 Feature 2288

#205 Feature 205

#208 Feature 208

#325 Feature 325

#2560 Feature 2560

#370 Feature 370

#950 Feature 950

#1205 Feature 1205

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#693 Feature 693

#607 Feature 607

#1175 Feature 1175

#410 Feature 410

#1858 Feature 1858

#2723 Feature 2723

#2608 Feature 2608

#1087 Feature 1087

#695 Feature 695

#2227 Feature 2227

#971 Feature 971

#1007 Feature 1007

#1509 Feature 1509

#2715 Feature 2715

#1185 Feature 1185

#1920 Feature 1920

#476 Feature 476

#316 Feature 316

#2503 Feature 2503

#2260 Historical Context & Development

#1317 Feature 1317

#2381 Feature 2381

#2320 Feature 2320

#932 Feature 932

#1063 Feature 1063

#2425 Feature 2425

#3032 Feature 3032

#2789 Feature 2789

#1481 Feature 1481

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#2623 Feature 2623

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#892 Feature 892

#430 Feature 430

#1295 Feature 1295

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#1973 Feature 1973

#138 Feature 138

#2755 Feature 2755

#2870 Feature 2870

#2045 Feature 2045

#2440 Feature 2440

#2437 Feature 2437

#2681 Feature 2681

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#1229 Feature 1229

#2014 Feature 2014

#2858 Feature 2858

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#1691 Feature 1691

#1992 Feature 1992

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#2339 Feature 2339

#842 Feature 842

#3001 Feature 3001

#2788 Feature 2788

#2732 Feature 2732

#250 Feature 250

#1388 Feature 1388

#515 Feature 515

#2785 Feature 2785

#1797 Feature 1797

#2146 Feature 2146

#525 Feature 525

#2461 Feature 2461

#1237 Feature 1237

#2561 Feature 2561

#2190 Feature 2190

#185 Feature 185

#1066 Feature 1066

#223 Feature 223

#1248 Feature 1248

#253 Feature 253

#588 Feature 588

#268 Feature 268

#2255 Feature 2255

#416 Feature 416

#905 Feature 905

#1758 Feature 1758

#886 Feature 886

#1819 Feature 1819

#313 Feature 313

#1681 Feature 1681

#177 Feature 177

#2306 Feature 2306

#2254 Feature 2254

#2292 Feature 2292

#222 Feature 222

#1837 Feature 1837

#1495 Feature 1495

#1660 Feature 1660

#2010 Feature 2010

#1513 Feature 1513

#1312 Feature 1312

#528 Feature 528

#2454 Feature 2454

#2646 Feature 2646

#2516 Feature 2516

#1113 Feature 1113

#2563 Feature 2563

#1456 Feature 1456

#1829 Feature 1829

#1148 Feature 1148

#578 Feature 578

#891 Feature 891

#2041 Feature 2041

#2972 Sensory-Motor Integration

#307 Feature 307

#2436 Feature 2436

#1223 Feature 1223

#2676 Feature 2676

#2481 Feature 2481

#2580 Feature 2580

#2209 Feature 2209

#2487 Feature 2487

#958 Feature 958

#2945 Feature 2945

#2089 Feature 2089

#524 Feature 524

#1072 Feature 1072

#150 Feature 150

#1777 Feature 1777

#1625 Feature 1625

#2535 Feature 2535

#2585 Feature 2585

#2669 Feature 2669

#2985 Feature 2985

#1686 Feature 1686

#2698 Feature 2698

#2999 Feature 2999

#221 Feature 221

#2903 Feature 2903

#1964 Feature 1964

#2163 Feature 2163

#1196 Feature 1196

#2886 Feature 2886

#2553 Feature 2553

#1323 Feature 1323

#1422 Feature 1422

#2643 Feature #2643

#633 Feature 633

#1749 Feature 1749

#1265 Feature 1265

#770 Feature 770

#231 Feature 231

#2265 Feature 2265

#111 Feature 111

#845 Feature 845

#3049 Feature 3049

#2079 Feature 2079

#1452 Feature 1452

#981 Feature 981

#1094 Feature 1094

#2404 Feature 2404

#3023 Feature 3023

#2097 Feature 2097

#600 Feature 600

#2229 Feature 2229

#2807 Feature 2807

#475 Feature 475

#1869 Feature 1869

#1197 Feature 1197

#2283 Feature 2283

#481 Feature 481

#2748 Feature 2748

#1286 Feature 1286

#2532 Feature 2532

#2028 Feature 2028

#2598 Feature 2598

#2408 Feature 2408

#617 Feature 617

#2992 Feature 2992

#3006 Feature 3006

#2846 Feature 2846

#2527 Feature 2527

#1494 Feature 1494

#1671 Feature 1671

#2204 Feature 2204

#1056 Feature 1056

#1570 Feature 1570

#1232 Feature 1232

#249 Feature 249

#1845 Feature 1845

#1538 Feature 1538

#1738 Feature 1738

#1726 Feature 1726

#1000 Feature 1000

#190 Feature 190

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#2042 Feature 2042

#841 Feature 841

#956 Feature 956

#2394 Feature 2394

#1925 Feature 1925

#1447 Feature 1447

#1628 Feature 1628

#519 Feature 519

#874 Feature 874

#2519 Feature 2519

#1763 Feature 1763

#1360 Feature 1360

#2422 Feature 2422

#1055 Feature 1055

#133 Feature 133

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#1828 Feature 1828

#2483 Feature 2483

#518 Feature 518

#2135 Feature 2135

#1607 Feature 1607

#2432 Feature 2432

#1200 Feature 1200

#1633 Feature 1633

#898 Feature 898

#739 Feature 739

#482 Feature 482

#1369 Feature 1369

#1383 Feature 1383

#2677 Feature 2677

#128 Feature 128

#572 Feature 572

#1760 Feature 1760

#1139 Feature 1139

#577 Feature 577

#1088 Feature 1088

#714 Feature 714

#1719 Feature 1719

#2733 Feature 2733

#2318 Feature 2318

#2995 Feature 2995

#1908 Feature 1908

#2533 Feature 2533

#374 Medical Imaging and Oncology

#1901 Feature 1901

#749 Feature 749

#2348 Feature 2348

#961 Feature 961

#2909 Feature 2909

#1458 Feature 1458

#243 Feature 243

#2716 Feature 2716

#427 Feature 427

#380 Feature 380

#2030 Feature 2030

#1793 Feature 1793

#2156 Feature 2156

#2399 Feature 2399

#1318 Feature 1318

#1993 Feature 1993

#1903 Feature 1903

#1677 Feature 1677

#980 Feature 980

#2223 Feature 2223

#1523 Feature 1523

#1184 Feature 1184

#1927 Feature 1927

#2121 Feature 2121

#836 Feature 836

#220 Feature 220

#1516 Feature 1516

#2243 Feature 2243

#1877 Feature 1877

#1399 Feature 1399

#1276 Feature 1276

#1101 Feature 1101

#3022 Feature 3022

#1646 Feature 1646

#1217 Feature 1217

#877 Feature 877

#516 Feature 516

#688 Feature 688

#108 Feature 108

#2963 Feature 2963

#2704 Feature 2704

#254 Feature 254

#1308 Feature 1308

#541 Feature 541

#2184 Feature 2184

#251 Feature 251

#2372 Feature 2372

#839 Feature 839

#1960 Feature 1960

#2022 Feature 2022

#2351 Feature 2351

#1182 Feature 1182

#2526 Feature 2526

#2772 Feature 2772

#647 Feature 647

#530 Feature 530

#1924 Feature 1924

#536 Feature 536

#2003 Feature 2003

#1956 Feature 1956

#2687 Feature 2687

#3070 Spiritual and Holistic Care in Healthcare

#2737 Feature 2737

#1970 Feature 1970

#3026 Feature 3026

#1434 Feature 1434

#2518 Feature 2518

#1160 Feature 1160

#1612 Feature 1612

#302 Feature 302

#2573 Feature 2573

#2074 Feature 2074

#1914 Feature 1914

#3037 Feature 3037

#2305 Feature 2305

#2336 Feature 2336

#1449 Feature 1449

#2567 Feature 2567

#786 Feature 786

#1761 Feature 1761

#112 Feature 112

#2447 Feature 2447

#1893 Feature 1893

#2976 Feature 2976

#1890 Feature 1890

#2510 Feature 2510

#1238 Feature 1238

#2720 Feature 2720

#2271 Feature 2271

#776 Feature 776

#2802 Feature 2802

#2546 Feature 2546

#2940 Feature 2940

#392 Feature 392

#409 Feature 409

#1586 Feature 1586

#2490 Feature 2490

#2538 Feature 2538

#1658 Feature 1658

#1464 Feature 1464

#1755 Feature 1755

#1526 Feature 1526

#1012 Feature 1012

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#2323 Feature 2323

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#2885 Feature 2885

#2531 Feature 2531

#390 Feature 390

#3053 Feature 3053

#2907 Feature 2907

#2628 Feature 2628

#2087 Feature 2087

#255 Feature 255

#158 Feature 158

#2617 Feature 2617

#857 Feature 857

#2403 Feature 2403

#1125 Feature 1125

#237 Feature 237

#2473 Feature 2473

#576 Feature 576

#3042 Feature 3042

#1592 Feature 1592

#1050 Feature 1050

#2421 Feature 2421

#319 Feature 319

#1263 Feature 1263

#1861 Feature 1861

#777 Feature 777

#452 Feature 452

#1821 Feature 1821

#689 Feature 689

#100 Feature 100

#1247 Feature 1247

#344 Feature 344

#1714 Feature 1714

#1549 Feature 1549

#2199 Feature 2199

#1870 Feature 1870

#1391 Feature 1391

#2649 Feature 2649

#2068 Feature 2068

#1802 Feature 1802

#1767 Feature 1767

#1013 Feature 1013

#2088 Feature 2088

#976 Feature 976

#2709 Feature 2709

#1839 Feature 1839

#435 Feature 435

#1161 Feature 1161

#284 Feature 284

#2624 Feature 2624

#189 Feature 189

#783 Feature 783

#1251 Feature 1251

#1375 Feature 1375

#2373 Feature 2373

#2103 Feature 2103

#1231 Feature 1231

#2593 Feature 2593

#809 Feature 809

#873 Feature 873

#1642 Feature 1642

#1535 Feature 1535

#1504 Feature 1504

#2761 Feature 2761

#771 Feature 771

#1352 Feature 1352

#732 Feature 732

#1307 Feature 1307

#1301 Feature 1301

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#774 Feature 774

#2767 Feature 2767

#615 Feature 615

#314 Feature 314

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#1609 Feature 1609

#1645 Feature 1645

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#2462 Feature #2462

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#1926 Feature 1926

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#2766 Feature 2766

#1696 Feature 1696

#1239 Feature 1239

#880 Feature 880

#199 Feature 199

#1132 Feature 1132

#824 Feature 824

#492 Feature 492

#2245 Feature 2245

#623 Feature 623

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#1299 Feature #1299

#1445 Feature 1445

#723 Feature 723

#1227 Feature 1227

#2353 Feature 2353

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#420 Feature 420

#2746 Feature 2746

#1673 Feature 1673

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#1514 Feature 1514

#1187 Feature 1187

#1981 Feature 1981

#884 Feature 884

#897 Feature 897

#2464 Feature 2464

#130 Feature 130

#687 Feature 687

#1506 Justification/Rationale for Actions

#110 Feature 110

#2232 Medical Case Reports & Cancer Research

#2205 Feature 2205

#1999 Feature 1999

#271 Feature 271

#2798 Feature 2798

#1652 Feature 1652

#2048 Feature 2048

#710 Feature 710

#2375 Feature 2375

#144 Feature 144

#2237 Feature 2237

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#2082 Feature 2082

#157 Feature 157

#1545 Feature 1545

#1337 Feature 1337

#2524 Feature 2524

#1181 Feature 1181

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#2682 Feature 2682

#1972 Feature 1972

#2875 Feature 2875

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#1580 Feature 1580

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#331 Feature 331

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#850 Feature 850

#1935 Feature 1935

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#440 Feature 440

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#1222 Feature 1222

#2242 Feature 2242

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#2099 Feature 2099

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#272 Feature 272

#2026 Feature 2026

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#2939 Feature 2939

#1665 Feature 1665

#1996 Feature 1996

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#1952 Feature 1952

#1627 Feature 1627

#102 Feature 102

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#413 Feature 413

#1505 Feature 1505

#2261 Feature 2261

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#1428 Feature 1428

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#826 Feature 826

#1620 Feature 1620

#1816 Feature 1816

#2632 Feature 2632

#2749 Feature 2749

#2577 Feature 2577

#1712 Feature 1712

#2969 Feature 2969

#1043 Feature 1043

#356 Feature 356

#1725 Feature 1725

#1497 Feature 1497

#2185 Feature 2185

#677 Feature 677

#1971 Feature 1971

#2191 Feature 2191

#1623 Feature 1623

#2007 Developmental Disparities & Intervention

#1058 Feature 1058

#2377 Feature 2377

#2343 Feature 2343

#2950 Feature 2950

#2900 Feature 2900

#1611 Feature 1611

#1731 Feature 1731

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#2534 Feature 2534

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#1322 Feature 1322

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#2991 Feature 2991

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#829 Feature 829

#2668 Feature 2668

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#2334 Feature 2334

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#632 Feature 632

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#2433 Feature 2433

#2500 Feature 2500

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#357 Feature 357

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#911 Feature 911

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#323 Feature 323

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#347 Feature 347

#2645 Feature 2645

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#215 Feature 215

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#2779 Feature 2779

#665 Feature 665

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#923 Feature 923

#814 Feature 814

#373 Feature 373

#2369 Feature 2369

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#748 Feature 748

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#656 Feature 656

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#580 Feature 580

#1020 Feature 1020

#2157 Feature 2157

#107 Feature 107

#502 Feature 502

#1699 Feature 1699

#965 Feature 965

#2658 Feature 2658

#819 Feature 819

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#933 Feature 933

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#2362 Feature 2362

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#1822 Feature 1822

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#2021 Feature 2021

#790 Feature 790

#2910 Feature 2910

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#3015 Feature 3015

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#2002 Feature 2002

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#2304 Feature 2304

#927 Feature 927

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#127 Feature 127

#554 Feature 554

#2374 Feature 2374

#23 Neuronal Circuitry and Cellular Processes

#2439 Feature 2439

#1631 Feature 1631

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#2867 Feature 2867

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#1084 Feature 1084

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#1233 Feature 1233

#811 Feature 811

#2264 Feature 2264

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#2633 Feature 2633

#559 Feature 559

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#1643 Feature 1643

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#662 Feature 662

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#1518 Feature 1518

#894 Feature 894

#1540 Feature #1540

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#2076 Feature 2076

#1765 Feature 1765

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#3009 Feature 3009

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#2345 Feature 2345

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#1390 Feature 1390

#1932 Feature #1932

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#1076 Feature 1076

#1944 Feature 1944

#2653 Feature 2653

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#258 Feature 258

#1462 Feature 1462

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#1687 Feature 1687

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#2299 Feature 2299

#2216 Feature 2216

#510 Feature 510

#300 Feature 300

#2869 Feature 2869

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#537 Feature 537

#1413 Feature 1413

#2968 Feature 2968

#1977 Feature 1977

#610 Feature 610

#2124 Feature 2124

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#1351 Feature 1351

#2830 Feature 2830

#2027 Feature 2027

#2690 Feature 2690

#2512 Feature 2512

#567 Feature 567

#846 Feature 846

#547 Feature 547

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#1314 Feature 1314

#1485 Feature 1485

#671 Feature 671

#1865 Feature 1865

#1565 Feature 1565

#802 Feature 802

#855 Feature 855

#1784 Feature 1784

#1424 Feature 1424

#252 Feature 252

#2040 Feature 2040

#1134 Feature 1134

#2384 Feature 2384

#2485 Feature 2485

#963 Feature 963

#1624 Feature 1624

#167 Feature 167

#1119 Feature 1119

#764 Feature 764

#1121 Feature 1121

#879 Feature 879

#186 Feature 186

#1269 Feature 1269

#2652 Feature 2652

#2390 Feature 2390

#1905 Feature 1905

#203 Feature 203

#2066 Feature 2066

#1790 Feature 1790

#1418 Feature 1418

#2111 Feature 2111

#2835 Feature 2835

#2841 Feature 2841

#441 Feature 441

#318 Feature 318

#1153 Feature 1153

#2325 Feature 2325

#2913 Feature 2913

#2934 Feature 2934

#3061 Feature 3061

#1948 Feature 1948

#1280 Feature 1280

#773 Feature 773

#2549 Feature 2549

#2507 Feature 2507

#2424 Feature 2424

#402 Feature 402

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#630 Feature 630

#1051 Feature 1051

#1716 Feature 1716

#1082 Feature 1082

#2233 Feature 2233

#2667 Feature 2667

#354 Feature 354

#360 Feature 360

#2332 Feature 2332

#861 Feature 861

#2063 Feature 2063

#2189 Feature 2189

#2406 Feature 2406

#679 Feature 679

#1528 Feature 1528

#2036 Feature 2036

#2887 Feature 2887

#640 Feature 640

#1735 Feature 1735

#321 Feature 321

#920 Feature 920

#2523 Feature 2523

#636 Feature 636

#2173 Feature 2173

#745 Feature 745

#1444 Feature 1444

#1589 Feature 1589

#2917 Feature 2917

#369 Feature 369

#2693 Feature 2693

#1813 Feature 1813

#198 Feature 198

#1289 Feature 1289

#983 Feature 983

#2414 Feature 2414

#964 Feature 964

#153 Feature 153

#2470 Feature 2470

#1662 Feature 1662

#1873 Feature 1873

#1005 Feature 1005

#2692 Feature 2692

#594 Feature 594

#1348 Feature 1348

#2202 Feature 2202

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Document Content

Efficacy of various doses and schedules of second-generation tyrosine kinase inhibitors.
Imatinib is one of the most potent cancer therapeutic agents identified to date. Before the introduction of this tyrosine kinase inhibitor (TKI), 5-year survival in chronic myeloid leukemia (CML) was approximately 40%-60%, but since the introduction of imatinib, overall survival has increased to approximately 90% for patients with chronic-phase disease. However, nearly one fifth of patients are intolerant or resistant to imatinib, resulting in patients with persistent or progressive disease. Recent research has identified a number of additional compounds that more efficiently inhibit the Abl tyrosine kinase and additional kinases that potentially play a role in imatinib resistance. The advent of dasatinib and nilotinib has provided additional options for patients with progressive disease. A number of phase II clinical trials have recently demonstrated that these second-generation TKIs are well tolerated and effective in patients with Philadelphia chromosome-positive (Ph+) leukemias. Recent clinical trial developments raise questions regarding the proper dosage and schedule of these newer agents as well as the timing of their use in the treatment of patients with CML. Additionally, the development of nonoverlapping resistance patterns with sequential drug exposure argues for the possibility of a drug selection scheme that might limit the development of resistant disease. As the era of personalized medicine has begun to take shape in the 21st century, the addition of newer TKIs might facilitate this trend in the treatment of Ph+ leukemias.

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