Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1535

MIN ACTIVATION

0.0

Details List

#165 Feature 165

#1842 Feature 1842

#1778 Feature 1778

#1147 Feature 1147

#1873 Feature 1873

#2304 Feature 2304

#2832 Feature 2832

#1510 Feature 1510

#1993 Feature 1993

#524 Feature 524

#2905 Feature 2905

#1279 Feature 1279

#1537 Feature 1537

#1332 Feature 1332

#1468 Feature 1468

#2790 Feature 2790

#2316 Feature 2316

#2817 Feature 2817

#2306 Feature 2306

#603 Feature 603

#2616 Feature 2616

#354 Feature 354

#2164 Feature 2164

#1209 Feature 1209

#2242 Feature 2242

#1017 Feature 1017

#441 Feature 441

#548 Feature 548

#226 Feature 226

#797 Feature 797

#1298 Feature 1298

#2435 Feature 2435

#1671 Feature 1671

#1180 Feature 1180

#1149 Feature 1149

#494 Feature 494

#2127 Feature 2127

#1590 Feature 1590

#2495 Feature 2495

#1822 Feature 1822

#2309 Feature 2309

#2732 Feature 2732

#2022 Feature 2022

#206 Feature 206

#3060 Feature 3060

#1133 Feature 1133

#1192 Feature 1192

#2649 Feature 2649

#580 Feature 580

#544 Feature 544

#240 Feature 240

#751 Feature 751

#2456 Feature 2456

#639 Feature 639

#2992 Feature 2992

#1924 Feature 1924

#2356 Feature 2356

#906 Feature 906

#803 Feature 803

#859 Feature 859

#1315 Feature 1315

#2279 Feature 2279

#987 Feature 987

#1880 Feature 1880

#247 Feature 247

#1230 Feature 1230

#2666 Feature 2666

#180 Feature 180

#2317 Feature 2317

#1137 Feature 1137

#2783 Feature 2783

#2730 Feature 2730

#1280 Feature 1280

#1343 Feature 1343

#732 Feature 732

#613 Feature 613

#2994 Feature 2994

#1820 Feature 1820

#2009 Feature 2009

#2997 Feature 2997

#1390 Feature 1390

#2036 Feature 2036

#1459 Feature 1459

#563 Feature 563

#1965 Feature 1965

#2524 Feature 2524

#1307 Feature 1307

#1086 Feature 1086

#388 Feature 388

#831 Feature 831

#2681 Feature 2681

#2507 Feature 2507

#600 Feature 600

#856 Feature 856

#474 Surgical Procedures & Gastrointestinal Issues

#1112 Feature 1112

#763 Feature 763

#315 Feature 315

#767 Feature 767

#1110 Feature 1110

#2750 Feature 2750

#449 Feature 449

#2637 Feature 2637

#2491 Feature 2491

#2587 Feature 2587

#1512 Feature 1512

#1829 Feature 1829

#1419 Feature 1419

#853 Feature 853

#648 Feature 648

#2166 Feature 2166

#791 Feature 791

#2840 Feature 2840

#383 Feature 383

#1726 Feature 1726

#1061 Feature 1061

#2488 Feature 2488

#2656 Feature 2656

#483 Feature 483

#1290 Feature 1290

#1974 Feature 1974

#1807 Feature 1807

#408 Feature 408

#1273 Feature 1273

#2098 Feature 2098

#1139 Feature 1139

#1168 Feature 1168

#1521 Feature 1521

#2030 Feature 2030

#107 Feature 107

#454 Feature 454

#2528 Feature 2528

#368 Feature 368

#2399 Feature 2399

#2429 Feature 2429

#174 Feature 174

#1466 Feature 1466

#430 Feature 430

#2989 Feature 2989

#1310 Feature 1310

#469 Feature 469

#2991 Feature 2991

#810 Feature 810

#1885 Feature 1885

#1391 Feature 1391

#2216 Feature 2216

#1611 Feature 1611

#539 Feature 539

#2990 Feature 2990

#2569 Feature 2569

#1205 Feature 1205

#267 Feature 267

#2069 Feature 2069

#2003 Feature 2003

#2297 Feature 2297

#1937 Feature 1937

#929 Feature 929

#1436 Feature 1436

#1138 Feature 1138

#2764 Feature 2764

#3063 Feature 3063

#110 Feature 110

#1070 Feature 1070

#2320 Feature 2320

#923 Feature 923

#2644 Feature 2644

#1357 Feature 1357

#1042 Feature 1042

#2108 Feature 2108

#241 Feature 241

#2601 Feature 2601

#1661 Feature 1661

#2218 Feature 2218

#760 Feature 760

#2443 Feature 2443

#1793 Feature 1793

#2224 Feature 2224

#1011 Feature 1011

#505 Feature 505

#2623 Feature 2623

#2192 Feature 2192

#1195 Feature 1195

#898 Feature 898

#2932 Feature 2932

#921 Feature 921

#1953 Feature 1953

#258 Feature 258

#1891 Feature 1891

#2827 Feature 2827

#490 Feature 490

#1557 Feature 1557

#1719 Feature 1719

#2451 Feature #2451

#2912 Feature 2912

#2646 Feature 2646

#1713 Feature 1713

#2227 Feature 2227

#2151 Feature 2151

#2206 Feature 2206

#238 Feature 238

#2373 Feature 2373

#1255 Feature 1255

#2266 Feature 2266

#2037 Feature 2037

#1901 Feature 1901

#1814 Feature 1814

#1041 Feature 1041

#1286 Feature 1286

#647 Feature 647

#2031 Feature 2031

#868 Feature 868

#1386 Feature 1386

#575 Feature 575

#350 Feature 350

#578 Feature 578

#2492 Feature 2492

#163 Feature 163

#715 Feature 715

#805 Feature 805

#2432 Feature 2432

#2442 Feature 2442

#1123 Feature 1123

#1970 Feature 1970

#1191 Feature 1191

#1400 Feature 1400

#1158 Feature 1158

#2329 Feature 2329

#1715 Feature 1715

#561 Feature 561

#1652 Feature 1652

#2378 Feature 2378

#318 Feature 318

#2888 Feature 2888

#340 Feature 340

#437 Feature 437

#819 Feature 819

#1487 Feature 1487

#2654 Feature 2654

#951 Feature 951

#2614 Feature #2614

#1740 Feature 1740

#2264 Feature 2264

#719 Feature 719

#1987 Feature 1987

#1936 Feature 1936

#1802 Feature 1802

#252 Feature 252

#977 Feature 977

#2564 Feature 2564

#1900 Feature 1900

#1140 Feature 1140

#2147 Feature 2147

#1689 Feature 1689

#1178 Feature 1178

#780 Feature 780

#2458 Feature 2458

#2292 Feature 2292

#1941 Feature 1941

#2194 Feature 2194

#543 Feature 543

#2980 Feature 2980

#403 Feature 403

#167 Feature 167

#2258 Feature 2258

#1838 Feature 1838

#1824 Feature 1824

#1572 Feature 1572

#455 Feature 455

#1085 Feature 1085

#2592 Feature 2592

#1515 Feature 1515

#741 Feature 741

#1897 Feature 1897

#2833 Feature 2833

#2490 Feature 2490

#2247 Feature 2247

#419 Feature 419

#1593 Feature 1593

#1248 Feature 1248

#1633 Feature 1633

#612 Feature 612

#2033 Feature 2033

#2350 Feature 2350

#1863 Feature 1863

#460 Feature 460

#2955 Feature 2955

#2331 Feature 2331

#1690 Feature 1690

#1502 Feature 1502

#948 Feature 948

#1128 Feature 1128

#1183 Feature 1183

#2521 Feature 2521

#615 Feature 615

#1944 Feature 1944

#1079 Feature 1079

#1841 Feature 1841

#698 Feature 698

#3059 Feature 3059

#815 Feature 815

#1145 Feature 1145

#3033 Feature 3033

#2588 Feature 2588

#1697 Feature 1697

#1751 Feature 1751

#410 Feature 410

#1375 Feature 1375

#302 Feature 302

#2312 Feature 2312

#123 Feature 123

#432 Feature 432

#2067 Feature 2067

#183 Feature 183

#1014 Feature 1014

#2928 Feature 2928

#2753 Feature 2753

#1503 Feature 1503

#2284 Feature 2284

#2208 Feature 2208

#3057 Feature 3057

#1894 Feature 1894

#1404 Feature 1404

#371 Feature 371

#2204 Feature 2204

#2463 Feature 2463

#1632 Feature 1632

#2960 Feature 2960

#922 Feature 922

#1093 Feature 1093

#1922 Feature 1922

#1819 Feature 1819

#1831 Feature 1831

#2110 Feature 2110

#150 Feature 150

#136 Feature 136

#879 Feature 879

#609 Feature 609

#181 Feature 181

#1818 Feature 1818

#860 Feature 860

#2954 Feature 2954

#2987 Feature 2987

#2175 Feature 2175

#727 Feature 727

#2221 Feature 2221

#954 Feature 954

#1377 Feature 1377

#2410 Feature 2410

#384 Feature 384

#1308 Feature 1308

#3048 Feature 3048

#168 Feature 168

#1067 Feature 1067

#2898 Feature 2898

#2706 Feature 2706

#1766 Feature 1766

#565 Feature 565

#2739 Feature 2739

#477 Feature 477

#552 Feature 552

#847 Feature 847

#2559 Feature 2559

#1544 Feature 1544

#827 Feature 827

#712 Feature 712

#2474 Feature 2474

#2121 Feature 2121

#1163 Feature 1163

#218 Feature 218

#2710 Feature 2710

#2244 Feature 2244

#2765 Feature 2765

#2918 Feature 2918

#2581 Feature 2581

#1695 Feature 1695

#2240 Feature 2240

#2430 Feature 2430

#2702 Feature 2702

#1267 Feature 1267

#270 Feature 270

#1843 Feature 1843

#1853 Feature 1853

#887 Feature 887

#2001 Feature 2001

#1903 Feature 1903

#1082 Feature 1082

#1991 Feature 1991

#1277 Feature 1277

#1784 Feature 1784

#1659 Feature 1659

#1250 Feature 1250

#443 Feature 443

#1030 Feature 1030

#2452 Feature 2452

#928 Feature 928

#2858 Feature 2858

#695 Feature 695

#558 Feature 558

#1389 Feature 1389

#716 Feature 716

#1430 Feature 1430

#820 Feature 820

#2626 Feature 2626

#978 Feature 978

#159 Feature 159

#2561 Feature 2561

#2766 Feature 2766

#124 Feature 124

#1410 Feature 1410

#105 Feature 105

#1739 Feature 1739

#1728 Feature 1728

#938 Feature 938

#576 Feature 576

#2978 Feature 2978

#229 Feature 229

#1588 Feature 1588

#2663 Feature 2663

#787 Feature 787

#671 Feature 671

#882 Feature 882

#2047 Feature 2047

#2290 Feature 2290

#2957 Feature 2957

#244 Feature 244

#784 Feature 784

#2084 Feature 2084

#2920 Feature 2920

#1576 Feature 1576

#1378 Feature 1378

#3043 Feature 3043

#358 Feature 358

#1296 Feature 1296

#2393 Feature 2393

#1337 Feature 1337

#1119 Feature 1119

#586 Feature 586

#2000 Feature 2000

#1700 Feature 1700

#2698 Feature 2698

#431 Feature 431

#2177 Feature 2177

#973 Feature 973

#1325 Feature 1325

#393 Feature 393

#1113 Feature 1113

#2286 Feature 2286

#2842 Feature 2842

#2434 Feature 2434

#2099 Feature 2099

#2202 Feature 2202

#2977 Feature 2977

#1919 Feature 1919

#1188 Feature 1188

#1190 Feature 1190

#415 Feature 415

#857 Feature 857

#1177 Feature 1177

#346 Feature 346

#2267 Feature 2267

#2939 Feature 2939

#1757 Feature 1757

#640 Feature 640

#1316 Feature 1316

#758 Feature 758

#1318 Feature 1318

#3028 Feature 3028

#980 Feature 980

#2539 Feature 2539

#1171 Feature 1171

#138 Feature 138

#1932 Feature 1932

#499 Feature 499

#672 Feature 672

#1654 Feature 1654

#362 Feature 362

#1050 Feature 1050

#3005 Feature 3005

#1062 Feature 1062

#2214 Feature 2214

#1640 Feature 1640

#1395 Feature 1395

#205 Feature 205

#2771 Feature 2771

#2650 Feature 2650

#394 Feature 394

#2358 Feature 2358

#1351 Feature 1351

#1910 Feature 1910

#1194 Feature 1194

#2369 Feature 2369

#1660 Feature 1660

#2885 Feature 2885

#1361 Feature 1361

#1032 Feature 1032

#1519 Feature 1519

#1962 Feature 1962

#365 Feature 365

#2762 Feature 2762

#2056 Feature 2056

#2423 Feature 2423

#2140 Feature 2140

#2348 Feature 2348

#1808 Feature 1808

#1801 Feature 1801

#1916 Feature 1916

#2262 Feature 2262

#148 Feature 148

#2123 Feature 2123

#2831 Feature 2831

#1320 Feature 1320

#2856 Feature 2856

#306 Feature 306

#3029 Feature 3029

#952 Feature 952

#1229 Feature 1229

#2241 Feature 2241

#151 Feature 151

#744 Feature 744

#1020 Feature 1020

#1078 Feature 1078

#1828 Feature 1828

#766 Feature 766

#317 Feature 317

#475 Feature 475

#2180 Feature 2180

#2460 Feature 2460

#153 Feature 153

#1889 Feature 1889

#1346 Feature 1346

#1166 Feature 1166

#334 Feature 334

#1531 Feature 1531

#549 Feature 549

#1749 Feature 1749

#999 Feature 999

#1686 Feature 1686

#377 Feature 377

#553 Feature 553

#1522 Feature 1522

#485 Feature 485

#3064 Surgical Complications and Physiological Stress

#1813 Feature 1813

#1514 Feature 1514

#961 Feature 961

#3032 Feature 3032

#491 Feature 491

#131 Feature 131

#381 Feature 381

#2826 Feature 2826

#2502 Feature 2502

#855 Feature 855

#555 Feature 555

#1033 Feature 1033

#1152 Feature 1152

#290 Feature 290

#1000 Feature 1000

#2311 Feature 2311

#2467 Feature 2467

#1638 Feature 1638

#512 Feature 512

#1053 Feature 1053

#160 Feature 160

#2327 Feature 2327

#268 Feature 268

#172 Feature 172

#735 Feature 735

#2398 Feature 2398

#211 Feature 211

#2133 Feature 2133

#2794 Feature 2794

#1704 Feature 1704

#366 Feature 366

#2767 Feature 2767

#2904 Feature 2904

#1441 Feature 1441

#164 Feature 164

#1724 Feature 1724

#2404 Feature 2404

#225 Feature 225

#280 Feature 280

#960 Feature 960

#1878 Feature 1878

#2215 Feature 2215

#1380 Feature 1380

#2462 Feature 2462

#2736 Feature 2736

#786 Feature 786

#285 Feature 285

#835 Feature 835

#2114 Feature 2114

#1680 Feature 1680

#673 Feature 673

#303 Feature 303

#1883 Feature 1883

#1721 Feature 1721

#161 Feature 161

#3021 Feature 3021

#1281 Feature 1281

#2575 Feature 2575

#2613 Feature 2613

#2552 Feature 2552

#102 Feature 102

#444 Feature 444

#1933 Feature 1933

#1186 Feature 1186

#1911 Feature 1911

#2138 Feature 2138

#664 Feature 664

#2496 Feature 2496

#2533 Feature 2533

#1454 Feature 1454

#1101 Feature 1101

#1237 Feature 1237

#2958 Feature 2958

#414 Feature 414

#965 Feature 965

#1431 Feature 1431

#2679 Feature 2679

#447 Feature 447

#2384 Feature 2384

#930 Feature 930

#1976 Feature 1976

#1553 Feature 1553

#527 Feature 527

#1743 Feature 1743

#2966 Feature 2966

#1481 Feature 1481

#2854 Feature 2854

#1289 Feature 1289

#924 Feature 924

#417 Feature 417

#2223 Feature 2223

#2134 Feature 2134

#581 Feature 581

#1125 Feature 1125

#1939 Feature 1939

#2526 Feature 2526

#2824 Feature 2824

#2506 Feature 2506

#1997 Feature 1997

#2270 Feature 2270

#528 Feature 528

#2690 Feature 2690

#2217 Feature 2217

#1097 Feature 1097

#2424 Feature 2424

#2479 Feature 2479

#740 Feature 740

#2761 Feature 2761

#1877 Feature 1877

#587 Feature 587

#3037 Feature 3037

#1720 Feature 1720

#1360 Feature 1360

#589 Feature 589

#1526 Feature 1526

#2397 Feature 2397

#2094 Feature 2094

#983 Feature 983

#841 Feature 841

#2058 Feature 2058

#2132 Feature 2132

#628 Feature 628

#1834 Feature 1834

#1523 Feature 1523

#2924 Feature 2924

#688 Feature 688

#2439 Feature 2439

#1890 Feature 1890

#273 Feature 273

#448 Feature 448

#2352 Feature 2352

#822 Feature 822

#1453 Feature 1453

#2191 Feature 2191

#2343 Feature 2343

#1182 Feature 1182

#2289 Feature 2289

#1226 Feature 1226

#1565 Feature 1565

#1866 Feature 1866

#714 Feature 714

#610 Feature 610

#1947 Feature 1947

#530 Feature 530

#668 Feature 668

#582 Feature 582

#933 Feature 933

#2633 Feature 2633

#1275 Feature 1275

#141 Feature 141

#2605 Feature 2605

#2723 Feature 2723

#2855 Feature 2855

#2416 Feature 2416

#849 Feature 849

#1609 Feature 1609

#2012 Feature 2012

#127 Feature 127

#338 Feature 338

#2049 Feature 2049

#2337 Feature 2337

#762 Feature 762

#2152 Feature 2152

#175 Feature 175

#1063 Feature 1063

#262 Feature 262

#2866 Feature 2866

#2562 Feature 2562

#2380 Feature 2380

#2228 Feature 2228

#396 Feature 396

#1293 Feature 1293

#216 Feature 216

#1217 Feature 1217

#2659 Feature 2659

#2798 Feature 2798

#1614 Feature 1614

#686 Feature 686

#2385 Feature 2385

#968 Feature 968

#2984 Feature 2984

#1685 Feature 1685

#1855 Feature 1855

#537 Feature 537

#1401 Feature 1401

#985 Feature 985

#2577 Feature 2577

#2483 Feature 2483

#2075 Feature 2075

#399 Feature 399

#903 Feature 903

#677 Feature 677

#2198 Feature 2198

#2034 Feature 2034

#1420 Feature 1420

#1043 Feature 1043

#871 Feature 871

#510 Feature 510

#2310 Feature 2310

#1516 Feature 1516

#418 Feature 418

#249 Feature 249

#1115 Feature 1115

#182 Feature 182

#1753 Feature 1753

#975 Feature 975

#800 Feature 800

#601 Feature 601

#1107 Feature 1107

#1260 Feature 1260

#3018 Feature 3018

#1668 Feature 1668

#2042 Feature 2042

#2236 Feature 2236

#2901 Feature 2901

#2233 Feature 2233

#705 Feature 705

#1584 Feature 1584

#1484 Feature 1484

#2106 Feature 2106

#2390 Feature 2390

#1984 Feature 1984

#298 Feature 298

#833 Feature 833

#532 Feature 532

#2252 Feature 2252

#2779 Feature 2779

#910 Feature 910

#1055 Feature 1055

#2894 Feature 2894

#269 Feature 269

#679 Feature 679

#1413 Feature 1413

#2505 Feature 2505

#996 Feature 996

#439 Feature 439

#118 Feature 118

#1446 Feature 1446

#2685 Feature 2685

#2077 Feature 2077

#3015 Feature 3015

#406 Feature 406

#865 Feature 865

#3023 Feature 3023

#1840 Feature 1840

#1904 Feature 1904

#2196 Feature 2196

#2860 Feature 2860

#2441 Feature 2441

#2737 Feature 2737

#1760 Feature 1760

#599 Feature 599

#2769 Feature 2769

#756 Feature 756

#425 Feature 425

#1718 Feature 1718

#2497 Feature 2497

#2565 Feature 2565

#675 Feature 675

#616 Feature 616

#125 Feature 125

#330 Feature 330

#1762 Feature 1762

#2407 Feature 2407

#3003 Feature 3003

#2501 Feature 2501

#1983 Feature 1983

#2859 Feature 2859

#2402 Feature 2402

#1578 Feature 1578

#1639 Feature 1639

#1312 Feature 1312

#1774 Feature 1774

#1734 Feature 1734

#1069 Feature 1069

#2721 Feature 2721

#2549 Feature 2549

#796 Feature 796

#1088 Feature 1088

#1189 Feature 1189

#1844 Feature 1844

#2603 Instructional/Educational Content

#2874 Feature 2874

#947 Feature 947

#1328 Feature 1328

#1329 Feature 1329

#982 Feature 982

#703 Feature 703

#1857 Feature 1857

#2363 Feature 2363

#1266 Feature 1266

#1764 Feature 1764

#201 Feature 201

#3049 Feature 3049

#2345 Feature 2345

#1539 Feature 1539

#1207 Feature 1207

#2024 Feature 2024

#3030 Feature 3030

#2157 Feature 2157

#2864 Feature 2864

#3042 Feature 3042

#2268 Feature 2268

#2657 Feature 2657

#1365 Feature 1365

#826 Feature 826

#445 Feature 445

#272 Feature 272

#620 Feature 620

#2041 Feature 2041

#1469 Feature 1469

#2548 Feature 2548

#571 Feature 571

#2083 Feature 2083

#875 Feature 875

#700 Feature 700

#2149 Feature 2149

#101 Feature 101

#1246 Feature 1246

#1415 Feature 1415

#2087 Feature 2087

#2305 Feature 2305

#2596 Feature 2596

#798 Feature 798

#764 Feature 764

#2795 Feature 2795

#2534 Feature 2534

#1533 Feature 1533

#2893 Feature 2893

#2676 Feature 2676

#1084 Feature 1084

#1254 Feature 1254

#1136 Feature 1136

#1259 Feature 1259

#2607 Feature 2607

#2813 Feature 2813

#1971 Feature 1971

#1467 Feature 1467

#2025 Feature 2025

#1241 Feature 1241

#1921 Feature 1921

#1300 Feature 1300

#1790 Feature 1790

#2948 Feature 2948

#515 Feature 515

#2784 Feature 2784

#1426 Feature 1426

#2922 Feature 2922

#1859 Feature 1859

#126 Feature 126

#2291 Feature 2291

#1554 Feature 1554

#1077 Feature 1077

#3017 Feature 3017

#2752 Feature 2752

#286 Feature 286

#1886 Feature 1886

#3010 Feature 3010

#1392 Feature 1392

#2011 Feature 2011

#2433 Feature 2433

#598 Feature 598

#261 Feature 261

#1461 Feature 1461

#1141 Feature 1141

#535 Feature 535

#2104 Feature 2104

#284 Feature 284

#202 Feature 202

#390 Feature 390

#263 Feature 263

#1388 Feature 1388

#2468 Feature 2468

#1185 Feature 1185

#2318 Feature 2318

#2908 Feature 2908

#3001 Feature 3001

#2961 Feature 2961

#1731 Feature 1731

#1238 Feature 1238

#482 Feature 482

#1809 Feature 1809

#2155 Feature 2155

#1126 Feature 1126

#2806 Feature 2806

#957 Feature 957

#2836 Feature 2836

#3055 Feature 3055

#1703 Feature 1703

#1330 Feature 1330

#2360 Feature 2360

#506 Feature 506

#2647 Feature 2647

#1025 Feature 1025

#398 Feature 398

#2176 Feature 2176

#1574 Feature 1574

#1439 Feature 1439

#1556 Feature 1556

#1104 Feature 1104

#651 Feature 651

#1026 Feature 1026

#799 Feature 799

#1927 Feature 1927

#264 Feature 264

#1600 Feature 1600

#1048 Feature 1048

#1214 Feature 1214

#2849 Feature 2849

#989 Feature 989

#642 Feature 642

#2055 Feature 2055

#1768 Feature 1768

#2682 Feature 2682

#2558 Feature 2558

#1650 Feature 1650

#2867 Feature 2867

#149 Feature 149

#1742 Feature 1742

#704 Feature 704

#1369 Feature 1369

#846 Feature 846

#2248 Feature 2248

#1535 Feature 1535

#2060 Feature 2060

#1995 Feature 1995

#1687 Feature 1687

#1405 Feature 1405

#1711 Feature 1711

#2910 Feature 2910

#1129 Feature 1129

#2851 Feature 2851

#1162 Feature 1162

#1619 Feature 1619

#2952 Feature 2952

#817 Feature 817

#3047 Feature 3047

#1376 Feature 1376

#367 Feature 367

#1448 Feature 1448

#2128 Feature 2128

#2787 Feature 2787

#1243 Feature 1243

#720 Feature 720

#1763 Feature 1763

#818 Feature 818

#1270 Feature 1270

#496 Feature 496

#1353 Feature 1353

#224 Feature 224

#2014 Feature 2014

#2983 Feature 2983

#1500 Feature 1500

#233 Feature 233

#2455 Feature 2455

#935 Feature 935

#2785 Feature 2785

#1495 Feature 1495

#1434 Feature 1434

#1036 Feature 1036

#1385 Feature 1385

#2943 Feature 2943

#2509 Feature 2509

#1827 Feature 1827

#3019 Feature 3019

#692 Feature 692

#2396 Feature 2396

#227 Feature 227

#2273 Feature 2273

#2119 Feature 2119

#693 Feature 693

#2567 Feature 2567

#2181 Feature 2181

#427 Feature 427

#2210 Feature 2210

#1755 Feature 1755

#2600 Feature 2600

#2808 Feature 2808

#1782 Feature 1782

#2245 Feature 2245

#1455 Feature 1455

#1575 Feature 1575

#3036 Feature 3036

#255 Feature 255

#1261 Feature 1261

#2293 Feature 2293

#1383 Feature 1383

#2005 Feature 2005

#2117 Feature 2117

#2530 Feature 2530

#2554 Feature 2554

#2886 Feature 2886

#200 Feature 200

#1783 Feature 1783

#1635 Feature 1635

#2645 Feature 2645

#1425 Feature 1425

#1770 Feature 1770

#129 Feature 129

#2740 Feature 2740

#2819 Feature 2819

#941 Feature 941

#339 Feature 339

#901 Feature 901

#1622 Feature 1622

#1501 Feature 1501

#1121 Feature 1121

#1794 Feature 1794

#478 Feature 478

#2780 Feature 2780

#939 Feature 939

#1884 Feature 1884

#608 Feature 608

#2303 Feature 2303

#434 Feature 434

#1458 Feature 1458

#1529 Feature 1529

#2823 Feature 2823

#1021 Feature 1021

#2302 Feature 2302

#2201 Feature 2201

#1355 Feature 1355

#230 Feature 230

#2235 Feature 2235

#3007 Feature 3007

#2945 Feature 2945

#1037 Feature 1037

#2020 Feature 2020

#1165 Feature 1165

#680 Feature 680

#918 Feature 918

#2660 Feature 2660

#2063 Feature 2063

#2890 Feature 2890

#1038 Feature 1038

#2288 Feature 2288

#1722 Feature 1722

#1979 Feature 1979

#2182 Feature 2182

#2956 Feature 2956

#355 Feature 355

#1071 Feature 1071

#1075 Feature 1075

#691 Feature 691

#809 Feature 809

#1489 Feature 1489

#360 Feature 360

#1608 Feature 1608

#1406 Feature 1406

#2334 Feature 2334

#2713 Feature 2713

#2073 Feature 2073

#1645 Feature 1645

#748 Feature 748

#1625 Feature 1625

#1399 Feature 1399

#1449 Feature 1449

#1618 Feature 1618

#1585 Feature 1585

#1852 Feature 1852

#574 Feature 574

#633 Feature 633

#761 Feature 761

#357 Feature 357

#1955 Feature 1955

#838 Feature 838

#2550 Feature 2550

#336 Feature 336

#2873 Feature 2873

#115 Feature 115

#2861 Feature 2861

#2445 Feature 2445

#1785 Feature 1785

#1691 Feature 1691

#550 Feature 550

#794 Feature 794

#1716 Feature 1716

#1150 Feature 1150

#1476 Feature 1476

#2275 Feature 2275

#251 Feature 251

#1949 Feature 1949

#1606 Feature 1606

#2008 Feature 2008

#2113 Feature 2113

#949 Feature 949

#2103 Feature 2103

#305 Feature 305

#708 Drug Resistance Mechanisms in Cancer

#1520 Feature 1520

#2035 Feature 2035

#489 Feature 489

#1049 Feature 1049

#904 Feature 904

#1787 Feature 1787

#1812 Feature 1812

#3051 Feature 3051

#2727 Feature 2727

#296 Feature 296

#1862 Feature 1862

#3045 Feature 3045

#438 Feature 438

#3053 Feature 3053

#1712 Feature 1712

#659 Feature 659

#2375 Feature 2375

#2082 Feature 2082

#1090 Feature 1090

#1354 Feature 1354

#2353 Feature 2353

#2372 Feature 2372

#2624 Feature 2624

#884 Feature 884

#2848 Feature 2848

#1649 Feature 1649

#793 Feature 793

#866 Feature 866

#1221 Feature 1221

#669 Feature 669

#1065 Feature 1065

#757 Feature 757

#3044 Feature 3044

#2969 Feature 2969

#2970 Feature 2970

#1408 Feature 1408

#1276 Feature 1276

#533 Feature 533

#2812 Feature 2812

#2511 Feature 2511

#1372 Feature 1372

#2673 Feature 2673

#1080 Feature 1080

#899 Feature 899

#508 Feature 508

#1303 Feature 1303

#2716 Feature 2716

#2461 Feature 2461

#1667 Feature 1667

#2543 Feature 2543

#1423 Feature 1423

#3014 Feature 3014

#2746 Feature 2746

#2367 Feature 2367

#1963 Feature 1963

#2174 Feature 2174

#683 Feature 683

#1727 Feature 1727

#196 Feature 196

#2776 Feature 2776

#737 Feature 737

#356 Feature 356

#1367 Feature 1367

#1964 Feature 1964

#845 Feature 845

#2064 Feature 2064

#937 Feature 937

#1202 Feature 1202

#2540 Feature 2540

#723 Feature 723

#666 Feature 666

#435 Feature 435

#2686 Feature 2686

#992 Feature 992

#2877 Feature 2877

#739 Feature 739

#2741 Feature 2741

#1016 Feature 1016

#140 Feature 140

#958 Feature 958

#660 Feature 660

#1708 Feature 1708

#2179 Feature 2179

#464 Feature 464

#361 Feature 361

#995 Feature 995

#2503 Feature 2503

#2595 Feature 2595

#117 Feature 117

#2018 Feature 2018

#2171 Molecular and Cellular Biological Processes

#2728 Feature 2728

#1161 Feature 1161

#2566 Feature 2566

#1568 Feature 1568

#1604 Feature 1604

#1313 Feature 1313

#1418 Feature 1418

#2222 Feature 2222

#1653 Feature 1653

#1912 Feature 1912

#348 Feature 348

#1004 Feature 1004

#2431 Feature 2431

#2006 Feature 2006

#1966 Feature 1966

#547 Feature 547

#711 Feature 711

#1333 Feature 1333

#870 Feature 870

#2072 Feature 2072

#2438 Feature 2438

#1630 Feature 1630

#632 Feature 632

#1959 Feature 1959

#1252 Feature 1252

#534 Feature 534

#2313 Feature 2313

#2703 Feature 2703

#567 Feature 567

#1009 Feature 1009

#562 Feature 562

#2797 Feature 2797

#137 Feature 137

#1407 Feature 1407

#2652 Feature 2652

#1327 Feature 1327

#2444 Feature 2444

#1236 Feature 1236

#1334 Feature 1334

#1350 Feature 1350

#2251 Feature 2251

#2725 Feature 2725

#1893 Feature 1893

#1915 Feature 1915

#1491 Feature 1491

#1795 Feature 1795

#1954 Feature 1954

#1746 Feature 1746

#658 Feature 658

#2448 Feature 2448

#2027 Feature 2027

#1294 Feature 1294

#1797 Feature 1797

#1777 Feature 1777

#1274 Feature 1274

#363 Feature 363

#492 Feature 492

#2694 Feature 2694

#1181 Feature 1181

#143 Feature 143

#593 Feature 593

#541 Feature 541

#1295 Feature 1295

#655 Feature 655

#2692 Feature 2692

#423 Feature 423

#2090 Feature 2090

#1643 Feature 1643

#2884 Feature 2884

#2701 Feature 2701

#3013 Feature 3013

#1288 Feature 1288

#152 Feature 152

#656 Feature 656

#644 Feature 644

#2135 Feature 2135

#2109 Feature 2109

#2950 Feature 2950

#1647 Feature 1647

#2597 Feature 2597

#631 Feature 631

#312 Feature 312

#682 Feature 682

#749 Feature 749

#2212 Feature 2212

#446 Feature 446

#1675 Feature 1675

#2079 Feature 2079

#2178 Feature 2178

#2354 Feature 2354

#2231 Feature 2231

#2427 Feature 2427

#1001 Feature 1001

#1532 Feature 1532

#1867 Feature 1867

#1644 Feature 1644

#2381 Feature 2381

#1322 Feature 1322

#1394 Feature 1394

#1612 Feature 1612

#1629 Feature 1629

#1861 Feature 1861

#981 Feature 981

#2010 Feature 2010

#2841 Feature 2841

#1196 Feature 1196

#2361 Feature 2361

#1504 Feature 1504

#2982 Feature 2982

#2004 Feature 2004

#2847 Feature 2847

#1483 Feature 1483

#1148 Feature 1148

#2879 Feature 2879

#2805 Feature 2805

#1008 Feature 1008

#2693 Feature 2693

#1729 Feature 1729

#106 Feature 106

#1823 Feature 1823

#3039 Feature 3039

#885 Feature 885

#500 Feature 500

#869 Feature 869

#837 Feature 837

#155 Feature 155

#1736 Feature 1736

#2988 Feature 2988

#2828 Feature 2828

#1239 Feature 1239

#2272 Feature 2272

#1199 Feature 1199

#2662 Feature 2662

#1542 Feature 1542

#1896 Feature 1896

#1060 Feature 1060

#979 Feature 979

#3024 Feature 3024

#1257 Feature 1257

#1723 Feature 1723

#2906 Feature 2906

#467 Feature 467

#234 Feature 234

#1772 Feature 1772

#1040 Feature 1040

#2126 Feature 2126

#326 Feature 326

#310 Feature 310

#207 Feature 207

#413 Feature 413

#778 Feature 778

#2865 Feature 2865

#572 Feature 572

#2576 Feature 2576

#2032 Feature 2032

#1442 Feature 1442

#2513 Feature 2513

#1100 Feature 1100

#3066 Feature 3066

#2899 Feature 2899

#2408 Feature 2408

#119 Feature 119

#279 Feature 279

#1508 Feature 1508

#2425 Feature 2425

#806 Feature 806

#2045 Feature 2045

#2076 Feature 2076

#2718 Feature 2718

#3061 Feature 3061

#2440 Feature 2440

#997 Feature 997

#2095 Feature 2095

#811 Feature 811

#1605 Feature 1605

#2339 Feature 2339

#2220 Feature 2220

#2707 Feature 2707

#2917 Feature 2917

#1216 Feature 1216

#473 Feature 473

#931 Feature 931

#2863 Feature 2863

#194 Feature 194

#1943 Feature 1943

#2869 Feature 2869

#1117 Feature 1117

#834 Feature 834

#667 Feature 667

#1282 Feature 1282

#676 Feature 676

#2230 Feature 2230

#1552 Feature 1552

#514 Feature 514

#1914 Feature 1914

#162 Feature 162

#331 Feature 331

#2162 Feature 2162

#754 Feature 754

#239 Feature 239

#2677 Feature 2677

#1349 Feature 1349

#566 Feature 566

#2285 Feature 2285

#1323 Feature 1323

#1292 Feature 1292

#2631 Feature 2631

#253 Feature 253

#2853 Feature 2853

#1930 Feature 1930

#1907 Feature 1907

#1490 Feature 1490

#991 Feature 991

#1517 Feature 1517

#2498 Feature 2498

#2065 Feature 2065

#1447 Feature 1447

#2070 Feature 2070

#2478 Feature 2478

#1561 Feature 1561

#457 Feature 457

#1577 Feature 1577

#2820 Feature 2820

#178 Feature 178

#462 Feature 462

#1518 Feature 1518

#745 Feature 745

#1507 Feature 1507

#2608 Feature 2608

#2965 Feature 2965

#411 Feature 411

#2301 Feature 2301

#2712 Feature 2712

#1370 Feature 1370

#433 Feature 433

#2760 Feature 2760

#100 Feature 100

#988 Feature 988

#638 Feature 638

#1184 Feature 1184

#197 Feature 197

#1131 Feature 1131

#545 Feature 545

#2246 Feature 2246

#2046 Feature 2046

#902 Feature 902

#2773 Feature 2773

#2469 Feature 2469

#630 Feature 630

#802 Feature 802

#1111 Feature 1111

#2081 Feature 2081

#825 Feature 825

#670 Feature 670

#2582 Feature 2582

#277 Feature 277

#2257 Feature 2257

#895 Feature 895

#265 Feature 265

#2365 Feature 2365

#2876 Feature 2876

#299 Feature 299

#293 Feature 293

Document Content

Translocation of deltaPKC to mitochondria during cardiac reperfusion enhances superoxide anion production and induces loss in mitochondrial function.
Activation of the delta-isoform of protein kinase C (deltaPKC) by certain conditions of oxidative stress results in translocation of the kinase to the mitochondria leading to release of cytochrome c and the induction of apoptosis. In the current study, the effects of myocardial reperfusion-induced deltaPKC translocation on mitochondrial function were assessed. Mitochondria isolated from hearts that had undergone ischemia (30 min) followed by reperfusion (15 min) exhibited a significant increase in the rate of superoxide anion (O(2)(-)) generation. This was associated with the translocation of deltaPKC to the mitochondria within the first 5 min of reperfusion. deltaPKC translocation occurred exclusively during reperfusion and could be mimicked by infusion of intact hearts with H(2)O(2) suggesting redox-dependent activation during reperfusion. Infusion of a peptide inhibitor (deltaV(1-1)) specific to the delta-isoform of PKC significantly reduced reperfusion-induced increases in mitochondrial O(2)(-) generation. Finally, the decline in mitochondrial respiratory activity evident upon prolonged reperfusion (120min) was completely prevented by inhibition of deltaPKC translocation. Thus, deltaPKC represents a cytosolic redox-sensitive molecule that plays an important role in amplification of O(2)(-) production and subsequent declines in mitochondrial function during reperfusion.

Similar Documents