Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1491

MIN ACTIVATION

0.0

Details List

#1324 Feature 1324

#337 Feature 337

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#1731 Feature 1731

#2880 Feature 2880

#2355 Feature 2355

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#708 Drug Resistance Mechanisms in Cancer

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#2551 Feature 2551

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#1988 Feature 1988

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#1548 Feature 1548

#340 Feature 340

#2575 Feature 2575

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#1414 Feature 1414

#1344 Feature 1344

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#783 Feature 783

#2562 Feature 2562

#2353 Feature 2353

#2694 Feature 2694

#3070 Spiritual and Holistic Care in Healthcare

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#2336 Feature 2336

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#1833 Feature 1833

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#2132 Feature 2132

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#905 Feature 905

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#695 Feature 695

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#2220 Feature 2220

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#1407 Feature 1407

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#2206 Feature 2206

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#336 Feature 336

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#616 Feature 616

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#161 Feature 161

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#1730 Feature 1730

#2832 Feature 2832

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#393 Feature 393

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#3018 Feature 3018

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#1199 Feature 1199

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#1818 Feature 1818

#2108 Feature 2108

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#215 Feature 215

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#1837 Feature 1837

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#2115 Feature 2115

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#2683 Feature 2683

#127 Feature 127

#1816 Feature 1816

#2955 Feature 2955

#981 Feature 981

#1791 Feature 1791

#2831 Feature 2831

#1311 Molecular Mechanisms and Biological Processes

#693 Feature 693

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#1446 Feature 1446

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#2165 Feature 2165

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#2224 Feature 2224

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#2451 Feature #2451

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#1342 Feature 1342

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#2119 Feature 2119

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#1321 Feature 1321

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#374 Medical Imaging and Oncology

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#264 Feature 264

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#2007 Developmental Disparities & Intervention

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#2260 Historical Context & Development

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#406 Feature 406

#2471 Feature 2471

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#2966 Feature 2966

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Document Content

Oral administration of lyophilized Dunaliella salina, a carotenoid-rich marine alga, reduces tumor progression in mammary cancer induced rats.
Dunaliella salina is a photosynthetic cell factory used for the commercial production of food additives, cattle stock feed and cosmetics as well as active ingredients for pharmaceutical industries. The investigation of the in vivo antitumor activity of D. salina lyophilized powder (DSLP) against 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary carcinogenesis in female Wistar rats indicated a dose-dependent effect of DSLP. We studied the effect of DSLP at two different dosages of 500 and 1000 mg per kg bw on DMBA induced mammary cancer in rats by measuring the status of antioxidant enzymes, phase I and phase II detoxification enzymes, lipid peroxidation, and glycoconjugated proteins and by investigating the expression pattern of cell proliferation (Ki-67), hormonal receptor (ER, PR and HER2) status by immunohistochemical analysis, and apoptotic (caspase-3 and -9) and pro-inflammatory (COX-2) markers by colorimetric analysis. After 16 weeks of the study, we observed 100% tumor formation (including high tumor incidence and tumor volume) and a significant increase in the level of hormonal receptors, cell proliferation, and pro-inflammatory and apoptosis markers in tumor-bearing animals compared to the control. The oral administration of DSLP (1000 mg per kg bw) to the DMBA treated animals showed up to 83.4% reduction of tumors and effectively restored the levels of biochemical markers in the mammary tissues in addition to the downregulation of the expression of molecular markers. In conclusion, DSLP was found to show a chemopreventive effect against breast cancer induced in rats through the suppression of cell proliferation and the induction of apoptosis.

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