Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1489

MIN ACTIVATION

0.0

Details List

#2247 Feature 2247

#2575 Feature 2575

#1113 Feature 1113

#2534 Feature 2534

#302 Feature 302

#1971 Feature 1971

#1695 Feature 1695

#1925 Feature 1925

#806 Feature 806

#2132 Feature 2132

#1170 Feature 1170

#2796 Feature 2796

#1888 Feature 1888

#886 Feature 886

#677 Feature 677

#2078 Feature 2078

#558 Feature 558

#1501 Feature 1501

#1476 Feature 1476

#2593 Feature 2593

#911 Feature 911

#2766 Feature 2766

#1930 Feature 1930

#1425 Feature 1425

#2483 Feature 2483

#319 Feature 319

#900 Feature 900

#1017 Feature 1017

#2392 Feature 2392

#2336 Feature 2336

#2862 Feature 2862

#1466 Feature 1466

#1573 Feature 1573

#1896 Feature 1896

#2335 Feature 2335

#100 Feature 100

#1687 Feature 1687

#894 Feature 894

#1352 Feature 1352

#287 Feature 287

#178 Feature 178

#409 Feature 409

#179 Feature 179

#498 Feature 498

#909 Feature 909

#1565 Feature 1565

#767 Feature 767

#2608 Feature 2608

#2992 Feature 2992

#981 Feature 981

#659 Feature 659

#2704 Feature 2704

#932 Feature 932

#2412 Feature 2412

#1518 Feature 1518

#3039 Feature 3039

#2521 Feature 2521

#451 Feature 451

#464 Feature 464

#2066 Feature 2066

#1233 Feature 1233

#2654 Feature 2654

#2821 Feature 2821

#2561 Feature 2561

#1538 Feature 1538

#2176 Feature 2176

#2495 Feature 2495

#1921 Feature 1921

#1915 Feature 1915

#233 Feature 233

#1843 Feature 1843

#1510 Feature 1510

#1110 Feature 1110

#1069 Feature 1069

#1355 Feature 1355

#1284 Feature 1284

#1332 Feature 1332

#1159 Feature 1159

#1785 Feature 1785

#1722 Feature 1722

#809 Feature 809

#1662 Feature 1662

#1867 Feature 1867

#1839 Feature 1839

#2828 Feature 2828

#1512 Feature 1512

#2049 Feature 2049

#591 Feature 591

#1622 Feature 1622

#1936 Feature 1936

#532 Feature 532

#2438 Feature 2438

#693 Feature 693

#632 Feature 632

#2286 Feature 2286

#286 Feature 286

#2932 Feature 2932

#862 Feature 862

#2562 Feature 2562

#288 Feature 288

#913 Feature 913

#2827 Feature 2827

#1031 Feature 1031

#2804 Feature 2804

#1920 Feature 1920

#1756 Feature 1756

#1479 Feature 1479

#1018 Feature 1018

#1677 Feature 1677

#1666 Feature 1666

#1633 Feature 1633

#297 Feature 297

#131 Feature 131

#1165 Feature 1165

#183 Feature 183

#2950 Feature 2950

#380 Feature 380

#2597 Feature 2597

#3044 Feature 3044

#1844 Feature 1844

#2055 Feature 2055

#2777 Feature 2777

#2341 Feature 2341

#2467 Feature 2467

#2792 Feature 2792

#1726 Feature 1726

#334 Feature 334

#2092 Feature 2092

#1024 Feature 1024

#1483 Feature 1483

#2799 Feature 2799

#1504 Feature 1504

#2128 Feature 2128

#1858 Feature 1858

#2373 Feature 2373

#1285 Feature 1285

#1515 Feature 1515

#105 Feature 105

#1866 Feature 1866

#628 Feature 628

#196 Feature 196

#2111 Feature 2111

#1192 Feature 1192

#2551 Feature 2551

#796 Feature 796

#2380 Feature 2380

#2225 Feature 2225

#2374 Feature 2374

#3022 Feature 3022

#728 Feature 728

#1786 Feature 1786

#1522 Feature 1522

#1555 Feature 1555

#2309 Feature 2309

#1632 Feature 1632

#2443 Feature 2443

#1568 Feature 1568

#1710 Feature 1710

#1804 Feature 1804

#600 Feature 600

#1046 Feature 1046

#1056 Feature 1056

#363 Feature 363

#2996 Feature 2996

#2914 Feature 2914

#1709 Feature 1709

#2083 Feature 2083

#465 Feature 465

#2539 Feature 2539

#2500 Feature 2500

#707 Feature 707

#2763 Feature 2763

#2214 Feature 2214

#857 Feature 857

#740 Feature 740

#668 Feature 668

#599 Feature 599

#430 Feature 430

#2264 Feature 2264

#375 Feature 375

#2968 Feature 2968

#3052 Feature 3052

#2512 Feature 2512

#2491 Feature 2491

#1652 Feature 1652

#1630 Feature 1630

#1794 Feature 1794

#2101 Feature 2101

#138 Feature 138

#1237 Feature 1237

#556 Feature 556

#500 Feature 500

#2118 Feature 2118

#2164 Feature 2164

#2313 Feature 2313

#1500 Feature 1500

#732 Feature 732

#1840 Feature 1840

#3009 Feature 3009

#2012 Feature 2012

#2157 Feature 2157

#3023 Feature 3023

#2163 Feature 2163

#1266 Feature 1266

#1128 Feature 1128

#2615 Feature 2615

#167 Feature 167

#2086 Feature 2086

#938 Feature 938

#2094 Feature 2094

#1152 Feature 1152

#436 Feature 436

#2953 Feature 2953

#2781 Feature 2781

#1139 Feature 1139

#206 Feature 206

#2175 Feature 2175

#2713 Feature 2713

#2174 Feature 2174

#1308 Feature 1308

#2359 Feature 2359

#1834 Feature 1834

#1513 Feature 1513

#1877 Feature 1877

#912 Feature 912

#614 Feature 614

#2752 Feature 2752

#631 Feature 631

#1793 Feature 1793

#2675 Feature 2675

#1798 Feature 1798

#1310 Feature 1310

#1961 Feature 1961

#1588 Feature 1588

#1195 Feature 1195

#1219 Feature 1219

#396 Feature 396

#2544 Feature 2544

#1805 Feature 1805

#1831 Feature 1831

#221 Feature 221

#1669 Feature 1669

#1530 Feature 1530

#260 Feature 260

#1990 Feature 1990

#1907 Feature 1907

#2831 Feature 2831

#1406 Feature 1406

#1975 Feature 1975

#235 Feature 235

#691 Feature 691

#2602 Feature 2602

#1107 Feature 1107

#637 Feature 637

#2490 Feature 2490

#1487 Feature 1487

#1329 Feature 1329

#1992 Feature 1992

#2377 Feature 2377

#2599 Feature 2599

#150 Feature 150

#2030 Feature 2030

#1747 Feature 1747

#1294 Feature 1294

#2009 Feature 2009

#3042 Feature 3042

#2838 Feature 2838

#2117 Feature 2117

#2545 Feature 2545

#1842 Feature 1842

#1434 Feature 1434

#3067 Feature 3067

#1027 Feature 1027

#1489 Feature 1489

#2292 Feature 2292

#2739 Feature 2739

#1909 Feature 1909

#697 Feature 697

#590 Feature 590

#947 Feature 947

#1441 Feature 1441

#475 Feature 475

#3004 Feature 3004

#351 Nanomaterial Synthesis and Properties

#1101 Feature 1101

#2813 Feature 2813

#3048 Feature 3048

#2242 Feature 2242

#2215 Feature 2215

#563 Feature 563

#2919 Feature 2919

#1903 Feature 1903

#328 Feature 328

#190 Feature 190

#821 Feature 821

#788 Feature 788

#2633 Feature 2633

#2592 Feature 2592

#1208 Feature 1208

#2759 Feature 2759

#2528 Feature 2528

#2944 Feature 2944

#810 Feature 810

#180 Feature 180

#1952 Feature 1952

#370 Feature 370

#708 Drug Resistance Mechanisms in Cancer

#835 Feature 835

#670 Feature 670

#1946 Feature 1946

#2105 Feature 2105

#2432 Feature 2432

#1215 Feature 1215

#1782 Feature 1782

#2018 Feature 2018

#155 Feature 155

#1099 Feature 1099

#2898 Feature 2898

#1415 Feature 1415

#2144 Feature 2144

#1494 Feature 1494

#1611 Feature 1611

#554 Feature 554

#2224 Feature 2224

#1240 Feature 1240

#1996 Feature 1996

#867 Feature 867

#450 Feature 450

#2880 Feature 2880

#277 Feature 277

#1321 Feature 1321

#1745 Feature 1745

#2205 Feature 2205

#1523 Feature 1523

#2756 Feature 2756

#1013 Feature 1013

#1995 Feature 1995

#2165 Feature 2165

#1701 Feature 1701

#2668 Feature 2668

#2853 Feature 2853

#2284 Feature 2284

#3012 Feature 3012

#1420 Feature 1420

#2963 Feature 2963

#969 Feature 969

#856 Feature 856

#2301 Feature 2301

#2499 Feature 2499

#1742 Feature 1742

#622 Feature 622

#2486 Feature 2486

#1269 Feature 1269

#1784 Feature 1784

#644 Feature 644

#2462 Feature 2462

#3014 Feature 3014

#2228 Feature 2228

#223 Feature 223

#1259 Feature 1259

#1486 Feature 1486

#2526 Feature 2526

#1171 Feature 1171

#478 Feature 478

#2560 Feature 2560

#1370 Feature 1370

#2707 Feature 2707

#613 Feature 613

#2730 Feature 2730

#1576 Feature 1576

#2437 Feature 2437

#1232 Feature 1232

#1249 Feature 1249

#506 Feature 506

#2189 Feature 2189

#2129 Feature 2129

#1872 Feature 1872

#2579 Feature 2579

#1005 Feature 1005

#2090 Feature 2090

#598 Feature 598

#2740 Feature 2740

#773 Feature 773

#1339 Feature 1339

#1047 Feature 1047

#1379 Feature 1379

#1372 Feature 1372

#1397 Feature 1397

#1312 Feature 1312

#1151 Feature 1151

#1029 Feature 1029

#2609 Feature 2609

#1288 Feature 1288

#331 Feature 331

#2354 Feature 2354

#1100 Feature 1100

#2706 Feature 2706

#2692 Feature 2692

#1634 Feature 1634

#1950 Feature 1950

#896 Feature 896

#539 Feature 539

#1651 Feature 1651

#2447 Feature 2447

#119 Feature 119

#2256 Feature 2256

#228 Feature 228

#757 Feature 757

#1268 Feature 1268

#2846 Feature 2846

#2138 Feature 2138

#2022 Feature 2022

#1492 Feature 1492

#285 Feature 285

#2688 Feature #2688

#336 Feature 336

#2960 Feature 2960

#1462 Feature 1462

#2745 Feature 2745

#1569 Feature 1569

#546 Feature 546

#1464 Feature 1464

#3028 Feature 3028

#132 Feature 132

#1482 Feature 1482

#1828 Feature 1828

#1942 Feature 1942

#1776 Feature 1776

#616 Feature 616

#1357 Feature 1357

#509 Feature 509

#650 Feature 650

#610 Feature 610

#446 Feature 446

#985 Feature 985

#2912 Feature 2912

#588 Feature 588

#1200 Feature 1200

#330 Feature 330

#2110 Feature 2110

#1012 Feature 1012

#2414 Feature 2414

#2151 Feature 2151

#1042 Feature 1042

#977 Feature 977

#1006 Feature 1006

#1230 Feature 1230

#2732 Feature 2732

#2458 Feature 2458

#2511 Feature 2511

#2431 Feature 2431

#1571 Feature 1571

#2761 Feature 2761

#826 Feature 826

#1322 Feature 1322

#2206 Feature 2206

#730 Feature 730

#2263 Feature 2263

#681 Feature 681

#2245 Feature 2245

#1163 Feature 1163

#1003 Feature 1003

#383 Feature 383

#972 Feature 972

#2198 Feature 2198

#1770 Feature 1770

#1809 Feature 1809

#2524 Feature 2524

#2580 Feature 2580

#249 Feature 249

#2367 Feature 2367

#1153 Feature 1153

#2995 Feature 2995

#1134 Feature 1134

#1302 Sensing and Detection Technologies

#1246 Feature 1246

#1392 Feature 1392

#2170 Feature 2170

#2918 Feature 2918

#2994 Feature 2994

#1125 Feature 1125

#2523 Feature 2523

#1608 Feature 1608

#860 Feature 860

#1620 Feature 1620

#3017 Feature 3017

#2461 Feature 2461

#974 Feature 974

#2824 Feature 2824

#2427 Feature 2427

#1381 Feature 1381

#2686 Feature 2686

#2040 Feature 2040

#417 Feature 417

#1354 Feature 1354

#2127 Feature 2127

#2288 Feature 2288

#1109 Feature 1109

#505 Feature 505

#2355 Feature 2355

#434 Feature 434

#583 Feature 583

#127 Feature 127

#2725 Feature 2725

#1598 Feature 1598

#1080 Feature 1080

#1815 Feature 1815

#1135 Feature 1135

#1114 Feature 1114

#1091 Feature 1091

#2970 Feature 2970

#2319 Feature 2319

#902 Feature 902

#665 Feature 665

#844 Feature 844

#1077 Feature 1077

#2270 Feature 2270

#1461 Feature 1461

#1063 Feature 1063

#1954 Feature 1954

#2375 Feature 2375

#1112 Feature 1112

#2504 Feature 2504

#1819 Feature 1819

#2112 Feature 2112

#2543 Feature 2543

#662 Feature 662

#2708 Feature 2708

#2188 Feature 2188

#1102 Feature 1102

#494 Feature 494

#1330 Feature 1330

#536 Feature 536

#2034 Feature 2034

#1683 Feature 1683

#1965 Feature 1965

#1116 Feature 1116

#1085 Feature 1085

#162 Feature 162

#1407 Feature 1407

#1932 Feature 1932

#1223 Feature 1223

#2809 Feature 2809

#201 Feature 201

#149 Feature 149

#1554 Feature 1554

#2657 Feature 2657

#2334 Feature 2334

#377 Feature 377

#1516 Feature 1516

#186 Feature 186

#2285 Feature 2285

#253 Feature 253

#565 Feature 565

#2893 Feature 2893

#449 Feature 449

#1398 Feature 1398

#1073 Feature 1073

#1459 Feature 1459

#1700 Feature 1700

#2565 Feature 2565

#1496 Feature 1496

#373 Feature 373

#994 Feature 994

#2899 Feature 2899

#1179 Feature 1179

#2949 Feature 2949

#2370 Feature 2370

#1399 Feature 1399

#2148 Feature 2148

#273 Feature 273

#1860 Feature 1860

#941 Feature 941

#1547 Feature 1547

#550 Feature 550

#2533 Feature 2533

#1546 Feature 1546

#3066 Feature 3066

#1861 Feature 1861

#1393 Feature 1393

#548 Feature 548

#1980 Feature 1980

#2817 Feature 2817

#620 Feature 620

#2209 Feature 2209

#135 Feature 135

#2860 Feature 2860

#2997 Feature 2997

#720 Feature 720

#2153 Feature 2153

#1526 Feature 1526

#870 Feature 870

#552 Feature 552

#352 Feature 352

#2816 Feature 2816

#1741 Feature 1741

#1824 Feature 1824

#2925 Feature 2925

#2196 Feature 2196

#569 Feature 569

#264 Feature 264

#2302 Feature 2302

#817 Feature 817

#1361 Feature 1361

#2826 Feature 2826

#2172 Feature 2172

#2933 Feature 2933

#348 Feature 348

#1458 Feature 1458

#1527 Feature 1527

#1190 Feature 1190

#935 Feature 935

#1893 Feature 1893

#1408 Feature 1408

#459 Feature 459

#1193 Feature 1193

#140 Feature 140

#356 Feature 356

#1878 Feature 1878

#2147 Feature 2147

#185 Feature 185

#1078 Feature 1078

#1209 Feature 1209

#1065 Feature 1065

#2233 Feature 2233

#301 Feature 301

#2220 Feature 2220

#2784 Feature 2784

#1052 Feature 1052

#2550 Feature 2550

#887 Feature 887

#1350 Feature 1350

#1595 Feature 1595

#646 Feature 646

#2755 Feature 2755

#1589 Feature 1589

#497 Feature 497

#587 Feature 587

#2197 Feature 2197

#2812 Feature 2812

#982 Feature 982

#474 Surgical Procedures & Gastrointestinal Issues

#1781 Feature 1781

#934 Feature 934

#1730 Feature 1730

#746 Feature 746

#424 Feature 424

#859 Feature 859

#2254 Feature 2254

#146 Feature 146

#2003 Feature 2003

#787 Feature 787

#2065 Feature 2065

#990 Feature 990

#2312 Feature 2312

#159 Feature 159

#369 Feature 369

#158 Feature 158

#2098 Feature 2098

#892 Feature 892

#2559 Feature 2559

#1665 Feature 1665

#2568 Feature 2568

#2401 Feature 2401

#1829 Feature 1829

#769 Feature 769

#2797 Feature 2797

#1685 Feature 1685

#2496 Feature 2496

#1471 Feature 1471

#2182 Feature 2182

#2399 Feature 2399

#1161 Feature 1161

#2722 Feature 2722

#799 Feature 799

#413 Feature 413

#661 Feature 661

#1976 Feature 1976

#1353 Feature 1353

#1067 Feature 1067

#2323 Feature 2323

#1869 Feature 1869

#811 Feature 811

#2532 Feature 2532

#1802 Feature 1802

#2121 Feature 2121

#1673 Feature 1673

#936 Feature 936

#1535 Feature 1535

#2283 Feature 2283

#433 Feature 433

#2325 Feature 2325

#1058 Feature 1058

#2630 Feature 2630

#2344 Feature 2344

#1431 Feature 1431

#2621 Feature 2621

#2005 Feature 2005

#1943 Feature 1943

#698 Feature 698

#2961 Feature 2961

#2719 Feature 2719

#1707 Feature 1707

#1115 Feature 1115

#940 Feature 940

#2056 Feature 2056

#435 Feature 435

#2332 Feature 2332

#551 Feature 551

#1981 Feature 1981

#1951 Feature 1951

#1693 Feature 1693

#2137 Feature 2137

#1934 Feature 1934

#2219 Feature 2219

#543 Feature 543

#906 Feature 906

#766 Feature 766

#1853 Feature 1853

#1549 Feature 1549

#920 Feature 920

#1947 Feature 1947

#404 Interactions and Mechanisms

#1023 Feature 1023

#901 Feature 901

#2423 Feature 2423

#2943 Feature 2943

#2698 Feature 2698

#2455 Feature 2455

#3049 Feature 3049

#2877 Feature 2877

#2939 Feature 2939

#557 Feature 557

#2416 Feature 2416

#1371 Feature 1371

#1964 Feature 1964

#2699 Feature 2699

#2660 Feature 2660

#824 Feature 824

#2394 Feature 2394

#2347 Feature 2347

#2193 Feature 2193

#2610 Feature 2610

#653 Feature 653

#1396 Feature 1396

#839 Feature 839

#2662 Feature 2662

#1136 Feature 1136

#2424 Feature 2424

#753 Feature 753

#386 Feature 386

#1375 Feature 1375

#1801 Feature 1801

#855 Feature 855

#1405 Feature 1405

#1704 Feature 1704

#184 Feature 184

#609 Feature 609

#1914 Feature 1914

#2867 Feature 2867

#251 Feature 251

#267 Feature 267

#378 Feature 378

#2879 Feature 2879

#357 Feature 357

#568 Feature 568

#1746 Feature 1746

#800 Feature 800

#467 Feature 467

#1004 Feature 1004

#1016 Feature 1016

#1452 Feature 1452

#1162 Feature 1162

#314 Feature 314

#1086 Feature 1086

#457 Feature 457

#2304 Feature 2304

#2938 Feature 2938

#1424 Feature 1424

#1817 Feature 1817

#268 Feature 268

#1953 Feature 1953

#198 Feature 198

#1534 Feature 1534

#1367 Feature 1367

#1577 Feature 1577

#2361 Feature 2361

#1650 Feature 1650

#2833 Feature 2833

#422 Feature 422

#2073 Feature 2073

#2184 Feature 2184

#2064 Feature 2064

#2395 Feature 2395

#2614 Feature #2614

#1244 Feature 1244

#986 Feature 986

#2297 Feature 2297

#2070 Feature 2070

#648 Feature 648

#1724 Feature 1724

#1318 Feature 1318

#1409 Feature 1409

#1803 Feature 1803

#967 Feature 967

#1231 Feature 1231

#1642 Feature 1642

#1222 Feature 1222

#1070 Feature 1070

#1157 Feature 1157

#1359 Feature 1359

#476 Feature 476

#2977 Feature 2977

#1098 Feature 1098

#1348 Feature 1348

#1394 Feature 1394

#1671 Feature 1671

#2222 Feature 2222

#2767 Feature 2767

#831 Feature 831

#2611 Feature 2611

#2929 Feature 2929

#1104 Feature 1104

#364 Feature 364

#2505 Feature 2505

#719 Feature 719

#2738 Feature 2738

#1404 Feature 1404

#2618 Feature 2618

#2459 Feature 2459

#1229 Feature 1229

#872 Feature 872

#1553 Feature 1553

#1205 Feature 1205

#1731 Feature 1731

#1423 Feature 1423

#2888 Feature 2888

#849 Feature 849

#1160 Feature 1160

#1103 Feature 1103

#838 Feature 838

#861 Feature 861

#869 Feature 869

#1428 Feature 1428

#2063 Feature 2063

#2842 Feature 2842

#2518 Feature 2518

#2986 Feature 2986

#3003 Feature 3003

#713 Feature 713

#1607 Feature 1607

#106 Feature 106

#760 Feature 760

#520 Feature 520

#2840 Feature 2840

#2477 Feature 2477

#405 Feature 405

#152 Feature 152

#425 Feature 425

#2967 Feature 2967

#2852 Feature 2852

#2187 Feature 2187

#976 Feature 976

#567 Feature 567

#1011 Feature 1011

#2658 Feature 2658

#124 Feature 124

#542 Feature 542

#3071 Feature 3071

#2531 Feature 2531

#1344 Feature 1344

#627 Feature 627

#629 Feature 629

#2279 Feature 2279

#1744 Feature 1744

#2208 Feature 2208

#2010 Feature 2010

#2130 Feature 2130

#759 Feature 759

#791 Feature 791

#714 Feature 714

#2607 Feature 2607

#1561 Feature 1561

#2634 Feature 2634

#875 Feature 875

#530 Feature 530

#2743 Feature 2743

#1422 Feature 1422

#2386 Feature 2386

#580 Feature 580

#128 Feature 128

#1800 Feature 1800

#136 Feature 136

#2790 Feature 2790

#362 Feature 362

#2033 Feature 2033

#463 Feature 463

#1166 Feature 1166

#752 Feature 752

#2979 Feature 2979

#381 Feature 381

#2612 Feature 2612

#823 Feature 823

#1289 Feature 1289

#2329 Feature 2329

#1343 Feature 1343

#1788 Feature 1788

#1609 Feature 1609

#1719 Feature 1719

#2645 Feature 2645

#2464 Feature 2464

#686 Feature 686

#1279 Feature 1279

#1055 Feature 1055

#1703 Feature 1703

#1691 Feature 1691

#984 Feature 984

#2186 Feature 2186

#685 Feature 685

#2261 Feature 2261

#1311 Molecular Mechanisms and Biological Processes

#315 Feature 315

#715 Feature 715

#2156 Feature 2156

#460 Feature 460

#2466 Feature 2466

#2393 Feature 2393

#2874 Feature 2874

#2463 Feature 2463

#1541 Feature 1541

#949 Feature 949

#808 Feature 808

#1050 Feature 1050

#1760 Feature 1760

#2305 Feature 2305

#2403 Feature 2403

#1267 Feature 1267

#1119 Feature 1119

#524 Feature 524

#1260 Feature 1260

#261 Feature 261

#1096 Feature 1096

#1265 Feature 1265

#790 Feature 790

#2990 Feature 2990

#884 Feature 884

#783 Feature 783

#360 Feature 360

#2905 Feature 2905

#3032 Feature 3032

#2180 Feature 2180

#657 Feature 657

#2661 Feature 2661

#751 Feature 751

#1552 Feature 1552

#1820 Feature 1820

#2998 Feature 2998

#959 Feature 959

#2714 Feature 2714

#103 Feature 103

#173 Feature 173

#472 Feature 472

#416 Feature 416

#1697 Feature 1697

#137 Feature 137

#873 Feature 873

#1427 Feature 1427

#2685 Feature 2685

#114 Feature 114

#1922 Feature 1922

#444 Feature 444

#2433 Feature 2433

#2391 Feature 2391

#2425 Feature 2425

#789 Feature 789

#1959 Feature 1959

#1667 Feature 1667

#716 Feature 716

#2485 Feature 2485

#641 Feature 641

#965 Feature 965

#671 Feature 671

#2659 Feature 2659

#2019 Feature 2019

#643 Feature 643

#1095 Feature 1095

#133 Feature 133

#2448 Feature 2448

#2227 Feature 2227

#2801 Feature 2801

#2606 Feature 2606

#779 Feature 779

#2547 Feature 2547

#1256 Feature 1256

#2924 Feature 2924

#293 Feature 293

#570 Feature 570

#440 Feature 440

#165 Feature 165

#584 Feature 584

#2574 Feature 2574

#1881 Feature 1881

#1702 Feature 1702

#1049 Feature 1049

#795 Feature 795

#1132 Feature 1132

#916 Feature 916

#2044 Feature 2044

#2383 Feature 2383

#3005 Feature 3005

#1536 Feature 1536

#1277 Feature 1277

#1034 Feature 1034

#1654 Feature 1654

#2672 Feature 2672

#2771 Feature 2771

#2326 Feature 2326

#2841 Feature 2841

#525 Feature 525

#1335 Feature 1335

#1958 Feature 1958

#1009 Feature 1009

#310 Feature 310

#2450 Feature 2450

#187 Feature 187

#230 Feature 230

#1130 Feature 1130

#166 Feature 166

#2102 Feature 2102

#846 Feature 846

#1833 Feature 1833

#1899 Feature 1899

#589 Feature 589

#1197 Feature 1197

#669 Feature 669

#2141 Feature 2141

#533 Feature 533

#2008 Feature 2008

#701 Feature 701

#1911 Feature 1911

#2181 Feature 2181

#226 Feature 226

#1639 Feature 1639

#469 Feature 469

#2664 Feature 2664

#1448 Feature 1448

#1556 Feature 1556

#1216 Feature 1216

#411 Feature 411

#2002 Feature 2002

#2507 Feature 2507

#2519 Feature 2519

#2673 Feature 2673

#3000 Feature 3000

#2641 Feature 2641

#1713 Feature 1713

#1454 Feature 1454

#101 Feature 101

#427 Feature 427

#2017 Feature 2017

#750 Feature 750

#2358 Feature 2358

#915 Feature 915

#2775 Feature 2775

#805 Feature 805

#814 Feature 814

#1882 Feature 1882

#3024 Feature 3024

#2014 Feature 2014

#2210 Feature 2210

#1615 Feature 1615

#1066 Feature 1066

#1280 Feature 1280

#2972 Sensory-Motor Integration

#2315 Feature 2315

#2471 Feature 2471

#1727 Feature 1727

#952 Feature 952

#481 Feature 481

#1856 Feature 1856

#2655 Feature 2655

#1108 Feature 1108

#225 Feature 225

#2640 Feature 2640

#2623 Feature 2623

#259 Feature 259

#200 Feature 200

#415 Feature 415

#1334 Feature 1334

#621 Feature 621

#2712 Feature 2712

#241 Feature 241

#1723 Feature 1723

#2307 Feature 2307

#1962 Feature 1962

#1897 Feature 1897

#2617 Feature 2617

#968 Feature 968

#2747 Feature 2747

#207 Feature 207

#1750 Feature 1750

#1612 Feature 1612

#2741 Feature 2741

#1627 Feature 1627

#23 Neuronal Circuitry and Cellular Processes

#2457 Feature 2457

#2382 Feature 2382

#1189 Feature 1189

#2819 Feature 2819

#1121 Feature 1121

#361 Feature 361

#2628 Feature 2628

#1657 Feature 1657

#339 Feature 339

#2272 Feature 2272

#2522 Feature 2522

#2616 Feature 2616

#1087 Feature 1087

#1749 Feature 1749

#2289 Feature 2289

#214 Feature 214

#1777 Feature 1777

#1376 Feature 1376

#2554 Feature 2554

#1606 Feature 1606

#2779 Feature 2779

#2216 Feature 2216

#1806 Feature 1806

#822 Feature 822

#1696 Feature 1696

#2798 Feature 2798

#1437 Feature 1437

#928 Feature 928

#1711 Feature 1711

#3031 Feature 3031

#722 Feature 722

#2100 Feature 2100

#2387 Feature 2387

#1690 Feature 1690

#2848 Feature 2848

#749 Feature 749

#2965 Feature 2965

#3040 Feature 3040

#2298 Feature 2298

#963 Feature 963

#1181 Feature 1181

#945 Feature 945

#2758 Feature 2758

#2107 Feature 2107

#3008 Feature 3008

#793 Feature 793

#2402 Feature 2402

#1681 Feature 1681

#2371 Feature 2371

#322 Feature 322

#555 Feature 555

#601 Feature 601

#1590 Feature 1590

#630 Feature 630

#652 Feature 652

#2764 Feature 2764

#215 Feature 215

#566 Feature 566

#1743 Feature 1743

#1412 Feature 1412

#2468 Feature 2468

#171 Feature 171

#2397 Feature 2397

#3043 Feature 3043

#745 Feature 745

#1291 Feature 1291

#2653 Feature 2653

#2566 Feature 2566

#2652 Feature 2652

#2074 Feature 2074

#2237 Feature 2237

#1706 Feature 1706

#1463 Feature 1463

#1283 Feature 1283

#2705 Feature 2705

#1382 Feature 1382

#2729 Feature 2729

#2872 Feature 2872

#1419 Feature 1419

#777 Feature 777

#692 Feature 692

#2546 Feature 2546

#161 Feature 161

#199 Feature 199

#2223 Feature 2223

#2629 Feature 2629

#2179 Feature 2179

#2956 Feature 2956

#895 Feature 895

#2258 Feature 2258

#819 Feature 819

#898 Feature 898

#1949 Feature 1949

#2676 Feature 2676

#1225 Feature 1225

#148 Feature 148

#2679 Feature 2679

#818 Feature 818

#1885 Feature 1885

#678 Feature 678

#801 Feature 801

#1520 Feature 1520

#923 Feature 923

#2859 Feature 2859

#2150 Feature 2150

#2516 Feature 2516

#2985 Feature 2985

#1775 Feature 1775

#355 Feature 355

#1043 Feature 1043

#213 Feature 213

#1574 Feature 1574

#2601 Feature 2601

#1586 Feature 1586

#1728 Feature 1728

#2506 Feature 2506

#3060 Feature 3060

#1717 Feature 1717

#3050 Feature 3050

#754 Feature 754

#1906 Feature 1906

#2267 Feature 2267

#1604 Feature 1604

#2964 Feature 2964

#1939 Feature 1939

#2613 Feature 2613

#2735 Feature 2735

#1368 Feature 1368

#2889 Feature 2889

#794 Feature 794

#1540 Feature 1540

#2047 Feature 2047

#2783 Feature 2783

#2185 Feature 2185

#2966 Feature 2966

#1679 Feature 1679

#448 Feature 448

#1123 Feature 1123

#292 Feature 292

#2076 Feature 2076

#950 Feature 950

#2832 Feature 2832

#683 Feature 683

#2589 Feature 2589

#333 Feature 333

#1349 Feature 1349

#337 Feature 337

#1883 Feature 1883

#802 Feature 802

#2520 Feature 2520

#2563 Feature 2563

#282 Feature 282

#593 Feature 593

#2352 Feature 2352

#731 Feature 731

#2407 Feature 2407

#1664 Feature 1664

#1579 Feature 1579

#1198 Feature 1198

#2440 Feature 2440

#182 Feature 182

#634 Feature 634

#581 Feature 581

#1498 Feature 1498

#1129 Feature 1129

#2378 Feature 2378

#541 Feature 541

#2011 Feature 2011

#2907 Feature 2907

#2515 Feature 2515

#1676 Feature 1676

#899 Feature 899

#2882 Feature 2882

#1864 Feature 1864

#768 Feature 768

#1779 Feature 1779

#676 Feature 676

#3070 Spiritual and Holistic Care in Healthcare

#1196 Feature 1196

#1753 Feature 1753

#1478 Feature 1478

#172 Feature 172

#1924 Feature 1924

#1127 Feature 1127

#2050 Feature 2050

#519 Feature 519

#1991 Feature 1991

#880 Feature 880

#212 Feature 212

#471 Feature 471

#376 Feature 376

#929 Feature 929

#3027 Feature 3027

#2265 Feature 2265

#761 Feature 761

#2390 Feature 2390

#1645 Feature 1645

#2989 Feature 2989

#2085 Feature 2085

#2072 Feature 2072

#758 Feature 758

#575 Feature 575

#704 Feature 704

#679 Feature 679

#1287 Feature 1287

#882 Feature 882

#1297 Feature 1297

#195 Feature 195

#420 Feature 420

#2896 Feature 2896

#842 Feature 842

#836 Feature 836

#2465 Feature 2465

#1600 Feature 1600

#2201 Feature 2201

#2974 Feature 2974

#1944 Feature 1944

#177 Feature 177

#1960 Feature 1960

#1147 Feature 1147

#122 Feature 122

#961 Feature 961

#1928 Feature 1928

#1649 Feature 1649

#2582 Feature 2582

#1663 Feature 1663

#2587 Feature 2587

#270 Feature 270

#1183 Feature 1183

#452 Feature 452

#2988 Feature 2988

#2277 Feature 2277

#2487 Feature 2487

#547 Feature 547

#1048 Feature 1048

#1014 Feature 1014

#3033 Feature 3033

#2576 Feature 2576

#1910 Feature 1910

#1917 Feature 1917

#2727 Feature 2727

#1658 Feature 1658

#431 Feature 431

#1472 Feature 1472

#1270 Feature 1270

#924 Feature 924

#1927 Feature 1927

#1931 Feature 1931

#1390 Feature 1390

#2622 Feature 2622

#2638 Feature 2638

#2404 Feature 2404

#120 Feature 120

#2146 Feature 2146

#116 Feature 116

#2769 Feature 2769

#121 Feature 121

#2864 Feature 2864

#203 Feature 203

#1436 Feature 1436

#1822 Feature 1822

#1346 Feature 1346

#2398 Feature 2398

#962 Feature 962

#455 Feature 455

#2866 Feature 2866

#368 Feature 368

#341 Feature 341

#473 Feature 473

#2199 Feature 2199

#2489 Feature 2489

#865 Feature 865

#922 Feature 922

#1015 Feature 1015

#602 Feature 602

#129 Feature 129

#2808 Feature 2808

#1880 Feature 1880

#2106 Feature 2106

#883 Feature 883

#2140 Feature 2140

#1364 Feature 1364

#2873 Feature 2873

#1124 Feature 1124

#526 Feature 526

#2760 Feature 2760

#2865 Feature 2865

#2541 Feature 2541

#246 Feature 246

#503 Feature 503

#1762 Feature 1762

#2983 Feature 2983

#1766 Feature 1766

#2419 Feature 2419

#549 Feature 549

#1807 Feature 1807

#1641 Feature 1641

#1045 Feature 1045

#673 Feature 673

#2300 Feature 2300

#492 Feature 492

#445 Feature 445

#1388 Feature 1388

#2748 Feature 2748

#2637 Feature 2637

#2981 Feature 2981

#725 Feature 725

#488 Feature 488

#2726 Feature 2726

#2351 Feature 2351

#2478 Feature 2478

#340 Feature 340

#2365 Feature 2365

#2928 Feature 2928

#1020 Feature 1020

#1818 Feature 1818

#1243 Feature 1243

#2249 Feature 2249

#1156 Feature 1156

#983 Feature 983

#2836 Feature 2836

#1757 Feature 1757

#1886 Feature 1886

#1176 Feature 1176

#208 Feature 208

#2829 Feature 2829

#877 Feature 877

#300 Feature 300

#1411 Feature 1411

#2921 Feature 2921

#2690 Feature 2690

#723 Feature 723

#1331 Feature 1331

#832 Feature 832

#2762 Feature 2762

#2097 Feature 2097

#1891 Feature 1891

#2418 Feature 2418

#2818 Feature 2818

Document Content

Evaluation of the cytotoxicity, genotoxicity and mucus permeation capacity of several surface modified poly(anhydride) nanoparticles designed for oral drug delivery.
The main concerns with drugs designed for oral administration are their inactivation or degradation in the harsh conditions of the gastrointestinal tract, their poor solubility through the gastrointestinal mucus gel layer, the poor intestinal epithelium permeability that limits their absorption, and their toxicity. In this context, poly(anhydride) nanoparticles are capable of protecting the drug from the harsh environment, reduce the drug's toxicity and, by virtue of surface modification, to enhance or reduce their mucus permeability and the bioadhesion to specific target cells. The copolymer between methyl vinyl ether and maleic anhydride (commercialized as Gantrez® AN 119) are part of the poly(anhydride) nanoparticles. These biocompatible and biodegradable nanoparticles (NPs) can be modified by using different ligands. Their usefulness as drug carriers and their bioadhesion with components of the intestinal mucosa have been described. However, their toxicity, genotoxicity and mucus permeation capacity has not been thoroughly studied. The aim of this work was to evaluate and compare the in vitro toxicity, cell viability and in vitro genotoxicity of the bioadhesive empty Gantrez® AN 119 NPs modified with dextran, aminodextran, 2-hydroxypropyl-β-cyclodextrin, mannosamine and poly-ethylene glycol of different molecular weights. Results showed that, in general, coated NPs exhibit better mucus permeability than the bare ones, those coated with mannosamine being the most permeable ones. The NPs studied did not affect cell metabolism, membrane integrity or viability of Caco-2 cells at the different conditions tested. Moreover, they did not induce a relevant level of DNA strand breaks and FPG-sensitive sites (as detected with the comet assay).

Similar Documents