Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1522

MIN ACTIVATION

0.0

Details List

#306 Feature 306

#803 Feature 803

#2890 Feature 2890

#1746 Feature 1746

#1392 Feature 1392

#957 Feature 957

#2858 Feature 2858

#2533 Feature 2533

#2954 Feature 2954

#1257 Feature 1257

#287 Feature 287

#1260 Feature 1260

#853 Feature 853

#433 Feature 433

#360 Feature 360

#2300 Feature 2300

#226 Feature 226

#2305 Feature 2305

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#639 Feature 639

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#1374 Feature 1374

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#401 Feature 401

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#143 Feature 143

#931 Feature 931

#3068 Feature 3068

#729 Feature 729

#1698 Feature 1698

#1600 Feature 1600

#23 Neuronal Circuitry and Cellular Processes

#1071 Feature 1071

#414 Feature 414

#2635 Feature 2635

#1605 Feature 1605

#1386 Feature 1386

#1017 Feature 1017

#977 Feature 977

#2297 Feature 2297

#3030 Feature 3030

#536 Feature 536

#2714 Feature 2714

#510 Feature 510

#2981 Feature 2981

#1959 Feature 1959

#2089 Feature 2089

#2359 Feature 2359

#275 Feature 275

#1859 Feature 1859

#1826 Feature 1826

#1628 Feature 1628

#1855 Feature 1855

#378 Feature 378

#362 Feature 362

#1419 Feature 1419

#1343 Feature 1343

#2470 Feature 2470

#253 Feature 253

#641 Feature 641

#138 Feature 138

#365 Feature 365

#2571 Feature 2571

#1597 Feature 1597

#2572 Feature 2572

#735 Feature 735

#505 Feature 505

#541 Feature 541

#420 Feature 420

#3037 Feature 3037

#1624 Feature 1624

#845 Feature 845

#2992 Feature 2992

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#2316 Feature 2316

#1112 Feature 1112

#2686 Feature 2686

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#827 Feature 827

#781 Feature 781

#2984 Feature 2984

#2428 Feature 2428

#2000 Feature 2000

#1830 Feature 1830

#2888 Feature 2888

#170 Feature 170

#2024 Feature 2024

#1181 Feature 1181

#1537 Feature 1537

#195 Feature 195

#898 Feature 898

#2442 Feature 2442

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#2020 Feature 2020

#1621 Feature 1621

#1672 Feature 1672

#875 Feature 875

#2946 Feature 2946

#586 Feature 586

#915 Feature 915

#2276 Feature 2276

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#1544 Feature 1544

#2328 Feature 2328

#565 Feature 565

#141 Feature 141

#1471 Feature 1471

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#1576 Feature 1576

#768 Feature 768

#2609 Feature 2609

#1738 Feature 1738

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#1472 Feature 1472

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#1180 Feature 1180

#751 Feature 751

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#2707 Feature 2707

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#1957 Feature 1957

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#2456 Feature 2456

#2905 Feature 2905

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#2118 Feature 2118

#580 Feature 580

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#2314 Feature 2314

#2140 Feature 2140

#490 Feature 490

#1417 Feature 1417

#2625 Feature 2625

#1429 Feature 1429

#2658 Feature 2658

#2058 Feature 2058

#2295 Feature 2295

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#3000 Feature 3000

#2969 Feature 2969

#1917 Feature 1917

#870 Feature 870

#2782 Feature 2782

#2209 Feature 2209

#604 Feature 604

#2418 Feature 2418

#2709 Feature 2709

#2319 Feature 2319

#2922 Feature 2922

#1549 Feature 1549

#683 Feature 683

#2626 Feature 2626

#939 Feature 939

#818 Feature 818

#1974 Feature 1974

#171 Feature 171

#727 Feature 727

#1122 Feature 1122

#280 Feature 280

#1001 Feature 1001

#2134 Feature 2134

#1579 Feature 1579

#2569 Feature 2569

#550 Feature 550

#1027 Feature 1027

#943 Feature 943

#1073 Feature 1073

#2901 Feature 2901

#700 Feature 700

#954 Feature 954

#2752 Feature 2752

#1167 Feature 1167

#2119 Feature 2119

#2778 Hippocampal Memory and Cognitive Function

#2062 Feature 2062

#2071 Feature 2071

#2072 Feature 2072

#3028 Feature 3028

#1364 Feature 1364

#2338 Feature 2338

#1350 Feature 1350

#371 Feature 371

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#2205 Feature 2205

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#338 Feature 338

#2096 Feature 2096

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#303 Feature 303

#2431 Feature 2431

#1388 Feature 1388

#852 Feature 852

#1778 Feature 1778

#638 Feature 638

#1763 Feature 1763

#469 Feature 469

#921 Feature 921

#1571 Feature 1571

#496 Feature 496

#2048 Feature 2048

#1651 Feature 1651

#3065 Feature 3065

#2587 Feature 2587

#3023 Feature 3023

#2766 Feature 2766

#1968 Feature 1968

#1183 Feature 1183

#1823 Feature 1823

#1050 Feature 1050

#2173 Feature 2173

#1986 Feature 1986

#1345 Feature 1345

#416 Feature 416

#239 Feature 239

#2154 Feature 2154

#1067 Feature 1067

#619 Feature 619

#1068 Feature 1068

#2175 Feature 2175

#643 Feature 643

#721 Feature 721

#2591 Feature 2591

#1590 Feature 1590

#247 Feature 247

#2092 Feature 2092

#926 Feature 926

#2806 Feature 2806

#2772 Feature 2772

#830 Feature 830

#3069 Feature 3069

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#251 Feature 251

#1557 Feature 1557

#833 Feature 833

#1817 Feature 1817

#750 Feature 750

#1936 Feature 1936

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#1994 Feature 1994

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#2231 Feature 2231

#2066 Feature 2066

#2034 Feature 2034

#1131 Feature 1131

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#2955 Feature 2955

#2320 Feature 2320

#2046 Feature 2046

#903 Feature 903

#2474 Feature 2474

#773 Feature 773

#1166 Feature 1166

#2194 Feature 2194

#522 Feature 522

#2459 Feature 2459

#2909 Feature 2909

#1117 Feature 1117

#2296 Feature 2296

#2080 Feature 2080

#1659 Feature 1659

#1953 Feature 1953

#1225 Feature 1225

#1103 Feature 1103

#2331 Feature 2331

#1279 Feature 1279

#2710 Feature 2710

#3046 Feature 3046

#2823 Feature 2823

#1095 Feature 1095

#1939 Feature 1939

#2926 Feature 2926

#1999 Feature 1999

#1202 Feature 1202

#2151 Feature 2151

#1635 Feature 1635

#1463 Feature 1463

#2597 Feature 2597

#2818 Feature 2818

#2567 Feature 2567

#175 Feature 175

#1104 Feature 1104

#2704 Feature 2704

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#659 Feature 659

#1190 Feature 1190

#1613 Feature 1613

#305 Feature 305

#2964 Feature 2964

#873 Feature 873

#1332 Feature 1332

#391 Feature 391

#199 Feature 199

#2661 Feature 2661

#2484 Feature 2484

#310 Feature 310

#1369 Feature 1369

#3039 Feature 3039

#2881 Feature 2881

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#1204 Feature 1204

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#1611 Feature 1611

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#1401 Feature 1401

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#1339 Feature 1339

#712 Feature 712

#1482 Feature 1482

#1347 Feature 1347

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#2552 Feature 2552

#1938 Feature 1938

#269 Feature 269

#1689 Feature 1689

#1465 Feature 1465

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#1212 Feature 1212

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#2706 Feature 2706

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#332 Feature 332

#1572 Feature 1572

#526 Feature 526

#1351 Feature 1351

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#514 Feature 514

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#1878 Feature 1878

#1066 Feature 1066

#889 Feature 889

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#241 Feature 241

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#2831 Feature 2831

#3009 Feature 3009

#2590 Feature 2590

#556 Feature 556

#2950 Feature 2950

#985 Feature 985

#146 Feature 146

#2960 Feature 2960

#2357 Feature 2357

#1422 Feature 1422

#731 Feature 731

#2694 Feature 2694

#2923 Feature 2923

#1779 Feature 1779

#1690 Feature 1690

#2329 Feature 2329

#347 Feature 347

#2139 Feature 2139

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#2930 Feature 2930

#1601 Feature 1601

#2265 Feature 2265

#2765 Feature 2765

#1776 Feature 1776

#361 Feature 361

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#1616 Feature 1616

#2260 Historical Context & Development

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#353 Feature 353

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#1995 Feature 1995

#1116 Feature 1116

#1483 Feature 1483

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#2855 Feature 2855

#2620 Feature 2620

#2003 Feature 2003

#254 Feature 254

#740 Feature 740

#1703 Feature 1703

#2549 Feature 2549

#2271 Feature 2271

#2147 Feature 2147

#2754 Feature 2754

#1822 Feature 1822

#1100 Feature 1100

#2507 Feature 2507

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#2241 Feature 2241

#665 Feature 665

#323 Feature 323

#2614 Feature #2614

#1039 Feature 1039

#1390 Feature 1390

#2885 Feature 2885

#815 Feature 815

#2401 Feature 2401

#824 Feature 824

#2347 Feature 2347

#1307 Feature 1307

#1209 Feature 1209

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#336 Feature 336

#3061 Feature 3061

#315 Feature 315

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#443 Feature 443

#2863 Feature 2863

#1840 Feature 1840

#1214 Feature 1214

#575 Feature 575

#2285 Feature 2285

#2755 Feature 2755

#1139 Feature 1139

#2674 Feature 2674

#554 Feature 554

#1912 Feature 1912

#272 Feature 272

#2600 Feature 2600

#376 Feature 376

#634 Feature 634

#1516 Feature 1516

#2417 Feature 2417

#270 Feature 270

#2979 Feature 2979

#1438 Feature 1438

#1142 Feature 1142

#603 Feature 603

#2688 Feature #2688

#3060 Feature 3060

#2074 Feature 2074

#386 Feature 386

#2187 Feature 2187

#602 Feature 602

#209 Feature 209

#1108 Feature 1108

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#1085 Feature 1085

#792 Feature 792

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#2534 Feature 2534

#732 Feature 732

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#2318 Feature 2318

#2607 Feature 2607

#1300 Feature 1300

#1558 Feature 1558

#210 Feature 210

#1555 Feature 1555

#950 Feature 950

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#594 Feature 594

#2777 Feature 2777

#1641 Feature 1641

#2836 Feature 2836

#2302 Feature 2302

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#168 Feature 168

#220 Feature 220

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#1469 Feature 1469

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#3015 Feature 3015

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#2532 Feature 2532

#2054 Feature 2054

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#2517 Feature 2517

#163 Feature 163

#198 Feature 198

#482 Feature 482

#264 Feature 264

#764 Feature 764

#2435 Feature 2435

#1134 Feature 1134

#1821 Feature 1821

#2233 Feature 2233

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#1900 Feature 1900

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#1713 Feature 1713

#1683 Feature 1683

#2509 Feature 2509

#348 Feature 348

#1740 Feature 1740

#1554 Feature 1554

#922 Feature 922

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#3054 Feature 3054

#2201 Feature 2201

#1932 Feature 1932

#1653 Feature 1653

#1853 Feature 1853

#855 Feature 855

#2652 Feature 2652

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#1451 Feature 1451

#2202 Feature 2202

#2727 Feature 2727

#1352 Feature 1352

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#2114 Feature 2114

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#2767 Feature 2767

#664 Feature 664

#1935 Feature 1935

#3026 Feature 3026

#823 Feature 823

#844 Feature 844

#535 Feature 535

#466 Feature 466

#1733 Feature 1733

#2683 Feature 2683

#473 Feature 473

#1954 Feature 1954

#911 Feature 911

#2378 Feature 2378

#2222 Feature 2222

#2238 Feature 2238

#485 Feature 485

#1091 Feature 1091

#3064 Surgical Complications and Physiological Stress

#2168 Feature 2168

#2384 Feature 2384

#381 Feature 381

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#424 Feature 424

#2944 Feature 2944

#2038 Feature 2038

#2928 Feature 2928

#1311 Molecular Mechanisms and Biological Processes

#1603 Feature 1603

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#2281 Feature 2281

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#435 Feature 435

#281 Feature 281

#623 Feature 623

#2448 Feature 2448

#2638 Feature 2638

#530 Feature 530

#1216 Feature 1216

#2229 Feature 2229

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#380 Feature 380

#3062 Feature 3062

#2006 Feature 2006

#2452 Feature 2452

#805 Feature 805

#2631 Feature 2631

#2501 Feature 2501

#2076 Feature 2076

#474 Surgical Procedures & Gastrointestinal Issues

#134 Feature 134

#1697 Feature 1697

#1592 Feature 1592

#1129 Feature 1129

#452 Feature 452

#1664 Feature 1664

#174 Feature 174

#2212 Feature 2212

#2049 Feature 2049

#2619 Feature 2619

#330 Feature 330

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#765 Feature 765

#2198 Feature 2198

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#909 Feature 909

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#1344 Feature 1344

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#2193 Feature 2193

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#2218 Feature 2218

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#3004 Feature 3004

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#861 Feature 861

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#1512 Feature 1512

#2641 Feature 2641

#1875 Feature 1875

#2268 Feature 2268

#1276 Feature 1276

#1430 Feature 1430

#1967 Feature 1967

#2337 Feature 2337

#467 Feature 467

#1790 Feature 1790

#1675 Feature 1675

#191 Feature 191

#966 Feature 966

#2262 Feature 2262

#2920 Feature 2920

#1915 Feature 1915

#1220 Feature 1220

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#1261 Feature 1261

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#2434 Feature 2434

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#1833 Feature 1833

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#1710 Feature 1710

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#2416 Feature 2416

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#1914 Feature 1914

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#1476 Feature 1476

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#2322 Feature 2322

#724 Feature 724

#1944 Feature 1944

#1373 Feature 1373

#1904 Feature 1904

#2859 Feature 2859

#2127 Feature 2127

#2570 Feature 2570

#123 Feature 123

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#267 Feature 267

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#200 Feature 200

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#681 Feature 681

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#3036 Feature 3036

#1928 Feature 1928

#232 Feature 232

#1399 Feature 1399

#382 Feature 382

#547 Feature 547

#248 Feature 248

#439 Feature 439

#2691 Feature 2691

#895 Feature 895

#1177 Feature 1177

#1660 Feature 1660

#2032 Feature 2032

#2421 Feature 2421

#668 Feature 668

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#1098 Feature 1098

#1686 Feature 1686

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#1522 Feature 1522

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#716 Feature 716

#1101 Feature 1101

#835 Feature 835

#2486 Feature 2486

#295 Feature 295

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#136 Feature 136

#227 Feature 227

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#2153 Feature 2153

#1794 Feature 1794

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#2026 Feature 2026

#3021 Feature 3021

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#801 Feature 801

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#2372 Feature 2372

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#2830 Feature 2830

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#2115 Feature 2115

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#1633 Feature 1633

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#2427 Feature 2427

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#2177 Feature 2177

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#357 Feature 357

#1694 Feature 1694

#2377 Feature 2377

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#789 Feature 789

#2972 Sensory-Motor Integration

#1475 Feature 1475

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#2991 Feature 2991

#1397 Feature 1397

#988 Feature 988

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#629 Feature 629

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#109 Feature 109

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#162 Feature 162

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#1000 Feature 1000

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#880 Feature 880

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#421 Feature 421

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#235 Feature 235

#621 Feature 621

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#2528 Feature 2528

#1491 Feature 1491

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#3051 Feature 3051

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#458 Feature 458

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#3067 Feature 3067

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#1171 Feature 1171

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#2645 Feature 2645

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#128 Feature 128

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#975 Feature 975

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#633 Feature 633

#2237 Feature 2237

#2919 Feature 2919

#309 Feature 309

#2016 Feature 2016

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#2563 Feature 2563

#1178 Feature 1178

#2172 Feature 2172

#477 Feature 477

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#1069 Feature 1069

#573 Feature 573

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#775 Feature 775

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#533 Feature 533

#893 Feature 893

#2333 Feature 2333

#767 Feature 767

#245 Feature 245

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#2837 Feature 2837

#1295 Feature 1295

#1569 Feature 1569

#525 Feature 525

#2155 Feature 2155

#3049 Feature 3049

#426 Feature 426

#1565 Feature 1565

#2551 Feature 2551

#1885 Feature 1885

#719 Feature 719

#1089 Feature 1089

#555 Feature 555

#2740 Feature 2740

#1542 Feature 1542

#1510 Feature 1510

#2152 Feature 2152

#2580 Feature 2580

#364 Feature 364

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#1329 Feature 1329

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#2160 Feature 2160

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#2516 Feature 2516

#2364 Feature 2364

#2310 Feature 2310

#3006 Feature 3006

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#640 Feature 640

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#1566 Feature 1566

#816 Feature 816

#297 Feature 297

#2523 Feature 2523

#1684 Feature 1684

#2344 Feature 2344

#3063 Feature 3063

#1640 Feature 1640

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Document Content

Evidence for two distinct lysophospholipase activities that degrade lysophosphatidylcholine and lysophosphatidic acid in neuronal nuclei of cerebral cortex.
Neuronal nuclei were isolated from immature rabbit cerebral cortex and nuclear lysophospholipase activities studied using two different 1-acyl lysophospholipids: lysophosphatidylcholine (lysoPC) and lysophosphatidic acid (lysoPA). Our interest in these two lysolipids arose from the observation that lysoPA could promote the acetylation of lysoPC by substantially inhibiting a very active nuclear lysoPC lysophospholipase activity, in a competitive manner (R.R. Baker, H. -y. Chang, Mol. Cell. Biochem. (1999) in press). As there was also evidence for nuclear lysoPA deacylation, it was of interest to see whether one activity could possibly utilize both lysolipid substrates. We now have evidence for two separate lysophospholipase activities in neuronal nuclei. The lysoPC lysophospholipase activity was the more active, more highly enriched in the neuronal nuclei, and showed optimal activity at pH 8.4-9, while the lysoPA lysophospholipase activity was maintained over a much broader pH range. The lysoPC activity was substantially inhibited by free fatty acid, and showed considerable stimulation by serum albumin, while the activity utilizing lysoPA was much less affected by these agents. When lysoPC was added to incubations containing radioactive lysoPA, there was no significant inhibition found in rates of release of radioactive fatty acid, indicating that the lysoPA lysophospholipase activity did not utilize the lysoPC substrate. In incubations with lysoPC, MgATP and CoA brought about a sizable formation of phosphatidylcholine whose radioactivity was equally distributed between the sn-1 and sn-2 positions suggesting labelling both directly from the lysoPC substrate and from fatty acid produced by the lysophospholipase activity. By comparison, with the radioactive lysoPA substrate, MgATP and CoA promoted relatively lower levels of phosphatidic acid formation whose principal labelling came directly from the radioactive lysoPA. Largely because of the high activity of the nuclear lysoPC lysophospholipase, there is considerable potential in the neuronal nucleus to limit the use of lysoPC in other reactions, such as the formation of acylPAF (1-acyl analogue of platelet activating factor). It is of interest that conditions associated with brain ischaemia such as increased free fatty acid levels, falling pH and declines in MgATP may allow a preservation of neuronal nuclear lysoPC levels for acetylation. The existence of a separate lysophospholipase activity for lysoPA allows an independent control of lysoPA which can serve as an important regulator of the nuclear lysoPC lysophospholipase.

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