Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1497

MIN ACTIVATION

0.0

Details List

#1455 Feature 1455

#2188 Feature 2188

#163 Feature 163

#778 Feature 778

#2710 Feature 2710

#1071 Feature 1071

#1541 Feature 1541

#251 Feature 251

#2766 Feature 2766

#759 Feature 759

#736 Feature 736

#2909 Feature 2909

#1186 Feature 1186

#2222 Feature 2222

#357 Feature 357

#2672 Feature 2672

#2619 Feature 2619

#1683 Feature 1683

#2970 Feature 2970

#2333 Feature 2333

#1776 Feature 1776

#693 Feature 693

#1550 Feature 1550

#2658 Feature 2658

#1693 Feature 1693

#965 Feature 965

#681 Feature 681

#872 Feature 872

#1420 Feature 1420

#238 Feature 238

#2354 Feature 2354

#1591 Feature 1591

#205 Feature 205

#2408 Feature 2408

#1572 Feature 1572

#503 Feature 503

#1159 Feature 1159

#2546 Feature 2546

#2297 Feature 2297

#1205 Feature 1205

#798 Feature 798

#701 Feature 701

#1958 Feature 1958

#175 Feature 175

#1119 Feature 1119

#1436 Feature 1436

#1844 Feature 1844

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#3069 Feature 3069

#1404 Feature 1404

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#1083 Feature 1083

#2415 Feature 2415

#3052 Feature 3052

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#590 Feature 590

#2081 Feature 2081

#2337 Feature 2337

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#2118 Feature 2118

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#402 Feature 402

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#1763 Feature 1763

#641 Feature 641

#669 Feature 669

#1526 Feature 1526

#2850 Feature 2850

#2727 Feature 2727

#2556 Feature 2556

#3067 Feature 3067

#2016 Feature 2016

#2105 Feature 2105

#831 Feature 831

#531 Feature 531

#2467 Feature 2467

#1551 Feature 1551

#2309 Feature 2309

#2961 Feature 2961

#2663 Feature 2663

#2496 Feature 2496

#2301 Feature 2301

#2398 Feature 2398

#247 Feature 247

#1503 Feature 1503

#1994 Feature 1994

#673 Feature 673

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#1015 Feature 1015

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#3005 Feature 3005

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#2015 Feature 2015

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#1925 Feature 1925

#957 Feature 957

#1209 Feature 1209

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#2795 Feature 2795

#2119 Feature 2119

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#538 Feature 538

#2423 Feature 2423

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#2416 Feature 2416

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#1970 Feature 1970

#2123 Feature 2123

#2774 Feature 2774

#431 Feature 431

#1192 Feature 1192

#2936 Feature 2936

#316 Feature 316

#404 Interactions and Mechanisms

#2357 Feature 2357

#960 Feature 960

#1011 Feature 1011

#1932 Feature 1932

#672 Feature 672

#2873 Feature 2873

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#1818 Feature 1818

#1260 Feature 1260

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#1149 Feature 1149

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#704 Feature 704

#1179 Feature 1179

#1593 Feature 1593

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#1085 Feature 1085

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#248 Feature 248

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#3026 Feature 3026

#1029 Feature 1029

#1337 Feature 1337

#2554 Feature 2554

#1367 Feature 1367

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#1914 Feature 1914

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#780 Feature 780

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#2144 Feature 2144

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#2331 Feature 2331

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#835 Feature 835

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#2033 Feature 2033

#1030 Feature 1030

#1930 Feature 1930

#334 Feature 334

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#2837 Feature 2837

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#1402 Feature 1402

#1038 Feature 1038

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#563 Feature 563

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#1816 Feature 1816

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#2825 Feature 2825

#1409 Feature 1409

#2791 Feature 2791

#1620 Feature 1620

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#290 Feature 290

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#2360 Feature 2360

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#3003 Feature 3003

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#1864 Feature 1864

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#889 Feature 889

#1212 Feature 1212

#2438 Feature 2438

#2805 Feature 2805

#1619 Feature 1619

#2005 Feature 2005

#576 Feature 576

#869 Feature 869

#1101 Feature 1101

#192 Feature 192

#2122 Feature 2122

#420 Feature 420

#2459 Feature 2459

#2974 Feature 2974

#2525 Feature 2525

#1419 Feature 1419

#609 Feature 609

#194 Feature 194

#1873 Feature 1873

#1308 Feature 1308

#224 Feature 224

#2920 Feature 2920

#168 Feature 168

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#551 Feature 551

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#119 Feature 119

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#1429 Feature 1429

#245 Feature 245

#3002 Feature 3002

#823 Feature 823

#847 Feature 847

#1819 Feature 1819

#162 Feature 162

#1410 Feature 1410

#151 Feature 151

#1286 Feature 1286

#2610 Feature 2610

#2991 Feature 2991

#1421 Feature 1421

#2258 Feature 2258

#1609 Feature 1609

#901 Feature 901

#1896 Feature 1896

#2352 Feature 2352

#2863 Feature 2863

#2418 Feature 2418

#436 Feature 436

#294 Feature 294

#848 Feature 848

#1749 Feature 1749

#2053 Feature 2053

#1976 Feature 1976

#1424 Feature 1424

#2124 Feature 2124

#988 Feature 988

#1837 Feature 1837

#1651 Feature 1651

#417 Feature 417

#389 Feature 389

#2521 Feature 2521

#1067 Feature 1067

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#2240 Feature 2240

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#2343 Feature 2343

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#2622 Feature 2622

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#2462 Feature 2462

#2146 Feature 2146

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#1697 Feature 1697

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#1590 Feature 1590

#2631 Feature 2631

#1892 Feature 1892

#1070 Feature 1070

#2637 Feature 2637

#772 Feature 772

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#2257 Feature 2257

#296 Feature 296

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#2113 Feature 2113

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#2884 Feature 2884

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#810 Feature 810

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#1301 Feature 1301

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#698 Feature 698

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#2175 Feature 2175

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#410 Feature 410

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#1137 Feature 1137

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#331 Feature 331

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#1903 Feature 1903

#1540 Feature 1540

#2527 Feature 2527

#2740 Feature 2740

#2681 Feature 2681

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#754 Feature 754

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#435 Feature 435

#2549 Feature 2549

#1633 Feature 1633

#2351 Feature 2351

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#2325 Feature 2325

#2427 Feature 2427

#1434 Feature 1434

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#1100 Feature 1100

#159 Feature 159

#2228 Feature 2228

#966 Feature 966

#2279 Feature 2279

#1051 Feature 1051

#3023 Feature 3023

#1741 Feature 1741

#3010 Feature 3010

#2322 Feature 2322

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#2082 Feature 2082

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#3028 Feature 3028

#1849 Feature 1849

#1314 Feature 1314

#130 Feature 130

#3021 Feature 3021

#1369 Feature 1369

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#2121 Feature 2121

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#880 Feature 880

#1305 Feature 1305

#1538 Feature 1538

#1341 Feature 1341

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#855 Feature 855

#2088 Feature 2088

#2457 Feature 2457

#2039 Feature 2039

#2342 Feature 2342

#2212 Feature 2212

#1902 Feature 1902

#631 Feature 631

#971 Feature 971

#1806 Feature 1806

#2908 Feature 2908

#633 Feature 633

#935 Feature 935

#520 Feature 520

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#2073 Feature 2073

#750 Feature 750

#1147 Feature 1147

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#2400 Feature 2400

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#2502 Feature 2502

#1218 Feature 1218

#1075 Feature 1075

#1291 Feature 1291

#1766 Feature 1766

#2433 Feature 2433

#675 Feature 675

#606 Feature 606

#1758 Feature 1758

#2025 Feature 2025

#1997 Feature 1997

#480 Feature 480

#1546 Feature 1546

#2391 Feature 2391

#1696 Feature 1696

#2335 Feature 2335

#1543 Feature 1543

#2764 Feature 2764

#1775 Feature 1775

#539 Feature 539

#904 Feature 904

#254 Feature 254

#1016 Feature 1016

#2187 Feature 2187

#850 Feature 850

#2430 Feature 2430

#1949 Feature 1949

#1605 Feature 1605

#456 Feature 456

#1112 Feature 1112

#115 Feature 115

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#1713 Feature 1713

#3018 Feature 3018

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#1814 Feature 1814

#1524 Feature 1524

#2789 Feature 2789

#2226 Feature 2226

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#186 Feature 186

#565 Feature 565

#1895 Feature 1895

#1778 Feature 1778

#188 Feature 188

#1185 Feature 1185

#2848 Feature 2848

#472 Feature 472

#397 Feature 397

#1983 Feature 1983

#2853 Feature 2853

#2590 Feature 2590

#169 Feature 169

#921 Feature 921

#2847 Feature 2847

#1215 Feature 1215

#253 Feature 253

#1552 Feature 1552

#2966 Feature 2966

#412 Feature 412

#2743 Feature 2743

#648 Feature 648

#185 Feature 185

#687 Feature 687

#2781 Feature 2781

#2206 Feature 2206

#405 Feature 405

#462 Feature 462

#1660 Feature 1660

#1148 Feature 1148

#679 Feature 679

#2915 Feature 2915

#108 Feature 108

#2183 Feature 2183

#1285 Feature 1285

#569 Feature 569

#2193 Feature 2193

#2152 Feature 2152

#566 Feature 566

#2932 Feature 2932

#2477 Feature 2477

#865 Feature 865

#1833 Feature 1833

#2102 Feature 2102

#1732 Feature 1732

#502 Feature 502

#1234 Feature 1234

#2386 Feature 2386

#2163 Feature 2163

#1197 Feature 1197

#2800 Feature 2800

#2555 Feature 2555

#1825 Feature 1825

#1653 Feature 1653

#950 Feature 950

#3036 Feature 3036

#1504 Feature 1504

#2261 Feature 2261

#2417 Feature 2417

#927 Feature 927

#1793 Feature 1793

#733 Feature 733

#2476 Feature 2476

#191 Feature 191

#1359 Feature 1359

#700 Feature 700

#1907 Feature 1907

#1513 Feature 1513

#2579 Feature 2579

#3040 Feature 3040

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#2491 Feature 2491

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#739 Feature 739

#1800 Feature 1800

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#1266 Feature 1266

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#1427 Feature 1427

#2403 Feature 2403

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#244 Feature 244

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#1621 Feature 1621

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#1020 Feature 1020

#241 Feature 241

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#310 Feature 310

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#1131 Feature 1131

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#1208 Feature 1208

#222 Feature 222

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#2960 Feature 2960

#3071 Feature 3071

#2425 Feature 2425

#1431 Feature 1431

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#2375 Feature 2375

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#1216 Feature 1216

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#2167 Feature 2167

#2004 Feature 2004

#2310 Feature 2310

#295 Feature 295

#370 Feature 370

#2821 Feature 2821

#2232 Medical Case Reports & Cancer Research

#2374 Feature 2374

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#3015 Feature 3015

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#2210 Feature 2210

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#1123 Feature 1123

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#2469 Feature 2469

#1338 Feature 1338

#2104 Feature 2104

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#265 Feature 265

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#1831 Feature 1831

#2725 Feature 2725

#1133 Feature 1133

#2614 Feature #2614

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#1023 Feature 1023

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#218 Feature 218

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#1922 Feature 1922

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#3016 Feature 3016

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#2368 Feature 2368

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#1178 Feature 1178

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#882 Feature 882

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#103 Feature 103

#2992 Feature 2992

#2716 Feature 2716

#2535 Feature 2535

#1229 Feature 1229

#1852 Feature 1852

#368 Feature 368

#1946 Feature 1946

#945 Feature 945

#2442 Feature 2442

#2006 Feature 2006

#1807 Feature 1807

#1247 Feature 1247

#1996 Feature 1996

#2505 Feature 2505

#2737 Feature 2737

#1345 Feature 1345

#2922 Feature 2922

#1779 Feature 1779

#2171 Molecular and Cellular Biological Processes

#2002 Feature 2002

#1163 Feature 1163

#3070 Spiritual and Holistic Care in Healthcare

#1036 Feature 1036

#2260 Historical Context & Development

#2567 Feature 2567

#2259 Feature 2259

#1223 Feature 1223

#2667 Feature 2667

#554 Feature 554

#2684 Feature 2684

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#2616 Feature 2616

#2311 Feature 2311

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#2585 Feature 2585

#2250 Feature 2250

#787 Feature 787

#1555 Feature 1555

#1024 Feature 1024

#817 Feature 817

#1520 Feature 1520

#833 Feature 833

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#2701 Feature 2701

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#1442 Feature 1442

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#2646 Feature 2646

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#3011 Feature 3011

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#1797 Feature 1797

#1193 Feature 1193

#2944 Feature 2944

#2888 Feature 2888

#473 Feature 473

#2666 Feature 2666

#336 Feature 336

#915 Feature 915

#2643 Feature 2643

#1001 Feature 1001

#355 Feature 355

#1035 Feature 1035

#658 Feature 658

#2241 Feature 2241

#2858 Feature 2858

#2291 Feature 2291

#2383 Feature 2383

#1912 Feature 1912

#683 Feature 683

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#2294 Feature 2294

#198 Feature 198

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#1114 Feature 1114

#2116 Feature 2116

#3037 Feature 3037

#2132 Feature 2132

#1231 Feature 1231

#1950 Feature 1950

#653 Feature 653

#1638 Feature 1638

#598 Feature 598

#1544 Feature 1544

#2052 Feature 2052

#1823 Feature 1823

#1753 Feature 1753

#1680 Feature 1680

#1077 Feature 1077

#2130 Feature 2130

#1227 Feature 1227

#1888 Feature 1888

#1521 Feature 1521

#1822 Feature 1822

#1832 Feature 1832

#197 Feature 197

#3064 Surgical Complications and Physiological Stress

#522 Feature 522

#350 Feature 350

#1466 Feature 1466

#1397 Feature 1397

#123 Feature 123

#1058 Feature 1058

#1474 Feature 1474

#564 Feature 564

#726 Feature 726

#932 Feature 932

#1078 Feature 1078

#1545 Feature 1545

#2638 Feature 2638

#2162 Feature 2162

#990 Feature 990

#1874 Feature 1874

#371 Feature 371

#1947 Feature 1947

#2736 Feature 2736

#3017 Feature 3017

#1911 Feature 1911

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Document Content

Generation of histo-blood group B transferase by replacing the N-acetyl-D-galactosamine recognition domain of human A transferase with the galactose-recognition domain of evolutionarily related murine alpha1,3-galactosyltransferase.
The alpha1,3-galactosyl epitope (alpha1-3Gal epitope), a major xenotransplant antigen, is synthesized by alpha1,3-galactosyltransferase (alpha1-3Gal transferase), which is evolutionarily related to the histo-blood group A/B transferases. We constructed structural chimeras between the human type A and murine alpha1-3Gal transferases and examined their activity and specificity. In many instances, a total loss of transferase activity was observed. Certain areas could be exchanged, with a potential diminishing of activity. With a few constructs, changes in acceptor substrate specificity were suspected. Unexpectedly, a functional conversion from A to B transferase activity was observed after replacing the short sequence of human A transferase with the corresponding sequence from murine alpha1-3Gal transferase. Because these two paralogous enzymes differ in 16 positions of the 38 amino acid residues in the replaced region, our finding may suggest that despite separate evolution and diversified acceptors, these glycosyltransferases still share the three-dimensional domain structure that is responsible for their sugar specificity, arguing against the functional requirement of a strong purifying selection playing a role in the evolution of the ABO family of genes.

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