Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1535

MIN ACTIVATION

0.0

Details List

#779 Feature 779

#2072 Feature 2072

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#781 Feature 781

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#2972 Sensory-Motor Integration

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#2007 Developmental Disparities & Intervention

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#1001 Feature 1001

#1313 Feature 1313

#1438 Feature 1438

#2815 Feature 2815

#2956 Feature 2956

#1303 Feature 1303

#2161 Medical/Scientific Discourse with Ethical/Social Implications

#395 Feature 395

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#2816 Feature 2816

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#1506 Justification/Rationale for Actions

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#23 Neuronal Circuitry and Cellular Processes

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#1952 Feature 1952

#1731 Feature 1731

#1826 Feature 1826

#910 Feature 910

#2411 Feature 2411

#1486 Feature 1486

#2171 Molecular and Cellular Biological Processes

#1589 Feature 1589

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#2778 Hippocampal Memory and Cognitive Function

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#474 Surgical Procedures & Gastrointestinal Issues

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#2224 Feature 2224

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Document Content

Daily variation of brain-derived neurotrophic factor and cortisol in women with normal menstrual cycles, undergoing oral contraception and in postmenopause.
Plasma brain-derived neurotrophic factor (BDNF) levels are associated with the hormonal status of women. Moreover, the suprachiasmatic nucleus appears to be implicated in the modulation of BDNF central levels. We aimed to investigate whether BDNF circadian rhythms exist in women and if there is a relationship with cortisol circadian rhythmicity. Moreover, we aimed to establish whether the hormonal status influences BDNF diurnal variations. A total of 30 women were studied: 10 fertile ovulatory women, 10 women undergoing oral contraceptive (OC) therapy and 10 post-menopausal women. Basal BDNF and estradiol levels were assayed in blood samples collected after overnight fasting at regular intervals (08:00, 12:00, 16:00, 20:00, 24:00). BDNF and cortisol levels were measured in samples collected during the follicular and luteal phases in ovulatory women and once a month in OC and post-menopausal women. Luteal BDNF levels were significantly higher than follicular levels in fertile women (P < 0.001). In OC women, BDNF levels were similar to the follicular BDNF levels, whereas in post-menopausal women, they were significantly lower (P < 0.001). BDNF showed a diurnal rhythm in the follicular phase and in women undergoing OC, although the diurnal rhythm was blunted in the luteal phase. In post-menopausal women, BDNF and cortisol levels significantly decreased during the day. BDNF has a diurnal variation in women that is somewhat analogous to cortisol variation; however, the amplitude of the variation in BDNF levels appears to be influenced by ovarian function. Interactions between BDNF, the hypothalamus-pituitary-adrenal axis and sex steroids might play a critical role in the human homeostasis and adaptation.

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