Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1508

MIN ACTIVATION

0.0

Details List

#1144 Feature 1144

#2065 Feature 2065

#541 Feature 541

#450 Feature 450

#791 Feature 791

#187 Feature 187

#2007 Developmental Disparities & Intervention

#829 Feature 829

#1716 Feature 1716

#332 Feature 332

#2889 Feature 2889

#1917 Feature 1917

#1682 Feature 1682

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#2828 Feature 2828

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#1597 Feature 1597

#2336 Feature 2336

#2316 Feature 2316

#23 Neuronal Circuitry and Cellular Processes

#2435 Feature 2435

#264 Feature 264

#382 Feature 382

#2219 Feature 2219

#3039 Feature 3039

#2553 Feature 2553

#1345 Feature 1345

#414 Feature 414

#2283 Feature 2283

#721 Feature 721

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#1516 Feature 1516

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#2314 Feature 2314

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#934 Feature 934

#1675 Feature 1675

#235 Feature 235

#932 Feature 932

#2522 Feature 2522

#1511 Feature 1511

#1540 Feature 1540

#155 Feature 155

#1533 Feature 1533

#574 Feature 574

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#2260 Historical Context & Development

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#2839 Feature 2839

#316 Feature 316

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#263 Feature 263

#272 Feature 272

#1771 Feature 1771

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#2724 Feature 2724

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#2079 Feature 2079

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#916 Feature 916

#251 Feature 251

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#416 Feature 416

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#3011 Feature 3011

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#306 Feature 306

#1747 Feature 1747

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#2723 Feature 2723

#911 Feature 911

#1365 Feature 1365

#233 Feature 233

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#1865 Feature 1865

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#2225 Feature 2225

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#359 Feature 359

#2315 Feature 2315

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#478 Feature 478

#1375 Feature 1375

#2084 Feature 2084

#1585 Feature 1585

#599 Feature 599

#1366 Feature 1366

#1700 Feature 1700

#241 Feature 241

#2972 Sensory-Motor Integration

#771 Feature 771

#1433 Feature 1433

#639 Feature 639

#2209 Feature 2209

#2708 Feature 2708

#629 Feature 629

#2591 Feature 2591

#401 Feature 401

#1502 Feature 1502

#841 Feature 841

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#2651 Feature 2651

#2732 Feature 2732

#2969 Feature 2969

#2778 Hippocampal Memory and Cognitive Function

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#3000 Feature 3000

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#1610 Feature 1610

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#556 Feature 556

#3046 Feature 3046

#1069 Feature 1069

#439 Feature 439

#2089 Feature 2089

#2474 Feature 2474

#1698 Feature 1698

#1569 Feature 1569

#708 Drug Resistance Mechanisms in Cancer

#1050 Feature 1050

#2687 Feature 2687

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#2223 Feature 2223

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#2201 Feature 2201

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#1351 Feature 1351

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#1219 Feature 1219

#1671 Feature 1671

#152 Feature 152

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#2243 Feature 2243

#2328 Feature 2328

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#399 Feature 399

#1336 Feature 1336

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#275 Feature 275

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#1183 Feature 1183

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#3017 Feature 3017

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#1922 Feature 1922

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#214 Feature 214

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#1603 Feature 1603

#2729 Feature 2729

#824 Feature 824

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#2362 Feature 2362

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#1472 Feature 1472

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#250 Feature 250

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Document Content

The α₂ adrenergic antagonist fipamezole improves quality of levodopa action in Parkinsonian primates.
Reduction in the antiparkinsonian benefit of levodopa is a major complication of long-term levodopa treatment in advanced Parkinson's disease (PD). Such loss of benefit arises because of reduced duration of action and appearance of disabling dyskinesia. We assess the potential of the α(2) adrenergic antagonist fipamezole to reduce motor complications in parkinsonian macaques. MPTP-lesioned macaques were treated acutely with fipamezole (10 mg/kg) alone and in combination with two doses of levodopa. Fipamezole extended both duration and quality of antiparkinsonian action of levodopa. Duration of antiparkinsonian action, on time, was increased by up to 75% while "good-quality" on time, i.e., that not associated with disabling dyskinesia, was increased by up to 98%. Combination of fipamezole with the lower dose of levodopa provided antiparkinsonian benefit at least equivalent to that provided by the higher dose levodopa alone. However, with the combination, antiparkinsonian benefit was of much better quality. The proportion of on time without disabling dyskinesia (79%) was significantly greater than that with high dose levodopa alone (45%). Increased duration and quality of levodopa action may represent therapeutically valuable actions of α(2) adrenergic antagonists.

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