Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1480

MIN ACTIVATION

0.0

Details List

#1401 Feature 1401

#2582 Feature 2582

#1290 Feature 1290

#1419 Feature 1419

#1257 Feature 1257

#778 Feature 778

#684 Feature 684

#431 Feature 431

#3026 Feature 3026

#2873 Feature 2873

#872 Feature 872

#931 Feature 931

#2865 Feature 2865

#1337 Feature 1337

#915 Feature 915

#2135 Feature 2135

#276 Feature 276

#2279 Feature 2279

#2282 Feature 2282

#1659 Feature 1659

#2438 Feature 2438

#1931 Feature 1931

#402 Feature 402

#245 Feature 245

#295 Feature 295

#1851 Feature 1851

#2795 Feature 2795

#3065 Feature 3065

#2016 Feature 2016

#294 Feature 294

#2855 Feature 2855

#2102 Feature 2102

#1834 Feature 1834

#837 Feature 837

#2297 Feature 2297

#143 Feature 143

#977 Feature 977

#1846 Feature 1846

#2716 Feature 2716

#2291 Feature 2291

#251 Feature 251

#1067 Feature 1067

#2408 Feature 2408

#2304 Feature 2304

#3005 Feature 3005

#1809 Feature 1809

#1777 Feature 1777

#1439 Feature 1439

#1641 Feature 1641

#261 Feature 261

#988 Feature 988

#170 Feature 170

#2576 Feature 2576

#2978 Feature 2978

#354 Feature 354

#898 Feature 898

#2338 Feature 2338

#1982 Feature 1982

#2425 Feature 2425

#506 Feature 506

#2884 Feature 2884

#1045 Feature 1045

#2538 Feature 2538

#1690 Feature 1690

#1976 Feature 1976

#1010 Feature 1010

#2088 Feature 2088

#306 Feature 306

#2240 Feature 2240

#2658 Feature 2658

#1374 Feature 1374

#2623 Feature 2623

#117 Feature 117

#2769 Feature 2769

#1185 Feature 1185

#1649 Feature 1649

#1840 Feature 1840

#1592 Feature 1592

#973 Feature 973

#2045 Feature 2045

#1526 Feature 1526

#2742 Feature 2742

#2398 Feature 2398

#357 Feature 357

#819 Feature 819

#1700 Feature 1700

#1368 Feature 1368

#2635 Feature 2635

#2596 Feature 2596

#2358 Feature 2358

#940 Feature 940

#257 Feature 257

#1364 Feature 1364

#2310 Feature 2310

#2333 Feature 2333

#1859 Feature 1859

#2286 Feature 2286

#2962 Feature 2962

#2303 Feature 2303

#1225 Feature 1225

#1209 Feature 1209

#2533 Feature 2533

#2825 Feature 2825

#2022 Feature 2022

#1210 Feature 1210

#1873 Feature 1873

#1983 Feature 1983

#2660 Feature 2660

#3028 Feature 3028

#1618 Feature 1618

#2859 Feature 2859

#921 Feature 921

#2001 Feature 2001

#2429 Feature 2429

#567 Feature 567

#2829 Feature 2829

#880 Feature 880

#1233 Feature 1233

#1651 Feature 1651

#129 Feature 129

#1506 Justification/Rationale for Actions

#810 Feature 810

#222 Feature 222

#1866 Feature 1866

#2231 Feature 2231

#1807 Feature 1807

#1603 Feature 1603

#2259 Feature 2259

#750 Feature 750

#2766 Feature 2766

#2409 Feature 2409

#650 Feature 650

#1430 Feature 1430

#3023 Feature 3023

#1170 Feature 1170

#2577 Feature 2577

#3054 Feature 3054

#2702 Feature 2702

#2290 Feature 2290

#2220 Feature 2220

#2858 Feature 2858

#2123 Feature 2123

#2005 Feature 2005

#1472 Feature 1472

#281 Feature 281

#823 Feature 823

#364 Feature 364

#736 Feature 736

#1094 Feature 1094

#1054 Feature 1054

#1161 Feature 1161

#2602 Feature 2602

#2144 Feature 2144

#2867 Feature 2867

#2672 Feature 2672

#2715 Feature 2715

#755 Feature 755

#468 Feature 468

#795 Feature 795

#3004 Feature 3004

#2285 Feature 2285

#2477 Feature 2477

#2020 Feature 2020

#1797 Feature 1797

#2175 Feature 2175

#534 Feature 534

#365 Feature 365

#1543 Feature 1543

#960 Feature 960

#586 Feature 586

#2083 Feature 2083

#2707 Feature 2707

#2800 Feature 2800

#1609 Feature 1609

#619 Feature 619

#563 Feature 563

#1104 Feature 1104

#926 Feature 926

#1702 Feature 1702

#1791 Feature 1791

#2376 Feature 2376

#2770 Feature 2770

#1049 Feature 1049

#773 Feature 773

#2354 Feature 2354

#436 Feature 436

#3048 Feature 3048

#2081 Feature 2081

#2458 Feature 2458

#1762 Feature 1762

#1082 Feature 1082

#2143 Feature 2143

#1134 Feature 1134

#2309 Feature 2309

#1330 Feature 1330

#2881 Feature 2881

#1328 Feature 1328

#2919 Feature 2919

#2313 Feature 2313

#1604 Feature 1604

#2989 Feature 2989

#1080 Feature 1080

#1713 Feature 1713

#2798 Feature 2798

#767 Feature 767

#1039 Feature 1039

#1429 Feature 1429

#2837 Feature 2837

#2112 Feature 2112

#1550 Feature 1550

#2909 Feature 2909

#2531 Feature 2531

#1994 Feature 1994

#2496 Feature 2496

#1665 Feature 1665

#1677 Feature 1677

#1673 Feature 1673

#1666 Feature 1666

#1013 Feature 1013

#2163 Feature 2163

#2985 Feature 2985

#323 Feature 323

#888 Feature 888

#2874 Feature 2874

#2467 Feature 2467

#2710 Feature 2710

#808 Feature 808

#2525 Feature 2525

#301 Feature 301

#2006 Feature 2006

#1308 Feature 1308

#2534 Feature 2534

#2938 Feature 2938

#2824 Feature 2824

#1126 Feature 1126

#2320 Feature 2320

#889 Feature 889

#403 Feature 403

#2186 Feature 2186

#1148 Feature 1148

#1202 Feature 1202

#633 Feature 633

#2076 Feature 2076

#1461 Feature 1461

#244 Feature 244

#2682 Feature 2682

#2548 Feature 2548

#1260 Feature 1260

#1280 Feature 1280

#1928 Feature 1928

#2901 Feature 2901

#2078 Feature 2078

#227 Feature 227

#1289 Feature 1289

#1421 Feature 1421

#1283 Feature 1283

#1611 Feature 1611

#989 Feature 989

#994 Feature 994

#1698 Feature 1698

#2232 Medical Case Reports & Cancer Research

#201 Feature 201

#2183 Feature 2183

#1629 Feature 1629

#2688 Feature #2688

#1952 Feature 1952

#2414 Feature 2414

#490 Feature 490

#1787 Feature 1787

#2589 Feature 2589

#2745 Feature 2745

#1541 Feature 1541

#1653 Feature 1653

#1131 Feature 1131

#2922 Feature 2922

#1664 Feature 1664

#2973 Feature 2973

#932 Feature 932

#1770 Feature 1770

#2322 Feature 2322

#2217 Feature 2217

#2280 Feature 2280

#247 Feature 247

#2027 Feature 2027

#1390 Feature 1390

#574 Feature 574

#2753 Feature 2753

#1508 Feature 1508

#580 Feature 580

#1316 Feature 1316

#772 Feature 772

#1020 Feature 1020

#672 Feature 672

#2740 Feature 2740

#2823 Feature 2823

#2058 Feature 2058

#2905 Feature 2905

#1068 Feature 1068

#320 Feature 320

#2312 Feature 2312

#2619 Feature 2619

#514 Feature 514

#1689 Feature 1689

#727 Feature 727

#1362 Feature 1362

#2527 Feature 2527

#559 Feature 559

#548 Feature 548

#963 Feature 963

#1355 Feature 1355

#1106 Feature 1106

#1397 Feature 1397

#2646 Feature 2646

#2956 Feature 2956

#199 Feature 199

#2119 Feature 2119

#2018 Feature 2018

#3060 Feature 3060

#2299 Feature 2299

#1691 Feature 1691

#591 Feature 591

#2164 Feature 2164

#2984 Feature 2984

#843 Feature 843

#565 Feature 565

#698 Feature 698

#1102 Feature 1102

#751 Feature 751

#2046 Feature 2046

#1820 Feature 1820

#341 Feature 341

#2627 Feature 2627

#2988 Feature 2988

#2789 Feature 2789

#2252 Feature 2252

#1796 Feature 1796

#1469 Feature 1469

#1259 Feature 1259

#3071 Feature 3071

#243 Feature 243

#1066 Feature 1066

#2659 Feature 2659

#2765 Feature 2765

#270 Feature 270

#2383 Feature 2383

#1814 Feature 1814

#723 Feature 723

#2885 Feature 2885

#253 Feature 253

#2048 Feature 2048

#462 Feature 462

#2535 Feature 2535

#673 Feature 673

#620 Feature 620

#1531 Feature 1531

#1538 Feature 1538

#1111 Feature 1111

#1188 Feature 1188

#516 Feature 516

#2151 Feature 2151

#2767 Feature 2767

#1549 Feature 1549

#524 Feature 524

#831 Feature 831

#649 Feature 649

#2890 Feature 2890

#3020 Feature 3020

#645 Feature 645

#1241 Feature 1241

#781 Feature 781

#957 Feature 957

#638 Feature 638

#1557 Feature 1557

#1424 Feature 1424

#928 Feature 928

#517 Feature 517

#413 Feature 413

#598 Feature 598

#1442 Feature 1442

#2666 Feature 2666

#169 Feature 169

#2951 Feature 2951

#1525 Feature 1525

#3015 Feature 3015

#2632 Feature 2632

#112 Feature 112

#2222 Feature 2222

#386 Feature 386

#2162 Feature 2162

#830 Feature 830

#1186 Feature 1186

#1895 Feature 1895

#120 Feature 120

#606 Feature 606

#1017 Feature 1017

#858 Feature 858

#1178 Feature 1178

#1758 Feature 1758

#1988 Feature 1988

#1969 Feature 1969

#943 Feature 943

#218 Feature 218

#1074 Feature 1074

#1046 Feature 1046

#1585 Feature 1585

#503 Feature 503

#2656 Feature 2656

#1092 Feature 1092

#2483 Feature 2483

#188 Feature 188

#835 Feature 835

#2686 Feature 2686

#759 Feature 759

#780 Feature 780

#576 Feature 576

#399 Feature 399

#3035 Feature 3035

#790 Feature 790

#611 Feature 611

#2464 Feature 2464

#2982 Feature 2982

#1088 Feature 1088

#1588 Feature 1588

#2784 Feature 2784

#3053 Feature 3053

#1479 Feature 1479

#2374 Feature 2374

#1794 Feature 1794

#1266 Feature 1266

#2351 Feature 2351

#2579 Feature 2579

#1163 Feature 1163

#625 Feature 625

#3030 Feature 3030

#1692 Feature 1692

#1600 Feature 1600

#1261 Feature 1261

#1516 Feature 1516

#618 Feature 618

#2634 Feature 2634

#374 Medical Imaging and Oncology

#2752 Feature 2752

#2540 Feature 2540

#1906 Feature 1906

#3001 Feature 3001

#2663 Feature 2663

#2936 Feature 2936

#2604 Feature 2604

#1490 Feature 1490

#2009 Feature 2009

#363 Feature 363

#2640 Feature 2640

#754 Feature 754

#2188 Feature 2188

#584 Feature 584

#2167 Feature 2167

#825 Feature 825

#1027 Feature 1027

#2638 Feature 2638

#2997 Feature 2997

#1065 Feature 1065

#1804 Feature 1804

#575 Feature 575

#1158 Feature 1158

#486 Feature 486

#224 Feature 224

#1682 Feature 1682

#256 Feature 256

#175 Feature 175

#342 Feature 342

#1459 Feature 1459

#2681 Feature 2681

#1661 Feature 1661

#206 Feature 206

#865 Feature 865

#660 Feature 660

#1345 Feature 1345

#1621 Feature 1621

#1436 Feature 1436

#1123 Feature 1123

#1946 Feature 1946

#594 Feature 594

#2068 Feature 2068

#3066 Feature 3066

#391 Feature 391

#2267 Feature 2267

#412 Feature 412

#345 Feature 345

#539 Feature 539

#460 Feature 460

#453 Feature 453

#1367 Feature 1367

#2403 Feature 2403

#1191 Feature 1191

#726 Feature 726

#2895 Feature 2895

#2116 Feature 2116

#150 Feature 150

#2739 Feature 2739

#2154 Feature 2154

#1109 Feature 1109

#115 Feature 115

#2970 Feature 2970

#2359 Feature 2359

#2071 Feature 2071

#900 Feature 900

#1921 Feature 1921

#766 Feature 766

#2613 Feature 2613

#1925 Feature 1925

#2434 Feature 2434

#1674 Feature 1674

#219 Feature 219

#1540 Feature 1540

#1576 Feature 1576

#2085 Feature 2085

#1112 Feature 1112

#1380 Feature 1380

#2451 Feature #2451

#2637 Feature 2637

#615 Feature 615

#324 Feature 324

#1697 Feature 1697

#670 Feature 670

#1947 Feature 1947

#252 Feature 252

#1137 Feature 1137

#1628 Feature 1628

#2023 Feature 2023

#1684 Feature 1684

#2221 Feature 2221

#1177 Feature 1177

#876 Feature 876

#2381 Feature 2381

#1890 Feature 1890

#1144 Feature 1144

#2043 Feature 2043

#2191 Feature 2191

#353 Feature 353

#407 Feature 407

#2644 Feature 2644

#2916 Feature 2916

#2393 Feature 2393

#1250 Feature 1250

#515 Feature 515

#1392 Feature 1392

#1915 Feature 1915

#415 Feature 415

#1455 Feature 1455

#1179 Feature 1179

#2430 Feature 2430

#822 Feature 822

#2357 Feature 2357

#1418 Feature 1418

#710 Feature 710

#2096 Feature 2096

#1848 Feature 1848

#1037 Feature 1037

#2999 Feature 2999

#464 Feature 464

#314 Feature 314

#2729 Feature 2729

#2631 Feature 2631

#2140 Feature 2140

#139 Feature 139

#2562 Feature 2562

#2343 Feature 2343

#2917 Feature 2917

#492 Feature 492

#735 Feature 735

#1891 Feature 1891

#753 Feature 753

#925 Feature 925

#472 Feature 472

#897 Feature 897

#2294 Feature 2294

#1951 Feature 1951

#2257 Feature 2257

#1695 Feature 1695

#1849 Feature 1849

#1395 Feature 1395

#786 Feature 786

#2029 Feature 2029

#452 Feature 452

#1799 Feature 1799

#3064 Surgical Complications and Physiological Stress

#873 Feature 873

#1141 Feature 1141

#1958 Feature 1958

#2161 Medical/Scientific Discourse with Ethical/Social Implications

#1719 Feature 1719

#1817 Feature 1817

#2274 Feature 2274

#1990 Feature 1990

#902 Feature 902

#564 Feature 564

#537 Feature 537

#1606 Feature 1606

#145 Feature 145

#2461 Feature 2461

#2190 Feature 2190

#2673 Feature 2673

#181 Feature 181

#1544 Feature 1544

#1747 Feature 1747

#1944 Feature 1944

#639 Feature 639

#1528 Feature 1528

#2302 Feature 2302

#2262 Feature 2262

#2928 Feature 2928

#1370 Feature 1370

#146 Feature 146

#2266 Feature 2266

#3067 Feature 3067

#124 Feature 124

#1774 Feature 1774

#1274 Feature 1274

#747 Feature 747

#681 Feature 681

#1070 Feature 1070

#299 Feature 299

#2591 Feature 2591

#875 Feature 875

#1945 Feature 1945

#1340 Feature 1340

#1652 Feature 1652

#1149 Feature 1149

#860 Feature 860

#740 Feature 740

#3036 Feature 3036

#1889 Feature 1889

#1420 Feature 1420

#2868 Feature 2868

#395 Feature 395

#260 Feature 260

#2415 Feature 2415

#1226 Feature 1226

#728 Feature 728

#2836 Feature 2836

#2053 Feature 2053

#106 Feature 106

#552 Feature 552

#2992 Feature 2992

#2714 Feature 2714

#1000 Feature 1000

#1959 Feature 1959

#2394 Feature 2394

#2737 Feature 2737

#2743 Feature 2743

#1954 Feature 1954

#1620 Feature 1620

#238 Feature 238

#2193 Feature 2193

#2146 Feature 2146

#2871 Feature 2871

#1038 Feature 1038

#870 Feature 870

#2839 Feature 2839

#103 Feature 103

#310 Feature 310

#522 Feature 522

#1818 Feature 1818

#999 Feature 999

#2069 Feature 2069

#160 Feature 160

#1212 Feature 1212

#2194 Feature 2194

#2207 Feature 2207

#2879 Feature 2879

#1916 Feature 1916

#2866 Feature 2866

#608 Feature 608

#2248 Feature 2248

#2160 Feature 2160

#2930 Feature 2930

#151 Feature 151

#1934 Feature 1934

#547 Feature 547

#2578 Feature 2578

#1869 Feature 1869

#907 Feature 907

#1263 Feature 1263

#738 Feature 738

#626 Feature 626

#1744 Feature 1744

#2323 Feature 2323

#2241 Feature 2241

#2907 Feature 2907

#3024 Feature 3024

#2899 Feature 2899

#824 Feature 824

#1707 Feature 1707

#1839 Feature 1839

#782 Feature 782

#1336 Feature 1336

#3044 Feature 3044

#648 Feature 648

#758 Feature 758

#2092 Feature 2092

#2455 Feature 2455

#1190 Feature 1190

#2490 Feature 2490

#1888 Feature 1888

#2410 Feature 2410

#194 Feature 194

#225 Feature 225

#2456 Feature 2456

#800 Feature 800

#2678 Feature 2678

#2418 Feature 2418

#1670 Feature 1670

#2764 Feature 2764

#1276 Feature 1276

#2545 Feature 2545

#1511 Feature 1511

#2224 Feature 2224

#1320 Feature 1320

#1956 Feature 1956

#789 Feature 789

#2059 Feature 2059

#2661 Feature 2661

#1580 Feature 1580

#2030 Feature 2030

#1253 Feature 1253

#924 Feature 924

#1304 Feature 1304

#2353 Feature 2353

#2926 Feature 2926

#1445 Feature 1445

#1169 Feature 1169

#2691 Feature 2691

#457 Feature 457

#1034 Feature 1034

#635 Feature 635

#2326 Feature 2326

#1835 Feature 1835

#1913 Feature 1913

#2416 Feature 2416

#2031 Feature 2031

#1287 Feature 1287

#1733 Feature 1733

#526 Feature 526

#2198 Feature 2198

#1391 Feature 1391

#1953 Feature 1953

#2605 Feature 2605

#1503 Feature 1503

#540 Feature 540

#1590 Feature 1590

#813 Feature 813

#1050 Feature 1050

#1229 Feature 1229

#1551 Feature 1551

#621 Feature 621

#1238 Feature 1238

#1491 Feature 1491

#1523 Feature 1523

#2955 Feature 2955

#1552 Feature 1552

#1837 Feature 1837

#1383 Feature 1383

#2621 Feature 2621

#1616 Feature 1616

#774 Feature 774

#1776 Feature 1776

#2445 Feature 2445

#1573 Feature 1573

#2697 Feature 2697

#1101 Feature 1101

#2024 Feature 2024

#193 Feature 193

#803 Feature 803

#132 Feature 132

#1833 Feature 1833

#1446 Feature 1446

#2877 Feature 2877

#2189 Feature 2189

#2335 Feature 2335

#2478 Feature 2478

#229 Feature 229

#376 Feature 376

#947 Feature 947

#410 Feature 410

#847 Feature 847

#1997 Feature 1997

#2168 Feature 2168

#1577 Feature 1577

#3037 Feature 3037

#1765 Feature 1765

#1376 Feature 1376

#1757 Feature 1757

#1427 Feature 1427

#2082 Feature 2082

#603 Feature 603

#2328 Feature 2328

#840 Feature 840

#1681 Feature 1681

#2625 Feature 2625

#1453 Feature 1453

#302 Feature 302

#1119 Feature 1119

#1437 Feature 1437

#595 Feature 595

#3021 Feature 3021

#2568 Feature 2568

#2807 Feature 2807

#2296 Feature 2296

#3040 Feature 3040

#2822 Feature 2822

#1892 Feature 1892

#668 Feature 668

#545 Feature 545

#183 Feature 183

#2371 Feature 2371

#2806 Feature 2806

#1746 Feature 1746

#327 Feature 327

#2187 Feature 2187

#715 Feature 715

#1798 Feature 1798

#1071 Feature 1071

#2684 Feature 2684

#1792 Metastatic Cancer

#1579 Feature 1579

#1593 Feature 1593

#481 Feature 481

#1893 Feature 1893

#1514 Feature 1514

#2226 Feature 2226

#1194 Feature 1194

#185 Feature 185

#2182 Feature 2182

#1912 Feature 1912

#1622 Feature 1622

#495 Feature 495

#1855 Feature 1855

#1351 Feature 1351

#2794 Feature 2794

#392 Feature 392

#1180 Feature 1180

#1880 Feature 1880

#2271 Feature 2271

#1373 Feature 1373

#426 Feature 426

#918 Feature 918

#1011 Feature 1011

#2532 Feature 2532

#1201 Feature 1201

#1227 Feature 1227

#2008 Feature 2008

#1192 Feature 1192

#2067 Feature 2067

#579 Feature 579

#694 Feature 694

#2870 Feature 2870

#1565 Feature 1565

#2431 Feature 2431

#2236 Feature 2236

#1069 Feature 1069

#696 Feature 696

#798 Feature 798

#2734 Feature 2734

#1107 Feature 1107

#2947 Feature 2947

#1378 Feature 1378

#1189 Feature 1189

#2062 Feature 2062

#936 Feature 936

#1451 Feature 1451

#541 Feature 541

#828 Feature 828

#1939 Feature 1939

#2711 Feature 2711

#133 Feature 133

#2703 Feature 2703

#1342 Feature 1342

#1410 Feature 1410

#2954 Feature 2954

#2033 Feature 2033

#2056 Feature 2056

#123 Feature 123

#1494 Feature 1494

#2674 Feature 2674

#2493 Feature 2493

#1398 Feature 1398

#2396 Feature 2396

#683 Feature 683

#1015 Feature 1015

#965 Feature 965

#544 Feature 544

#1808 Feature 1808

#2642 Feature 2642

#2149 Feature 2149

#811 Feature 811

#2913 Feature 2913

#1475 Feature 1475

#163 Feature 163

#1063 Feature 1063

#174 Feature 174

#1902 Feature 1902

#1722 Feature 1722

#1782 Feature 1782

#2195 Feature 2195

#3000 Feature 3000

#2216 Feature 2216

#2156 Feature 2156

#590 Feature 590

#2424 Feature 2424

#284 Feature 284

#714 Feature 714

#491 Feature 491

#2559 Feature 2559

#764 Feature 764

#2300 Feature 2300

#1599 Feature 1599

#2061 Feature 2061

#946 Feature 946

#2818 Feature 2818

#631 Feature 631

#2708 Feature 2708

#2209 Feature 2209

#3022 Feature 3022

#2891 Feature 2891

#1343 Feature 1343

#1001 Feature 1001

#995 Feature 995

#3038 Feature 3038

#1708 Feature 1708

#2272 Feature 2272

#518 Feature 518

#2421 Feature 2421

#433 Feature 433

#2488 Feature 2488

#204 Feature 204

#1831 Feature 1831

#2406 Feature 2406

#2831 Feature 2831

#2797 Feature 2797

#1083 Feature 1083

#2567 Feature 2567

#1899 Feature 1899

#849 Feature 849

#2679 Feature 2679

#1483 Feature 1483

#2590 Feature 2590

#573 Feature 573

#1030 Feature 1030

#3061 Feature 3061

#1693 Feature 1693

#818 Feature 818

#2355 Feature 2355

#906 Feature 906

#732 Feature 732

#604 Feature 604

#895 Feature 895

#2878 Feature 2878

#2325 Feature 2325

#1014 Feature 1014

#2869 Feature 2869

#1561 Feature 1561

#2278 Feature 2278

#950 Feature 950

#303 Feature 303

#2367 Feature 2367

#2050 Feature 2050

#2205 Feature 2205

#1002 Feature 1002

#2047 Feature 2047

#2643 Feature 2643

#1319 Feature 1319

#1022 Feature 1022

#1026 Feature 1026

#1273 Feature 1273

#1193 Feature 1193

#396 Feature 396

#385 Feature 385

#2475 Feature 2475

#2473 Feature 2473

#2446 Feature 2446

#2746 Feature 2746

#289 Feature 289

#1615 Feature 1615

#913 Feature 913

#845 Feature 845

#2958 Feature 2958

#1140 Feature 1140

#148 Feature 148

#211 Feature 211

#1271 Feature 1271

#1680 Feature 1680

#1966 Feature 1966

#3068 Feature 3068

#1256 Feature 1256

#2614 Feature #2614

#493 Feature 493

#561 Feature 561

#2616 Feature 2616

#1863 Feature 1863

#1435 Feature 1435

#2601 Feature 2601

#2459 Feature 2459

#1824 Feature 1824

#2204 Feature 2204

#2920 Feature 2920

#2089 Feature 2089

#785 Feature 785

#1505 Feature 1505

#220 Feature 220

#1530 Feature 1530

#2139 Feature 2139

#2242 Feature 2242

#329 Feature 329

#473 Feature 473

#2965 Feature 2965

#1243 Feature 1243

#1473 Feature 1473

#983 Feature 983

#2821 Feature 2821

#2833 Feature 2833

#642 Feature 642

#853 Feature 853

#1768 Feature 1768

#3047 Feature 3047

#3055 Feature 3055

#2073 Feature 2073

#469 Feature 469

#763 Feature 763

#2440 Feature 2440

#942 Feature 942

#557 Feature 557

#814 Feature 814

#892 Feature 892

#1876 Feature 1876

#510 Feature 510

#966 Feature 966

#669 Feature 669

#1409 Feature 1409

#377 Feature 377

#2044 Feature 2044

#2192 Feature 2192

#1537 Feature 1537

#232 Feature 232

#2318 Feature 2318

#1093 Feature 1093

#2065 Feature 2065

#2391 Feature 2391

#1293 Feature 1293

#2914 Feature 2914

#2556 Feature 2556

#1079 Feature 1079

#2118 Feature 2118

#1639 Feature 1639

#3031 Feature 3031

#553 Feature 553

#1333 Feature 1333

#535 Feature 535

#2347 Feature 2347

#1108 Feature 1108

#765 Feature 765

#1564 Feature 1564

#797 Feature 797

#2479 Feature 2479

#2695 Feature 2695

#978 Feature 978

#372 Feature 372

#166 Feature 166

#2481 Feature 2481

#3027 Feature 3027

#439 Feature 439

#2664 Feature 2664

#140 Feature 140

#273 Feature 273

#2466 Feature 2466

#2105 Feature 2105

#2961 Feature 2961

#2086 Feature 2086

#2693 Feature 2693

#2422 Feature 2422

#2197 Feature 2197

#1116 Feature 1116

#2021 Feature 2021

#968 Feature 968

#2957 Feature 2957

#2536 Feature 2536

#1619 Feature 1619

#483 Feature 483

#2057 Feature 2057

#2812 Feature 2812

#855 Feature 855

#1215 Feature 1215

#1790 Feature 1790

#1357 Feature 1357

#2171 Molecular and Cellular Biological Processes

#356 Feature 356

#1772 Feature 1772

#2387 Feature 2387

#359 Feature 359

#2448 Feature 2448

#2517 Feature 2517

#2365 Feature 2365

#1678 Feature 1678

#3006 Feature 3006

#2181 Feature 2181

#2856 Feature 2856

#2305 Feature 2305

#2529 Feature 2529

#2700 Feature 2700

#2131 Feature 2131

#2583 Feature 2583

#210 Feature 210

#981 Feature 981

#1146 Feature 1146

#729 Feature 729

#1162 Feature 1162

#1359 Feature 1359

#1499 Feature 1499

#2696 Feature 2696

#296 Feature 296

#368 Feature 368

#1597 Feature 1597

#2847 Feature 2847

#1388 Feature 1388

#678 Feature 678

#703 Feature 703

#585 Feature 585

#2011 Feature 2011

#725 Feature 725

#2111 Feature 2111

#1751 Feature 1751

#315 Feature 315

#1248 Feature 1248

#1408 Feature 1408

#1352 Feature 1352

#3002 Feature 3002

#2787 Feature 2787

#2114 Feature 2114

#1231 Feature 1231

#1763 Feature 1763

#1466 Feature 1466

#1658 Feature 1658

#1574 Feature 1574

#1268 Feature 1268

#1572 Feature 1572

#2790 Feature 2790

#1633 Feature 1633

#3051 Feature 3051

#1219 Feature 1219

#2554 Feature 2554

#2670 Feature 2670

#1033 Feature 1033

#2564 Feature 2564

#2129 Feature 2129

#1232 Feature 1232

#692 Feature 692

#1962 Feature 1962

#2136 Feature 2136

#1613 Feature 1613

#2494 Feature 2494

#1657 Feature 1657

#1608 Feature 1608

#2404 Feature 2404

#613 Feature 613

#2401 Feature 2401

#190 Feature 190

#448 Feature 448

#2692 Feature 2692

#2155 Feature 2155

#1575 Feature 1575

#882 Feature 882

#679 Feature 679

#848 Feature 848

#1995 Feature 1995

#686 Feature 686

#1198 Feature 1198

#207 Feature 207

#2796 Feature 2796

#2896 Feature 2896

#467 Feature 467

#2945 Feature 2945

#993 Feature 993

#198 Feature 198

#1314 Feature 1314

#519 Feature 519

#2774 Feature 2774

#2894 Feature 2894

#1029 Feature 1029

#2470 Feature 2470

#1822 Feature 1822

#1896 Feature 1896

#2334 Feature 2334

#272 Feature 272

#556 Feature 556

#2337 Feature 2337

#887 Feature 887

#1795 Feature 1795

#770 Feature 770

#1739 Feature 1739

#1236 Feature 1236

#2427 Feature 2427

#109 Feature 109

#2600 Feature 2600

#445 Feature 445

#1643 Feature 1643

#1291 Feature 1291

#599 Feature 599

#596 Feature 596

#2968 Feature 2968

#756 Feature 756

#2518 Feature 2518

#2515 Feature 2515

#159 Feature 159

#806 Feature 806

#2910 Feature 2910

#1265 Feature 1265

#571 Feature 571

#2025 Feature 2025

#2897 Feature 2897

#2507 Feature 2507

#2200 Feature 2200

#2153 Feature 2153

#1036 Feature 1036

#2214 Feature 2214

#861 Feature 861

#2903 Feature 2903

#2960 Feature 2960

#1334 Feature 1334

#761 Feature 761

#1938 Feature 1938

#375 Feature 375

#592 Feature 592

#2713 Feature 2713

#184 Feature 184

#2671 Feature 2671

#1623 Feature 1623

#1496 Feature 1496

#1879 Feature 1879

#2474 Feature 2474

#1114 Feature 1114

#1897 Feature 1897

#2099 Feature 2099

#2468 Feature 2468

#658 Feature 658

#2759 Feature 2759

#2802 Feature 2802

#1745 Feature 1745

#1771 Feature 1771

#2054 Feature 2054

#1331 Feature 1331

#2781 Feature 2781

#334 Feature 334

#641 Feature 641

#2260 Historical Context & Development

#131 Feature 131

#878 Feature 878

#833 Feature 833

#2852 Feature 2852

#1117 Feature 1117

#477 Feature 477

#2749 Feature 2749

#2655 Feature 2655

#250 Feature 250

#2254 Feature 2254

#2709 Feature 2709

#2629 Feature 2629

#2587 Feature 2587

#1968 Feature 1968

#1852 Feature 1852

#1562 Feature 1562

#2364 Feature 2364

#1533 Feature 1533

#919 Feature 919

#397 Feature 397

#852 Feature 852

#568 Feature 568

#428 Feature 428

#838 Feature 838

#1970 Feature 1970

#2676 Feature 2676

#432 Feature 432

#2091 Feature 2091

#144 Feature 144

#2607 Feature 2607

#216 Feature 216

#479 Feature 479

#1142 Feature 1142

#1742 Feature 1742

#2471 Feature 2471

#1282 Feature 1282

#1736 Feature 1736

#695 Feature 695

#1875 Feature 1875

#653 Feature 653

#258 Feature 258

#2777 Feature 2777

#1638 Feature 1638

#2450 Feature 2450

#480 Feature 480

#1941 Feature 1941

#801 Feature 801

#1058 Feature 1058

#903 Feature 903

#128 Feature 128

#1344 Feature 1344

#2372 Feature 2372

#1671 Feature 1671

#443 Feature 443

#1203 Feature 1203

#826 Feature 826

#2771 Feature 2771

#2399 Feature 2399

#154 Feature 154

#196 Feature 196

#2530 Feature 2530

#802 Feature 802

#1610 Feature 1610

#2003 Feature 2003

#2993 Feature 2993

#1870 Feature 1870

#2292 Feature 2292

#348 Feature 348

#812 Feature 812

#371 Feature 371

#2718 Feature 2718

#337 Feature 337

#1221 Feature 1221

#794 Feature 794

#1930 Feature 1930

#2863 Feature 2863

#344 Feature 344

#910 Feature 910

#636 Feature 636

#529 Feature 529

#2610 Feature 2610

#322 Feature 322

#2463 Feature 2463

#1267 Feature 1267

#2948 Feature 2948

#601 Feature 601

#2032 Feature 2032

#1602 Feature 1602

#1323 Feature 1323

#487 Feature 487

#1631 Feature 1631

#2117 Feature 2117

#230 Feature 230

#3010 Feature 3010

#1591 Feature 1591

#2377 Feature 2377

#1724 Feature 1724

#1816 Feature 1816

#1948 Feature 1948

#205 Feature 205

#2810 Feature 2810

#2362 Feature 2362

#1460 Feature 1460

#2791 Feature 2791

#2778 Hippocampal Memory and Cognitive Function

#1299 Feature 1299

#1905 Feature 1905

#2732 Feature 2732

#2015 Feature 2015

#240 Feature 240

#2180 Feature 2180

#2908 Feature 2908

#1228 Feature 1228

#1842 Feature 1842

#488 Feature 488

#2340 Feature 2340

#203 Feature 203

#2498 Feature 2498

#110 Feature 110

#663 Feature 663

#1237 Feature 1237

#1581 Feature 1581

#307 Feature 307

#2452 Feature 2452

#2706 Feature 2706

#1457 Feature 1457

#1465 Feature 1465

#3032 Feature 3032

#2830 Feature 2830

#1369 Feature 1369

#1779 Feature 1779

#971 Feature 971

#2261 Feature 2261

#1159 Feature 1159

#2834 Feature 2834

#1322 Feature 1322

#1546 Feature 1546

#799 Feature 799

#1630 Feature 1630

#627 Feature 627

#173 Feature 173

#1686 Feature 1686

#390 Feature 390

#748 Feature 748

#1803 Feature 1803

#2443 Feature 2443

#2332 Feature 2332

#1321 Feature 1321

#2762 Feature 2762

#116 Feature 116

#226 Feature 226

#2555 Feature 2555

#1737 Feature 1737

#283 Feature 283

#1507 Feature 1507

#427 Feature 427

#2486 Feature 2486

#1176 Feature 1176

#313 Feature 313

#1100 Feature 1100

#2943 Feature 2943

#884 Feature 884

#2846 Feature 2846

#304 Feature 304

#2782 Feature 2782

#1208 Feature 1208

#331 Feature 331

#717 Feature 717

#1715 Feature 1715

#2435 Feature 2435

#1723 Feature 1723

#2390 Feature 2390

#2484 Feature 2484

#2880 Feature 2880

#1712 Feature 1712

#1327 Feature 1327

#1903 Feature 1903

#2887 Feature 2887

#1731 Feature 1731

Document Content

Localization of a pernicious anaemia autoantibody epitope on the alpha-subunit of human H,K-adenosine triphosphatase.
Four cDNA fragments encoding different portions of the alpha-subunit of human H,K-adenosine triphosphatase (ATPase) were amplified by means of the polymerase chain reaction technique, ligated into the plasmid pGEX-2T, and expressed as glutathione S-transferase fusion proteins in Escherichia coli. The fragments A (residues 163-313), Ba (residues 360-797), Bb (residues 526-797), and C (residues 822-1031) together encompass 77% of the alpha-subunit and cover most of its cytosolic part. The reactivities of autoantibodies in the sera from patients with pernicious anaemia with the recombinant fusion proteins were analysed by immunoblotting. One autoantigenic epitope was found in the NH2-terminal part of the Ba fragment--that is, between residues 360 and 525. No epitope was detected in the other fragments. The Ba fragment was cleaved off from the glutathione S-transferase fusion protein by the action of thrombin and was then further purified. By means of enzyme-linked immunosorbent assay, 28 of 42 sera (67%) from patients with pernicious anaemia were positive against the purified Ba fragment. The present results provide a final proof that the human H,K-ATPase alpha-subunit is a major autoantigen in the parietal cell and that the major epitope is located between residues 360 to 525 on the cytosolic side of the secretory membrane.

Similar Documents