PRISMΔDB

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Active Features

1524

0.0
Details List
#2950 Feature 2950
2.4
#97 Feature 97
2.3
#2072 Feature 2072
2.3
#2972 Sensory-Motor Integration
2.3
#1219 Feature 1219
2.3
#745 Feature 745
2.2
#536 Feature 536
2.2
#146 Feature 146
2.1
#1717 Feature 1717
2.1
#2796 Feature 2796
2.1
#1533 Feature 1533
2.1
#1305 Feature 1305
2.0
#599 Feature 599
2.0
#1800 Feature 1800
2.0
#662 Feature 662
2.0
#2007 Developmental Disparities & Intervention
1.9
#734 Feature 734
1.9
#2828 Feature 2828
1.9
#1220 Feature 1220
1.9
#2114 Feature 2114
1.9
#57 Feature 57
1.9
#2683 Feature 2683
1.8
#2575 Feature 2575
1.8
#2864 Feature 2864
1.8
#332 Feature 332
1.8
#1597 Feature 1597
1.8
#604 Feature 604
1.8
#1313 Feature 1313
1.7
#450 Feature 450
1.7
#23 Neuronal Circuitry and Cellular Processes
1.7
#1445 Feature 1445
1.7
#2714 Feature 2714
1.6
#30 Feature 30
1.6
#2891 Feature 2891
1.6
#1672 Feature 1672
1.5
#1349 Feature 1349
1.5
#2553 Feature 2553
1.5
#867 Feature 867
1.5
#1356 Feature 1356
1.5
#954 Feature 954
1.5
#2101 Feature 2101
1.5
#1826 Feature 1826
1.5
#269 Feature 269
1.5
#232 Feature 232
1.5
#2763 Feature 2763
1.5
#2271 Feature 2271
1.5
#330 Feature 330
1.5
#2038 Feature 2038
1.5
#2810 Feature 2810
1.5
#2283 Feature 2283
1.5
#210 Feature 210
1.5
#2362 Feature 2362
1.4
#1438 Feature 1438
1.4
#742 Feature 742
1.4
#924 Feature 924
1.4
#1249 Feature 1249
1.4
#1821 Feature 1821
1.4
#842 Feature 842
1.4
#3063 Feature 3063
1.4
#2580 Feature 2580
1.4
#721 Feature 721
1.4
#744 Feature 744
1.4
#2778 Hippocampal Memory and Cognitive Function
1.4
#706 Feature 706
1.3
#2519 Feature 2519
1.3
#385 Feature 385
1.3
#478 Feature 478
1.3
#2359 Feature 2359
1.3
#1624 Feature 1624
1.3
#1173 Feature 1173
1.3
#1344 Feature 1344
1.3
#9 Feature 9
1.3
#2688 Feature #2688
1.3
#2984 Feature 2984
1.3
#916 Feature 916
1.3
#984 Feature 984
1.3
#2186 Feature 2186
1.3
#1569 Feature 1569
1.3
#2349 Feature 2349
1.3
#1301 Feature 1301
1.3
#1687 Feature 1687
1.3
#380 Feature 380
1.3
#2707 Feature 2707
1.3
#225 Feature 225
1.3
#2408 Feature 2408
1.2
#914 Feature 914
1.2
#1669 Feature 1669
1.2
#444 Feature 444
1.2
#1223 Feature 1223
1.2
#1477 Feature 1477
1.2
#1289 Feature 1289
1.2
#1509 Feature 1509
1.2
#1824 Feature 1824
1.2
#2325 Feature 2325
1.2
#2998 Feature 2998
1.2
#83 Feature 83
1.2
#416 Feature 416
1.2
#2691 Feature 2691
1.2
#73 Feature 73
1.2
#791 Feature 791
1.2
#2708 Feature 2708
1.2
#1952 Feature 1952
1.2
#500 Feature 500
1.2
#32 Feature 32
1.2
#1865 Feature 1865
1.2
#1480 Feature 1480
1.2
#2194 Feature 2194
1.2
#2167 Feature 2167
1.2
#816 Feature 816
1.2
#908 Feature 908
1.2
#72 Feature 72
1.2
#1620 Feature 1620
1.2
#167 Feature 167
1.2
#1586 Feature 1586
1.2
#2787 Feature 2787
1.2
#2065 Feature 2065
1.2
#1579 Feature 1579
1.2
#2267 Feature 2267
1.2
#1808 Feature 1808
1.2
#580 Feature 580
1.2
#565 Feature 565
1.2
#2474 Feature 2474
1.1
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1.1
#356 Feature 356
1.1
#394 Feature 394
1.1
#2010 Feature 2010
1.1
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1.1
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1.1
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1.1
#2752 Feature 2752
1.1
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1.1
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1.1
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1.1
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1.1
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1.1
#1122 Feature 1122
1.1
#2428 Feature 2428
1.1
#1705 Feature 1705
1.1
#2771 Feature 2771
1.1
#2558 Feature 2558
1.1
#1746 Feature 1746
1.1
#906 Feature 906
1.1
#941 Feature 941
1.1
#392 Feature 392
1.1
#1766 Feature 1766
1.1
#1213 Feature 1213
1.1
#701 Feature 701
1.1
#2855 Feature 2855
1.1
#484 Feature 484
1.1
#1771 Feature 1771
1.1
#829 Feature 829
1.1
#251 Feature 251
1.1
#264 Feature 264
1.1
#5 Feature 5
1.1
#2745 Feature 2745
1.1
#226 Feature 226
1.1
#1688 Feature 1688
1.1
#277 Feature 277
1.1
#1992 Feature 1992
1.1
#2053 Feature 2053
1.1
#1073 Feature 1073
1.1
#992 Feature 992
1.1
#1157 Feature 1157
1.1
#2723 Feature 2723
1.1
#977 Feature 977
1.1
#2295 Feature 2295
1.1
#540 Feature 540
1.1
#2241 Feature 2241
1.1
#287 Feature 287
1.1
#951 Feature 951
1.1
#1049 Feature 1049
1.1
#873 Feature 873
1.1
#1578 Feature 1578
1.1
#2512 Feature 2512
1.0
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1.0
#932 Feature 932
1.0
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1.0
#2078 Feature 2078
1.0
#1725 Feature 1725
1.0
#20 Feature 20
1.0
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1.0
#2916 Feature 2916
1.0
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1.0
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1.0
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1.0
#275 Feature 275
1.0
#315 Feature 315
1.0
#291 Feature 291
1.0
#187 Feature 187
1.0
#63 Feature 63
1.0
#92 Feature 92
1.0
#1554 Feature 1554
1.0
#1933 Feature 1933
1.0
#177 Feature 177
1.0
#1600 Feature 1600
1.0
#382 Feature 382
1.0
#2718 Feature 2718
1.0
#474 Surgical Procedures & Gastrointestinal Issues
1.0
#192 Feature 192
1.0
#1626 Feature 1626
1.0
#7 Feature 7
1.0
#2530 Feature 2530
1.0
#2712 Feature 2712
1.0
#1656 Feature 1656
1.0
#2625 Feature 2625
1.0
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1.0
#3046 Feature 3046
1.0
#424 Feature 424
1.0
#866 Feature 866
1.0
#3071 Feature 3071
1.0
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1.0
#3062 Feature 3062
1.0
#1840 Feature 1840
1.0
#3017 Feature 3017
1.0
#1259 Feature 1259
1.0
#581 Feature 581
1.0
#981 Feature 981
1.0
#2980 Feature 2980
1.0
#707 Feature 707
1.0
#1623 Feature 1623
1.0
#1116 Feature 1116
1.0
#414 Feature 414
1.0
#2025 Feature 2025
1.0
#466 Feature 466
1.0
#1565 Feature 1565
1.0
#1782 Feature 1782
1.0
#2148 Feature 2148
0.9
#1052 Feature 1052
0.9
#2727 Feature 2727
0.9
#254 Feature 254
0.9
#2697 Feature 2697
0.9
#872 Feature 872
0.9
#1094 Feature 1094
0.9
#233 Feature 233
0.9
#1512 Feature 1512
0.9
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0.9
#505 Feature 505
0.9
#1796 Feature 1796
0.9
#1375 Feature 1375
0.9
#1027 Feature 1027
0.9
#2178 Feature 2178
0.9
#2377 Feature 2377
0.9
#199 Feature 199
0.9
#2953 Feature 2953
0.9
#2486 Feature 2486
0.9
#2249 Feature 2249
0.9
#1525 Feature 1525
0.9
#1155 Feature 1155
0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
#2393 Feature 2393
0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.9
#2741 Feature 2741
0.9
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0.9
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0.9
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0.9
#743 Feature 743
0.9
#2262 Feature 2262
0.9
#1206 Feature 1206
0.9
#2081 Feature 2081
0.9
#300 Feature 300
0.9
#2765 Feature 2765
0.9
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0.9
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0.9
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0.9
#39 Feature 39
0.9
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0.9
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0.9
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0.9
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0.9
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0.9
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.8
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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0.7
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Document Content

Intranasal application of dopamine reduces activity and improves attention in Naples High Excitability rats that feature the mesocortical variant of ADHD.
Based on findings of a profound action of intranasally applied dopamine (DA) on dopamine release in the striatum, we examined the possibility that intranasal application of DA would influence indices of attention and activity in juvenile male rats of the Naples High Excitability line. This rat model features the main aspects of Attention Deficit/Hyperactivity Disorder (ADHD). Juvenile NHE rats received an intranasal application of either DA (0.075 mg/kg, 0.15 mg/kg and 0.3 mg/kg) or vehicle into both nostrils daily for 15 days. On day 14, 1 h after treatment, they were tested in the Làt maze, and one day later, in the eight arm radial maze. Activity in the Làt maze: The highest dose of DA (0.3 mg/kg) decreased horizontal (HA) and vertical (VA) activity during the first 10 min of the test. No effect was found for rearing duration (RD), which indexes non-selective attention (NSA). Activity in the radial maze: No treatment effects were found for HA and VA components, and for RD. Attention indices: The intermediate dose of DA (0.15 mg/kg) significantly improved the number of arms visited before the first repetitive arm entry in the radial maze, an index of selective spatial attention (SSA). In conclusion, intranasal application of DA reduced hyperactivity at the highest dose used, whereas the intermediate dose improved attention in an animal model of ADHD. These results suggest the potential of employing intranasal DA for therapeutic purposes.