Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1530

MIN ACTIVATION

0.0

Details List

#1401 Feature 1401

#1913 Feature 1913

#2973 Feature 2973

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#663 Feature 663

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#402 Feature 402

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#2135 Feature 2135

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#667 Feature 667

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#3005 Feature 3005

#1531 Feature 1531

#958 Feature 958

#721 Feature 721

#2518 Feature 2518

#928 Feature 928

#1328 Feature 1328

#2564 Feature 2564

#23 Neuronal Circuitry and Cellular Processes

#173 Feature 173

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#2825 Feature 2825

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#1336 Feature 1336

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#1213 Feature 1213

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#2104 Feature 2104

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#2186 Feature 2186

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#1049 Feature 1049

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#384 Feature 384

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#1833 Feature 1833

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#2313 Feature 2313

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#1287 Feature 1287

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#2558 Feature 2558

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#375 Feature 375

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#327 Feature 327

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#2310 Feature 2310

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#1125 Feature 1125

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#671 Feature 671

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#1478 Feature 1478

#1191 Feature 1191

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#1062 Feature 1062

#3038 Feature 3038

#2113 Feature 2113

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#130 Feature 130

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#1450 Feature 1450

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#612 Feature 612

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#374 Medical Imaging and Oncology

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#772 Feature 772

#2117 Feature 2117

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#3070 Spiritual and Holistic Care in Healthcare

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#2603 Instructional/Educational Content

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#550 Feature 550

#2701 Feature 2701

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Document Content

[Case of drug-induced hypersensitivity syndrome due to lamotrigine: demonstration of sequential reactivation of herpesviruses].
Drug-induced hypersensitivity syndrome (DIHS) is a rare but severe multiorgan disorder. The reactivation of human herpesvirus-6 (HHV-6) and other human herpesviruses has been reported to be associated with its pathogenesis. We herein report a case of 14-year-old female who developed DIHS during the treatment with lamotrigine, a novel antiepileptic drug. She initially presented with fever, skin rash, cervical lymphadenopathy, leukocytosis with eosinophilia and atypical lymphocytosis, liver dysfunction and hypogammaglobulinemia. Discontinuation of the drug and administration of prednisolone led to improvement;however, tapering of prednisolone and administration of midazolam and ketamine thereafter triggered clinical deterioration. She subsequently developed hyperthyroidism followed by hypothyroidism. Herpesviral loads were determined in her peripheral blood by real-time PCR during the course of the treatment, and sequential reactivation of Epstein-Barr virus (EBV), HHV-6 and cytomegalovirus was demonstrated. EBV viremia was detected throughout the course, except for a short period when HHV-6 viremia was at the peak. HHV-6 viremia developed after the secondary deterioration. Cytomegalovirus viremia appeared transiently before the hyperthyroidic state reversed and became hypothyroidic. Although this syndrome should be regarded as a systemic reaction induced by a complex interplay among herpesviruses and the immune responses against viral infections and drugs, it remains unknown how such a sequential reactivation is related to the pathogenesis of the condition.

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