Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1502

MIN ACTIVATION

0.0

Details List

#1706 Feature 1706

#2481 Feature 2481

#1562 Feature 1562

#2697 Feature 2697

#145 Feature 145

#154 Feature 154

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#1252 Feature 1252

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#23 Neuronal Circuitry and Cellular Processes

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#2007 Developmental Disparities & Intervention

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#1792 Metastatic Cancer

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#2044 Feature 2044

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#2778 Hippocampal Memory and Cognitive Function

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#1345 Feature 1345

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#2979 Feature 2979

#466 Feature 466

#195 Feature 195

#412 Feature 412

#3070 Spiritual and Holistic Care in Healthcare

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#1803 Feature 1803

#949 Feature 949

#834 Feature 834

#2709 Feature 2709

#971 Feature 971

#1090 Feature 1090

#2453 Feature 2453

#2161 Medical/Scientific Discourse with Ethical/Social Implications

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#808 Feature 808

#2221 Feature 2221

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#2211 Feature 2211

#1506 Justification/Rationale for Actions

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#2232 Medical Case Reports & Cancer Research

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#404 Interactions and Mechanisms

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#703 Feature 703

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Document Content

The Changing Age of Individuals Seeking Presymptomatic Genetic Testing for Huntington Disease.
Huntington disease (HD) is a progressive neurodegenerative disorder. Presymptomatic genetic testing allows at-risk individuals to clarify their risk status. Understanding the characteristics and motivations of individuals seeking HD presymptomatic genetic testing better equips genetic counselors and other healthcare professionals to provide comprehensive and personalized care. The aims of this study were to (1) determine whether the average age when individuals seek presymptomatic HD genetic testing has decreased over time, (2) assess motivations for seeking testing, (3) explore whether there is a relationship between age and motivations, and (4) explore genetic counselors' perceptions of the shift in age. Data from the US HD testing centers (N = 4) were analyzed. A small but statistically significant decrease in age of individuals seeking presymptomatic testing was observed (p = 0.045). HD community members (N = 77) were surveyed regarding presymptomatic testing motivations. Younger individuals were more likely than older individuals to cite "To learn whether or not you would develop HD" and "To make choices about further education or a career" compared to older individuals (p < 0.05). Conversely, older individuals more frequently cited "To give children a better idea of their risk" (p < 0.002). Sixteen percent of genetic counselors surveyed (6/37) perceived a change in age of testing. All of these respondents had provided HD testing for ten or more years and anecdotally believed the age at testing has decreased over time. Study results help providers personalize counseling based on patient's age and serve as a starting point for more research into the relationship between age at testing and motivations for testing.

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