Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1487

MIN ACTIVATION

0.0

Details List

#653 Feature 653

#2009 Feature 2009

#1301 Feature 1301

#730 Feature 730

#251 Feature 251

#2483 Feature 2483

#256 Feature 256

#400 Feature 400

#244 Feature 244

#1793 Feature 1793

#977 Feature 977

#1722 Feature 1722

#2196 Feature 2196

#2415 Feature 2415

#168 Feature 168

#547 Feature 547

#1053 Feature 1053

#2495 Feature 2495

#2752 Feature 2752

#2524 Feature 2524

#1633 Feature 1633

#612 Feature 612

#2288 Feature 2288

#2715 Feature 2715

#2961 Feature 2961

#310 Feature 310

#1578 Feature 1578

#572 Feature 572

#2131 Feature 2131

#2146 Feature 2146

#1605 Feature 1605

#1525 Feature 1525

#892 Feature 892

#1225 Feature 1225

#391 Feature 391

#1670 Feature 1670

#2134 Feature 2134

#1677 Feature 1677

#1779 Feature 1779

#2559 Feature 2559

#1833 Feature 1833

#2789 Feature 2789

#2535 Feature 2535

#1127 Feature 1127

#2794 Feature 2794

#2546 Feature 2546

#3040 Feature 3040

#1139 Feature 1139

#2732 Feature 2732

#1503 Feature 1503

#648 Feature 648

#1812 Feature 1812

#973 Feature 973

#2884 Feature 2884

#672 Feature 672

#2828 Feature 2828

#2030 Feature 2030

#286 Feature 286

#3037 Feature 3037

#2866 Feature 2866

#356 Feature 356

#980 Feature 980

#2686 Feature 2686

#1038 Feature 1038

#2274 Feature 2274

#1140 Feature 1140

#966 Feature 966

#2714 Feature 2714

#1600 Feature 1600

#2242 Feature 2242

#3054 Feature 3054

#2795 Feature 2795

#1479 Feature 1479

#2467 Feature 2467

#1420 Feature 1420

#2977 Feature 2977

#1853 Feature 1853

#886 Feature 886

#167 Feature 167

#180 Feature 180

#2058 Feature 2058

#619 Feature 619

#357 Feature 357

#2728 Feature 2728

#1343 Feature 1343

#1259 Feature 1259

#541 Feature 541

#2677 Feature 2677

#1157 Feature 1157

#783 Feature 783

#1372 Feature 1372

#529 Feature 529

#1541 Feature 1541

#551 Feature 551

#780 Feature 780

#2076 Feature 2076

#1227 Feature 1227

#800 Feature 800

#2537 Feature 2537

#1570 Feature 1570

#876 Feature 876

#1402 Feature 1402

#2675 Feature 2675

#1619 Feature 1619

#1205 Feature 1205

#2324 Feature 2324

#1849 Feature 1849

#1815 Feature 1815

#2998 Feature 2998

#2114 Feature 2114

#1261 Feature 1261

#759 Feature 759

#2779 Feature 2779

#531 Feature 531

#389 Feature 389

#686 Feature 686

#1614 Feature 1614

#1421 Feature 1421

#822 Feature 822

#472 Feature 472

#2926 Feature 2926

#1147 Feature 1147

#2358 Feature 2358

#2163 Feature 2163

#1939 Feature 1939

#2307 Feature 2307

#1370 Feature 1370

#1538 Feature 1538

#2160 Feature 2160

#294 Feature 294

#1190 Feature 1190

#2053 Feature 2053

#287 Feature 287

#1665 Feature 1665

#2604 Feature 2604

#2277 Feature 2277

#537 Feature 537

#1829 Feature 1829

#249 Feature 249

#1171 Feature 1171

#2310 Feature 2310

#2198 Feature 2198

#728 Feature 728

#2936 Feature 2936

#1552 Feature 1552

#2623 Feature 2623

#2802 Feature 2802

#911 Feature 911

#326 Feature 326

#1359 Feature 1359

#2078 Feature 2078

#1807 Feature 1807

#2629 Feature 2629

#1451 Feature 1451

#1401 Feature 1401

#238 Feature 238

#2678 Feature 2678

#1993 Feature 1993

#1337 Feature 1337

#2684 Feature 2684

#2300 Feature 2300

#1034 Feature 1034

#2468 Feature 2468

#867 Feature 867

#539 Feature 539

#1333 Feature 1333

#1649 Feature 1649

#1291 Feature 1291

#2218 Feature 2218

#2029 Feature 2029

#823 Feature 823

#831 Feature 831

#2178 Feature 2178

#1419 Feature 1419

#666 Feature 666

#1846 Feature 1846

#1483 Feature 1483

#3029 Feature 3029

#152 Feature 152

#2955 Feature 2955

#2190 Feature 2190

#1931 Feature 1931

#1121 Feature 1121

#3027 Feature 3027

#135 Feature 135

#1571 Feature 1571

#2777 Feature 2777

#1176 Feature 1176

#1992 Feature 1992

#2920 Feature 2920

#202 Feature 202

#850 Feature 850

#1695 Feature 1695

#2919 Feature 2919

#1087 Feature 1087

#1523 Feature 1523

#417 Feature 417

#559 Feature 559

#303 Feature 303

#690 Feature 690

#1065 Feature 1065

#989 Feature 989

#731 Feature 731

#2083 Feature 2083

#1588 Feature 1588

#1687 Feature 1687

#1102 Feature 1102

#1579 Feature 1579

#2233 Feature 2233

#1667 Feature 1667

#448 Feature 448

#407 Feature 407

#582 Feature 582

#2185 Feature 2185

#956 Feature 956

#909 Feature 909

#123 Feature 123

#1028 Feature 1028

#2001 Feature 2001

#231 Feature 231

#307 Feature 307

#130 Feature 130

#1455 Feature 1455

#1933 Feature 1933

#2804 Feature 2804

#1391 Feature 1391

#2589 Feature 2589

#1777 Feature 1777

#615 Feature 615

#1275 Feature 1275

#111 Feature 111

#1742 Feature 1742

#2147 Feature 2147

#1858 Feature 1858

#1181 Feature 1181

#377 Feature 377

#2957 Feature 2957

#965 Feature 965

#2951 Feature 2951

#2127 Feature 2127

#957 Feature 957

#2047 Feature 2047

#364 Feature 364

#1814 Feature 1814

#881 Feature 881

#2658 Feature 2658

#2558 Feature 2558

#2584 Feature 2584

#1925 Feature 1925

#2903 Feature 2903

#848 Feature 848

#2761 Feature 2761

#2975 Feature 2975

#770 Feature 770

#1311 Molecular Mechanisms and Biological Processes

#2017 Feature 2017

#1185 Feature 1185

#1457 Feature 1457

#858 Feature 858

#2954 Feature 2954

#2729 Feature 2729

#2301 Feature 2301

#426 Feature 426

#2988 Feature 2988

#480 Feature 480

#2532 Feature 2532

#735 Feature 735

#2879 Feature 2879

#1383 Feature 1383

#665 Feature 665

#854 Feature 854

#2381 Feature 2381

#2944 Feature 2944

#809 Feature 809

#2949 Feature 2949

#2243 Feature 2243

#576 Feature 576

#1947 Feature 1947

#1883 Feature 1883

#2494 Feature 2494

#1427 Feature 1427

#166 Feature 166

#599 Feature 599

#985 Feature 985

#2698 Feature 2698

#562 Feature 562

#921 Feature 921

#2091 Feature 2091

#1757 Feature 1757

#2425 Feature 2425

#1905 Feature 1905

#2797 Feature 2797

#1193 Feature 1193

#1216 Feature 1216

#1151 Feature 1151

#344 Feature 344

#434 Feature 434

#2541 Feature 2541

#2710 Feature 2710

#1096 Feature 1096

#359 Feature 359

#2781 Feature 2781

#2068 Feature 2068

#2016 Feature 2016

#1443 Feature 1443

#1537 Feature 1537

#1339 Feature 1339

#1448 Feature 1448

#1952 Feature 1952

#894 Feature 894

#2175 Feature 2175

#505 Feature 505

#2833 Feature 2833

#2968 Feature 2968

#443 Feature 443

#2238 Feature 2238

#3063 Feature 3063

#1439 Feature 1439

#1895 Feature 1895

#217 Feature 217

#987 Feature 987

#1629 Feature 1629

#1641 Feature 1641

#2348 Feature 2348

#794 Feature 794

#2505 Feature 2505

#2607 Feature 2607

#2079 Feature 2079

#2302 Feature 2302

#1737 Feature 1737

#745 Feature 745

#351 Nanomaterial Synthesis and Properties

#476 Feature 476

#2431 Feature 2431

#2423 Feature 2423

#1669 Feature 1669

#1229 Feature 1229

#1466 Feature 1466

#796 Feature 796

#2408 Feature 2408

#689 Feature 689

#807 Feature 807

#872 Feature 872

#1045 Feature 1045

#2540 Feature 2540

#2788 Feature 2788

#2108 Feature 2108

#2280 Feature 2280

#1242 Feature 1242

#439 Feature 439

#2876 Feature 2876

#1644 Feature 1644

#1515 Feature 1515

#504 Feature 504

#923 Feature 923

#1292 Feature 1292

#495 Feature 495

#1410 Feature 1410

#1325 Feature 1325

#684 Feature 684

#2129 Feature 2129

#940 Feature 940

#2234 Feature 2234

#2754 Feature 2754

#2575 Feature 2575

#1590 Feature 1590

#499 Feature 499

#590 Feature 590

#1592 Feature 1592

#515 Feature 515

#2476 Feature 2476

#761 Feature 761

#280 Feature 280

#1346 Feature 1346

#1430 Feature 1430

#1247 Feature 1247

#1551 Feature 1551

#2090 Feature 2090

#999 Feature 999

#1759 Feature 1759

#967 Feature 967

#260 Feature 260

#1162 Feature 1162

#2253 Feature 2253

#2251 Feature 2251

#709 Feature 709

#248 Feature 248

#829 Feature 829

#1318 Feature 1318

#508 Feature 508

#2255 Feature 2255

#2187 Feature 2187

#1783 Feature 1783

#868 Feature 868

#1237 Feature 1237

#1378 Feature 1378

#2203 Feature 2203

#207 Feature 207

#2443 Feature 2443

#656 Feature 656

#1463 Feature 1463

#2847 Feature 2847

#2928 Feature 2928

#2530 Feature 2530

#628 Feature 628

#523 Feature 523

#895 Feature 895

#2617 Feature 2617

#3008 Feature 3008

#2513 Feature 2513

#1703 Feature 1703

#802 Feature 802

#2180 Feature 2180

#641 Feature 641

#583 Feature 583

#128 Feature 128

#2628 Feature 2628

#2640 Feature 2640

#2036 Feature 2036

#2790 Feature 2790

#1960 Feature 1960

#1145 Feature 1145

#2177 Feature 2177

#621 Feature 621

#1487 Feature 1487

#782 Feature 782

#875 Feature 875

#1618 Feature 1618

#1842 Feature 1842

#2282 Feature 2282

#1591 Feature 1591

#2702 Feature 2702

#890 Feature 890

#1555 Feature 1555

#2823 Feature 2823

#2594 Feature 2594

#736 Feature 736

#3032 Feature 3032

#1376 Feature 1376

#3022 Feature 3022

#2809 Feature 2809

#1775 Feature 1775

#762 Feature 762

#2681 Feature 2681

#1932 Feature 1932

#392 Feature 392

#1699 Feature 1699

#3036 Feature 3036

#1569 Feature 1569

#3003 Feature 3003

#1950 Feature 1950

#2665 Feature 2665

#694 Feature 694

#410 Feature 410

#2744 Feature 2744

#1046 Feature 1046

#1907 Feature 1907

#1245 Feature 1245

#1563 Feature 1563

#491 Feature 491

#363 Feature 363

#2355 Feature 2355

#574 Feature 574

#743 Feature 743

#186 Feature 186

#487 Feature 487

#1290 Feature 1290

#929 Feature 929

#1595 Feature 1595

#1049 Feature 1049

#1088 Feature 1088

#2857 Feature 2857

#304 Feature 304

#2159 Feature 2159

#2384 Feature 2384

#1017 Feature 1017

#1655 Feature 1655

#2881 Feature 2881

#2244 Feature 2244

#1273 Feature 1273

#1200 Feature 1200

#3061 Feature 3061

#245 Feature 245

#2574 Feature 2574

#883 Feature 883

#2182 Feature 2182

#1892 Feature 1892

#1657 Feature 1657

#2812 Feature 2812

#2099 Feature 2099

#2735 Feature 2735

#738 Feature 738

#423 Feature 423

#2445 Feature 2445

#1274 Feature 1274

#2694 Feature 2694

#2986 Feature 2986

#1954 Feature 1954

#2690 Feature 2690

#2144 Feature 2144

#729 Feature 729

#2292 Feature 2292

#946 Feature 946

#493 Feature 493

#402 Feature 402

#1991 Feature 1991

#1844 Feature 1844

#532 Feature 532

#138 Feature 138

#2533 Feature 2533

#2739 Feature 2739

#2057 Feature 2057

#147 Feature 147

#2552 Feature 2552

#2631 Feature 2631

#1748 Feature 1748

#342 Feature 342

#2737 Feature 2737

#2786 Feature 2786

#369 Feature 369

#1910 Feature 1910

#2184 Feature 2184

#1114 Feature 1114

#2852 Feature 2852

#1664 Feature 1664

#2921 Feature 2921

#109 Feature 109

#384 Feature 384

#860 Feature 860

#2862 Feature 2862

#2880 Feature 2880

#2350 Feature 2350

#3020 Feature 3020

#224 Feature 224

#1710 Feature 1710

#1058 Feature 1058

#2747 Feature 2747

#1609 Feature 1609

#2446 Feature 2446

#554 Feature 554

#334 Feature 334

#2151 Feature 2151

#2630 Feature 2630

#445 Feature 445

#250 Feature 250

#2849 Feature 2849

#196 Feature 196

#1866 Feature 1866

#2411 Feature 2411

#3031 Feature 3031

#1659 Feature 1659

#2174 Feature 2174

#2100 Feature 2100

#898 Feature 898

#218 Feature 218

#2806 Feature 2806

#1241 Feature 1241

#2347 Feature 2347

#2810 Feature 2810

#1640 Feature 1640

#1928 Feature 1928

#188 Feature 188

#2086 Feature 2086

#2725 Feature 2725

#2894 Feature 2894

#2183 Feature 2183

#1497 Feature 1497

#2711 Feature 2711

#2380 Feature 2380

#701 Feature 701

#314 Feature 314

#2500 Feature 2500

#774 Feature 774

#409 Feature 409

#2212 Feature 2212

#707 Feature 707

#2204 Feature 2204

#315 Feature 315

#2769 Feature 2769

#575 Feature 575

#1774 Feature 1774

#2401 Feature 2401

#220 Feature 220

#2319 Feature 2319

#2671 Feature 2671

#560 Feature 560

#623 Feature 623

#657 Feature 657

#1739 Feature 1739

#1794 Feature 1794

#1342 Feature 1342

#926 Feature 926

#1262 Feature 1262

#1621 Feature 1621

#2336 Feature 2336

#2110 Feature 2110

#637 Feature 637

#2913 Feature 2913

#3021 Feature 3021

#339 Feature 339

#2332 Feature 2332

#834 Feature 834

#381 Feature 381

#1683 Feature 1683

#2971 Feature 2971

#2458 Feature 2458

#1011 Feature 1011

#2231 Feature 2231

#1685 Feature 1685

#201 Feature 201

#1278 Feature 1278

#2343 Feature 2343

#2463 Feature 2463

#2992 Feature 2992

#257 Feature 257

#645 Feature 645

#1996 Feature 1996

#1030 Feature 1030

#1726 Feature 1726

#337 Feature 337

#2085 Feature 2085

#1069 Feature 1069

#928 Feature 928

#1663 Feature 1663

#2304 Feature 2304

#2141 Feature 2141

#625 Feature 625

#1755 Feature 1755

#642 Feature 642

#1032 Feature 1032

#1010 Feature 1010

#1404 Feature 1404

#268 Feature 268

#2831 Feature 2831

#785 Feature 785

#2391 Feature 2391

#2019 Feature 2019

#1475 Feature 1475

#1166 Feature 1166

#2111 Feature 2111

#388 Feature 388

#878 Feature 878

#888 Feature 888

#2364 Feature 2364

#2590 Feature 2590

#902 Feature 902

#1516 Feature 1516

#561 Feature 561

#2712 Feature 2712

#2413 Feature 2413

#845 Feature 845

#258 Feature 258

#558 Feature 558

#724 Feature 724

#1078 Feature 1078

#2579 Feature 2579

#1482 Feature 1482

#405 Feature 405

#2429 Feature 2429

#1308 Feature 1308

#2398 Feature 2398

#772 Feature 772

#793 Feature 793

#1536 Feature 1536

#2130 Feature 2130

#627 Feature 627

#246 Feature 246

#174 Feature 174

#1719 Feature 1719

#1024 Feature 1024

#3067 Feature 3067

#2334 Feature 2334

#2226 Feature 2226

#365 Feature 365

#1976 Feature 1976

#705 Feature 705

#1492 Feature 1492

#393 Feature 393

#2762 Feature 2762

#1533 Feature 1533

#719 Feature 719

#939 Feature 939

#2022 Feature 2022

#1398 Feature 1398

#1276 Feature 1276

#1476 Feature 1476

#2064 Feature 2064

#1355 Feature 1355

#1919 Feature 1919

#601 Feature 601

#2284 Feature 2284

#2536 Feature 2536

#2707 Feature 2707

#1913 Feature 1913

#1666 Feature 1666

#1875 Feature 1875

#1055 Feature 1055

#712 Feature 712

#2708 Feature 2708

#1556 Feature 1556

#474 Surgical Procedures & Gastrointestinal Issues

#1238 Feature 1238

#1116 Feature 1116

#1310 Feature 1310

#3009 Feature 3009

#387 Feature 387

#1254 Feature 1254

#2270 Feature 2270

#2522 Feature 2522

#1179 Feature 1179

#1462 Feature 1462

#2370 Feature 2370

#668 Feature 668

#1766 Feature 1766

#149 Feature 149

#2164 Feature 2164

#1433 Feature 1433

#353 Feature 353

#662 Feature 662

#1279 Feature 1279

#698 Feature 698

#998 Feature 998

#308 Feature 308

#650 Feature 650

#2660 Feature 2660

#2638 Feature 2638

#931 Feature 931

#2605 Feature 2605

#632 Feature 632

#1329 Feature 1329

#1246 Feature 1246

#2897 Feature 2897

#1057 Feature 1057

#1091 Feature 1091

#1041 Feature 1041

#348 Feature 348

#2646 Feature 2646

#2186 Feature 2186

#2306 Feature 2306

#2662 Feature 2662

#2121 Feature 2121

#1522 Feature 1522

#2945 Feature 2945

#2987 Feature 2987

#777 Feature 777

#183 Feature 183

#1547 Feature 1547

#1763 Feature 1763

#424 Feature 424

#2616 Feature 2616

#2140 Feature 2140

#2780 Feature 2780

#2473 Feature 2473

#2529 Feature 2529

#1194 Feature 1194

#2067 Feature 2067

#2285 Feature 2285

#2480 Feature 2480

#1512 Feature 1512

#2402 Feature 2402

#1985 Feature 1985

#1941 Feature 1941

#1873 Feature 1873

#261 Feature 261

#419 Feature 419

#2814 Feature 2814

#1384 Feature 1384

#354 Feature 354

#2772 Feature 2772

#1585 Feature 1585

#2033 Feature 2033

#2271 Feature 2271

#222 Feature 222

#945 Feature 945

#2444 Feature 2444

#269 Feature 269

#1938 Feature 1938

#2297 Feature 2297

#1309 Feature 1309

#2946 Feature 2946

#2622 Feature 2622

#464 Feature 464

#1356 Feature 1356

#2222 Feature 2222

#2450 Feature 2450

#162 Feature 162

#437 Feature 437

#3052 Feature 3052

#597 Feature 597

#1622 Feature 1622

#431 Feature 431

#185 Feature 185

#457 Feature 457

#1468 Feature 1468

#856 Feature 856

#877 Feature 877

#172 Feature 172

#206 Feature 206

#1648 Feature 1648

#1170 Feature 1170

#2165 Feature 2165

#2571 Feature 2571

#415 Feature 415

#1016 Feature 1016

#2265 Feature 2265

#2293 Feature 2293

#1824 Feature 1824

#358 Feature 358

#2004 Feature 2004

#1263 Feature 1263

#2426 Feature 2426

#2010 Feature 2010

#2873 Feature 2873

#1948 Feature 1948

#2664 Feature 2664

#129 Feature 129

#773 Feature 773

#2877 Feature 2877

#1498 Feature 1498

#2031 Feature 2031

#899 Feature 899

#2991 Feature 2991

#586 Feature 586

#2858 Feature 2858

#1328 Feature 1328

#2461 Feature 2461

#506 Feature 506

#2406 Feature 2406

#609 Feature 609

#696 Feature 696

#1524 Feature 1524

#1540 Feature 1540

#1943 Feature 1943

#1371 Feature 1371

#1746 Feature 1746

#1684 Feature 1684

#142 Feature 142

#758 Feature 758

#1014 Feature 1014

#1219 Feature 1219

#2763 Feature 2763

#593 Feature 593

#140 Feature 140

#1215 Feature 1215

#2213 Feature 2213

#119 Feature 119

#1365 Feature 1365

#978 Feature 978

#2534 Feature 2534

#322 Feature 322

#1048 Feature 1048

#232 Feature 232

#338 Feature 338

#3050 Feature 3050

#1758 Feature 1758

#1820 Feature 1820

#991 Feature 991

#3010 Feature 3010

#350 Feature 350

#1688 Feature 1688

#1650 Feature 1650

#2824 Feature 2824

#1767 Feature 1767

#2730 Feature 2730

#2892 Feature 2892

#2679 Feature 2679

#253 Feature 253

#982 Feature 982

#2171 Molecular and Cellular Biological Processes

#1390 Feature 1390

#1597 Feature 1597

#2576 Feature 2576

#975 Feature 975

#2012 Feature 2012

#229 Feature 229

#2545 Feature 2545

#639 Feature 639

#1881 Feature 1881

#2194 Feature 2194

#1174 Feature 1174

#1527 Feature 1527

#2360 Feature 2360

#2487 Feature 2487

#153 Feature 153

#281 Feature 281

#526 Feature 526

#370 Feature 370

#2647 Feature 2647

#298 Feature 298

#2745 Feature 2745

#2176 Feature 2176

#211 Feature 211

#2339 Feature 2339

#2143 Feature 2143

#2599 Feature 2599

#2082 Feature 2082

#803 Feature 803

#2181 Feature 2181

#2447 Feature 2447

#1894 Feature 1894

#674 Feature 674

#667 Feature 667

#1869 Feature 1869

#2326 Feature 2326

#1909 Feature 1909

#371 Feature 371

#974 Feature 974

#2896 Feature 2896

#2837 Feature 2837

#343 Feature 343

#1175 Feature 1175

#301 Feature 301

#2217 Feature 2217

#2499 Feature 2499

#2424 Feature 2424

#1131 Feature 1131

#1368 Feature 1368

#212 Feature 212

#2976 Feature 2976

#323 Feature 323

#163 Feature 163

#1753 Feature 1753

#1180 Feature 1180

#1637 Feature 1637

#2245 Feature 2245

#1630 Feature 1630

#2220 Feature 2220

#331 Feature 331

#496 Feature 496

#538 Feature 538

#1584 Feature 1584

#2815 Feature 2815

#1361 Feature 1361

#1319 Feature 1319

#2839 Feature 2839

#2410 Feature 2410

#1335 Feature 1335

#1700 Feature 1700

#2403 Feature 2403

#1232 Feature 1232

#859 Feature 859

#107 Feature 107

#711 Feature 711

#1611 Feature 1611

#2485 Feature 2485

#1027 Feature 1027

#1786 Feature 1786

#700 Feature 700

#1360 Feature 1360

#2506 Feature 2506

#1413 Feature 1413

#786 Feature 786

#1743 Feature 1743

#1636 Feature 1636

#1969 Feature 1969

#2994 Feature 2994

#604 Feature 604

#1206 Feature 1206

#1040 Feature 1040

#2803 Feature 2803

#3042 Feature 3042

#2758 Feature 2758

#2353 Feature 2353

#1208 Feature 1208

#237 Feature 237

#412 Feature 412

#2900 Feature 2900

#2248 Feature 2248

#484 Feature 484

#1725 Feature 1725

#2850 Feature 2850

#2813 Feature 2813

#189 Feature 189

#2225 Feature 2225

#2620 Feature 2620

#355 Feature 355

#170 Feature 170

#2827 Feature 2827

#2626 Feature 2626

#992 Feature 992

#2818 Feature 2818

#3007 Feature 3007

#2685 Feature 2685

#1534 Feature 1534

#1574 Feature 1574

#530 Feature 530

#2859 Feature 2859

#843 Feature 843

#2924 Feature 2924

#2214 Feature 2214

#1112 Feature 1112

#2585 Feature 2585

#1573 Feature 1573

#1823 Feature 1823

#2978 Feature 2978

#517 Feature 517

#2414 Feature 2414

#1966 Feature 1966

#1553 Feature 1553

#2256 Feature 2256

#1095 Feature 1095

#1689 Feature 1689

#2279 Feature 2279

#1834 Feature 1834

#1006 Feature 1006

#1761 Feature 1761

#241 Feature 241

#2720 Feature 2720

#1788 Feature 1788

#1734 Feature 1734

#1964 Feature 1964

#1155 Feature 1155

#1461 Feature 1461

#501 Feature 501

#692 Feature 692

#1031 Feature 1031

#2123 Feature 2123

#2202 Feature 2202

#1617 Feature 1617

#951 Feature 951

#1518 Feature 1518

#1393 Feature 1393

#2861 Feature 2861

#277 Feature 277

#1610 Feature 1610

#171 Feature 171

#1382 Feature 1382

#1330 Feature 1330

#305 Feature 305

#2291 Feature 2291

#1386 Feature 1386

#2984 Feature 2984

#144 Feature 144

#2309 Feature 2309

#1510 Feature 1510

#1119 Feature 1119

#2372 Feature 2372

#678 Feature 678

#3049 Feature 3049

#1990 Feature 1990

#543 Feature 543

#2488 Feature 2488

#618 Feature 618

#112 Feature 112

#2375 Feature 2375

#1983 Feature 1983

#1601 Feature 1601

#2608 Feature 2608

#936 Feature 936

#1550 Feature 1550

#1698 Feature 1698

#1047 Feature 1047

#846 Feature 846

#2621 Feature 2621

#2709 Feature 2709

#1561 Feature 1561

#2868 Feature 2868

#2979 Feature 2979

#2838 Feature 2838

#2989 Feature 2989

#2906 Feature 2906

#1542 Feature 1542

#2834 Feature 2834

#1891 Feature 1891

#1197 Feature 1197

#2027 Feature 2027

#1440 Feature 1440

#1686 Feature 1686

#102 Feature 102

#1150 Feature 1150

#2937 Feature 2937

#2038 Feature 2038

#1672 Feature 1672

#703 Feature 703

#470 Feature 470

#2420 Feature 2420

#450 Feature 450

#2008 Feature 2008

#962 Feature 962

#460 Feature 460

#2377 Feature 2377

#1656 Feature 1656

#716 Feature 716

#1583 Feature 1583

#3062 Feature 3062

#720 Feature 720

#1284 Feature 1284

#2501 Feature 2501

#1587 Feature 1587

#764 Feature 764

#1056 Feature 1056

#1364 Feature 1364

#1749 Feature 1749

#1459 Feature 1459

#252 Feature 252

#390 Feature 390

#1394 Feature 1394

#1009 Feature 1009

#1506 Justification/Rationale for Actions

#1809 Feature 1809

#2333 Feature 2333

#787 Feature 787

#362 Feature 362

#2959 Feature 2959

#1929 Feature 1929

#2556 Feature 2556

#2612 Feature 2612

#695 Feature 695

#805 Feature 805

#2661 Feature 2661

#1673 Feature 1673

#2382 Feature 2382

#1721 Feature 1721

#1638 Feature 1638

#2888 Feature 2888

#2066 Feature 2066

#221 Feature 221

#2428 Feature 2428

#553 Feature 553

#600 Feature 600

#1428 Feature 1428

#1377 Feature 1377

#2663 Feature 2663

#1495 Feature 1495

#2940 Feature 2940

#2104 Feature 2104

#436 Feature 436

#3033 Feature 3033

#1067 Feature 1067

#2073 Feature 2073

#3065 Feature 3065

#1760 Feature 1760

#1137 Feature 1137

#1452 Feature 1452

#1864 Feature 1864

#2258 Feature 2258

#1422 Feature 1422

#1257 Feature 1257

#2278 Feature 2278

#2260 Historical Context & Development

#996 Feature 996

#775 Feature 775

#2486 Feature 2486

#510 Feature 510

#2785 Feature 2785

#2634 Feature 2634

#2045 Feature 2045

#306 Feature 306

#1234 Feature 1234

#1217 Feature 1217

#1852 Feature 1852

#2286 Feature 2286

#981 Feature 981

#2668 Feature 2668

#1424 Feature 1424

#345 Feature 345

#2074 Feature 2074

#1385 Feature 1385

#2454 Feature 2454

#1437 Feature 1437

#300 Feature 300

#1526 Feature 1526

#673 Feature 673

#1643 Feature 1643

#995 Feature 995

#2798 Feature 2798

#319 Feature 319

#1135 Feature 1135

#2087 Feature 2087

#2305 Feature 2305

#228 Feature 228

#2210 Feature 2210

#2672 Feature 2672

#606 Feature 606

#2667 Feature 2667

#2264 Feature 2264

#2261 Feature 2261

#2511 Feature 2511

#1100 Feature 1100

#139 Feature 139

#1911 Feature 1911

#408 Feature 408

#262 Feature 262

#2561 Feature 2561

#2070 Feature 2070

#2418 Feature 2418

#2990 Feature 2990

#2840 Feature 2840

#2054 Feature 2054

#1086 Feature 1086

#3058 Feature 3058

#2020 Feature 2020

#1094 Feature 1094

#194 Feature 194

#2335 Feature 2335

#1632 Feature 1632

#2748 Feature 2748

#1434 Feature 1434

#198 Feature 198

#1528 Feature 1528

#1442 Feature 1442

#1445 Feature 1445

#861 Feature 861

#1256 Feature 1256

#3035 Feature 3035

#516 Feature 516

#200 Feature 200

#1546 Feature 1546

#1071 Feature 1071

#1173 Feature 1173

#1207 Feature 1207

#497 Feature 497

#2942 Feature 2942

#1885 Feature 1885

#1353 Feature 1353

#2832 Feature 2832

#2883 Feature 2883

#2328 Feature 2328

#806 Feature 806

#2843 Feature 2843

#1484 Feature 1484

#1802 Feature 1802

#1103 Feature 1103

#2504 Feature 2504

#1099 Feature 1099

#1557 Feature 1557

#1412 Feature 1412

#1285 Feature 1285

#852 Feature 852

#1159 Feature 1159

#1472 Feature 1472

#2290 Feature 2290

#591 Feature 591

#1713 Feature 1713

#3066 Feature 3066

#481 Feature 481

#960 Feature 960

#1244 Feature 1244

#826 Feature 826

#1754 Feature 1754

#1064 Feature 1064

#1867 Feature 1867

#3001 Feature 3001

#605 Feature 605

#804 Feature 804

#386 Feature 386

#1090 Feature 1090

#2275 Feature 2275

#1532 Feature 1532

#2489 Feature 2489

#2316 Feature 2316

#1320 Feature 1320

#1879 Feature 1879

#841 Feature 841

#1576 Feature 1576

#920 Feature 920

#3041 Feature 3041

#1317 Feature 1317

#2077 Feature 2077

#2299 Feature 2299

#1143 Feature 1143

#2003 Feature 2003

#1979 Feature 1979

#2526 Feature 2526

#2128 Feature 2128

#2659 Feature 2659

#1093 Feature 1093

#2642 Feature 2642

#1097 Feature 1097

#885 Feature 885

#828 Feature 828

#1362 Feature 1362

#118 Feature 118

#2572 Feature 2572

#2369 Feature 2369

#2915 Feature 2915

#897 Feature 897

#428 Feature 428

#2567 Feature 2567

#2023 Feature 2023

#1772 Feature 1772

#2985 Feature 2985

#616 Feature 616

#970 Feature 970

#1294 Feature 1294

#568 Feature 568

#1886 Feature 1886

#2149 Feature 2149

#1172 Feature 1172

#2080 Feature 2080

#2407 Feature 2407

#1474 Feature 1474

#869 Feature 869

#3047 Feature 3047

#336 Feature 336

#429 Feature 429

#2716 Feature 2716

#489 Feature 489

#1581 Feature 1581

#2162 Feature 2162

#176 Feature 176

#2886 Feature 2886

#2560 Feature 2560

#2966 Feature 2966

#2891 Feature 2891

#2088 Feature 2088

#833 Feature 833

#148 Feature 148

#2095 Feature 2095

#1863 Feature 1863

#1575 Feature 1575

#1456 Feature 1456

#2263 Feature 2263

#2317 Feature 2317

#2654 Feature 2654

#595 Feature 595

#2531 Feature 2531

#1800 Feature 1800

#913 Feature 913

#2717 Feature 2717

#1004 Feature 1004

#2434 Feature 2434

#1848 Feature 1848

#1280 Feature 1280

#2062 Feature 2062

#725 Feature 725

#949 Feature 949

#1199 Feature 1199

#1626 Feature 1626

#2493 Feature 2493

#272 Feature 272

#1271 Feature 1271

#2257 Feature 2257

#3015 Feature 3015

#788 Feature 788

#2043 Feature 2043

#2817 Feature 2817

#442 Feature 442

#1593 Feature 1593

#2056 Feature 2056

#2312 Feature 2312

#1676 Feature 1676

#1019 Feature 1019

#1520 Feature 1520

#1399 Feature 1399

#2724 Feature 2724

#1747 Feature 1747

#2841 Feature 2841

#947 Feature 947

#1639 Feature 1639

#2437 Feature 2437

#255 Feature 255

#2439 Feature 2439

#2394 Feature 2394

#1776 Feature 1776

#2094 Feature 2094

#2927 Feature 2927

#1446 Feature 1446

#1161 Feature 1161

#832 Feature 832

#197 Feature 197

#2475 Feature 2475

#502 Feature 502

#918 Feature 918

#1602 Feature 1602

#2688 Feature #2688

#2006 Feature 2006

#2939 Feature 2939

#449 Feature 449

#325 Feature 325

#213 Feature 213

#1066 Feature 1066

#2619 Feature 2619

#924 Feature 924

#2482 Feature 2482

#1577 Feature 1577

#2050 Feature 2050

#1494 Feature 1494

#1813 Feature 1813

#2653 Feature 2653

#1826 Feature 1826

#2962 Feature 2962

#187 Feature 187

#906 Feature 906

#199 Feature 199

#1380 Feature 1380

#259 Feature 259

#2126 Feature 2126

#2387 Feature 2387

#1944 Feature 1944

#1732 Feature 1732

#2956 Feature 2956

#427 Feature 427

#2869 Feature 2869

#2885 Feature 2885

#677 Feature 677

#1195 Feature 1195

#2331 Feature 2331

#1505 Feature 1505

#1981 Feature 1981

#2701 Feature 2701

#2018 Feature 2018

#2052 Feature 2052

#1435 Feature 1435

#2229 Feature 2229

#1388 Feature 1388

#3017 Feature 3017

#2349 Feature 2349

#651 Feature 651

#295 Feature 295

#214 Feature 214

#1449 Feature 1449

#1480 Feature 1480

#1118 Feature 1118

#271 Feature 271

#2049 Feature 2049

#2736 Feature 2736

#441 Feature 441

#290 Feature 290

#3011 Feature 3011

#1381 Feature 1381

#312 Feature 312

#1682 Feature 1682

#430 Feature 430

#1300 Feature 1300

#1209 Feature 1209

#1133 Feature 1133

#2345 Feature 2345

#1502 Feature 1502

#527 Feature 527

#161 Feature 161

#849 Feature 849

#1975 Feature 1975

#2740 Feature 2740

#1890 Feature 1890

Document Content

Recombinant human interleukin-8 is a potent activator of canine neutrophil aggregation, migration, and leukotriene B4 biosynthesis.
Interleukin-8 (IL-8), formerly known as NAP-1, is formed by a variety of cells upon stimulation with IL-1 or tumor necrosis factor (TNF). The biologic activity of the cytokine involves activation of almost every neutrophil function studied so far in different species. In the present study, we compared the effects of recombinant human IL-8 (rIL-8) and the lipid mediators, leukotriene B4 (LTB4) and platelet-activating factor (PAF), on neutrophil functions in dogs. All three chemotactic factors induced neutrophil aggregation and chemotaxis, with rIL-8 being far more potent than LTB4 and PAF. The migration induced by rIL-8 was significantly greater than that observed towards LTB4 and PAF. In the aggregation assay, rIL-8 was shown for the first time to be a potent stimulant. The aggregation response was more persistent than that obtained with LTB4 and PAF and the potency of rIL-8 was greater. An intradermal dose-response study showed that rIL-8 is an extremely potent inducer of selective neutrophil infiltration in canine skin. The infiltration was more pronounced than following injection of LTB4 or PAF. It was proposed that the superior effect of rIL-8 was caused by a synergistic effect between injected rIL-8 and LTB4, which was shown to be produced in biologically active amounts by canine neutrophils stimulated with rIL-8. From a therapeutic point of view, the simultaneous presence of rIL-8 and LTB4 in inflammatory skin diseases highlights the need to develop drugs that inhibit the production and/or effect of both mediators.

Similar Documents