Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1517

MIN ACTIVATION

0.0

Details List

#2174 Feature 2174

#1323 Feature 1323

#1028 Feature 1028

#1805 Feature 1805

#2790 Feature 2790

#672 Feature 672

#548 Feature 548

#708 Drug Resistance Mechanisms in Cancer

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#2090 Feature 2090

#1896 Feature 1896

#2467 Feature 2467

#838 Feature 838

#1130 Feature 1130

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#2931 Feature 2931

#218 Feature 218

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#518 Feature 518

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#1198 Feature 1198

#1994 Feature 1994

#965 Feature 965

#1447 Feature 1447

#2340 Feature 2340

#1903 Feature 1903

#3023 Feature 3023

#2460 Feature 2460

#2471 Feature 2471

#187 Feature 187

#1604 Feature 1604

#1063 Feature 1063

#2857 Feature 2857

#3060 Feature 3060

#746 Feature 746

#579 Feature 579

#1807 Feature 1807

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#1867 Feature 1867

#1965 Feature 1965

#1094 Feature 1094

#2992 Feature 2992

#1444 Feature 1444

#1002 Feature 1002

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#990 Feature 990

#2132 Feature 2132

#420 Feature 420

#227 Feature 227

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#2720 Feature 2720

#2245 Feature 2245

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#2160 Feature 2160

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#1925 Feature 1925

#1369 Feature 1369

#671 Feature 671

#254 Feature 254

#2803 Feature 2803

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#2291 Feature 2291

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#2333 Feature 2333

#436 Feature 436

#2088 Feature 2088

#2870 Feature 2870

#2999 Feature 2999

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#334 Feature 334

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#2086 Feature 2086

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#1691 Feature 1691

#476 Feature 476

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#1889 Feature 1889

#1834 Feature 1834

#766 Feature 766

#633 Feature 633

#2561 Feature 2561

#115 Feature 115

#1452 Feature 1452

#1993 Feature 1993

#1238 Feature 1238

#790 Feature 790

#190 Feature 190

#475 Feature 475

#138 Feature 138

#2394 Feature 2394

#2673 Feature 2673

#405 Feature 405

#2260 Historical Context & Development

#2252 Feature 2252

#1476 Feature 1476

#2997 Feature 2997

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#1158 Feature 1158

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#2213 Feature 2213

#634 Feature 634

#1318 Feature 1318

#1909 Feature 1909

#841 Feature 841

#2305 Feature 2305

#1973 Feature 1973

#826 Feature 826

#2715 Feature 2715

#1739 Feature 1739

#3070 Spiritual and Holistic Care in Healthcare

#1576 Feature 1576

#228 Feature 228

#1492 Feature 1492

#1217 Feature 1217

#237 Feature 237

#152 Feature 152

#1391 Feature 1391

#2797 Feature 2797

#2292 Feature 2292

#1262 Feature 1262

#1934 Feature 1934

#1572 Feature 1572

#2108 Feature 2108

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#1646 Feature 1646

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#2039 Feature 2039

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#811 Feature 811

#492 Feature 492

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#607 Feature 607

#2227 Feature 2227

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#389 Feature 389

#1702 Feature 1702

#1383 Feature 1383

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#272 Feature 272

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#2410 Feature 2410

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#2864 Feature 2864

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#1392 Feature 1392

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#2288 Feature 2288

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#1237 Feature 1237

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#919 Feature 919

#1388 Feature 1388

#370 Feature 370

#2845 Feature 2845

#1623 Feature 1623

#363 Feature 363

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#100 Feature 100

#1247 Feature 1247

#1346 Feature 1346

#1227 Feature 1227

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#802 Feature 802

#2138 Feature 2138

#1113 Feature 1113

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#2543 Feature 2543

#627 Feature 627

#2734 Feature 2734

#1425 Feature 1425

#2609 Feature 2609

#1523 Feature 1523

#738 Feature 738

#133 Feature 133

#1968 Feature 1968

#2623 Feature 2623

#1424 Feature 1424

#413 Feature 413

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#1714 Feature 1714

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#911 Feature 911

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#411 Feature 411

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#3007 Feature 3007

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#2723 Feature 2723

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#1610 Feature 1610

#430 Feature 430

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#129 Feature 129

#2359 Feature 2359

#250 Feature 250

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#2079 Feature 2079

#1167 Feature 1167

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#174 Feature 174

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#2665 Feature 2665

#2979 Feature 2979

#891 Feature 891

#205 Feature 205

#3022 Feature 3022

#1893 Feature 1893

#2672 Feature 2672

#2674 Feature 2674

#1307 Feature 1307

#784 Feature 784

#2109 Feature 2109

#2439 Feature 2439

#2368 Feature 2368

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#3005 Feature 3005

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#2872 Feature 2872

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#2112 Feature 2112

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#1699 Feature 1699

#776 Feature 776

#114 Feature 114

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#2497 Feature 2497

#2807 Feature 2807

#283 Feature 283

#2206 Feature 2206

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#630 Feature 630

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#2535 Feature 2535

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#360 Feature 360

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#3042 Feature 3042

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#1516 Feature 1516

#2601 Feature 2601

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#1904 Feature 1904

#422 Feature 422

#740 Feature 740

#1092 Feature 1092

#1456 Feature 1456

#570 Feature 570

#1709 Feature 1709

#943 Feature 943

#533 Feature 533

#2030 Feature 2030

#1620 Feature 1620

#1753 Feature 1753

#3030 Feature 3030

#2250 Feature 2250

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#1494 Feature 1494

#799 Feature 799

#688 Feature 688

#1837 Feature 1837

#2966 Feature 2966

#1445 Feature 1445

#255 Feature 255

#3059 Feature 3059

#313 Feature 313

#2412 Feature 2412

#1248 Feature 1248

#2538 Feature 2538

#2156 Feature 2156

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#2041 Feature 2041

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#2481 Feature 2481

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#1205 Feature 1205

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#1537 Feature 1537

#265 Feature 265

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#2345 Feature 2345

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#2016 Feature 2016

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#401 Feature 401

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#1265 Feature 1265

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#1535 Feature 1535

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#1777 Feature 1777

#2005 Feature 2005

#2977 Feature 2977

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#1960 Feature 1960

#316 Feature 316

#23 Neuronal Circuitry and Cellular Processes

#2330 Feature 2330

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#1726 Feature 1726

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#2035 Feature 2035

#1538 Feature 1538

#1501 Feature 1501

#2413 Feature 2413

#2510 Feature 2510

#2914 Feature 2914

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#2007 Developmental Disparities & Intervention

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#1506 Justification/Rationale for Actions

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#1723 Feature 1723

#1239 Feature 1239

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#322 Feature 322

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#221 Feature 221

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#2526 Feature 2526

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#2022 Feature 2022

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#2190 Feature 2190

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#1901 Feature 1901

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#2310 Feature 2310

#2386 Feature 2386

#1271 Feature 1271

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Document Content

Azacitidine in untreated acute myeloid leukemia: a report on 149 patients.
Limited data are available on azacitidine (AZA) treatment and its prognostic factors in acute myeloid leukemia (AML). One hundred and forty-nine previously untreated AML patients considered ineligible for intensive chemotherapy received AZA in a compassionate patient-named program. AML diagnosis was de novo, post-myelodysplastic syndromes (MDS), post-MPN, and therapy-related AML in 51, 55, 13, and 30 patients, respectively. Median age was 74 years, median white blood cell count (WBC) was 3.2 × 10⁹ /L and 58% of the patients had ≥ 30% marrow blasts. Cytogenetics was adverse in 60 patients. Patients received AZA for a median of five cycles (range 1-31). Response rate (including complete remission/CR with incomplete recovery/partial remission) was 27.5% after a median of three cycles (initial response), and 33% at any time (best response). Only adverse cytogenetics predicted poorer response. Median overall survival (OS) was 9.4 months. Two-year OS was 51% in responders and 10% in non-responders (P<0.0001). Adverse cytogenetics, WBC >15 × 10⁹ /L and ECOG-PS ≥ 2 predicted poorer OS, while age and marrow blast percentage had no impact. Using MDS IWG 2006 response criteria, among patients with stable disease, those with hematological improvement had no significant survival benefit in a 7 months landmark analysis. Outcomes observed in this high-risk AML population treated with AZA deserve comparison with those of patients treated intensively in prospective studies.

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