Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1590

MIN ACTIVATION

0.0

Details List

#2407 Feature 2407

#1086 Feature 1086

#1686 Feature 1686

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#2832 Feature 2832

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#240 Feature 240

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#2356 Feature 2356

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#1822 Feature 1822

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#2451 Feature #2451

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#2232 Medical Case Reports & Cancer Research

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#2316 Feature 2316

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#2103 Feature 2103

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#1557 Feature 1557

#1014 Feature 1014

#2220 Feature 2220

#2668 Feature 2668

#2841 Feature 2841

#913 Feature 913

#2393 Feature 2393

#474 Surgical Procedures & Gastrointestinal Issues

#1032 Feature 1032

#2298 Feature 2298

#1236 Feature 1236

#1871 Feature 1871

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#1728 Feature 1728

#2455 Feature 2455

#375 Feature 375

#268 Feature 268

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#1311 Molecular Mechanisms and Biological Processes

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#1221 Feature 1221

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#922 Feature 922

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#2522 Feature 2522

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#2625 Feature 2625

#2060 Feature 2060

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#2047 Feature 2047

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#753 Feature 753

#3049 Feature 3049

#2223 Feature 2223

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#633 Feature 633

#1132 Feature 1132

#2056 Feature 2056

#2009 Feature 2009

#1854 Feature 1854

#2201 Feature 2201

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#600 Feature 600

#2831 Feature 2831

#813 Feature 813

#1671 Feature 1671

#769 Feature 769

#2588 Feature 2588

#2765 Feature 2765

#1309 Feature 1309

#2121 Feature 2121

#2510 Feature 2510

#649 Feature 649

#181 Feature 181

#613 Feature 613

#1807 Feature 1807

#985 Feature 985

#2436 Feature 2436

#1372 Feature 1372

#1792 Metastatic Cancer

#2291 Feature 2291

#1446 Feature 1446

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#2067 Feature 2067

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#1506 Justification/Rationale for Actions

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#2828 Feature 2828

#1242 Feature 1242

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#2603 Instructional/Educational Content

#2984 Feature 2984

#1331 Feature 1331

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#1541 Feature 1541

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#3064 Surgical Complications and Physiological Stress

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#2260 Historical Context & Development

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#2428 Feature 2428

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Document Content

Depletion of plasma vitamin C but not of vitamin E in response to cardiac operations.
The whole-body inflammatory response produced by cardiopulmonary bypass is an important cause of perioperative morbidity after cardiac operations. This inflammatory response produces reactive oxygen species and other cytotoxic substances, such as the cytokines. The generation of reactive oxygen species might deplete principal antioxidant micronutrients, that is, vitamins C and E and the carotenoids. Therefore, we have investigated the time course of the plasma concentrations of vitamins C and E and the carotenoids in 18 patients undergoing coronary bypass operations after randomization for previous vitamin E supplementation (300 mg dl-alpha-acetyl-tocopherol 3 times daily for 4 weeks) or placebo. Supplementation with alpha-tocopherol doubled the lipid-standardized plasma vitamin E concentration to 63.7 +/- 14.5 mumol/L when compared with that of the control subjects (31.2 +/- 9.0 mumol/L) before the operation. The plasma concentrations of vitamin C (36.0 +/- 19.0 mumol/L and 44.0 +/- 21.7 mumol/L, respectively) and of the carotenoids were not statistically different between the two groups at baseline. The absolute plasma concentrations of both vitamin E and the carotenoids decreased during and after cardiopulmonary bypass, but after correction for hemodilution the plasma concentrations of vitamin E and the carotenoids showed no decrease. The vitamin E concentrations in the erythrocytes did not change either. In contrast, the plasma concentration of vitamin C decreased in all subjects within 24 hours after the operation by roughly 70%. Correction for hemodilution still revealed a significant decrease in plasma vitamin C that persisted in most patients up to 2 weeks. In conclusion, the vitamin E and the carotenoid plasma concentrations are of no major concern during and after cardiac operations. In contrast, the serious depletion of vitamin C may deteriorate the defense against reactive oxygen species-induced injury during cardiac operations.

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