Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1507

MIN ACTIVATION

0.0

Details List

#1674 Feature 1674

#480 Feature 480

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#1439 Feature 1439

#1570 Feature 1570

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#1123 Feature 1123

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#368 Feature 368

#2203 Feature 2203

#3064 Surgical Complications and Physiological Stress

#1094 Feature 1094

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#1578 Feature 1578

#2335 Feature 2335

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#2218 Feature 2218

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#2856 Feature 2856

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#2325 Feature 2325

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#867 Feature 867

#2909 Feature 2909

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#2086 Feature 2086

#3015 Feature 3015

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#1792 Metastatic Cancer

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#316 Feature 316

#834 Feature 834

#726 Feature 726

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#2393 Feature 2393

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#2712 Feature 2712

#2019 Feature 2019

#1698 Feature 1698

#1937 Feature 1937

#2168 Feature 2168

#2062 Feature 2062

#1409 Feature 1409

#932 Feature 932

#2478 Feature 2478

#404 Interactions and Mechanisms

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#2956 Feature 2956

#974 Feature 974

#1931 Feature 1931

#2260 Historical Context & Development

#2690 Feature 2690

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#400 Feature 400

#1255 Feature 1255

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#1518 Feature 1518

#1796 Feature 1796

#1625 Feature 1625

#1836 Feature 1836

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Document Content

Experimental primary and secondary infections of domestic dogs with Ehrlichia ewingii.
In this study, the infection dynamics of Ehrlichia ewingii, causative agent of granulocytotropic ehrlichiosis in dogs and humans, was examined in experimentally infected dogs by using a combination of physical examination, hematologic and biochemical analyses, and molecular and serologic assays. For the experimental trials, blood from an E. ewingii-infected dog was inoculated intravenously into two naïve dogs and two dogs with prior experimental exposure to E. ewingii (both were negative for E. ewingii DNA by polymerase chain reaction (PCR) assay, but seropositive from initial infection 8 and 10 months prior to challenge). A negative control dog was inoculated with blood from a negative dog. The two primary infection dogs were positive for E. ewingii DNA on DPI 4, remained consistently positive until DPI 60, and were intermittently positive until the end of the study (DPI 144). The two primary infection dogs developed antibodies reactive to E. ewingii by DPI 28 and remained seropositive for the duration of the study. Primary infected dogs had intermittent fever, thrombocytopenia, and leukopenia and some dogs were hyperphosphatemic and/or had elevated ALP levels. The two challenge dogs were positive for E. ewingii DNA on DPI 4 and 18, which was similar to the primary infection dogs, but the duration of E. ewingii DNA detection was shorter. Also, the two challenged dogs did not develop pyrexia or show any hematologic or biochemical abnormalities. E. ewingii was successfully transmitted between dogs by Amblyomma americanum, but not Rhipicephalus sanguineus. This study provides data on the infection dynamics of E. ewingii in dogs during primary and challenge infections and suggests that prior exposure may lessen clinical disease during subsequent infections.

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