Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1508

MIN ACTIVATION

0.0

Details List

#2033 Feature 2033

#1069 Feature 1069

#253 Feature 253

#1337 Feature 1337

#847 Feature 847

#490 Feature 490

#648 Feature 648

#1766 Feature 1766

#2732 Feature 2732

#1253 Feature 1253

#2908 Feature 2908

#1093 Feature 1093

#2465 Feature 2465

#3030 Feature 3030

#1743 Feature 1743

#3037 Feature 3037

#394 Feature 394

#404 Interactions and Mechanisms

#1229 Feature 1229

#159 Feature 159

#1419 Feature 1419

#2391 Feature 2391

#1526 Feature 1526

#2485 Feature 2485

#1415 Feature 1415

#2102 Feature 2102

#1039 Feature 1039

#1941 Feature 1941

#2605 Feature 2605

#758 Feature 758

#1701 Feature 1701

#1302 Sensing and Detection Technologies

#2979 Feature 2979

#1692 Feature 1692

#175 Feature 175

#2853 Feature 2853

#938 Feature 938

#1048 Feature 1048

#3069 Feature 3069

#2496 Feature 2496

#2333 Feature 2333

#1388 Feature 1388

#1781 Feature 1781

#2076 Feature 2076

#1677 Feature 1677

#2224 Feature 2224

#931 Feature 931

#2335 Feature 2335

#2996 Feature 2996

#2502 Feature 2502

#2767 Feature 2767

#3010 Feature 3010

#1170 Feature 1170

#126 Feature 126

#1501 Feature 1501

#2417 Feature 2417

#2021 Feature 2021

#2188 Feature 2188

#1929 Feature 1929

#961 Feature 961

#1776 Feature 1776

#1103 Feature 1103

#2400 Feature 2400

#1328 Feature 1328

#215 Feature 215

#2562 Feature 2562

#2805 Feature 2805

#668 Feature 668

#836 Feature 836

#1289 Feature 1289

#1203 Feature 1203

#2569 Feature 2569

#1487 Feature 1487

#2682 Feature 2682

#2304 Feature 2304

#546 Feature 546

#549 Feature 549

#194 Feature 194

#2169 Feature 2169

#1430 Feature 1430

#2806 Feature 2806

#2863 Feature 2863

#1014 Feature 1014

#1620 Feature 1620

#2559 Feature 2559

#1641 Feature 1641

#2668 Feature 2668

#2873 Feature 2873

#1124 Feature 1124

#1076 Feature 1076

#2207 Feature 2207

#2300 Feature 2300

#810 Feature 810

#2494 Feature 2494

#2301 Feature 2301

#2273 Feature 2273

#2749 Feature 2749

#677 Feature 677

#728 Feature 728

#776 Feature 776

#1891 Feature 1891

#2005 Feature 2005

#1995 Feature 1995

#1211 Feature 1211

#1434 Feature 1434

#352 Feature 352

#1119 Feature 1119

#143 Feature 143

#870 Feature 870

#1721 Feature 1721

#2023 Feature 2023

#106 Feature 106

#1161 Feature 1161

#1238 Feature 1238

#1980 Feature 1980

#153 Feature 153

#2974 Feature 2974

#2220 Feature 2220

#114 Feature 114

#2573 Feature 2573

#264 Feature 264

#391 Feature 391

#795 Feature 795

#2016 Feature 2016

#934 Feature 934

#539 Feature 539

#1353 Feature 1353

#2482 Feature 2482

#2587 Feature 2587

#1873 Feature 1873

#2119 Feature 2119

#2440 Feature 2440

#1268 Feature 1268

#2739 Feature 2739

#1003 Feature 1003

#2874 Feature 2874

#1689 Feature 1689

#238 Feature 238

#2909 Feature 2909

#947 Feature 947

#1262 Feature 1262

#2658 Feature 2658

#2841 Feature 2841

#2489 Feature 2489

#2735 Feature 2735

#2545 Feature 2545

#381 Feature 381

#1011 Feature 1011

#2338 Feature 2338

#513 Feature 513

#1857 Feature 1857

#1143 Feature 1143

#537 Feature 537

#2491 Feature 2491

#2073 Feature 2073

#1653 Feature 1653

#2803 Feature 2803

#3028 Feature 3028

#1812 Feature 1812

#2006 Feature 2006

#1572 Feature 1572

#2940 Feature 2940

#2236 Feature 2236

#2581 Feature 2581

#2416 Feature 2416

#1049 Feature 1049

#145 Feature 145

#1888 Feature 1888

#910 Feature 910

#2726 Feature 2726

#2572 Feature 2572

#1068 Feature 1068

#1307 Feature 1307

#294 Feature 294

#1179 Feature 1179

#2818 Feature 2818

#3040 Feature 3040

#2858 Feature 2858

#2859 Feature 2859

#948 Feature 948

#2490 Feature 2490

#1237 Feature 1237

#617 Feature 617

#1859 Feature 1859

#811 Feature 811

#1062 Feature 1062

#1551 Feature 1551

#1150 Feature 1150

#1106 Feature 1106

#492 Feature 492

#1263 Feature 1263

#1648 Feature 1648

#781 Feature 781

#2267 Feature 2267

#2613 Feature 2613

#1693 Feature 1693

#2865 Feature 2865

#1590 Feature 1590

#2221 Feature 2221

#806 Feature 806

#1479 Feature 1479

#1851 Feature 1851

#1549 Feature 1549

#2784 Feature 2784

#436 Feature 436

#1562 Feature 1562

#2675 Feature 2675

#554 Feature 554

#955 Feature 955

#464 Feature 464

#2944 Feature 2944

#883 Feature 883

#2269 Feature 2269

#2351 Feature 2351

#2661 Feature 2661

#1527 Feature 1527

#1556 Feature 1556

#2396 Feature 2396

#2877 Feature 2877

#930 Feature 930

#730 Feature 730

#1082 Feature 1082

#2999 Feature 2999

#2153 Feature 2153

#2113 Feature 2113

#435 Feature 435

#2303 Feature 2303

#2479 Feature 2479

#951 Feature 951

#1409 Feature 1409

#183 Feature 183

#782 Feature 782

#2078 Feature 2078

#256 Feature 256

#1024 Feature 1024

#1869 Feature 1869

#823 Feature 823

#685 Feature 685

#2467 Feature 2467

#1659 Feature 1659

#790 Feature 790

#1244 Feature 1244

#1500 Feature 1500

#708 Drug Resistance Mechanisms in Cancer

#1227 Feature 1227

#401 Feature 401

#1541 Feature 1541

#2934 Feature 2934

#1359 Feature 1359

#2438 Feature 2438

#1140 Feature 1140

#2446 Feature 2446

#322 Feature 322

#2927 Feature 2927

#2083 Feature 2083

#875 Feature 875

#2936 Feature 2936

#2229 Feature 2229

#614 Feature 614

#239 Feature 239

#198 Feature 198

#743 Feature 743

#2521 Feature 2521

#2309 Feature 2309

#2895 Feature 2895

#2360 Feature 2360

#2706 Feature 2706

#1186 Feature 1186

#594 Feature 594

#831 Feature 831

#1853 Feature 1853

#2262 Feature 2262

#2420 Feature 2420

#723 Feature 723

#2472 Feature 2472

#2930 Feature 2930

#766 Feature 766

#457 Feature 457

#630 Feature 630

#1741 Feature 1741

#2406 Feature 2406

#1470 Feature 1470

#1417 Feature 1417

#563 Feature 563

#2876 Feature 2876

#1818 Feature 1818

#1393 Feature 1393

#584 Feature 584

#2905 Feature 2905

#1793 Feature 1793

#2954 Feature 2954

#1260 Feature 1260

#2701 Feature 2701

#2585 Feature 2585

#588 Feature 588

#2796 Feature 2796

#3020 Feature 3020

#954 Feature 954

#426 Feature 426

#1756 Feature 1756

#2742 Feature 2742

#1770 Feature 1770

#1628 Feature 1628

#1000 Feature 1000

#2025 Feature 2025

#2462 Feature #2462

#559 Feature 559

#241 Feature 241

#479 Feature 479

#1180 Feature 1180

#822 Feature 822

#2230 Feature 2230

#2791 Feature 2791

#2514 Feature 2514

#792 Feature 792

#396 Feature 396

#1178 Feature 1178

#2887 Feature 2887

#2740 Feature 2740

#1165 Feature 1165

#2708 Feature 2708

#2252 Feature 2252

#2855 Feature 2855

#224 Feature 224

#472 Feature 472

#1004 Feature 1004

#3039 Feature 3039

#2270 Feature 2270

#133 Feature 133

#2212 Feature 2212

#762 Feature 762

#973 Feature 973

#2778 Hippocampal Memory and Cognitive Function

#1424 Feature 1424

#848 Feature 848

#798 Feature 798

#818 Feature 818

#2600 Feature 2600

#2848 Feature 2848

#2692 Feature 2692

#886 Feature 886

#314 Feature 314

#1020 Feature 1020

#1846 Feature 1846

#2456 Feature 2456

#2395 Feature 2395

#3014 Feature 3014

#1974 Feature 1974

#380 Feature 380

#1312 Feature 1312

#1392 Feature 1392

#2122 Feature 2122

#775 Feature 775

#599 Feature 599

#1232 Feature 1232

#2380 Feature 2380

#244 Feature 244

#1455 Feature 1455

#442 Feature 442

#1141 Feature 1141

#1656 Feature 1656

#2453 Feature 2453

#1865 Feature 1865

#1091 Feature 1091

#2022 Feature 2022

#2358 Feature 2358

#2729 Feature 2729

#179 Feature 179

#868 Feature 868

#2599 Feature 2599

#517 Feature 517

#2477 Feature 2477

#515 Feature 515

#1953 Feature 1953

#302 Feature 302

#1631 Feature 1631

#683 Feature 683

#669 Feature 669

#2967 Feature 2967

#1515 Feature 1515

#1333 Feature 1333

#259 Feature 259

#1892 Feature 1892

#1379 Feature 1379

#1940 Feature 1940

#2142 Feature 2142

#759 Feature 759

#1552 Feature 1552

#1355 Feature 1355

#1546 Feature 1546

#1330 Feature 1330

#962 Feature 962

#1385 Feature 1385

#533 Feature 533

#2856 Feature 2856

#123 Feature 123

#727 Feature 727

#110 Feature 110

#595 Feature 595

#2899 Feature 2899

#700 Feature 700

#2295 Feature 2295

#3024 Feature 3024

#1451 Feature 1451

#548 Feature 548

#471 Feature 471

#2629 Feature 2629

#2531 Feature 2531

#2983 Feature 2983

#2921 Feature 2921

#495 Feature 495

#754 Feature 754

#437 Feature 437

#855 Feature 855

#1821 Feature 1821

#2237 Feature 2237

#2062 Feature 2062

#1649 Feature 1649

#1746 Feature 1746

#1280 Feature 1280

#2852 Feature 2852

#2445 Feature 2445

#1565 Feature 1565

#2419 Feature 2419

#1991 Feature 1991

#2555 Feature 2555

#1740 Feature 1740

#1072 Feature 1072

#1630 Feature 1630

#2118 Feature 2118

#1361 Feature 1361

#2628 Feature 2628

#1095 Feature 1095

#927 Feature 927

#2932 Feature 2932

#2052 Feature 2052

#1700 Feature 1700

#361 Feature 361

#1368 Feature 1368

#2546 Feature 2546

#2757 Feature 2757

#1592 Feature 1592

#964 Feature 964

#778 Feature 778

#412 Feature 412

#2904 Feature 2904

#2412 Feature 2412

#494 Feature 494

#1085 Feature 1085

#1744 Feature 1744

#2289 Feature 2289

#2957 Feature 2957

#2956 Feature 2956

#918 Feature 918

#1844 Feature 1844

#2705 Feature 2705

#2372 Feature 2372

#425 Feature 425

#2011 Feature 2011

#1378 Feature 1378

#482 Feature 482

#2973 Feature 2973

#2461 Feature 2461

#2244 Feature 2244

#1750 Feature 1750

#242 Feature 242

#1212 Feature 1212

#1831 Feature 1831

#1279 Feature 1279

#112 Feature 112

#395 Feature 395

#2614 Feature #2614

#755 Feature 755

#1615 Feature 1615

#1816 Feature 1816

#432 Feature 432

#1079 Feature 1079

#1123 Feature 1123

#2366 Feature 2366

#2652 Feature 2652

#1896 Feature 1896

#789 Feature 789

#726 Feature 726

#2695 Feature 2695

#327 Feature 327

#1545 Feature 1545

#503 Feature 503

#1745 Feature 1745

#2297 Feature 2297

#514 Feature 514

#225 Feature 225

#1215 Feature 1215

#1466 Feature 1466

#581 Feature 581

#1159 Feature 1159

#1577 Feature 1577

#1732 Feature 1732

#1043 Feature 1043

#1194 Feature 1194

#2755 Feature 2755

#2769 Feature 2769

#1257 Feature 1257

#1308 Feature 1308

#1235 Feature 1235

#2331 Feature 2331

#2423 Feature 2423

#2533 Feature 2533

#1414 Feature 1414

#2721 Feature 2721

#180 Feature 180

#943 Feature 943

#1272 Feature 1272

#1964 Feature 1964

#1757 Feature 1757

#1017 Feature 1017

#2611 Feature 2611

#240 Feature 240

#1753 Feature 1753

#1374 Feature 1374

#2105 Feature 2105

#1858 Feature 1858

#1895 Feature 1895

#2425 Feature 2425

#2457 Feature 2457

#2655 Feature 2655

#1366 Feature 1366

#534 Feature 534

#2850 Feature 2850

#828 Feature 828

#2403 Feature 2403

#1486 Feature 1486

#2512 Feature 2512

#971 Feature 971

#824 Feature 824

#2673 Feature 2673

#1575 Feature 1575

#480 Feature 480

#958 Feature 958

#1400 Feature 1400

#1990 Feature 1990

#438 Feature 438

#3016 Feature 3016

#942 Feature 942

#1496 Feature 1496

#1983 Feature 1983

#2193 Feature 2193

#583 Feature 583

#1674 Feature 1674

#296 Feature 296

#1371 Feature 1371

#3001 Feature 3001

#2795 Feature 2795

#1933 Feature 1933

#1944 Feature 1944

#2663 Feature 2663

#2088 Feature 2088

#1508 Feature 1508

#2215 Feature 2215

#592 Feature 592

#1866 Feature 1866

#2885 Feature 2885

#787 Feature 787

#3045 Feature 3045

#1662 Feature 1662

#664 Feature 664

#1461 Feature 1461

#898 Feature 898

#2055 Feature 2055

#1606 Feature 1606

#1576 Feature 1576

#2525 Feature 2525

#2059 Feature 2059

#2808 Feature 2808

#562 Feature 562

#591 Feature 591

#2057 Feature 2057

#374 Medical Imaging and Oncology

#1404 Feature 1404

#843 Feature 843

#1790 Feature 1790

#1994 Feature 1994

#1607 Feature 1607

#2604 Feature 2604

#270 Feature 270

#2515 Feature 2515

#230 Feature 230

#1667 Feature 1667

#2666 Feature 2666

#2112 Feature 2112

#274 Feature 274

#337 Feature 337

#2163 Feature 2163

#1134 Feature 1134

#859 Feature 859

#981 Feature 981

#181 Feature 181

#321 Feature 321

#1581 Feature 1581

#2793 Feature 2793

#2310 Feature 2310

#693 Feature 693

#333 Feature 333

#1845 Feature 1845

#968 Feature 968

#2426 Feature 2426

#2823 Feature 2823

#651 Feature 651

#2844 Feature 2844

#1033 Feature 1033

#906 Feature 906

#2151 Feature 2151

#803 Feature 803

#504 Feature 504

#1759 Feature 1759

#2557 Feature 2557

#1864 Feature 1864

#2552 Feature 2552

#750 Feature 750

#1612 Feature 1612

#315 Feature 315

#2862 Feature 2862

#567 Feature 567

#511 Feature 511

#2037 Feature 2037

#1045 Feature 1045

#547 Feature 547

#1131 Feature 1131

#957 Feature 957

#2409 Feature 2409

#783 Feature 783

#2030 Feature 2030

#3071 Feature 3071

#2392 Feature 2392

#772 Feature 772

#439 Feature 439

#1305 Feature 1305

#1928 Feature 1928

#771 Feature 771

#1903 Feature 1903

#174 Feature 174

#1650 Feature 1650

#2725 Feature 2725

#227 Feature 227

#699 Feature 699

#2700 Feature 2700

#839 Feature 839

#1493 Feature 1493

#2589 Feature 2589

#2135 Feature 2135

#719 Feature 719

#524 Feature 524

#912 Feature 912

#1380 Feature 1380

#600 Feature 600

#2125 Feature 2125

#2026 Feature 2026

#358 Feature 358

#1145 Feature 1145

#1901 Feature 1901

#117 Feature 117

#1167 Feature 1167

#1523 Feature 1523

#977 Feature 977

#2302 Feature 2302

#2050 Feature 2050

#1152 Feature 1152

#459 Feature 459

#1573 Feature 1573

#819 Feature 819

#1543 Feature 1543

#1403 Feature 1403

#1539 Feature 1539

#413 Feature 413

#2549 Feature 2549

#1678 Feature 1678

#2872 Feature 2872

#1086 Feature 1086

#860 Feature 860

#1196 Feature 1196

#2634 Feature 2634

#465 Feature 465

#2475 Feature 2475

#2337 Feature 2337

#640 Feature 640

#1160 Feature 1160

#2971 Feature 2971

#1218 Feature 1218

#834 Feature 834

#2286 Feature 2286

#1600 Feature 1600

#192 Feature 192

#2506 Feature 2506

#807 Feature 807

#1503 Feature 1503

#266 Feature 266

#397 Feature 397

#166 Feature 166

#1458 Feature 1458

#155 Feature 155

#1199 Feature 1199

#1411 Feature 1411

#2963 Feature 2963

#2799 Feature 2799

#1077 Feature 1077

#2710 Feature 2710

#666 Feature 666

#2474 Feature 2474

#641 Feature 641

#488 Feature 488

#1064 Feature 1064

#217 Feature 217

#1354 Feature 1354

#1071 Feature 1071

#2197 Feature 2197

#1696 Feature 1696

#1081 Feature 1081

#226 Feature 226

#463 Feature 463

#1386 Feature 1386

#2248 Feature 2248

#1209 Feature 1209

#1295 Feature 1295

#373 Feature 373

#1016 Feature 1016

#849 Feature 849

#1657 Feature 1657

#116 Feature 116

#279 Feature 279

#650 Feature 650

#701 Feature 701

#1841 Feature 1841

#2174 Feature 2174

#2476 Feature 2476

#3048 Feature 3048

#1098 Feature 1098

#993 Feature 993

#740 Feature 740

#1370 Feature 1370

#2126 Feature 2126

#1629 Feature 1629

#2346 Feature 2346

#613 Feature 613

#1680 Feature 1680

#2010 Feature 2010

#1558 Feature 1558

#2812 Feature 2812

#2281 Feature 2281

#2925 Feature 2925

#2547 Feature 2547

#550 Feature 550

#2907 Feature 2907

#2831 Feature 2831

#1369 Feature 1369

#1499 Feature 1499

#900 Feature 900

#2913 Feature 2913

#1034 Feature 1034

#2992 Feature 2992

#1052 Feature 1052

#2945 Feature 2945

#2929 Feature 2929

#2674 Feature 2674

#1428 Feature 1428

#2259 Feature 2259

#1761 Feature 1761

#1830 Feature 1830

#751 Feature 751

#3006 Feature 3006

#673 Feature 673

#2048 Feature 2048

#2313 Feature 2313

#2898 Feature 2898

#552 Feature 552

#2082 Feature 2082

#1949 Feature 1949

#1561 Feature 1561

#2437 Feature 2437

#1204 Feature 1204

#658 Feature 658

#2953 Feature 2953

#2470 Feature 2470

#324 Feature 324

#2510 Feature 2510

#1126 Feature 1126

#1833 Feature 1833

#1854 Feature 1854

#2171 Molecular and Cellular Biological Processes

#1946 Feature 1946

#578 Feature 578

#1395 Feature 1395

#1294 Feature 1294

#392 Feature 392

#201 Feature 201

#1695 Feature 1695

#2352 Feature 2352

#2564 Feature 2564

#430 Feature 430

#1026 Feature 1026

#1349 Feature 1349

#1950 Feature 1950

#2662 Feature 2662

#629 Feature 629

#2816 Feature 2816

#267 Feature 267

#420 Feature 420

#872 Feature 872

#245 Feature 245

#1346 Feature 1346

#152 Feature 152

#923 Feature 923

#1731 Feature 1731

#1444 Feature 1444

#1801 Feature 1801

#1112 Feature 1112

#928 Feature 928

#1311 Molecular Mechanisms and Biological Processes

#2349 Feature 2349

#893 Feature 893

#2092 Feature 2092

#1599 Feature 1599

#516 Feature 516

#1598 Feature 1598

#111 Feature 111

#2451 Feature #2451

#1450 Feature 1450

#355 Feature 355

#1840 Feature 1840

#347 Feature 347

#1193 Feature 1193

#698 Feature 698

#176 Feature 176

#2228 Feature 2228

#171 Feature 171

#2493 Feature 2493

#3015 Feature 3015

#1749 Feature 1749

#1205 Feature 1205

#2150 Feature 2150

#1397 Feature 1397

#2381 Feature 2381

#1101 Feature 1101

#1111 Feature 1111

#2947 Feature 2947

#917 Feature 917

#523 Feature 523

#2383 Feature 2383

#1113 Feature 1113

#1210 Feature 1210

#2794 Feature 2794

#1609 Feature 1609

#2249 Feature 2249

#642 Feature 642

#1402 Feature 1402

#2144 Feature 2144

#2253 Feature 2253

#1065 Feature 1065

#1445 Feature 1445

#1290 Feature 1290

#1827 Feature 1827

#1315 Feature 1315

#2535 Feature 2535

#2582 Feature 2582

#1897 Feature 1897

#889 Feature 889

#1453 Feature 1453

#135 Feature 135

#185 Feature 185

#1742 Feature 1742

#2507 Feature 2507

#1730 Feature 1730

#1345 Feature 1345

#565 Feature 565

#223 Feature 223

#2175 Feature 2175

#873 Feature 873

#636 Feature 636

#402 Feature 402

#1834 Feature 1834

#2678 Feature 2678

#858 Feature 858

#1334 Feature 1334

#716 Feature 716

#2179 Feature 2179

#2773 Feature 2773

#2731 Feature 2731

#301 Feature 301

#2920 Feature 2920

#645 Feature 645

#2031 Feature 2031

#162 Feature 162

#1954 Feature 1954

#1664 Feature 1664

#753 Feature 753

#1580 Feature 1580

#2635 Feature 2635

#1309 Feature 1309

#1270 Feature 1270

#764 Feature 764

#2704 Feature 2704

#1006 Feature 1006

#474 Surgical Procedures & Gastrointestinal Issues

#1618 Feature 1618

#1930 Feature 1930

#1431 Feature 1431

#2612 Feature 2612

#2291 Feature 2291

#2847 Feature 2847

#1863 Feature 1863

#2306 Feature 2306

#805 Feature 805

#1967 Feature 1967

#2430 Feature 2430

#1176 Feature 1176

#2164 Feature 2164

#705 Feature 705

#2686 Feature 2686

#1521 Feature 1521

#543 Feature 543

#148 Feature 148

#1396 Feature 1396

#1341 Feature 1341

#687 Feature 687

#1560 Feature 1560

#2013 Feature 2013

#1206 Feature 1206

#802 Feature 802

#365 Feature 365

#1166 Feature 1166

#1157 Feature 1157

#1652 Feature 1652

#768 Feature 768

#2277 Feature 2277

#147 Feature 147

#2888 Feature 2888

#2315 Feature 2315

#1802 Feature 1802

#2804 Feature 2804

#1293 Feature 1293

#2981 Feature 2981

#478 Feature 478

#667 Feature 667

#2279 Feature 2279

#2922 Feature 2922

#1074 Feature 1074

#1208 Feature 1208

#2034 Feature 2034

#887 Feature 887

#2219 Feature 2219

#1149 Feature 1149

#247 Feature 247

#1301 Feature 1301

#1591 Feature 1591

#1956 Feature 1956

#631 Feature 631

#2422 Feature 2422

#1525 Feature 1525

#2251 Feature 2251

#1567 Feature 1567

#2089 Feature 2089

#236 Feature 236

#1015 Feature 1015

#2293 Feature 2293

#2117 Feature 2117

#990 Feature 990

#580 Feature 580

#2960 Feature 2960

#833 Feature 833

#403 Feature 403

#3023 Feature 3023

#2577 Feature 2577

#2677 Feature 2677

#1473 Feature 1473

#2591 Feature 2591

#1375 Feature 1375

#1671 Feature 1671

#1623 Feature 1623

#222 Feature 222

#1799 Feature 1799

#2842 Feature 2842

#1850 Feature 1850

#2866 Feature 2866

#1634 Feature 1634

#987 Feature 987

#1684 Feature 1684

#1923 Feature 1923

#445 Feature 445

#419 Feature 419

#1747 Feature 1747

#2071 Feature 2071

#2069 Feature 2069

#2341 Feature 2341

#1303 Feature 1303

#1978 Feature 1978

#2361 Feature 2361

#2896 Feature 2896

#1646 Feature 1646

#1080 Feature 1080

#1292 Feature 1292

#146 Feature 146

#1405 Feature 1405

#2007 Developmental Disparities & Intervention

#2498 Feature 2498

#1769 Feature 1769

#915 Feature 915

#1460 Feature 1460

#632 Feature 632

#1168 Feature 1168

#2487 Feature 2487

#1056 Feature 1056

#1511 Feature 1511

#1504 Feature 1504

#1962 Feature 1962

#1916 Feature 1916

#427 Feature 427

#2715 Feature 2715

#1060 Feature 1060

#2379 Feature 2379

#1925 Feature 1925

#1022 Feature 1022

#1226 Feature 1226

#287 Feature 287

#2109 Feature 2109

#2871 Feature 2871

#2965 Feature 2965

#1435 Feature 1435

#694 Feature 694

#1878 Feature 1878

#994 Feature 994

#2802 Feature 2802

#2829 Feature 2829

#2132 Feature 2132

#1642 Feature 1642

#160 Feature 160

#2183 Feature 2183

#2902 Feature 2902

#2066 Feature 2066

#1710 Feature 1710

#1507 Feature 1507

#1100 Feature 1100

#1282 Feature 1282

#278 Feature 278

#541 Feature 541

#2067 Feature 2067

#1320 Feature 1320

#784 Feature 784

#821 Feature 821

#786 Feature 786

#2923 Feature 2923

#2280 Feature 2280

#306 Feature 306

#2676 Feature 2676

#2926 Feature 2926

#2382 Feature 2382

#1332 Feature 1332

#1348 Feature 1348

#1780 Feature 1780

#3035 Feature 3035

#2529 Feature 2529

#606 Feature 606

#3018 Feature 3018

#2387 Feature 2387

#2718 Feature 2718

#1468 Feature 1468

#408 Feature 408

#2004 Feature 2004

#2046 Feature 2046

#2571 Feature 2571

#2326 Feature 2326

#221 Feature 221

#1224 Feature 1224

#1407 Feature 1407

#360 Feature 360

#2937 Feature 2937

#3011 Feature 3011

#1183 Feature 1183

#443 Feature 443

#345 Feature 345

#1718 Feature 1718

#841 Feature 841

#2049 Feature 2049

#1252 Feature 1252

#1832 Feature 1832

#2707 Feature 2707

#557 Feature 557

#2354 Feature 2354

#1089 Feature 1089

#1820 Feature 1820

#1057 Feature 1057

#354 Feature 354

#141 Feature 141

#1824 Feature 1824

#2214 Feature 2214

#1406 Feature 1406

#2596 Feature 2596

#850 Feature 850

#3055 Feature 3055

#1935 Feature 1935

#2590 Feature 2590

#104 Feature 104

#1996 Feature 1996

#2530 Feature 2530

#1960 Feature 1960

#132 Feature 132

#483 Feature 483

#2138 Feature 2138

#2597 Feature 2597

#1976 Feature 1976

#1040 Feature 1040

#1054 Feature 1054

#780 Feature 780

#895 Feature 895

#2656 Feature 2656

#952 Feature 952

#814 Feature 814

#2427 Feature 2427

#2189 Feature 2189

#729 Feature 729

#1321 Feature 1321

#1454 Feature 1454

#2003 Feature 2003

#615 Feature 615

#154 Feature 154

#1885 Feature 1885

#2917 Feature 2917

#1467 Feature 1467

#1367 Feature 1367

#2958 Feature 2958

#2140 Feature 2140

#820 Feature 820

#293 Feature 293

#458 Feature 458

#2299 Feature 2299

#1316 Feature 1316

#785 Feature 785

#1246 Feature 1246

#736 Feature 736

#1413 Feature 1413

#2505 Feature 2505

#2977 Feature 2977

#2394 Feature 2394

#1970 Feature 1970

#448 Feature 448

#2939 Feature 2939

#318 Feature 318

#1810 Feature 1810

#336 Feature 336

#2234 Feature 2234

#1009 Feature 1009

#2359 Feature 2359

#590 Feature 590

#532 Feature 532

#1118 Feature 1118

#1894 Feature 1894

#2641 Feature 2641

#316 Feature 316

#2968 Feature 2968

#1092 Feature 1092

#1605 Feature 1605

#2903 Feature 2903

#2602 Feature 2602

#1952 Feature 1952

#2458 Feature 2458

#3052 Feature 3052

#2509 Feature 2509

#1751 Feature 1751

#2336 Feature 2336

#1640 Feature 1640

#788 Feature 788

#1138 Feature 1138

#2497 Feature 2497

#2094 Feature 2094

#2363 Feature 2363

#163 Feature 163

#216 Feature 216

#1550 Feature 1550

#2288 Feature 2288

#2320 Feature 2320

#1791 Feature 1791

#1352 Feature 1352

#269 Feature 269

#2696 Feature 2696

#1708 Feature 1708

#1876 Feature 1876

#300 Feature 300

#2147 Feature 2147

#1236 Feature 1236

#2266 Feature 2266

#2647 Feature 2647

#1828 Feature 1828

#1050 Feature 1050

#2548 Feature 2548

#3068 Feature 3068

#2914 Feature 2914

#1083 Feature 1083

#525 Feature 525

#2240 Feature 2240

#2644 Feature 2644

#1464 Feature 1464

#124 Feature 124

#130 Feature 130

#2322 Feature 2322

#2986 Feature 2986

#2864 Feature 2864

#298 Feature 298

#1690 Feature 1690

#2785 Feature 2785

#172 Feature 172

#1610 Feature 1610

#2879 Feature 2879

#1335 Feature 1335

#1733 Feature 1733

#219 Feature 219

#2292 Feature 2292

#1423 Feature 1423

#892 Feature 892

#2659 Feature 2659

#2316 Feature 2316

#2268 Feature 2268

#1758 Feature 1758

#386 Feature 386

#1596 Feature 1596

#461 Feature 461

#1669 Feature 1669

#2991 Feature 2991

#1722 Feature 1722

#2526 Feature 2526

#1798 Feature 1798

#2143 Feature 2143

#1188 Feature 1188

#1553 Feature 1553

#1471 Feature 1471

#670 Feature 670

#2085 Feature 2085

#1465 Feature 1465

#2386 Feature 2386

#2226 Feature 2226

#469 Feature 469

#453 Feature 453

#865 Feature 865

#1613 Feature 1613

#2519 Feature 2519

#2616 Feature 2616

#769 Feature 769

#644 Feature 644

#2970 Feature 2970

#1601 Feature 1601

#1794 Feature 1794

#2414 Feature 2414

#1472 Feature 1472

#1459 Feature 1459

#1924 Feature 1924

#2243 Feature 2243

#2261 Feature 2261

#1817 Feature 1817

#929 Feature 929

#1624 Feature 1624

#1107 Feature 1107

#2618 Feature 2618

#838 Feature 838

#801 Feature 801

#1654 Feature 1654

#444 Feature 444

#817 Feature 817

#377 Feature 377

#1029 Feature 1029

#1037 Feature 1037

#2222 Feature 2222

#2146 Feature 2146

#2781 Feature 2781

#307 Feature 307

#2551 Feature 2551

#2976 Feature 2976

#2190 Feature 2190

#1259 Feature 1259

#2203 Feature 2203

#1438 Feature 1438

#440 Feature 440

#2441 Feature 2441

#107 Feature 107

#1398 Feature 1398

#1889 Feature 1889

#1418 Feature 1418

#863 Feature 863

#2235 Feature 2235

#2766 Feature 2766

#1842 Feature 1842

#134 Feature 134

#3000 Feature 3000

#100 Feature 100

#2687 Feature 2687

#633 Feature 633

#320 Feature 320

#2241 Feature 2241

#1530 Feature 1530

#2065 Feature 2065

#1137 Feature 1137

#1116 Feature 1116

#1879 Feature 1879

#128 Feature 128

#882 Feature 882

#634 Feature 634

#173 Feature 173

#1714 Feature 1714

#2257 Feature 2257

#804 Feature 804

#907 Feature 907

#2263 Feature 2263

#1870 Feature 1870

#3060 Feature 3060

#2643 Feature 2643

#2429 Feature 2429

#161 Feature 161

#125 Feature 125

#2894 Feature 2894

#1125 Feature 1125

#2834 Feature 2834

#1921 Feature 1921

#2532 Feature 2532

#733 Feature 733

#2761 Feature 2761

#2606 Feature 2606

#1660 Feature 1660

#2817 Feature 2817

#2893 Feature 2893

#722 Feature 722

#323 Feature 323

#2619 Feature 2619

#1814 Feature 1814

#1882 Feature 1882

#879 Feature 879

#2703 Feature 2703

#3017 Feature 3017

#922 Feature 922

#2324 Feature 2324

#261 Feature 261

#911 Feature 911

#2196 Feature 2196

#1611 Feature 1611

#1709 Feature 1709

#2018 Feature 2018

#1715 Feature 1715

#690 Feature 690

#2043 Feature 2043

#1429 Feature 1429

#191 Feature 191

#2110 Feature 2110

#2679 Feature 2679

#1241 Feature 1241

#196 Feature 196

#2800 Feature 2800

#2782 Feature 2782

#475 Feature 475

#303 Feature 303

#1075 Feature 1075

#2368 Feature 2368

#696 Feature 696

#1512 Feature 1512

#2651 Feature 2651

#1808 Feature 1808

#489 Feature 489

#214 Feature 214

#2077 Feature 2077

#637 Feature 637

#2321 Feature 2321

#2764 Feature 2764

#2969 Feature 2969

#187 Feature 187

#992 Feature 992

#1372 Feature 1372

#2570 Feature 2570

#1861 Feature 1861

#1871 Feature 1871

#1172 Feature 1172

#2285 Feature 2285

#2941 Feature 2941

#692 Feature 692

#1537 Feature 1537

#779 Feature 779

#1943 Feature 1943

#1343 Feature 1343

#207 Feature 207

#867 Feature 867

#281 Feature 281

#1804 Feature 1804

#1595 Feature 1595

#985 Feature 985

#101 Feature 101

#1571 Feature 1571

#1683 Feature 1683

#1327 Feature 1327

#169 Feature 169

#997 Feature 997

#2019 Feature 2019

#2744 Feature 2744

#1651 Feature 1651

#1603 Feature 1603

#2688 Feature #2688

#1190 Feature 1190

#387 Feature 387

#131 Feature 131

#2247 Feature 2247

#1661 Feature 1661

#2825 Feature 2825

#612 Feature 612

#2513 Feature 2513

#1920 Feature 1920

#389 Feature 389

#1495 Feature 1495

#1266 Feature 1266

#1338 Feature 1338

#500 Feature 500

#142 Feature 142

#2478 Feature 2478

#1979 Feature 1979

#1989 Feature 1989

#1120 Feature 1120

#519 Feature 519

#1691 Feature 1691

#794 Feature 794

#656 Feature 656

#2699 Feature 2699

#2047 Feature 2047

#672 Feature 672

#2790 Feature 2790

#1144 Feature 1144

#481 Feature 481

#2155 Feature 2155

#799 Feature 799

#3065 Feature 3065

#3007 Feature 3007

#896 Feature 896

#1666 Feature 1666

#2516 Feature 2516

#956 Feature 956

#1248 Feature 1248

#2058 Feature 2058

#1767 Feature 1767

#341 Feature 341

#2393 Feature 2393

#2484 Feature 2484

#309 Feature 309

#1318 Feature 1318

#2826 Feature 2826

#121 Feature 121

#1128 Feature 1128

#1893 Feature 1893

#262 Feature 262

#1856 Feature 1856

#1720 Feature 1720

#1063 Feature 1063

Document Content

Signaling pathways coordinating the alkaline pH response confer resistance to the hevein-type plant antimicrobial peptide Pn-AMP1 in Saccharomyces cerevisiae.
Genome-wide screening of Saccharomyces cerevisiae revealed that signaling pathways related to the alkaline pH stress contribute to resistance to plant antimicrobial peptide, Pn-AMP1. Plant antimicrobial peptides (AMPs) are considered to be promising candidates for controlling phytopathogens. Pn-AMP1 is a hevein-type plant AMP that shows potent and broad-spectrum antifungal activity. Genome-wide chemogenomic screening was performed using heterozygous and homozygous diploid deletion pools of Saccharomyces cerevisiae as a chemogenetic model system to identify genes whose deletion conferred enhanced sensitivity to Pn-AMP1. This assay identified 44 deletion strains with fitness defects in the presence of Pn-AMP1. Strong fitness defects were observed in strains with deletions of genes encoding components of several pathways and complex known to participate in the adaptive response to alkaline pH stress, including the cell wall integrity (CWI), calcineurin/Crz1, Rim101, SNF1 pathways and endosomal sorting complex required for transport (ESCRT complex). Gene ontology (GO) enrichment analysis of these genes revealed that the most highly overrepresented GO term was "cellular response to alkaline pH". We found that 32 of the 44 deletion strains tested (72 %) showed significant growth defects compared with their wild type at alkaline pH. Furthermore, 9 deletion strains (20 %) exhibited enhanced sensitivity to Pn-AMP1 at ambient pH compared to acidic pH. Although several hundred plant AMPs have been reported, their modes of action remain largely uncharacterized. This study demonstrates that the signaling pathways that coordinate the adaptive response to alkaline pH also confer resistance to a hevein-type plant AMP in S. cerevisiae. Our findings have broad implications for the design of novel and potent antifungal agents.

Similar Documents