Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1532

MIN ACTIVATION

0.0

Details List

#1390 Feature 1390

#781 Feature 781

#2474 Feature 2474

#1348 Feature 1348

#1879 Feature 1879

#2330 Feature 2330

#2262 Feature 2262

#2769 Feature 2769

#2921 Feature 2921

#1144 Feature 1144

#1550 Feature 1550

#3046 Feature 3046

#1436 Feature 1436

#264 Feature 264

#3013 Feature 3013

#2479 Feature 2479

#140 Feature 140

#1493 Feature 1493

#519 Feature 519

#362 Feature 362

#1761 Feature 1761

#715 Feature 715

#959 Feature 959

#1706 Feature 1706

#1019 Feature 1019

#2980 Feature 2980

#779 Feature 779

#1705 Feature 1705

#2946 Feature 2946

#2314 Feature 2314

#1076 Feature 1076

#2457 Feature 2457

#107 Feature 107

#1861 Feature 1861

#1626 Feature 1626

#2547 Feature 2547

#1878 Feature 1878

#282 Feature 282

#1821 Feature 1821

#2706 Feature 2706

#1811 Feature 1811

#1899 Feature 1899

#356 Feature 356

#1512 Feature 1512

#721 Feature 721

#1575 Feature 1575

#1148 Feature 1148

#2829 Feature 2829

#2925 Feature 2925

#841 Feature 841

#1313 Feature 1313

#1343 Feature 1343

#1310 Feature 1310

#2404 Feature 2404

#2889 Feature 2889

#934 Feature 934

#2871 Feature 2871

#2891 Feature 2891

#679 Feature 679

#183 Feature 183

#478 Feature 478

#2399 Feature 2399

#416 Feature 416

#1959 Feature 1959

#1533 Feature 1533

#330 Feature 330

#332 Feature 332

#618 Feature 618

#915 Feature 915

#2200 Feature 2200

#1599 Feature 1599

#275 Feature 275

#1848 Feature 1848

#1846 Feature 1846

#644 Feature 644

#2828 Feature 2828

#1429 Feature 1429

#380 Feature 380

#1642 Feature 1642

#1527 Feature 1527

#771 Feature 771

#2558 Feature 2558

#2580 Feature 2580

#1655 Feature 1655

#567 Feature 567

#504 Feature 504

#1917 Feature 1917

#667 Feature 667

#2519 Feature 2519

#2471 Feature 2471

#289 Feature 289

#2836 Feature 2836

#233 Feature 233

#263 Feature 263

#1536 Feature 1536

#1308 Feature 1308

#2049 Feature 2049

#2997 Feature 2997

#2625 Feature 2625

#764 Feature 764

#1376 Feature 1376

#2753 Feature 2753

#896 Feature 896

#1195 Feature 1195

#2599 Feature 2599

#2386 Feature 2386

#2714 Feature 2714

#1649 Feature 1649

#1183 Feature 1183

#892 Feature 892

#1659 Feature 1659

#475 Feature 475

#699 Feature 699

#1463 Feature 1463

#608 Feature 608

#581 Feature 581

#473 Feature 473

#2996 Feature 2996

#1888 Feature 1888

#1765 Feature 1765

#2981 Feature 2981

#2067 Feature 2067

#1669 Feature 1669

#2572 Feature 2572

#235 Feature 235

#2905 Feature 2905

#2504 Feature 2504

#1710 Feature 1710

#2510 Feature 2510

#3011 Feature 3011

#2936 Feature 2936

#2765 Feature 2765

#1204 Feature 1204

#2092 Feature 2092

#1058 Feature 1058

#889 Feature 889

#936 Feature 936

#1945 Feature 1945

#1085 Feature 1085

#1008 Feature 1008

#2095 Feature 2095

#177 Feature 177

#1952 Feature 1952

#2708 Feature 2708

#1564 Feature 1564

#2533 Feature 2533

#1932 Feature #1932

#852 Feature 852

#2051 Feature 2051

#2332 Feature 2332

#668 Feature 668

#1021 Feature 1021

#187 Feature 187

#806 Feature 806

#1166 Feature 1166

#808 Feature 808

#386 Feature 386

#1656 Feature 1656

#1534 Feature 1534

#2376 Feature 2376

#1009 Feature 1009

#2993 Feature 2993

#1225 Feature 1225

#1262 Feature 1262

#1418 Feature 1418

#2959 Feature 2959

#1112 Feature 1112

#674 Feature 674

#212 Feature 212

#653 Feature 653

#288 Feature 288

#1068 Feature 1068

#2253 Feature 2253

#2865 Feature 2865

#2102 Feature 2102

#1254 Feature 1254

#507 Feature 507

#2651 Feature 2651

#821 Feature 821

#2985 Feature 2985

#2759 Feature 2759

#155 Feature 155

#922 Feature 922

#2553 Feature 2553

#639 Feature 639

#2541 Feature 2541

#2796 Feature 2796

#1336 Feature 1336

#2817 Feature 2817

#3004 Feature 3004

#2371 Feature 2371

#323 Feature 323

#905 Feature 905

#1606 Feature 1606

#1165 Feature 1165

#2910 Feature 2910

#1937 Feature 1937

#552 Feature 552

#1729 Feature 1729

#110 Feature 110

#2264 Feature 2264

#1822 Feature 1822

#1010 Feature 1010

#384 Feature 384

#278 Feature 278

#1478 Feature 1478

#2470 Feature 2470

#135 Feature 135

#1926 Feature 1926

#952 Feature 952

#2972 Sensory-Motor Integration

#457 Feature 457

#1358 Feature 1358

#382 Feature 382

#2139 Feature 2139

#762 Feature 762

#1580 Feature 1580

#1572 Feature 1572

#112 Feature 112

#1422 Feature 1422

#1090 Feature 1090

#2485 Feature 2485

#466 Feature 466

#1399 Feature 1399

#637 Feature 637

#2071 Feature 2071

#984 Feature 984

#272 Feature 272

#987 Feature 987

#290 Feature 290

#2636 Feature 2636

#2622 Feature 2622

#1999 Feature 1999

#862 Feature 862

#166 Feature 166

#743 Feature 743

#2641 Feature 2641

#1476 Feature 1476

#2723 Feature 2723

#1715 Feature 1715

#1116 Feature 1116

#226 Feature 226

#1513 Feature 1513

#898 Feature 898

#1069 Feature 1069

#2728 Feature 2728

#1170 Feature 1170

#2110 Feature 2110

#2494 Feature 2494

#1623 Feature 1623

#256 Feature 256

#682 Feature 682

#2965 Feature 2965

#414 Feature 414

#1826 Feature 1826

#2917 Feature 2917

#2687 Feature 2687

#291 Feature 291

#2667 Feature 2667

#2566 Feature 2566

#1428 Feature 1428

#1508 Feature 1508

#1249 Feature 1249

#1518 Feature 1518

#697 Feature 697

#2195 Feature 2195

#626 Feature 626

#2083 Feature 2083

#1503 Feature 1503

#2815 Feature 2815

#1969 Feature 1969

#908 Feature 908

#2047 Feature 2047

#2063 Feature 2063

#1558 Feature 1558

#1386 Feature 1386

#1716 Feature 1716

#1130 Feature 1130

#1800 Feature 1800

#744 Feature 744

#273 Feature 273

#2786 Feature 2786

#1687 Feature 1687

#1096 Feature 1096

#1266 Feature 1266

#2630 Feature 2630

#429 Feature 429

#1683 Feature 1683

#1487 Feature 1487

#2202 Feature 2202

#2344 Feature 2344

#805 Feature 805

#2043 Feature 2043

#2428 Feature 2428

#2249 Feature 2249

#1131 Feature 1131

#2705 Feature 2705

#301 Feature 301

#1037 Feature 1037

#767 Feature 767

#2492 Feature 2492

#2957 Feature 2957

#2283 Feature 2283

#735 Feature 735

#1913 Feature 1913

#2296 Feature 2296

#1950 Feature 1950

#2512 Feature 2512

#1771 Feature 1771

#2532 Feature 2532

#1104 Feature 1104

#2848 Feature 2848

#2694 Feature 2694

#1338 Feature 1338

#828 Feature 828

#1224 Feature 1224

#2133 Feature 2133

#900 Feature 900

#2204 Feature 2204

#178 Feature 178

#401 Feature 401

#544 Feature 544

#604 Feature 604

#1567 Feature 1567

#2452 Feature 2452

#1219 Feature 1219

#2393 Feature 2393

#2010 Feature 2010

#361 Feature 361

#1089 Feature 1089

#3042 Feature 3042

#381 Feature 381

#2752 Feature 2752

#1842 Feature 1842

#1720 Feature 1720

#1345 Feature 1345

#1817 Feature 1817

#527 Feature 527

#1145 Feature 1145

#1554 Feature 1554

#1284 Feature 1284

#1047 Feature 1047

#918 Feature 918

#2290 Feature 2290

#2336 Feature 2336

#1191 Feature 1191

#1305 Feature 1305

#2329 Feature 2329

#913 Feature 913

#2189 Feature 2189

#1073 Feature 1073

#2606 Feature 2606

#2908 Feature 2908

#511 Feature 511

#2716 Feature 2716

#1863 Feature 1863

#2224 Feature 2224

#2576 Feature 2576

#505 Feature 505

#1824 Feature 1824

#185 Feature 185

#2114 Feature 2114

#2358 Feature 2358

#2778 Hippocampal Memory and Cognitive Function

#2987 Feature 2987

#2998 Feature 2998

#3071 Feature 3071

#305 Feature 305

#2635 Feature 2635

#2648 Feature 2648

#2001 Feature 2001

#2559 Feature 2559

#2002 Feature 2002

#665 Feature 665

#3068 Feature 3068

#1395 Feature 1395

#2642 Feature 2642

#184 Feature 184

#1283 Feature 1283

#1856 Feature 1856

#367 Feature 367

#797 Feature 797

#763 Feature 763

#2499 Feature 2499

#663 Feature 663

#1053 Feature 1053

#2148 Feature 2148

#1175 Feature 1175

#2787 Feature 2787

#268 Feature 268

#100 Feature 100

#1226 Feature 1226

#2915 Feature 2915

#2178 Feature 2178

#953 Feature 953

#975 Feature 975

#1864 Feature 1864

#2731 Feature 2731

#2454 Feature 2454

#307 Feature 307

#1561 Feature 1561

#2214 Feature 2214

#521 Feature 521

#2912 Feature 2912

#194 Feature 194

#3026 Feature 3026

#2407 Feature 2407

#2491 Feature 2491

#1750 Feature 1750

#1828 Feature 1828

#2239 Feature 2239

#2382 Feature 2382

#1263 Feature 1263

#1301 Feature 1301

#2023 Feature 2023

#2089 Feature 2089

#2368 Feature 2368

#924 Feature 924

#311 Feature 311

#741 Feature 741

#3000 Feature 3000

#1393 Feature 1393

#1718 Feature 1718

#2160 Feature 2160

#1565 Feature 1565

#2410 Feature 2410

#225 Feature 225

#2184 Feature 2184

#2738 Feature 2738

#1734 Feature 1734

#1178 Feature 1178

#717 Feature 717

#2257 Feature 2257

#2445 Feature 2445

#1519 Feature 1519

#1805 Feature 1805

#1495 Feature 1495

#1680 Feature 1680

#550 Feature 550

#1060 Feature 1060

#1324 Feature 1324

#2757 Feature 2757

#2232 Medical Case Reports & Cancer Research

#2696 Feature 2696

#1658 Feature 1658

#757 Feature 757

#1290 Feature 1290

#890 Feature 890

#2834 Feature 2834

#506 Feature 506

#2476 Feature 2476

#1152 Feature 1152

#1833 Feature 1833

#2781 Feature 2781

#2595 Feature 2595

#2724 Feature 2724

#1125 Feature 1125

#1650 Feature 1650

#1603 Feature 1603

#1679 Feature 1679

#1079 Feature 1079

#3058 Feature 3058

#2853 Feature 2853

#636 Feature 636

#1631 Feature 1631

#124 Feature 124

#1746 Feature 1746

#843 Feature 843

#791 Feature 791

#2271 Feature 2271

#742 Feature 742

#2663 Feature 2663

#788 Feature 788

#1996 Feature 1996

#2649 Feature 2649

#2672 Feature 2672

#1915 Feature 1915

#1064 Feature 1064

#1933 Feature 1933

#1298 Feature 1298

#2384 Feature 2384

#1242 Feature 1242

#1045 Feature 1045

#2746 Feature 2746

#2562 Feature 2562

#725 Feature 725

#2173 Feature 2173

#3021 Feature 3021

#2401 Feature 2401

#801 Feature 801

#933 Feature 933

#277 Feature 277

#2729 Feature 2729

#1327 Feature 1327

#652 Feature 652

#2034 Feature 2034

#1892 Feature 1892

#467 Feature 467

#1087 Feature 1087

#1193 Feature 1193

#1600 Feature 1600

#1095 Feature 1095

#2664 Feature 2664

#1730 Feature 1730

#2490 Feature 2490

#1017 Feature 1017

#2515 Feature 2515

#1809 Feature #1809

#2654 Feature 2654

#2688 Feature #2688

#930 Feature 930

#1609 Feature 1609

#932 Feature 932

#2619 Feature 2619

#1294 Feature 1294

#417 Feature #417

#2859 Feature 2859

#2899 Feature 2899

#1353 Feature 1353

#2022 Feature 2022

#378 Feature 378

#500 Feature 500

#366 Feature 366

#719 Feature 719

#1870 Feature 1870

#295 Feature 295

#23 Neuronal Circuitry and Cellular Processes

#3031 Feature 3031

#2220 Feature 2220

#482 Feature 482

#1770 Feature 1770

#300 Feature 300

#1397 Feature 1397

#2263 Feature 2263

#2040 Feature 2040

#556 Feature 556

#2324 Feature 2324

#1157 Feature 1157

#2683 Feature 2683

#2085 Feature 2085

#2591 Feature 2591

#2734 Feature 2734

#465 Feature 465

#842 Feature 842

#443 Feature 443

#2698 Feature 2698

#189 Feature 189

#1192 Feature 1192

#1238 Feature 1238

#1200 Feature 1200

#593 Feature 593

#538 Feature 538

#948 Feature 948

#874 Feature 874

#101 Feature 101

#1403 Feature 1403

#2605 Feature 2605

#2361 Feature 2361

#2345 Feature 2345

#616 Feature 616

#252 Feature 252

#1759 Feature 1759

#2953 Feature 2953

#2079 Feature 2079

#1928 Feature 1928

#1992 Feature 1992

#2147 Feature 2147

#954 Feature 954

#3035 Feature 3035

#1043 Feature 1043

#2647 Feature 2647

#974 Feature 974

#136 Feature 136

#1260 Feature 1260

#1876 Feature 1876

#1339 Feature 1339

#1220 Feature 1220

#152 Feature 152

#2069 Feature 2069

#354 Feature 354

#1270 Feature 1270

#1202 Feature 1202

#2823 Feature 2823

#474 Surgical Procedures & Gastrointestinal Issues

#1648 Feature 1648

#167 Feature 167

#1547 Feature 1547

#1258 Feature 1258

#1553 Feature 1553

#1297 Feature 1297

#2327 Feature 2327

#2284 Feature 2284

#535 Feature 535

#1514 Feature 1514

#2832 Feature 2832

#2783 Feature 2783

#134 Feature 134

#1921 Feature 1921

#3039 Feature 3039

#1424 Feature 1424

#261 Feature 261

#2387 Feature 2387

#977 Feature 977

#832 Feature 832

#458 Feature 458

#2463 Feature 2463

#1384 Feature 1384

#1604 Feature 1604

#1586 Feature 1586

#1018 Feature 1018

#2991 Feature 2991

#146 Feature 146

#2048 Feature 2048

#2486 Feature 2486

#1050 Feature 1050

#1634 Feature 1634

#3020 Feature 3020

#712 Feature 712

#2157 Feature 2157

#1196 Feature 1196

#3034 Feature 3034

#2254 Feature 2254

#2082 Feature 2082

#1049 Feature 1049

#105 Feature 105

#1028 Feature 1028

#2017 Feature 2017

#787 Feature 787

#2436 Feature 2436

#1141 Feature 1141

#503 Feature 503

#2571 Feature 2571

#708 Drug Resistance Mechanisms in Cancer

#1409 Feature 1409

#1646 Feature 1646

#1441 Feature 1441

#2397 Feature 2397

#2316 Feature #2316

#321 Feature 321

#1063 Feature 1063

#2287 Feature 2287

#2675 Feature 2675

#716 Feature 716

#2215 Feature 2215

#1167 Feature 1167

#2111 Feature 2111

#2060 Feature 2060

#786 Feature 786

#615 Feature 615

#1344 Feature 1344

#496 Feature 496

#554 Feature 554

#2692 Feature 2692

#1859 Feature 1859

#772 Feature 772

#963 Feature 963

#1268 Feature 1268

#1071 Feature 1071

#1098 Feature 1098

#1315 Feature 1315

#2906 Feature 2906

#2197 Feature 2197

#453 Feature 453

#3018 Feature 3018

#1236 Feature 1236

#1451 Feature 1451

#2801 Feature 2801

#1160 Feature 1160

#2465 Feature 2465

#3016 Feature 3016

#2186 Feature 2186

#927 Feature 927

#1967 Feature 1967

#1628 Feature 1628

#1142 Feature 1142

#2567 Feature 2567

#111 Feature 111

#1672 Feature 1672

#433 Feature 433

#1101 Feature 1101

#1122 Feature 1122

#128 Feature 128

#2418 Feature 2418

#1042 Feature 1042

#131 Feature 131

#568 Feature 568

#1887 Feature 1887

#2159 Feature 2159

#2680 Feature 2680

#1029 Feature 1029

#3063 Feature 3063

#287 Feature 287

#1568 Feature 1568

#1995 Feature 1995

#1155 Feature 1155

#141 Feature 141

#1229 Feature 1229

#2243 Feature 2243

#1982 Feature 1982

#895 Feature 895

#160 Feature 160

#2311 Feature 2311

#3051 Feature 3051

#1722 Feature 1722

#1213 Feature 1213

#1731 Feature 1731

#179 Feature 179

#2623 Feature 2623

#1134 Feature 1134

#1607 Feature 1607

#2128 Feature 2128

#2059 Feature 2059

#1702 Feature 1702

#635 Feature 635

#2411 Feature 2411

#685 Feature 685

#1359 Feature 1359

#583 Feature 583

#1259 Feature 1259

#1667 Feature 1667

#2560 Feature 2560

#2942 Feature 2942

#790 Feature 790

#1312 Feature 1312

#316 Feature 316

#2037 Feature 2037

#2666 Feature 2666

#542 Feature 542

#1118 Feature 1118

#718 Feature 718

#2933 Feature 2933

#1094 Feature 1094

#1585 Feature 1585

#891 Feature 891

#1737 Feature 1737

#169 Feature 169

#1973 Feature 1973

#833 Feature 833

#1371 Feature 1371

#1682 Feature 1682

#2949 Feature 2949

#2219 Feature 2219

#901 Feature 901

#1066 Feature 1066

#990 Feature 990

#2577 Feature 2577

#171 Feature 171

#2792 Feature 2792

#2790 Feature 2790

#1013 Feature 1013

#2507 Feature 2507

#1938 Feature 1938

#352 Feature 352

#860 Feature 860

#1031 Feature 1031

#1688 Feature 1688

#558 Feature 558

#669 Feature 669

#2927 Feature 2927

#317 Feature 317

#2771 Feature 2771

#2313 Feature 2313

#1201 Feature 1201

#1823 Feature 1823

#2363 Feature 2363

#642 Feature 642

#998 Feature 998

#2877 Feature 2877

#1055 Feature 1055

#875 Feature 875

#614 Feature 614

#723 Feature 723

#2934 Feature 2934

#923 Feature 923

#1762 Feature 1762

#3053 Feature 3053

#885 Feature 885

#2598 Feature 2598

#2774 Feature 2774

#861 Feature 861

#1375 Feature 1375

#782 Feature 782

#2038 Feature 2038

#2084 Feature 2084

#1644 Feature 1644

#2838 Feature 2838

#2914 Feature 2914

#2281 Feature 2281

#2699 Feature 2699

#2655 Feature 2655

#811 Feature 811

#1986 Feature 1986

#2874 Feature 2874

#2690 Feature 2690

#1885 Feature 1885

#2435 Feature 2435

#555 Feature 555

#1535 Feature 1535

#158 Feature 158

#424 Feature 424

#1086 Feature 1086

#2902 Feature 2902

#1394 Feature 1394

#1504 Feature 1504

#2026 Feature 2026

#633 Feature 633

#2795 Feature 2795

#188 Feature 188

#3019 Feature 3019

#186 Feature 186

#560 Feature 560

#825 Feature 825

#2523 Feature 2523

#1472 Feature 1472

#2733 Feature 2733

#2937 Feature 2937

#1355 Feature 1355

#602 Feature 602

#1302 Sensing and Detection Technologies

#143 Feature 143

#2652 Feature 2652

#1450 Feature 1450

#2170 Feature 2170

#1838 Feature 1838

#3008 Feature 3008

#342 Feature 342

#630 Feature 630

#1203 Feature 1203

#175 Feature 175

#804 Feature 804

#1788 Feature 1788

#406 Feature 406

#2124 Feature 2124

#1303 Feature 1303

#865 Feature 865

#1880 Feature 1880

#928 Feature 928

#2118 Feature 2118

#2620 Feature 2620

#337 Feature 337

#408 Feature 408

#571 Feature 571

#1857 Feature 1857

#344 Feature 344

#2659 Feature 2659

#536 Feature 536

#2740 Feature 2740

#2531 Feature 2531

#1733 Feature 1733

#1237 Feature 1237

#2880 Feature 2880

#1416 Feature 1416

#2072 Feature 2072

#1346 Feature 1346

#306 Feature 306

#937 Feature 937

#477 Feature 477

#1890 Feature 1890

#2440 Feature 2440

#1749 Feature 1749

#1492 Feature 1492

#145 Feature 145

#2685 Feature 2685

#2888 Feature 2888

#1975 Feature 1975

#2310 Feature 2310

#2167 Feature 2167

#2529 Feature 2529

#1980 Feature 1980

#1062 Feature 1062

#1819 Feature 1819

#1918 Feature 1918

#1088 Feature 1088

#1717 Feature 1717

#3024 Feature 3024

#2719 Feature 2719

#2101 Feature 2101

#1151 Feature 1151

#1256 Feature 1256

#2718 Feature 2718

#1423 Feature 1423

#1954 Feature 1954

#2168 Feature 2168

#1378 Feature 1378

#2639 Feature 2639

#1542 Feature 1542

#700 Feature 700

#921 Feature 921

#1620 Feature 1620

#2273 Feature 2273

#269 Feature 269

#2218 Feature 2218

#1940 Feature 1940

#2833 Feature 2833

#666 Feature 666

#753 Feature 753

#910 Feature 910

#485 Feature 485

#334 Feature 334

#1057 Feature 1057

#980 Feature 980

#2228 Feature 2228

#867 Feature 867

#820 Feature 820

#1149 Feature 1149

#3032 Feature 3032

#1357 Feature 1357

#1946 Feature 1946

#2674 Feature 2674

#1675 Feature 1675

#818 Feature 818

#1769 Feature 1769

#148 Feature 148

#547 Feature 547

#395 Feature 395

#1023 Feature 1023

#481 Feature 481

#2941 Feature 2941

#1379 Feature 1379

#1728 Feature 1728

#2032 Feature 2032

#2700 Feature 2700

#161 Feature 161

#286 Feature 286

#270 Feature 270

#796 Feature 796

#1577 Feature 1577

#2974 Feature 2974

#1560 Feature 1560

#2210 Feature 2210

#2633 Feature 2633

#939 Feature 939

#659 Feature 659

#2546 Feature 2546

#1711 Feature 1711

#3037 Feature 3037

#2154 Feature 2154

#2318 Feature 2318

#1934 Feature 1934

#2604 Feature 2604

#1930 Feature 1930

#688 Feature 688

#2278 Feature 2278

#250 Feature 250

#863 Feature 863

#2294 Feature 2294

#2509 Feature 2509

#495 Feature 495

#2522 Feature 2522

#1251 Feature 1251

#882 Feature 882

#463 Feature 463

#1267 Feature 1267

#731 Feature 731

#1331 Feature 1331

#1074 Feature 1074

#2351 Feature 2351

#1366 Feature 1366

#165 Feature 165

#297 Feature 297

#2106 Feature 2106

#1735 Feature 1735

#2658 Feature 2658

#3023 Feature 3023

#1747 Feature 1747

#1221 Feature 1221

#1610 Feature 1610

#2737 Feature 2737

#543 Feature 543

#1943 Feature 1943

#2020 Feature 2020

#2075 Feature 2075

#1368 Feature 1368

#2417 Feature 2417

#208 Feature 208

#1457 Feature 1457

#992 Feature 992

#2924 Feature 2924

#284 Feature 284

#1701 Feature 1701

#997 Feature 997

#2715 Feature 2715

#1884 Feature 1884

#209 Feature 209

#509 Feature 509

#405 Feature 405

#2646 Feature 2646

#2596 Feature 2596

#274 Feature 274

#2006 Feature 2006

#938 Feature 938

#1956 Feature 1956

#524 Feature 524

#2236 Feature 2236

#1597 Feature 1597

#1052 Feature 1052

#1080 Feature 1080

#1689 Feature 1689

#2536 Feature 2536

#436 Feature 436

#641 Feature 641

#2145 Feature 2145

#460 Feature 460

#1392 Feature 1392

#3052 Feature 3052

#1976 Feature 1976

#2312 Feature 2312

#1588 Feature 1588

#2878 Feature 2878

#1960 Feature 1960

#2432 Feature 2432

#2721 Feature 2721

#276 Feature 276

#373 Feature 373

#1875 Feature 1875

#379 Feature 379

#883 Feature 883

#1781 Feature 1781

#601 Feature 601

#304 Feature 304

#2555 Feature 2555

#589 Feature 589

#404 Interactions and Mechanisms

#2990 Feature 2990

#180 Feature 180

#1330 Feature 1330

#2222 Feature 2222

#2103 Feature 2103

#241 Feature 241

#2057 Feature 2057

#830 Feature 830

#1102 Feature 1102

#2374 Feature 2374

#1370 Feature 1370

#834 Feature 834

#2977 Feature 2977

#855 Feature 855

#2054 Feature 2054

#1671 Feature 1671

#1686 Feature 1686

#2500 Feature 2500

#553 Feature 553

#430 Feature 430

#1126 Feature 1126

#996 Feature 996

#548 Feature 548

#813 Feature 813

#2583 Feature 2583

#758 Feature 758

#2302 Feature 2302

#2858 Feature 2858

#1830 Feature 1830

#1894 Feature 1894

#798 Feature #798

#283 Feature 283

#2234 Feature 2234

#2755 Feature 2755

#995 Feature 995

#3065 Feature 3065

#2003 Feature 2003

#104 Feature 104

#327 Feature 327

#266 Feature 266

#1694 Feature 1694

#1291 Feature 1291

#2192 Feature 2192

#2172 Feature 2172

#1164 Feature 1164

#510 Feature 510

#2028 Feature 2028

#1997 Feature 1997

#201 Feature 201

#2279 Feature 2279

#2258 Feature 2258

#2634 Feature 2634

#2748 Feature 2748

#2901 Feature 2901

#2143 Feature 2143

#2530 Feature 2530

#917 Feature 917

#2955 Feature 2955

#1335 Feature 1335

#2767 Feature 2767

#1382 Feature 1382

#2356 Feature 2356

#2966 Feature 2966

#1637 Feature 1637

#1971 Feature 1971

#1752 Feature 1752

#2802 Feature 2802

#1654 Feature 1654

#2909 Feature 2909

#2607 Feature 2607

#577 Feature 577

#747 Feature 747

#1583 Feature 1583

#802 Feature 802

#1834 Feature 1834

#2334 Feature 2334

#2843 Feature 2843

#3056 Feature 3056

#2317 Feature 2317

#476 Feature 476

#1630 Feature 1630

#2944 Feature 2944

#794 Feature 794

#2304 Feature 2304

#2963 Feature 2963

#966 Feature 966

#1232 Feature 1232

#1632 Feature 1632

#1084 Feature 1084

#539 Feature 539

#2127 Feature 2127

#2749 Feature 2749

#391 Feature 391

#2864 Feature 2864

#173 Feature 173

#2656 Feature 2656

#2459 Feature 2459

#517 Feature 517

#736 Feature 736

#489 Feature 489

#906 Feature 906

#2126 Feature 2126

#1977 Feature 1977

#1496 Feature 1496

#2321 Feature 2321

#442 Feature 442

#807 Feature 807

#432 Feature 432

#1869 Feature 1869

#349 Feature 349

#1528 Feature 1528

#709 Feature 709

#228 Feature 228

#2881 Feature 2881

#2068 Feature 2068

#2174 Feature 2174

#623 Feature 623

#946 Feature 946

#1775 Feature 1775

#115 Feature 115

#211 Feature 211

#2205 Feature 2205

#154 Feature 154

#522 Feature 522

#2171 Molecular and Cellular Biological Processes

#1668 Feature 1668

#773 Feature 773

#422 Feature 422

#1929 Feature 1929

#1615 Feature 1615

#2814 Feature 2814

#2352 Feature 2352

#981 Feature 981

#238 Feature 238

#1016 Feature 1016

#969 Feature 969

#455 Feature 455

#979 Feature 979

#784 Feature 784

#2373 Feature 2373

#656 Feature 656

#819 Feature 819

#1363 Feature 1363

#943 Feature 943

#2211 Feature 2211

#624 Feature 624

#1449 Feature 1449

#1837 Feature 1837

#1562 Feature 1562

#2578 Feature 2578

#2288 Feature 2288

#2691 Feature 2691

#1970 Feature 1970

#2045 Feature 2045

#1957 Feature 1957

#1820 Feature 1820

#1531 Feature 1531

#2293 Feature 2293

#2782 Feature 2782

#265 Feature 265

#1662 Feature 1662

#1214 Feature 1214

#1007 Feature 1007

#2392 Feature 2392

#768 Feature 768

#230 Feature 230

#2549 Feature 2549

#2388 Feature 2388

#338 Feature 338

#2235 Feature 2235

#1874 Feature 1874

#1832 Feature 1832

#2430 Feature 2430

#909 Feature 909

#181 Feature 181

#880 Feature 880

#2227 Feature 2227

#1411 Feature 1411

#1299 Feature #1299

#2644 Feature 2644

#565 Feature 565

#903 Feature 903

#2193 Feature 2193

#1601 Feature 1601

#1540 Feature #1540

#2958 Feature 2958

#2431 Feature 2431

#2831 Feature 2831

#2136 Feature 2136

#383 Feature 383

#2722 Feature 2722

#1506 Justification/Rationale for Actions

#394 Feature 394

#670 Feature 670

#2468 Feature 2468

#1442 Feature 1442

#2849 Feature 2849

#3012 Feature 3012

#1372 Feature 1372

#2844 Feature 2844

#174 Feature 174

#1988 Feature 1988

#1893 Feature 1893

#1158 Feature 1158

#439 Feature 439

#609 Feature 609

#2100 Feature 2100

#1721 Feature 1721

#2353 Feature 2353

#1234 Feature 1234

#617 Feature 617

#2405 Feature 2405

#1091 Feature 1091

#2760 Feature 2760

#1156 Feature 1156

#2600 Feature 2600

#1115 Feature 1115

#1569 Feature 1569

#1661 Feature 1661

#1199 Feature 1199

#1282 Feature 1282

#976 Feature 976

#2873 Feature 2873

#2701 Feature 2701

#315 Feature 315

#2375 Feature 2375

#595 Feature 595

#847 Feature 847

#1439 Feature 1439

#1005 Feature 1005

#1725 Feature 1725

#962 Feature 962

#2824 Feature 2824

#210 Feature 210

#2556 Feature 2556

#2291 Feature 2291

#1474 Feature 1474

#156 Feature 156

#2300 Feature 2300

#2208 Feature 2208

#486 Feature 486

#662 Feature 662

#1070 Feature 1070

#916 Feature 916

#2289 Feature 2289

#1491 Feature 1491

#516 Feature 516

#1430 Feature 1430

#2872 Feature 2872

#1544 Feature 1544

#2058 Feature 2058

#1356 Feature 1356

#497 Feature 497

#1994 Feature 1994

#559 Feature 559

#849 Feature 849

#369 Feature 369

#1124 Feature 1124

#368 Feature 368

#2177 Feature 2177

#376 Feature 376

#2267 Feature 2267

#2496 Feature 2496

#205 Feature 205

#540 Feature 540

#1295 Feature 1295

#1222 Feature 1222

#2338 Feature 2338

#971 Feature 971

#2477 Feature 2477

#887 Feature 887

#1529 Feature 1529

#2217 Feature 2217

#824 Feature 824

#2369 Feature 2369

#866 Feature 866

#1040 Feature 1040

#437 Feature 437

#2856 Feature 2856

#1364 Feature 1364

#2704 Feature 2704

#1143 Feature 1143

#1261 Feature 1261

#645 Feature 645

#1396 Feature 1396

#438 Feature 438

#1726 Feature 1726

#1862 Feature 1862

#313 Feature 313

#856 Feature 856

#1321 Feature 1321

#1783 Feature 1783

#2125 Feature 2125

#127 Feature 127

#1296 Feature 1296

#1881 Feature 1881

#612 Feature 612

#2584 Feature 2584

#470 Feature 470

#220 Feature 220

#326 Feature 326

#247 Feature 247

#620 Feature 620

#2299 Feature 2299

#2857 Feature 2857

#812 Feature 812

#2503 Feature 2503

#868 Feature 868

#244 Feature 244

#3028 Feature 3028

#1619 Feature 1619

#1780 Feature 1780

#2346 Feature 2346

#629 Feature 629

#138 Feature 138

#2443 Feature 2443

#1351 Feature 1351

#2379 Feature 2379

#3049 Feature 3049

#2989 Feature 2989

#914 Feature 914

#2907 Feature 2907

#1548 Feature 1548

#1657 Feature 1657

#575 Feature 575

#951 Feature 951

#2482 Feature 2482

#2535 Feature 2535

#2922 Feature 2922

#2191 Feature 2191

#198 Feature 198

#2561 Feature 2561

#2466 Feature 2466

#1665 Feature 1665

#541 Feature 541

#769 Feature 769

#324 Feature 324

#2086 Feature 2086

#2182 Feature 2182

#1138 Feature 1138

#1163 Feature 1163

#1132 Feature 1132

#2695 Feature 2695

#1413 Feature 1413

#1257 Feature 1257

#1489 Feature 1489

#611 Feature 611

#2403 Feature 2403

#1445 Feature 1445

#2950 Feature 2950

#2793 Feature 2793

#2919 Feature 2919

#2969 Feature 2969

#2741 Feature 2741

#634 Feature 634

#1855 Feature 1855

#242 Feature 242

#3054 Feature 3054

#1208 Feature 1208

#2552 Feature 2552

#1589 Feature 1589

#2064 Feature 2064

#638 Feature 638

#2166 Feature 2166

#2027 Feature 2027

#2359 Feature 2359

#2574 Feature 2574

#1046 Feature 1046

#296 Feature 296

#2804 Feature 2804

#964 Feature 964

#440 Feature 440

#1365 Feature 1365

#1354 Feature 1354

#441 Feature 441

#1566 Feature 1566

#1287 Feature 1287

#2190 Feature 2190

#147 Feature 147

#1485 Feature 1485

#1498 Feature 1498

#248 Feature 248

#125 Feature 125

#2632 Feature 2632

#1328 Feature 1328

#2653 Feature 2653

#1912 Feature 1912

#2012 Feature 2012

#447 Feature 447

#1515 Feature 1515

#2548 Feature 2548

#692 Feature 692

#1318 Feature 1318

#942 Feature 942

#2951 Feature 2951

#2053 Feature 2053

#479 Feature 479

#2029 Feature 2029

#1433 Feature 1433

#2280 Feature 2280

#1061 Feature 1061

#392 Feature 392

#1835 Feature 1835

#2481 Feature 2481

#2938 Feature 2938

#197 Feature 197

#2735 Feature 2735

#2276 Feature 2276

#1882 Feature 1882

#1739 Feature 1739

#2846 Feature 2846

#1432 Feature 1432

#133 Feature 133

#1616 Feature 1616

#1895 Feature 1895

#2134 Feature 2134

#2975 Feature 2975

#2165 Feature 2165

#1910 Feature 1910

#196 Feature 196

#705 Feature 705

#2119 Feature 2119

#610 Feature 610

#1003 Feature 1003

#1871 Feature 1871

#1574 Feature 1574

#1552 Feature 1552

#2744 Feature 2744

#594 Feature 594

#2657 Feature 2657

#2962 Feature 2962

#2400 Feature 2400

#2021 Feature 2021

#2097 Feature 2097

#2109 Feature 2109

#714 Feature 714

#1469 Feature 1469

#2947 Feature 2947

#1511 Feature 1511

#827 Feature 827

#2631 Feature 2631

#1778 Feature 1778

#864 Feature 864

#2355 Feature 2355

#2141 Feature 2141

#2087 Feature 2087

#2180 Feature 2180

#1325 Feature 1325

#2841 Feature 2841

#2847 Feature 2847

#1420 Feature 1420

#1964 Feature 1964

#200 Feature 200

#1279 Feature 1279

#621 Feature 621

#419 Feature 419

#1235 Feature 1235

#1113 Feature 1113

#2169 Feature 2169

#1990 Feature 1990

Document Content

Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation.
We evaluated the protective activity (expressed as ED50 values in mg/kg of phenobarbital (PB, 120 min before testing) and valproate (30 min) alone or combined with caffeine in male mice with seizures induced by maximal electroshock (MES). Both antiepileptic drugs (AEDs) were administered by intraperitoneal (i.p.) injection in a single dose to mice receiving intraperitoneal caffeine either in a single dose 30 min before the test or as pretreatment every 12 h for 3 and 14 days. In addition, we determined the ED50 values of the AEDs 24 and 72 h after 14-day treatment with caffeine. Finally, we studied the influence of a challenge dose of caffeine, injected in mice 24 and 72 h after 14 days of treatment with caffeine, on the protective activity of PB or VPA. Caffeine in a single dose of 23.1 mg/kg reduced the anticonvulsant effect of PB. Its protective activity was further impaired after 3 and 14 days of caffeine treatment. The ED50 for VPA was significantly increased both by the single dose of caffeine and by chronic treatment. The anticonvulsant activity of PB and VPA measured 24 and 72 h after 14-day treatment with caffeine did not differ from control values, but a challenge dose of caffeine injected 24 or 72 h after daily injections for 14 days resulted in a significant reduction in the protective activity of both AEDs. Measurement of the total plasma levels of caffeine, VPA, and PB did not suggest pharmacokinetic interactions as an explanation for our results. Our results indicate that chronic caffeine exposure may progressively reduce the antiepileptic potency of VPA and PB.

Similar Documents