Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1518

MIN ACTIVATION

0.0

Details List

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#356 Feature 356

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#1083 Feature 1083

#1247 Feature 1247

#2425 Feature 2425

#253 Feature 253

#630 Feature 630

#683 Feature 683

#708 Drug Resistance Mechanisms in Cancer

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#3070 Spiritual and Holistic Care in Healthcare

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Document Content

Intrahepatic cholestasis due to systemic mastocytosis: a case report and review of literature.
A 35-yr-old female presented with symptoms of obstructive jaundice. Liver biopsy, bone marrow aspiration, and biopsy revealed systemic mastocytosis and acute myeloid leukemia. The liver biopsy specimen showed infiltration of mast cells within portal tracts with periductal and portal edema, irregularity of interlobular duct epithelium, and centrizonal cholestasis. Endoscopic retrograde cholangiography was normal. Following chemotherapy treatment with idarubicin and cytarabine for seven days for AML, the bilirubin levels continued to increase for two weeks and then decreased, reaching normal levels in two months. Infiltration of mast cells in the liver leads to hepatomegaly, liver function abnormality and rarely portal hypertension. Intrahepatic cholestasis due to systemic mastocytosis has never been reported. We report a rare case of systemic mastocytosis causing intrahepatic cholestasis that resolved with remission of AML following chemotherapy.

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