Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1501

MIN ACTIVATION

0.0

Details List

#672 Feature 672

#1028 Feature 1028

#2146 Feature 2146

#115 Feature 115

#708 Drug Resistance Mechanisms in Cancer

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#2340 Feature 2340

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#375 Feature 375

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#2199 Feature 2199

#436 Feature 436

#205 Feature 205

#2589 Feature 2589

#2419 Feature 2419

#3026 Feature 3026

#3037 Feature 3037

#1604 Feature 1604

#374 Medical Imaging and Oncology

#838 Feature 838

#2715 Feature 2715

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#2245 Feature 2245

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#2160 Feature 2160

#1606 Feature 1606

#1386 Feature 1386

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#2309 Feature 2309

#2132 Feature 2132

#2592 Feature 2592

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#877 Feature 877

#2702 Feature 2702

#2174 Feature 2174

#1972 Feature 1972

#1996 Feature 1996

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#1424 Feature 1424

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#2026 Feature 2026

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#2901 Feature 2901

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#941 Feature 941

#971 Feature 971

#1422 Feature 1422

#766 Feature 766

#1318 Feature 1318

#362 Feature 362

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#648 Feature 648

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#1601 Feature 1601

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#1652 Feature 1652

#541 Feature 541

#1125 Feature 1125

#965 Feature 965

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#1757 Feature 1757

#1616 Feature 1616

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#2048 Feature 2048

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#1351 Feature 1351

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#2343 Feature 2343

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#2021 Feature 2021

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#2591 Feature 2591

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#2030 Feature 2030

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#2188 Feature 2188

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#2439 Feature 2439

#1085 Feature 1085

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#1216 Feature 1216

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#1066 Feature 1066

#2261 Feature 2261

#2561 Feature 2561

#891 Feature 891

#456 Feature 456

#350 Feature 350

#973 Feature 973

#510 Feature 510

#597 Feature 597

#1196 Feature 1196

#3070 Spiritual and Holistic Care in Healthcare

#1459 Feature 1459

#1181 Feature 1181

#1464 Feature 1464

#627 Feature 627

#899 Feature 899

#2792 Feature 2792

#1492 Feature 1492

#133 Feature 133

#2813 Feature 2813

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#150 Feature 150

#422 Feature 422

#1625 Feature 1625

#1953 Feature 1953

#1286 Feature 1286

#1921 Feature 1921

#2104 Feature 2104

#2138 Feature 2138

#2737 Feature 2737

#933 Feature 933

#770 Feature 770

#2665 Feature 2665

#2042 Feature 2042

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#1328 Feature 1328

#2668 Feature 2668

#2556 Feature 2556

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#610 Feature 610

#1793 Feature 1793

#1920 Feature 1920

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#2300 Feature 2300

#2535 Feature 2535

#2227 Feature 2227

#1496 Feature 1496

#819 Feature 819

#2333 Feature 2333

#693 Feature 693

#1304 Feature 1304

#2872 Feature 2872

#861 Feature 861

#1792 Metastatic Cancer

#1488 Feature 1488

#2025 Feature 2025

#222 Feature 222

#2113 Feature 2113

#2818 Feature 2818

#738 Feature 738

#839 Feature 839

#309 Feature 309

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#1227 Feature 1227

#1582 Feature 1582

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#334 Feature 334

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#1006 Feature 1006

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#3056 Feature 3056

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#1869 Feature 1869

#2623 Feature 2623

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#3006 Feature 3006

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#2600 Feature 2600

#1115 Feature 1115

#2647 Feature 2647

#979 Feature 979

#963 Feature 963

#1421 Feature 1421

#1083 Feature 1083

#1263 Feature 1263

#2687 Feature 2687

#1693 Feature 1693

#1082 Feature 1082

#2241 Feature 2241

#656 Feature 656

#690 Feature 690

#986 Feature 986

#1863 Feature 1863

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#576 Feature 576

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#129 Feature 129

#2002 Feature 2002

#1000 Feature 1000

#1106 Feature 1106

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#2121 Feature 2121

#2402 Feature 2402

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#2999 Feature 2999

#2089 Feature 2089

#2213 Feature 2213

#405 Feature 405

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#2503 Feature 2503

#409 Feature 409

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#2135 Feature 2135

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#1523 Feature 1523

#2004 Feature 2004

#2555 Feature 2555

#2401 Feature 2401

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#1377 Feature 1377

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#1116 Feature 1116

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#2339 Feature 2339

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#2682 Feature 2682

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#1385 Feature 1385

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#114 Feature 114

#1631 Feature 1631

#2187 Feature 2187

#2362 Feature 2362

#2845 Feature 2845

#2016 Feature 2016

#2260 Historical Context & Development

#2909 Feature 2909

#187 Feature 187

#756 Feature 756

#427 Feature 427

#319 Feature 319

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#2162 Feature 2162

#636 Feature 636

#1556 Feature 1556

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#874 Feature 874

#1696 Feature 1696

#1054 Feature 1054

#2781 Feature 2781

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#250 Feature 250

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#1170 Feature 1170

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#2633 Feature 2633

#2453 Feature 2453

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#1315 Feature 1315

#2646 Feature 2646

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#2273 Feature 2273

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#1611 Feature 1611

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#2097 Feature 2097

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#1352 Feature 1352

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#2295 Feature 2295

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#1059 Feature 1059

#416 Feature 416

#1137 Feature 1137

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#2083 Feature 2083

#799 Feature 799

#2869 Feature 2869

#2232 Medical Case Reports & Cancer Research

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#1322 Feature 1322

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#2533 Feature 2533

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#1630 Feature 1630

#2043 Feature 2043

#3064 Surgical Complications and Physiological Stress

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#2546 Feature 2546

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#2935 Feature 2935

#221 Feature 221

#2551 Feature 2551

#2161 Medical/Scientific Discourse with Ethical/Social Implications

#1316 Feature 1316

#2399 Feature 2399

#2917 Feature 2917

#934 Feature 934

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#1984 Feature 1984

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#1429 Feature 1429

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#2189 Feature 2189

#527 Feature 527

#1712 Feature 1712

#420 Feature 420

#271 Feature 271

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#2740 Feature 2740

#2330 Feature 2330

#1514 Feature 1514

#2336 Feature 2336

#335 Feature 335

#2667 Feature 2667

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#640 Feature 640

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#453 Feature 453

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#615 Feature 615

#1975 Feature 1975

#1802 Feature 1802

#2511 Feature 2511

#2739 Feature 2739

#1870 Feature 1870

#1160 Feature 1160

#3036 Feature 3036

#2464 Feature 2464

#197 Feature 197

#223 Feature 223

#1993 Feature 1993

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#1420 Feature 1420

#2211 Feature 2211

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#2256 Feature 2256

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#2907 Feature 2907

#1113 Feature 1113

#3002 Feature 3002

#2182 Feature 2182

#853 Feature 853

#2406 Feature 2406

#138 Feature 138

#801 Feature 801

#1434 Feature 1434

#1542 Feature 1542

#285 Feature 285

#2007 Developmental Disparities & Intervention

#1468 Feature 1468

#2361 Feature 2361

#202 Feature 202

#645 Feature 645

#586 Feature 586

#1649 Feature 1649

#595 Feature 595

#684 Feature 684

#2265 Feature 2265

#2483 Feature 2483

#1413 Feature 1413

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Document Content

[Resistance to tumor specific therapy with imatinib by clonal selection of mutated cells].
A 60-year-old woman presented with night-sweats and increasing weakness. Physical examination revealed no abnormalities. For 27 years she had been treated for Philadelphia-positive chronic myeloid leukemia (CML). Because of progressive disease treatment with the tyrosine kinase inhibitor imatinib (STI571, Glivec (R)) had been started 9 months before. She had achieved complete hematological remission within 8 weeks, but not a cytogenetic response. Elevated WBC count (26.7/nl) with a differential displaying typical features of acceleration in bone marrow aspirate confirmed CML in accelerated phase. Sequencing of the ATP binding site of the BCR-ABL gene, which - at protein level - is the target for imatinib, revealed the clonal selection of cells harboring a point mutation leading to the exchange of amino acid 253 from tyrosine to histidine. This was considered to be the cause of resistance to imatinib. Dose increase of imatinib up to 600 mg daily and administration of cytarabine did not overcome resistance. Imatinib therapy was discontinued; hematologic remission was induced by oral therapy with hydroxyurea and mercaptopurine. In the course of the following 6 months a gradual decrease of the resistant clone from 100 % down to lower than the detection limit of the method was demonstrated. Clonal mutations are often the cause of resistance to imatinib therapy. They can be detected by sequencing of the ATP binding site of BCR-ABL in specialized laboratories. This case shows that discontinuation of imatinib therapy can significantly reduce the mutated (resistant) clone and thereby restore sensitivity to imatinib.

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