Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1515

MIN ACTIVATION

0.0

Details List

#1849 Feature 1849

#469 Feature 469

#561 Feature 561

#2044 Feature 2044

#2143 Feature 2143

#1320 Feature 1320

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#1161 Feature 1161

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#3017 Feature 3017

#1785 Feature 1785

#622 Feature 622

#2477 Feature 2477

#1442 Feature 1442

#2567 Feature 2567

#812 Feature 812

#585 Feature 585

#2171 Molecular and Cellular Biological Processes

#400 Feature 400

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#2265 Feature 2265

#1536 Feature 1536

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#1822 Feature 1822

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#2920 Feature 2920

#2127 Feature 2127

#370 Feature 370

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#1510 Feature 1510

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#1675 Feature 1675

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#2061 Feature 2061

#383 Feature 383

#2126 Feature 2126

#1397 Feature 1397

#1887 Feature 1887

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#2319 Feature 2319

#1131 Feature 1131

#1401 Feature 1401

#2620 Feature 2620

#1452 Feature 1452

#1374 Feature 1374

#2186 Feature 2186

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#2940 Feature 2940

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#1619 Feature 1619

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#2132 Feature 2132

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#2183 Feature 2183

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#976 Feature 976

#2955 Feature 2955

#3011 Feature 3011

#578 Feature 578

#1737 Feature 1737

#787 Feature 787

#669 Feature 669

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#2603 Instructional/Educational Content

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#2507 Feature 2507

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#1391 Feature 1391

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#3016 Feature 3016

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#1972 Feature 1972

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#2811 Feature 2811

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#2862 Feature 2862

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#2254 Feature 2254

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#2461 Feature 2461

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#2869 Feature 2869

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#887 Feature 887

#1113 Feature 1113

#338 Feature 338

#555 Feature 555

#1759 Feature 1759

#1892 Feature 1892

#998 Feature 998

#217 Feature 217

#404 Interactions and Mechanisms

#398 Feature 398

#1207 Feature 1207

#1321 Feature 1321

#1464 Feature 1464

#150 Feature 150

#649 Feature 649

#925 Feature 925

#2946 Feature 2946

#1020 Feature 1020

#2650 Feature 2650

#2562 Feature 2562

#1185 Feature 1185

#122 Feature 122

#1373 Feature 1373

#806 Feature 806

#826 Feature 826

#945 Feature 945

#1699 Feature 1699

#926 Feature 926

#208 Feature 208

#2779 Feature 2779

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#2058 Feature 2058

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#1651 Feature 1651

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#1924 Feature 1924

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#2472 Feature 2472

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#2867 Feature 2867

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#2175 Feature 2175

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#415 Feature 415

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#1500 Feature 1500

#2416 Feature 2416

#1338 Feature 1338

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Document Content

Levels of metalloproteinase (MMP-3, MMP-9), NF-kappaB ligand (RANKL), and nitric oxide (NO) in peripheral blood of osteoarthritis (OA) patients.
The aim of this study was to judge whether there is a correlation between some biochemical features of knee osteoarthritic blood and clinical characteristics and to evaluate the potential relationship between osteoarthitis (OA) severity and putative biomarkers for the disease. 105 patients suffering from knee OA were analyzed clinically (Lequesne's index) and radiographically (Kellgren and Lawrence, K&L). Plasma and peripheral blood mononuclear cells (PBMC) were harvested separately. Specimens were analyzed for concentrations of nitric oxide (NO), matrix metalloproteinase-3 (MMP-3), and matrix metalloproteinase-9 (MMP-9). Transcript levels of the receptor activator of NF-kB ligand (RANKL) mRNA, MMP-3mRNA, and MMP-9mRNA were measured using real-time quantitative RT-PCR. Data certified significantly increasing concentrations of plasma MMP-3, MMP-9, and NO as well as transcript levels of RANKL mRNA and MMP-9 mRNA in early OA (at grade I). There was a positive correlation of MMP-3 and MMP-9 content in plasma and MMP-9 mRNA expression levels in PBMC with the severity of clinical symptoms (total Lequesne's scores) in early OA. NO content in plasma correlated with total Lequesne's scores, pain scores in response to pressure, and swelling scores of early OA patients (atgGrade I). Analogously, there were positive correlations of RANKL mRNA expression with total Lequesne's scores, pain scores in response to pressure, and swelling scores in OA patients at Grade I. [corrected] Some biochemical factors, including content of NO, MMP-3, MMP-9, and transcript levels of some genes, including MMP-9 mRNA and RANKL mRNA, may be specific and sensitive enough to diagnose OA diseases at an early stage in the pathological process of OA when radiological features do not reflect degradation of articular cartilage. Therefore, proper regulation of these factors may be a promising and realistic new target for the treatment of degenerative osteoarticular diseases.

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