PRISMΔDB

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Active Features

1488

0.0
CLICK TO OPEN
Details List
#2358 Feature 2358
2.8
#198 Feature 198
2.7
#2856 Feature 2856
2.5
#964 Feature 964
2.3
#2018 Feature 2018
2.1
#1157 Feature 1157
2.1
#2957 Feature 2957
2.1
#938 Feature 938
2.1
#2803 Feature 2803
2.1
#231 Feature 231
2.0
#708 Drug Resistance Mechanisms in Cancer
1.9
#2138 Feature 2138
1.9
#1069 Feature 1069
1.9
#1853 Feature 1853
1.8
#2440 Feature 2440
1.8
#2562 Feature 2562
1.8
#2888 Feature 2888
1.7
#238 Feature 238
1.7
#832 Feature 832
1.7
#2545 Feature 2545
1.7
#2682 Feature 2682
1.6
#302 Feature 302
1.6
#701 Feature 701
1.6
#1158 Feature 1158
1.6
#1586 Feature 1586
1.6
#381 Feature 381
1.6
#1439 Feature 1439
1.6
#389 Feature 389
1.6
#2292 Feature 2292
1.5
#2833 Feature 2833
1.5
#1386 Feature 1386
1.5
#2740 Feature 2740
1.5
#2381 Feature 2381
1.5
#695 Feature 695
1.4
#1452 Feature 1452
1.4
#437 Feature 437
1.4
#1097 Feature 1097
1.4
#31 Feature 31
1.4
#1677 Feature 1677
1.4
#1722 Feature 1722
1.4
#1652 Feature 1652
1.4
#1368 Feature 1368
1.3
#1082 Feature 1082
1.3
#2992 Feature 2992
1.3
#2354 Feature 2354
1.3
#1680 Feature 1680
1.3
#1469 Feature 1469
1.3
#951 Feature 951
1.3
#1628 Feature 1628
1.3
#2220 Feature 2220
1.3
#2533 Feature 2533
1.3
#409 Feature 409
1.3
#25 Feature 25
1.3
#730 Feature 730
1.2
#2944 Feature 2944
1.2
#1266 Feature 1266
1.2
#2589 Feature 2589
1.2
#84 Feature 84
1.2
#1701 Feature 1701
1.2
#1974 Feature 1974
1.2
#2392 Feature 2392
1.2
#102 Feature 102
1.2
#548 Feature 548
1.2
#2024 Feature 2024
1.2
#2887 Feature 2887
1.2
#264 Feature 264
1.2
#1445 Feature 1445
1.2
#627 Feature 627
1.2
#2495 Feature 2495
1.2
#2789 Feature 2789
1.2
#770 Feature 770
1.2
#2977 Feature 2977
1.2
#1475 Feature 1475
1.2
#1846 Feature 1846
1.2
#2338 Feature 2338
1.2
#1404 Feature 1404
1.2
#583 Feature 583
1.2
#1348 Feature 1348
1.2
#1774 Feature 1774
1.2
#1753 Feature 1753
1.2
#667 Feature 667
1.2
#56 Feature 56
1.2
#2208 Feature 2208
1.2
#2456 Feature 2456
1.2
#135 Feature 135
1.2
#2859 Feature 2859
1.2
#958 Feature 958
1.2
#2005 Feature 2005
1.2
#2417 Feature 2417
1.2
#1009 Feature 1009
1.2
#1857 Feature 1857
1.2
#2214 Feature 2214
1.2
#2659 Feature 2659
1.2
#2848 Feature 2848
1.2
#186 Feature 186
1.2
#615 Feature 615
1.2
#1398 Feature 1398
1.2
#322 Feature 322
1.2
#196 Feature 196
1.2
#1631 Feature 1631
1.2
#1461 Feature 1461
1.2
#450 Feature 450
1.2
#2599 Feature 2599
1.2
#1244 Feature 1244
1.2
#1916 Feature 1916
1.2
#2829 Feature 2829
1.2
#1823 Feature 1823
1.2
#126 Feature 126
1.2
#2465 Feature 2465
1.2
#2874 Feature 2874
1.2
#1208 Feature 1208
1.1
#1925 Feature 1925
1.1
#1063 Feature 1063
1.1
#1419 Feature 1419
1.1
#707 Feature 707
1.1
#2559 Feature 2559
1.1
#1926 Feature 1926
1.1
#3037 Feature 3037
1.1
#861 Feature 861
1.1
#1828 Feature 1828
1.1
#862 Feature 862
1.1
#1307 Feature 1307
1.1
#2353 Feature 2353
1.1
#1448 Feature 1448
1.1
#2794 Feature 2794
1.1
#1721 Feature 1721
1.1
#201 Feature 201
1.1
#2372 Feature 2372
1.1
#2079 Feature 2079
1.1
#2026 Feature 2026
1.1
#1017 Feature 1017
1.1
#38 Feature 38
1.1
#1960 Feature 1960
1.1
#630 Feature 630
1.1
#1371 Feature 1371
1.1
#838 Feature 838
1.1
#1750 Feature 1750
1.1
#2003 Feature 2003
1.1
#2230 Feature 2230
1.1
#2630 Feature 2630
1.1
#1215 Feature 1215
1.1
#1964 Feature 1964
1.1
#2336 Feature 2336
1.1
#1567 Feature 1567
1.1
#802 Feature 802
1.1
#260 Feature 260
1.1
#1582 Feature 1582
1.1
#2435 Feature 2435
1.1
#1011 Feature 1011
1.1
#1360 Feature 1360
1.1
#1901 Feature 1901
1.1
#1897 Feature 1897
1.1
#215 Feature 215
1.1
#2936 Feature 2936
1.1
#2973 Feature 2973
1.1
#158 Feature 158
1.1
#2937 Feature 2937
1.1
#743 Feature 743
1.0
#2976 Feature 2976
1.0
#2333 Feature 2333
1.0
#1346 Feature 1346
1.0
#3042 Feature 3042
1.0
#613 Feature 613
1.0
#594 Feature 594
1.0
#1106 Feature 1106
1.0
#727 Feature 727
1.0
#1352 Feature 1352
1.0
#1460 Feature 1460
1.0
#2282 Feature 2282
1.0
#1560 Feature 1560
1.0
#1731 Feature 1731
1.0
#648 Feature 648
1.0
#987 Feature 987
1.0
#2676 Feature 2676
1.0
#2563 Feature 2563
1.0
#662 Feature 662
1.0
#2898 Feature 2898
1.0
#1451 Feature 1451
1.0
#2043 Feature 2043
1.0
#1946 Feature 1946
1.0
#759 Feature 759
1.0
#1590 Feature 1590
1.0
#1324 Feature 1324
1.0
#1204 Feature 1204
1.0
#2432 Feature 2432
1.0
#1065 Feature 1065
1.0
#1196 Feature 1196
1.0
#919 Feature 919
1.0
#3030 Feature 3030
1.0
#562 Feature 562
1.0
#2707 Feature 2707
1.0
#1099 Feature 1099
1.0
#2261 Feature 2261
1.0
#2351 Feature 2351
1.0
#1342 Feature 1342
1.0
#1515 Feature 1515
1.0
#2253 Feature 2253
1.0
#949 Feature 949
1.0
#1267 Feature 1267
1.0
#2866 Feature 2866
1.0
#2698 Feature 2698
1.0
#2877 Feature 2877
1.0
#2721 Feature 2721
1.0
#261 Feature 261
1.0
#1695 Feature 1695
1.0
#1610 Feature 1610
1.0
#1992 Feature 1992
1.0
#2270 Feature 2270
1.0
#1879 Feature 1879
1.0
#2019 Feature 2019
1.0
#1049 Feature 1049
1.0
#623 Feature 623
1.0
#1304 Feature 1304
1.0
#1229 Feature 1229
1.0
#2757 Feature 2757
0.9
#2742 Feature 2742
0.9
#2284 Feature 2284
0.9
#2996 Feature 2996
0.9
#1929 Feature 1929
0.9
#2885 Feature 2885
0.9
#2861 Feature 2861
0.9
#2797 Feature 2797
0.9
#2350 Feature 2350
0.9
#21 Feature 21
0.9
#2561 Feature 2561
0.9
#559 Feature 559
0.9
#1821 Feature 1821
0.9
#2919 Feature 2919
0.9
#1506 Justification/Rationale for Actions
0.9
#2420 Feature 2420
0.9
#1542 Feature 1542
0.9
#773 Feature 773
0.9
#2196 Feature 2196
0.9
#2895 Feature 2895
0.9
#837 Feature 837
0.9
#1054 Feature 1054
0.9
#847 Feature 847
0.9
#253 Feature 253
0.9
#1289 Feature 1289
0.9
#612 Feature 612
0.9
#407 Feature 407
0.9
#2585 Feature 2585
0.9
#1012 Feature 1012
0.9
#259 Feature 259
0.9
#2535 Feature 2535
0.9
#1640 Feature 1640
0.9
#1928 Feature 1928
0.9
#390 Feature 390
0.9
#177 Feature 177
0.9
#1604 Feature 1604
0.9
#1512 Feature 1512
0.9
#779 Feature 779
0.9
#1332 Feature 1332
0.9
#1279 Feature 1279
0.9
#11 Feature 11
0.9
#1552 Feature 1552
0.9
#2066 Feature 2066
0.9
#2666 Feature 2666
0.9
#928 Feature 928
0.9
#2806 Feature 2806
0.9
#1064 Feature 1064
0.9
#1126 Feature 1126
0.9
#2174 Feature 2174
0.9
#194 Feature 194
0.9
#2419 Feature 2419
0.9
#1588 Feature 1588
0.9
#1849 Feature 1849
0.9
#285 Feature 285
0.9
#70 Feature 70
0.9
#1337 Feature 1337
0.9
#1193 Feature 1193
0.9
#875 Feature 875
0.9
#677 Feature 677
0.9
#2991 Feature 2991
0.9
#2498 Feature 2498
0.9
#2068 Feature 2068
0.9
#1894 Feature 1894
0.9
#1518 Feature 1518
0.9
#2067 Feature 2067
0.9
#1187 Feature 1187
0.9
#1514 Feature 1514
0.9
#1119 Feature 1119
0.9
#1254 Feature 1254
0.9
#2490 Feature 2490
0.9
#1997 Feature 1997
0.9
#876 Feature 876
0.8
#108 Feature 108
0.8
#872 Feature 872
0.8
#1903 Feature 1903
0.8
#309 Feature 309
0.8
#3021 Feature 3021
0.8
#2473 Feature 2473
0.8
#740 Feature 740
0.8
#1047 Feature 1047
0.8
#413 Feature 413
0.8
#1615 Feature 1615
0.8
#1201 Feature 1201
0.8
#2318 Feature 2318
0.8
#1116 Feature 1116
0.8
#107 Feature 107
0.8
#761 Feature 761
0.8
#592 Feature 592
0.8
#1262 Feature 1262
0.8
#1388 Feature 1388
0.8
#2550 Feature 2550
0.8
#1720 Feature 1720
0.8
#2903 Feature 2903
0.8
#2749 Feature 2749
0.8
#1124 Feature 1124
0.8
#2369 Feature 2369
0.8
#2732 Feature 2732
0.8
#2045 Feature 2045
0.8
#557 Feature 557
0.8
#564 Feature 564
0.8
#2718 Feature 2718
0.8
#3048 Feature 3048
0.8
#2251 Feature 2251
0.8
#426 Feature 426
0.8
#2926 Feature 2926
0.8
#495 Feature 495
0.8
#633 Feature 633
0.8
#963 Feature 963
0.8
#380 Feature 380
0.8
#2151 Feature 2151
0.8
#3045 Feature 3045
0.8
#2050 Feature 2050
0.8
#1328 Feature 1328
0.8
#2612 Feature 2612
0.8
#418 Feature 418
0.8
#2617 Feature 2617
0.8
#300 Feature 300
0.8
#384 Feature 384
0.8
#688 Feature 688
0.8
#148 Feature 148
0.8
#1954 Feature 1954
0.8
#1870 Feature 1870
0.8
#15 Feature 15
0.8
#1221 Feature 1221
0.8
#1503 Feature 1503
0.8
#2750 Feature 2750
0.8
#1002 Feature 1002
0.8
#898 Feature 898
0.8
#317 Feature 317
0.8
#639 Feature 639
0.8
#204 Feature 204
0.8
#2909 Feature 2909
0.8
#334 Feature 334
0.8
#2668 Feature 2668
0.8
#684 Feature 684
0.8
#2376 Feature 2376
0.8
#524 Feature 524
0.8
#1090 Feature 1090
0.8
#66 Feature 66
0.8
#2304 Feature 2304
0.8
#1921 Feature 1921
0.8
#1224 Feature 1224
0.8
#2696 Feature 2696
0.8
#245 Feature 245
0.8
#1539 Feature 1539
0.8
#532 Feature 532
0.8
#614 Feature 614
0.8
#651 Feature 651
0.8
#3 Feature 3
0.8
#2313 Feature 2313
0.8
#2948 Feature 2948
0.8
#2813 Feature 2813
0.8
#1778 Feature 1778
0.8
#1066 Feature 1066
0.8
#374 Medical Imaging and Oncology
0.8
#2339 Feature 2339
0.8
#1058 Feature 1058
0.8
#1868 Feature 1868
0.8
#2784 Feature 2784
0.7
#1570 Feature 1570
0.7
#167 Feature 167
0.7
#2802 Feature 2802
0.7
#640 Feature 640
0.7
#1962 Feature 1962
0.7
#49 Feature 49
0.7
#2335 Feature 2335
0.7
#1121 Feature 1121
0.7
#2871 Feature 2871
0.7
#2370 Feature 2370
0.7
#2295 Feature 2295
0.7
#1657 Feature 1657
0.7
#2552 Feature 2552
0.7
#93 Feature 93
0.7
#2945 Feature 2945
0.7
#2023 Feature 2023
0.7
#2202 Feature 2202
0.7
#488 Feature 488
0.7
#1209 Feature 1209
0.7
#1323 Feature 1323
0.7
#1467 Feature 1467
0.7
#535 Feature 535
0.7
#1109 Feature 1109
0.7
#2838 Feature 2838
0.7
#2387 Feature 2387
0.7
#2382 Feature 2382
0.7
#512 Feature 512
0.7
#461 Feature 461
0.7
#595 Feature 595
0.7
#2761 Feature 2761
0.7
#1834 Feature 1834
0.7
#19 Feature 19
0.7
#2078 Feature 2078
0.7
#1880 Feature 1880
0.7
#2107 Feature 2107
0.7
#3040 Feature 3040
0.7
#2201 Feature 2201
0.7
#1833 Feature 1833
0.7
#2499 Feature 2499
0.7
#1456 Feature 1456
0.7
#2135 Feature 2135
0.7
#98 Feature 98
0.7
#998 Feature 998
0.7
#1732 Feature 1732
0.7
#1052 Feature 1052
0.7
#563 Feature 563
0.7
#2967 Feature 2967
0.7
#1179 Feature 1179
0.7
#2628 Feature 2628
0.7
#206 Feature 206
0.7
#1004 Feature 1004
0.7
#2716 Feature 2716
0.7
#1661 Feature 1661
0.7
#2108 Feature 2108
0.7
#1487 Feature 1487
0.7
#1513 Feature 1513
0.7
#1134 Feature 1134
0.7
#470 Feature 470
0.7
#877 Feature 877
0.7
#1792 Metastatic Cancer
0.7
#272 Feature 272
0.7
#1181 Feature 1181
0.7
#858 Feature 858
0.7
#844 Feature 844
0.7
#712 Feature 712
0.7
#2672 Feature 2672
0.7
#2951 Feature 2951
0.7
#2771 Feature 2771
0.7
#2360 Feature 2360
0.7
#2905 Feature 2905
0.7
#140 Feature 140
0.7
#2368 Feature 2368
0.7
#2161 Medical/Scientific Discourse with Ethical/Social Implications
0.7
#735 Feature 735
0.7
#533 Feature 533
0.7
#1831 Feature 1831
0.7
#2366 Feature 2366
0.7
#184 Feature 184
0.7
#2467 Feature 2467
0.7
#729 Feature 729
0.7
#1581 Feature 1581
0.7
#1737 Feature 1737
0.7
#934 Feature 934
0.7
#2590 Feature 2590
0.7
#42 Feature 42
0.7
#1149 Feature 1149
0.7
#386 Feature 386
0.7
#1370 Feature 1370
0.7
#2739 Feature 2739
0.7
#200 Feature 200
0.7
#497 Feature 497
0.7
#2608 Feature 2608
0.7
#2572 Feature 2572
0.7
#478 Feature 478
0.7
#295 Feature 295
0.7
#1489 Feature 1489
0.7
#1705 Feature 1705
0.7
#286 Feature 286
0.7
#2296 Feature 2296
0.7
#1762 Feature 1762
0.7
#516 Feature 516
0.7
#728 Feature 728
0.7
#1907 Feature 1907
0.6
#2455 Feature 2455
0.6
#1303 Feature 1303
0.6
#1105 Feature 1105
0.6
#1777 Feature 1777
0.6
#2931 Feature 2931
0.6
#997 Feature 997
0.6
#2380 Feature 2380
0.6
#2516 Feature 2516
0.6
#2142 Feature 2142
0.6
#1014 Feature 1014
0.6
#183 Feature 183
0.6
#855 Feature 855
0.6
#1681 Feature 1681
0.6
#1977 Feature 1977
0.6
#1556 Feature 1556
0.6
#372 Feature 372
0.6
#2385 Feature 2385
0.6
#1758 Feature 1758
0.6
#2058 Feature 2058
0.6
#2658 Feature 2658
0.6
#1871 Feature 1871
0.6
#2049 Feature 2049
0.6
#150 Feature 150
0.6
#2755 Feature 2755
0.6
#154 Feature 154
0.6
#2320 Feature 2320
0.6
#860 Feature 860
0.6
#1340 Feature 1340
0.6
#690 Feature 690
0.6
#2966 Feature 2966
0.6
#2033 Feature 2033
0.6
#290 Feature 290
0.6
#1430 Feature 1430
0.6
#2790 Feature 2790
0.6
#776 Feature 776
0.6
#1243 Feature 1243
0.6
#505 Feature 505
0.6
#1578 Feature 1578
0.6
#588 Feature 588
0.6
#2686 Feature 2686
0.6
#73 Feature 73
0.6
#1733 Feature 1733
0.6
#2772 Feature 2772
0.6
#1114 Feature 1114
0.6
#2062 Feature 2062
0.6
#357 Feature 357
0.6
#164 Feature 164
0.6
#2179 Feature 2179
0.6
#1886 Feature 1886
0.6
#892 Feature 892
0.6
#1634 Feature 1634
0.6
#1330 Feature 1330
0.6
#127 Feature 127
0.6
#103 Feature 103
0.6
#387 Feature 387
0.6
#501 Feature 501
0.6
#1548 Feature 1548
0.6
#131 Feature 131
0.6
#1980 Feature 1980
0.6
#205 Feature 205
0.6
#1107 Feature 1107
0.6
#2703 Feature 2703
0.6
#2175 Feature 2175
0.6
#3062 Feature 3062
0.6
#1334 Feature 1334
0.6
#1991 Feature 1991
0.6
#698 Feature 698
0.6
#2344 Feature 2344
0.6
#2604 Feature 2604
0.6
#899 Feature 899
0.6
#1561 Feature 1561
0.6
#91 Feature 91
0.6
#1694 Feature 1694
0.6
#242 Feature 242
0.6
#751 Feature 751
0.6
#686 Feature 686
0.6
#2947 Feature 2947
0.6
#554 Feature 554
0.6
#1995 Feature 1995
0.6
#771 Feature 771
0.6
#2799 Feature 2799
0.6
#2401 Feature 2401
0.6
#1611 Feature 1611
0.6
#2980 Feature 2980
0.6
#1779 Feature 1779
0.6
#1882 Feature 1882
0.6
#1205 Feature 1205
0.6
#683 Feature 683
0.6
#2956 Feature 2956
0.6
#2880 Feature 2880
0.6
#236 Feature 236
0.6
#2140 Feature 2140
0.6
#826 Feature 826
0.6
#868 Feature 868
0.6
#2415 Feature 2415
0.6
#464 Feature 464
0.6
#2425 Feature 2425
0.6
#13 Feature 13
0.6
#1534 Feature 1534
0.6
#913 Feature 913
0.6
#2705 Feature 2705
0.6
#1311 Molecular Mechanisms and Biological Processes
0.6
#3022 Feature 3022
0.6
#1333 Feature 1333
0.6
#1747 Feature 1747
0.6
#629 Feature 629
0.6
#506 Feature 506
0.6
#106 Feature 106
0.6
#3015 Feature 3015
0.6
#2822 Feature 2822
0.6
#48 Feature 48
0.6
#443 Feature 443
0.6
#144 Feature 144
0.6
#2940 Feature 2940
0.6
#400 Feature 400
0.6
#492 Feature 492
0.6
#129 Feature 129
0.6
#1911 Feature 1911
0.6
#1941 Feature 1941
0.6
#2001 Feature 2001
0.6
#2160 Feature 2160
0.6
#2858 Feature 2858
0.6
#341 Feature 341
0.6
#3032 Feature 3032
0.6
#2262 Feature 2262
0.6
#229 Feature 229
0.6
#1020 Feature 1020
0.6
#2340 Feature 2340
0.6
#1816 Feature 1816
0.6
#1755 Feature 1755
0.6
#235 Feature 235
0.6
#884 Feature 884
0.6
#567 Feature 567
0.6
#1236 Feature 1236
0.6
#2309 Feature 2309
0.5
#1210 Feature 1210
0.5
#1308 Feature 1308
0.5
#2782 Feature 2782
0.5
#1591 Feature 1591
0.5
#3000 Feature 3000
0.5
#1630 Feature 1630
0.5
#271 Feature 271
0.5
#2963 Feature 2963
0.5
#78 Feature 78
0.5
#10 Feature 10
0.5
#812 Feature 812
0.5
#2427 Feature 2427
0.5
#2849 Feature 2849
0.5
#1086 Feature 1086
0.5
#2008 Feature 2008
0.5
#1080 Feature 1080
0.5
#738 Feature 738
0.5
#68 Feature 68
0.5
#1295 Feature 1295
0.5
#377 Feature 377
0.5
#1441 Feature 1441
0.5
#767 Feature 767
0.5
#1873 Feature 1873
0.5
#895 Feature 895
0.5
#2673 Feature 2673
0.5
#2073 Feature 2073
0.5
#1798 Feature 1798
0.5
#1625 Feature 1625
0.5
#1021 Feature 1021
0.5
#1245 Feature 1245
0.5
#2580 Feature 2580
0.5
#404 Interactions and Mechanisms
0.5
#2650 Feature 2650
0.5
#668 Feature 668
0.5
#2712 Feature 2712
0.5
#7 Feature 7
0.5
#121 Feature 121
0.5
#2751 Feature 2751
0.5
#741 Feature 741
0.5
#2016 Feature 2016
0.5
#114 Feature 114
0.5
#2949 Feature 2949
0.5
#1935 Feature 1935
0.5
#1103 Feature 1103
0.5
#2357 Feature 2357
0.5
#1700 Feature 1700
0.5
#110 Feature 110
0.5
#2163 Feature 2163
0.5
#2878 Feature 2878
0.5
#219 Feature 219
0.5
#161 Feature 161
0.5
#990 Feature 990
0.5
#208 Feature 208
0.5
#2248 Feature 2248
0.5
#885 Feature 885
0.5
#188 Feature 188
0.5
#2701 Feature 2701
0.5
#1349 Feature 1349
0.5
#2834 Feature 2834
0.5
#636 Feature 636
0.5
#1508 Feature 1508
0.5
#3044 Feature 3044
0.5
#2332 Feature 2332
0.5
#1125 Feature 1125
0.5
#1297 Feature 1297
0.5
#2762 Feature 2762
0.5
#337 Feature 337
0.5
#2086 Feature 2086
0.5
#327 Feature 327
0.5
#1162 Feature 1162
0.5
#1160 Feature 1160
0.5
#1015 Feature 1015
0.5
#2341 Feature 2341
0.5
#2767 Feature 2767
0.5
#547 Feature 547
0.5
#427 Feature 427
0.5
#1786 Feature 1786
0.5
#2359 Feature 2359
0.5
#2523 Feature 2523
0.5
#568 Feature 568
0.5
#2491 Feature 2491
0.5
#2649 Feature 2649
0.5
#14 Feature 14
0.5
#965 Feature 965
0.5
#669 Feature 669
0.5
#1005 Feature 1005
0.5
#845 Feature 845
0.5
#642 Feature 642
0.5
#352 Feature 352
0.5
#60 Feature 60
0.5
#1061 Feature 1061
0.5
#2451 Feature #2451
0.5
#1407 Feature 1407
0.5
#1829 Feature 1829
0.5
#1382 Feature 1382
0.5
#1674 Feature 1674
0.5
#1482 Feature 1482
0.5
#2379 Feature 2379
0.5
#2146 Feature 2146
0.5
#2664 Feature 2664
0.5
#1378 Feature 1378
0.5
#2447 Feature 2447
0.5
#681 Feature 681
0.5
#539 Feature 539
0.5
#2621 Feature 2621
0.5
#2416 Feature 2416
0.5
#123 Feature 123
0.5
#1618 Feature 1618
0.5
#517 Feature 517
0.5
#887 Feature 887
0.5
#2393 Feature 2393
0.5
#2687 Feature 2687
0.5
#1665 Feature 1665
0.5
#1744 Feature 1744
0.5
#2153 Feature 2153
0.5
#2864 Feature 2864
0.5
#1905 Feature 1905
0.5
#970 Feature 970
0.5
#1301 Feature 1301
0.5
#2059 Feature 2059
0.5
#1406 Feature 1406
0.5
#2502 Feature 2502
0.5
#643 Feature 643
0.5
#747 Feature 747
0.5
#3018 Feature 3018
0.5
#522 Feature 522
0.5
#2525 Feature 2525
0.5
#2247 Feature 2247
0.5
#2842 Feature 2842
0.5
#2752 Feature 2752
0.5
#436 Feature 436
0.5
#816 Feature 816
0.5
#1495 Feature 1495
0.5
#376 Feature 376
0.5
#2532 Feature 2532
0.5
#2831 Feature 2831
0.5
#2507 Feature 2507
0.5
#1483 Feature 1483
0.5
#1231 Feature 1231
0.5
#1924 Feature 1924
0.5
#1417 Feature 1417
0.5
#1218 Feature 1218
0.5
#1796 Feature 1796
0.5
#820 Feature 820
0.5
#1814 Feature 1814
0.5
#2500 Feature 2500
0.5
#2548 Feature 2548
0.5
#2191 Feature 2191
0.5
#1159 Feature 1159
0.4
#2680 Feature 2680
0.4
#1602 Feature 1602
0.4
#795 Feature 795
0.4
#2209 Feature 2209
0.4
#350 Feature 350
0.4
#475 Feature 475
0.4
#678 Feature 678
0.4
#463 Feature 463
0.4
#218 Feature 218
0.4
#503 Feature 503
0.4
#170 Feature 170
0.4
#1458 Feature 1458
0.4
#2914 Feature 2914
0.4
#1432 Feature 1432
0.4
#465 Feature 465
0.4
#977 Feature 977
0.4
#1915 Feature 1915
0.4
#1476 Feature 1476
0.4
#1087 Feature 1087
0.4
#605 Feature 605
0.4
#2274 Feature 2274
0.4
#1410 Feature 1410
0.4
#2613 Feature 2613
0.4
#2314 Feature 2314
0.4
#2986 Feature 2986
0.4
#2714 Feature 2714
0.4
#3004 Feature 3004
0.4
#2566 Feature 2566
0.4
#1607 Feature 1607
0.4
#347 Feature 347
0.4
#1856 Feature 1856
0.4
#880 Feature 880
0.4
#1764 Feature 1764
0.4
#1622 Feature 1622
0.4
#2729 Feature 2729
0.4
#809 Feature 809
0.4
#3005 Feature 3005
0.4
#2210 Feature 2210
0.4
#1111 Feature 1111
0.4
#863 Feature 863
0.4
#1076 Feature 1076
0.4
#553 Feature 553
0.4
#2083 Feature 2083
0.4
#2900 Feature 2900
0.4
#556 Feature 556
0.4
#2388 Feature 2388
0.4
#452 Feature 452
0.4
#2185 Feature 2185
0.4
#1203 Feature 1203
0.4
#1206 Feature 1206
0.4
#1347 Feature 1347
0.4
#2238 Feature 2238
0.4
#1994 Feature 1994
0.4
#1654 Feature 1654
0.4
#1238 Feature 1238
0.4
#128 Feature 128
0.4
#2522 Feature 2522
0.4
#2263 Feature 2263
0.4
#2971 Feature 2971
0.4
#1854 Feature 1854
0.4
#2438 Feature 2438
0.4
#2176 Feature 2176
0.4
#30 Feature 30
0.4
#762 Feature 762
0.4
#306 Feature 306
0.4
#910 Feature 910
0.4
#87 Feature 87
0.4
#1621 Feature 1621
0.4
#2134 Feature 2134
0.4
#2555 Feature 2555
0.4
#1434 Feature 1434
0.4
#922 Feature 922
0.4
#1858 Feature 1858
0.4
#2946 Feature 2946
0.4
#723 Feature 723
0.4
#1748 Feature 1748
0.4
#1468 Feature 1468
0.4
#1278 Feature 1278
0.4
#330 Feature 330
0.4
#2414 Feature 2414
0.4
#2411 Feature 2411
0.4
#591 Feature 591
0.4
#760 Feature 760
0.4
#2245 Feature 2245
0.4
#1409 Feature 1409
0.4
#2582 Feature 2582
0.4
#145 Feature 145
0.4
#2776 Feature 2776
0.4
#758 Feature 758
0.4
#2234 Feature 2234
0.4
#2374 Feature 2374
0.4
#1719 Feature 1719
0.4
#221 Feature 221
0.4
#1761 Feature 1761
0.4
#2293 Feature 2293
0.4
#2149 Feature 2149
0.4
#345 Feature 345
0.4
#538 Feature 538
0.4
#168 Feature 168
0.4
#2406 Feature 2406
0.4
#2129 Feature 2129
0.4
#1366 Feature 1366
0.4
#410 Feature 410
0.4
#1131 Feature 1131
0.4
#2836 Feature 2836
0.4
#2088 Feature 2088
0.4
#1359 Feature 1359
0.4
#1424 Feature 1424
0.4
#1525 Feature 1525
0.4
#1048 Feature 1048
0.4
#2286 Feature 2286
0.4
#2539 Feature 2539
0.4
#1380 Feature 1380
0.4
#2786 Feature 2786
0.4
#2215 Feature 2215
0.4
#1369 Feature 1369
0.4
#1428 Feature 1428
0.4
#2607 Feature 2607
0.4
#361 Feature 361
0.4
#1801 Feature 1801
0.4
#543 Feature 543
0.4
#1263 Feature 1263
0.4
#241 Feature 241
0.4
#2756 Feature 2756
0.4
#2865 Feature 2865
0.4
#1793 Feature 1793
0.4
#2839 Feature 2839
0.4
#1953 Feature 1953
0.4
#180 Feature 180
0.4
#2204 Feature 2204
0.4
#753 Feature 753
0.4
#2661 Feature 2661
0.4
#1820 Feature 1820
0.4
#1290 Feature 1290
0.4
#1137 Feature 1137
0.4
#189 Feature 189
0.4
#2860 Feature 2860
0.4
#1579 Feature 1579
0.4
#871 Feature 871
0.4
#2164 Feature 2164
0.4
#2638 Feature 2638
0.4
#474 Surgical Procedures & Gastrointestinal Issues
0.4
#1771 Feature 1771
0.4
#2512 Feature 2512
0.4
#2197 Feature 2197
0.4
#1555 Feature 1555
0.4
#1716 Feature 1716
0.4
#2723 Feature 2723
0.4
#430 Feature 430
0.4
#2377 Feature 2377
0.4
#3054 Feature 3054
0.4
#1351 Feature 1351
0.4
#2027 Feature 2027
0.4
#2233 Feature 2233
0.4
#480 Feature 480
0.4
#746 Feature 746
0.4
#1527 Feature 1527
0.4
#1782 Feature 1782
0.4
#1985 Feature 1985
0.4
#1851 Feature 1851
0.4
#1765 Feature 1765
0.3
#1770 Feature 1770
0.3
#2064 Feature 2064
0.3
#2431 Feature 2431
0.3
#2280 Feature 2280
0.3
#2102 Feature 2102
0.3
#1922 Feature 1922
0.3
#1836 Feature 1836
0.3
#1480 Feature 1480
0.3
#1098 Feature 1098
0.3
#883 Feature 883
0.3
#1435 Feature 1435
0.3
#247 Feature 247
0.3
#947 Feature 947
0.3
#2301 Feature 2301
0.3
#726 Feature 726
0.3
#1619 Feature 1619
0.3
#217 Feature 217
0.3
#2222 Feature 2222
0.3
#342 Feature 342
0.3
#2862 Feature 2862
0.3
#2983 Feature 2983
0.3
#569 Feature 569
0.3
#2011 Feature 2011
0.3
#1706 Feature 1706
0.3
#2521 Feature 2521
0.3
#382 Feature 382
0.3
#1350 Feature 1350
0.3
#2017 Feature 2017
0.3
#2765 Feature 2765
0.3
#1645 Feature 1645
0.3
#1554 Feature 1554
0.3
#1632 Feature 1632
0.3
#26 Feature 26
0.3
#2126 Feature 2126
0.3
#582 Feature 582
0.3
#2791 Feature 2791
0.3
#459 Feature 459
0.3
#354 Feature 354
0.3
#2316 Feature 2316
0.3
#2299 Feature 2299
0.3
#1338 Feature 1338
0.3
#356 Feature 356
0.3
#2551 Feature 2551
0.3
#1572 Feature 1572
0.3
#444 Feature 444
0.3
#2150 Feature 2150
0.3
#886 Feature 886
0.3
#1390 Feature 1390
0.3
#1016 Feature 1016
0.3
#1541 Feature 1541
0.3
#1902 Feature 1902
0.3
#2226 Feature 2226
0.3
#874 Feature 874
0.3
#2462 Feature 2462
0.3
#2021 Feature 2021
0.3
#2678 Feature 2678
0.3
#1805 Feature 1805
0.3
#2365 Feature 2365
0.3
#2347 Feature 2347
0.3
#2104 Feature 2104
0.3
#2394 Feature 2394
0.3
#2224 Feature 2224
0.3
#2964 Feature 2964
0.3
#1639 Feature 1639
0.3
#1976 Feature 1976
0.3
#1200 Feature 1200
0.3
#2876 Feature 2876
0.3
#162 Feature 162
0.3
#823 Feature 823
0.3
#1986 Feature 1986
0.3
#94 Feature 94
0.3
#2367 Feature 2367
0.3
#2121 Feature 2121
0.3
#1038 Feature 1038
0.3
#1282 Feature 1282
0.3
#939 Feature 939
0.3
#2131 Feature 2131
0.3
#1488 Feature 1488
0.3
#2461 Feature 2461
0.3
#435 Feature 435
0.3
#1867 Feature 1867
0.3
#2453 Feature 2453
0.3
#504 Feature 504
0.3
#2798 Feature 2798
0.3
#1888 Feature 1888
0.3
#363 Feature 363
0.3
#3029 Feature 3029
0.3
#1993 Feature 1993
0.3
#72 Feature 72
0.3
#420 Feature 420
0.3
#1040 Feature 1040
0.3
#233 Feature 233
0.3
#3019 Feature 3019
0.3
#2868 Feature 2868
0.3
#2095 Feature 2095
0.3
#2386 Feature 2386
0.3
#1216 Feature 1216
0.3
#1466 Feature 1466
0.3
#493 Feature 493
0.3
#1000 Feature 1000
0.3
#1091 Feature 1091
0.3
#2671 Feature 2671
0.3
#403 Feature 403
0.3
#644 Feature 644
0.3
#472 Feature 472
0.3
#2779 Feature 2779
0.3
#467 Feature 467
0.3
#810 Feature 810
0.3
#2653 Feature 2653
0.3
#2030 Feature 2030
0.3
#370 Feature 370
0.3
#687 Feature 687
0.3
#2127 Feature 2127
0.3
#2322 Feature 2322
0.3
#2921 Feature 2921
0.3
#353 Feature 353
0.3
#2190 Feature 2190
0.3
#1240 Feature 1240
0.3
#1140 Feature 1140
0.3
#2553 Feature 2553
0.3
#2556 Feature 2556
0.3
#396 Feature 396
0.3
#1633 Feature 1633
0.3
#955 Feature 955
0.3
#2006 Feature 2006
0.3
#2168 Feature 2168
0.3
#2631 Feature 2631
0.3
#974 Feature 974
0.3
#2496 Feature 2496
0.3
#405 Feature 405
0.3
#2896 Feature 2896
0.3
#599 Feature 599
0.3
#2489 Feature 2489
0.3
#2629 Feature 2629
0.3
#2493 Feature 2493
0.3
#2213 Feature 2213
0.3
#2260 Historical Context & Development
0.3
#1832 Feature 1832
0.3
#1166 Feature 1166
0.3
#679 Feature 679
0.3
#132 Feature 132
0.3
#2355 Feature 2355
0.3
#89 Feature 89
0.3
#2843 Feature 2843
0.3
#2158 Feature 2158
0.3
#2171 Molecular and Cellular Biological Processes
0.3
#17 Feature 17
0.3
#2246 Feature 2246
0.3
#631 Feature 631
0.3
#697 Feature 697
0.3
#1372 Feature 1372
0.3
#719 Feature 719
0.3
#792 Feature 792
0.3
#2920 Feature 2920
0.3
#2665 Feature 2665
0.3
#1692 Feature 1692
0.2
#2675 Feature 2675
0.2
#596 Feature 596
0.2
#2509 Feature 2509
0.2
#364 Feature 364
0.2
#2852 Feature 2852
0.2
#1043 Feature 1043
0.2
#3058 Feature 3058
0.2
#1942 Feature 1942
0.2
#637 Feature 637
0.2
#373 Feature 373
0.2
#2458 Feature 2458
0.2
#3012 Feature 3012
0.2
#2934 Feature 2934
0.2
#1671 Feature 1671
0.2
#2640 Feature 2640
0.2
#780 Feature 780
0.2
#515 Feature 515
0.2
#692 Feature 692
0.2
#867 Feature 867
0.2
#2056 Feature 2056
0.2
#2069 Feature 2069
0.2
#1689 Feature 1689
0.2
#1071 Feature 1071
0.2
#2792 Feature 2792
0.2
#305 Feature 305
0.2
#507 Feature 507
0.2
#251 Feature 251
0.2
#1629 Feature 1629
0.2
#1164 Feature 1164
0.2
#45 Feature 45
0.2
#365 Feature 365
0.2
#2913 Feature 2913
0.2
#2122 Feature 2122
0.2
#2437 Feature 2437
0.2
#2162 Feature 2162
0.2
#1161 Feature 1161
0.2
#2758 Feature 2758
0.2
#2371 Feature 2371
0.2
#1664 Feature 1664
0.2
#179 Feature 179
0.2
#325 Feature 325
0.2
#2091 Feature 2091
0.2
#1112 Feature 1112
0.2
#2930 Feature 2930
0.2
#2474 Feature 2474
0.2
#3065 Feature 3065
0.2
#2917 Feature 2917
0.2
#368 Feature 368
0.2
#1883 Feature 1883
0.2
#2092 Feature 2092
0.2
#1496 Feature 1496
0.2
#1791 Feature 1791
0.2
#3057 Feature 3057
0.2
#181 Feature 181
0.2
#2527 Feature 2527
0.2
#1893 Feature 1893
0.2
#2637 Feature 2637
0.2
#2326 Feature 2326
0.2
#1197 Feature 1197
0.2
#2291 Feature 2291
0.2
#252 Feature 252
0.2
#1006 Feature 1006
0.2
#2837 Feature 2837
0.2
#2089 Feature 2089
0.2
#621 Feature 621
0.2
#959 Feature 959
0.2
#0 Feature 0
0.2
#1315 Feature 1315
0.2
#155 Feature 155
0.2
#2400 Feature 2400
0.2
#1 Feature 1
0.2
#1355 Feature 1355
0.2
#2227 Feature 2227
0.2
#649 Feature 649
0.2
#211 Feature 211
0.2
#878 Feature 878
0.2
#2469 Feature 2469
0.2
#581 Feature 581
0.2
#2911 Feature 2911
0.2
#1869 Feature 1869
0.2
#1519 Feature 1519
0.2
#1465 Feature 1465
0.2
#1575 Feature 1575
0.2
#1557 Feature 1557
0.2
#2278 Feature 2278
0.2
#1859 Feature 1859
0.2
#2475 Feature 2475
0.2
#1172 Feature 1172
0.2
#2997 Feature 2997
0.2
#694 Feature 694
0.2
#1585 Feature 1585
0.2
#2478 Feature 2478
0.2
#2568 Feature 2568
0.2
#656 Feature 656
0.2
#2958 Feature 2958
0.2
#1504 Feature 1504
0.2
#2325 Feature 2325
0.2
#1723 Feature 1723
0.2
#693 Feature 693
0.2
#2231 Feature 2231
0.2
#806 Feature 806
0.2
#2428 Feature 2428
0.2
#2832 Feature 2832
0.2
#1523 Feature 1523
0.2
#2924 Feature 2924
0.2
#638 Feature 638
0.2
#359 Feature 359
0.2
#2275 Feature 2275
0.2
#566 Feature 566
0.2
#1979 Feature 1979
0.2
#175 Feature 175
0.2
#1874 Feature 1874
0.2
#2801 Feature 2801
0.2
#896 Feature 896
0.2
#288 Feature 288
0.2
#853 Feature 853
0.2
#2485 Feature 2485
0.2
#2434 Feature 2434
0.2
#1927 Feature 1927
0.2
#2824 Feature 2824
0.2
#2000 Feature 2000
0.2
#1433 Feature 1433
0.2
#446 Feature 446
0.2
#924 Feature 924
0.2
#715 Feature 715
0.2
#1537 Feature 1537
0.2
#622 Feature 622
0.2
#713 Feature 713
0.2
#1571 Feature 1571
0.2
#1223 Feature 1223
0.2
#932 Feature 932
0.2
#1260 Feature 1260
0.2
#2397 Feature 2397
0.2
#3007 Feature 3007
0.2
#1317 Feature 1317
0.2
#3059 Feature 3059
0.2
#673 Feature 673
0.2
#549 Feature 549
0.2
#2989 Feature 2989
0.2
#1176 Feature 1176
0.2
#1354 Feature 1354
0.2
#1037 Feature 1037
0.2
#1813 Feature 1813
0.2
#2266 Feature 2266
0.2
#2961 Feature 2961
0.2
#2560 Feature 2560
0.2
#1313 Feature 1313
0.2
#46 Feature 46
0.2
#817 Feature 817
0.2
#2731 Feature 2731
0.2
#1281 Feature 1281
0.2
#2965 Feature 2965
0.2
#1676 Feature 1676
0.2
#2593 Feature 2593
0.2
#293 Feature 293
0.2
#1505 Feature 1505
0.1
#2106 Feature 2106
0.1
#2579 Feature 2579
0.1
#2237 Feature 2237
0.1
#2587 Feature 2587
0.1
#174 Feature 174
0.1
#2300 Feature 2300
0.1
#2221 Feature 2221
0.1
#1018 Feature 1018
0.1
#1195 Feature 1195
0.1
#700 Feature 700
0.1
#796 Feature 796
0.1
#1624 Feature 1624
0.1
#2611 Feature 2611
0.1
#1286 Feature 1286
0.1
#2715 Feature 2715
0.1
#1526 Feature 1526
0.1
#415 Feature 415
0.1
#3020 Feature 3020
0.1
#1457 Feature 1457
0.1
#1520 Feature 1520
0.1
#1595 Feature 1595
0.1
#2632 Feature 2632
0.1
#1996 Feature 1996
0.1
#2594 Feature 2594
0.1
#654 Feature 654
0.1
#146 Feature 146
0.1
#1270 Feature 1270
0.1
#2070 Feature 2070
0.1
#402 Feature 402
0.1
#2819 Feature 2819
0.1
#489 Feature 489
0.1
#1025 Feature 1025
0.1
#2953 Feature 2953
0.1
#2623 Feature 2623
0.1
#442 Feature 442
0.1
#2446 Feature 2446
0.1
#1414 Feature 1414
0.1
#2345 Feature 2345
0.1
#2764 Feature 2764
0.1
#313 Feature 313
0.1
#44 Feature 44
0.1
#1070 Feature 1070
0.1
#1470 Feature 1470
0.1
#255 Feature 255
0.1
#803 Feature 803
0.1
#2987 Feature 2987
0.1
#2541 Feature 2541
0.1
#2928 Feature 2928
0.1
#338 Feature 338
0.1
#335 Feature 335
0.1
#894 Feature 894
0.1
#2881 Feature 2881
0.1
#968 Feature 968
0.1
#2814 Feature 2814
0.1
#799 Feature 799
0.1
#1029 Feature 1029
0.1
#314 Feature 314
0.1
#2648 Feature 2648
0.1
#1817 Feature 1817
0.1
#2515 Feature 2515
0.1
#398 Feature 398
0.1
#1077 Feature 1077
0.1
#1784 Feature 1784
0.1
#1288 Feature 1288
0.1
#319 Feature 319
0.1
#1027 Feature 1027
0.1
#1743 Feature 1743
0.1
#1178 Feature 1178
0.1
#1035 Feature 1035
0.1
#1878 Feature 1878
0.1
#1128 Feature 1128
0.1
#2477 Feature 2477
0.1
#923 Feature 923
0.1
#1510 Feature 1510
0.1
#1549 Feature 1549
0.1
#1219 Feature 1219
0.1
#490 Feature 490
0.1
#805 Feature 805
0.1
#2389 Feature 2389
0.1
#1688 Feature 1688
0.1
#1757 Feature 1757
0.1
#2307 Feature 2307
0.1
#1294 Feature 1294
0.1
#32 Feature 32
0.1
#1072 Feature 1072
0.1
#408 Feature 408
0.1
#2244 Feature 2244
0.1
#541 Feature 541
0.1
#482 Feature 482
0.1
#1959 Feature 1959
0.1
#1036 Feature 1036
0.1
#1937 Feature 1937
0.1
#593 Feature 593
0.1
#2725 Feature 2725
0.1
#2390 Feature 2390
0.1
#1075 Feature 1075
0.1
#213 Feature 213
0.1
#1844 Feature 1844
0.1
#971 Feature 971
0.1
#299 Feature 299
0.1
#2743 Feature 2743
0.1
#983 Feature 983
0.1
#2744 Feature 2744
0.1
#950 Feature 950
0.1
#2015 Feature 2015
0.1
#602 Feature 602
0.1
#2679 Feature 2679
0.1
#139 Feature 139
0.1
#2298 Feature 2298
0.1
#1949 Feature 1949
0.1
#2702 Feature 2702
0.1
#711 Feature 711
0.1
#778 Feature 778
0.1
#2639 Feature 2639
0.1
#2188 Feature 2188
0.1
#1872 Feature 1872
0.1
#2674 Feature 2674
0.1
#2657 Feature 2657
0.1
#18 Feature 18
0.1
#1269 Feature 1269
0.1
#1538 Feature 1538
0.1
#270 Feature 270
0.1
#1727 Feature 1727
0.1
#1636 Feature 1636
0.1
#811 Feature 811
0.1
#2620 Feature 2620
0.1
#1971 Feature 1971
0.1
#3070 Spiritual and Holistic Care in Healthcare
0.1
#1990 Feature 1990
0.1
#1592 Feature 1592
0.1
#1094 Feature 1094
0.1
#2704 Feature 2704
0.1
#1626 Feature 1626
0.1
#113 Feature 113
0.1
#2009 Feature 2009
0.1
#2907 Feature 2907
0.1
#2990 Feature 2990
0.1
#383 Feature 383
0.1
#570 Feature 570
0.1
#1660 Feature 1660
0.1
#1227 Feature 1227
0.1
#1175 Feature 1175
0.1
#2236 Feature 2236
0.1
#2329 Feature 2329
0.1
#391 Feature 391
0.1
#1291 Feature 1291
0.1
#2793 Feature 2793
0.1
#2277 Feature 2277
0.1
#2841 Feature 2841
0.1
#2362 Feature 2362
0.1
#2402 Feature 2402
0.1
#1605 Feature 1605
0.1
#3024 Feature 3024
0.1
#731 Feature 731
0.1
#682 Feature 682
0.1
#283 Feature 283
0.1
#2644 Feature 2644
0.1
#2933 Feature 2933
0.1
#1255 Feature 1255
0.1
#274 Feature 274
0.1
#2902 Feature 2902
0.1
#750 Feature 750
0.1
#2399 Feature 2399
0.1
#672 Feature 672
0.1
#125 Feature 125
0.1
#2823 Feature 2823
0.1
#696 Feature 696
0.1
#824 Feature 824
0.1
#849 Feature 849
0.1
#941 Feature 941
0.1
#1395 Feature 1395
0.1
#852 Feature 852
0.1
#1127 Feature 1127
0.1
#1139 Feature 1139
0.1
#2361 Feature 2361
0.1
#43 Feature 43
0.0
#2195 Feature 2195
0.0
#2785 Feature 2785
0.0
#1276 Feature 1276
0.0
#2910 Feature 2910
0.0
#2169 Feature 2169
0.0
#915 Feature 915
0.0
#358 Feature 358
0.0
#16 Feature 16
0.0
#1956 Feature 1956
0.0
#485 Feature 485
0.0
#980 Feature 980
0.0
#65 Feature 65
0.0
#2540 Feature 2540
0.0
#2256 Feature 2256
0.0
#865 Feature 865
0.0
#973 Feature 973
0.0
#2808 Feature 2808
0.0
#744 Feature 744
0.0
#1516 Feature 1516
0.0
#1085 Feature 1085
0.0
#1322 Feature 1322
0.0
#936 Feature 936
0.0
#926 Feature 926
0.0
#2211 Feature 2211
0.0
#1144 Feature 1144
0.0
#999 Feature 999
0.0
#3067 Feature 3067
0.0
#2076 Feature 2076
0.0
#783 Feature 783
0.0
#1966 Feature 1966
0.0
#1726 Feature 1726
0.0
#2942 Feature 2942
0.0
#1673 Feature 1673
0.0
#53 Feature 53
0.0
#1666 Feature 1666
0.0
#1343 Feature 1343
0.0
#655 Feature 655
0.0
#2289 Feature 2289
0.0
#2514 Feature 2514
0.0
#392 Feature 392
0.0
#2667 Feature 2667
0.0
#617 Feature 617
0.0
#378 Feature 378
0.0
#109 Feature 109
0.0
#2513 Feature 2513
0.0
#2975 Feature 2975
0.0
#754 Feature 754
0.0
#1246 Feature 1246
0.0
#1326 Feature 1326
0.0
#616 Feature 616
0.0
#1713 Feature 1713
0.0
#2728 Feature 2728
0.0
#118 Feature 118
0.0
#1845 Feature 1845
0.0
#502 Feature 502
0.0
#1273 Feature 1273
0.0
#1835 Feature 1835
0.0
#1808 Feature 1808
0.0
#2430 Feature 2430
0.0
#511 Feature 511
0.0
#2373 Feature 2373
0.0
#2683 Feature 2683
0.0
#3061 Feature 3061
0.0
#930 Feature 930
0.0
#2141 Feature 2141
0.0
#1299 Feature 1299
0.0
#100 Feature 100
0.0
#1383 Feature 1383
0.0
#1891 Feature 1891
0.0
#790 Feature 790
0.0
#2178 Feature 2178
0.0
#2288 Feature 2288
0.0
#675 Feature 675
0.0
#1529 Feature 1529
0.0
#2405 Feature 2405
0.0
#1146 Feature 1146
0.0
#249 Feature 249
0.0
#2172 Feature 2172
0.0
#316 Feature 316
0.0
Document Content

Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways.
Naringenin, the aglycone of naringin, has been reported to attenuate MUC5AC secretion by inhibiting activity of nuclear factor kappa B (NF-κB) via EGFR-PI3K-Akt/ERK MAPKinase signaling pathways. However, previous studies demonstrated that the MUC5AC promoter was located in two different regions: an activator protein-1 (AP-1) binding site and a NF-κB binding site. The current study comprehensively determined the involvement of MAPKs/AP-1 and IKKs/IκB/NF-κB in epidermal growth factor (EGF)-induced A549 cells, and sought to ascertain the signaling pathways of naringin imparted in suppression of EGF-induced MUC5AC secretion. The results showed that naringin of 100 μM not only significantly decreased EGF-induced overexpressions of both MUC5AC mucin and mRNA in A549 cells, but also suppressed the phosphorylation of EGF receptor, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK), as well as nucleus NF-κB p65 and AP-1. Moreover, any of three MAPKs inhibitors (PD98059, SB203580, and SP600125) significantly inhibited EGF-induced MUC5AC secretion. And as compared to MG132, the inhibitor κB (IκB) phosphorylation inhibitor of SN50 was more effective in reducing EGF-induced MUC5AC secretion because of suppression of nucleus AP-1. Meanwhile, as compared to naringin, both SP600125 and azithromycin were less effective in suppressing EGF-induced secretion of MUC5AC because of the unchanged nucleus NF-κB p65. These results indicated that naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs/AP-1 and IKKs/IκB/NF-κB signaling pathways.

Similar Documents