Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1521

MIN ACTIVATION

0.0

Details List

#997 Feature 997

#1695 Feature 1695

#1266 Feature 1266

#463 Feature 463

#2462 Feature 2462

#708 Drug Resistance Mechanisms in Cancer

#437 Feature 437

#436 Feature 436

#405 Feature 405

#1346 Feature 1346

#1367 Feature 1367

#1834 Feature 1834

#497 Feature 497

#2028 Feature 2028

#108 Feature 108

#2845 Feature 2845

#1116 Feature 1116

#960 Feature 960

#1548 Feature 1548

#317 Feature 317

#2914 Feature 2914

#565 Feature 565

#2033 Feature 2033

#2070 Feature 2070

#2291 Feature 2291

#2562 Feature 2562

#2692 Feature 2692

#627 Feature 627

#2251 Feature 2251

#1028 Feature 1028

#740 Feature 740

#150 Feature 150

#990 Feature 990

#2309 Feature 2309

#672 Feature 672

#144 Feature 144

#1965 Feature 1965

#633 Feature 633

#1805 Feature 1805

#1920 Feature 1920

#1492 Feature 1492

#1537 Feature 1537

#1487 Feature 1487

#2354 Feature 2354

#2090 Feature 2090

#1476 Feature 1476

#550 Feature 550

#2880 Feature 2880

#1130 Feature 1130

#1202 Feature 1202

#1905 Feature 1905

#2561 Feature 2561

#1025 Feature 1025

#1451 Feature 1451

#548 Feature 548

#1248 Feature 1248

#2495 Feature 2495

#1683 Feature 1683

#2459 Feature 2459

#1329 Feature 1329

#1042 Feature 1042

#1210 Feature 1210

#1484 Feature 1484

#1731 Feature 1731

#1888 Feature 1888

#1262 Feature 1262

#1481 Feature 1481

#2790 Feature 2790

#2208 Feature 2208

#886 Feature 886

#581 Feature 581

#1565 Feature 1565

#1896 Feature 1896

#555 Feature 555

#2657 Feature 2657

#1200 Feature 1200

#430 Feature 430

#1434 Feature 1434

#2632 Feature 2632

#2174 Feature 2174

#2015 Feature 2015

#283 Feature 283

#602 Feature 602

#2817 Feature 2817

#2531 Feature 2531

#253 Feature 253

#402 Feature 402

#133 Feature 133

#138 Feature 138

#1297 Feature 1297

#1935 Feature 1935

#334 Feature 334

#2160 Feature 2160

#1109 Feature 1109

#243 Feature 243

#3026 Feature 3026

#916 Feature 916

#223 Feature 223

#2243 Feature 2243

#1963 Feature 1963

#1425 Feature 1425

#374 Medical Imaging and Oncology

#180 Feature 180

#375 Feature 375

#757 Feature 757

#1488 Feature 1488

#386 Feature 386

#2555 Feature 2555

#1365 Feature 1365

#115 Feature 115

#1205 Feature 1205

#1582 Feature 1582

#183 Feature 183

#2545 Feature 2545

#2938 Feature 2938

#201 Feature 201

#316 Feature 316

#1668 Feature 1668

#1161 Feature 1161

#2676 Feature 2676

#2132 Feature 2132

#2867 Feature 2867

#913 Feature 913

#2111 Feature 2111

#838 Feature 838

#2372 Feature 2372

#600 Feature 600

#2649 Feature 2649

#1099 Feature 1099

#1004 Feature 1004

#1237 Feature 1237

#2022 Feature 2022

#1994 Feature 1994

#515 Feature 515

#2133 Feature 2133

#1809 Feature 1809

#2598 Feature 2598

#2946 Feature 2946

#1131 Feature 1131

#356 Feature 356

#1811 Feature 1811

#2608 Feature 2608

#1556 Feature 1556

#695 Feature 695

#2477 Feature 2477

#1377 Feature 1377

#2567 Feature 2567

#950 Feature 950

#2479 Feature 2479

#2318 Feature 2318

#3060 Feature 3060

#1515 Feature 1515

#936 Feature 936

#976 Feature 976

#1231 Feature 1231

#547 Feature 547

#3048 Feature 3048

#274 Feature 274

#2276 Feature 2276

#1738 Feature 1738

#767 Feature 767

#2803 Feature 2803

#2909 Feature 2909

#2636 Feature 2636

#2559 Feature 2559

#2720 Feature 2720

#2313 Feature 2313

#247 Feature 247

#1192 Feature 1192

#425 Feature 425

#2671 Feature 2671

#1868 Feature 1868

#1903 Feature 1903

#1984 Feature 1984

#196 Feature 196

#934 Feature 934

#2432 Feature 2432

#567 Feature 567

#1709 Feature 1709

#639 Feature 639

#637 Feature 637

#899 Feature 899

#753 Feature 753

#1897 Feature 1897

#670 Feature 670

#1198 Feature 1198

#1972 Feature 1972

#1874 Feature 1874

#761 Feature 761

#1085 Feature 1085

#2646 Feature 2646

#1149 Feature 1149

#580 Feature 580

#3044 Feature 3044

#1700 Feature 1700

#2085 Feature 2085

#510 Feature 510

#2358 Feature 2358

#1512 Feature 1512

#2419 Feature 2419

#1083 Feature 1083

#2572 Feature 2572

#443 Feature 443

#2156 Feature 2156

#808 Feature 808

#1610 Feature 1610

#2339 Feature 2339

#2440 Feature 2440

#507 Feature 507

#729 Feature 729

#2698 Feature 2698

#1950 Feature 1950

#1063 Feature 1063

#276 Feature 276

#2292 Feature 2292

#624 Feature 624

#773 Feature 773

#819 Feature 819

#861 Feature 861

#2163 Feature 2163

#2514 Feature 2514

#2453 Feature 2453

#1604 Feature 1604

#723 Feature 723

#309 Feature 309

#1114 Feature 1114

#1628 Feature 1628

#1852 Feature 1852

#2224 Feature 2224

#981 Feature 981

#2792 Feature 2792

#112 Feature 112

#1094 Feature 1094

#709 Feature 709

#2086 Feature 2086

#1011 Feature 1011

#1761 Feature 1761

#2662 Feature 2662

#1319 Feature 1319

#3032 Feature 3032

#2588 Feature 2588

#1050 Feature 1050

#1792 Metastatic Cancer

#698 Feature 698

#239 Feature 239

#2591 Feature 2591

#1115 Feature 1115

#3037 Feature 3037

#1831 Feature 1831

#738 Feature 738

#1911 Feature 1911

#1195 Feature 1195

#1339 Feature 1339

#2767 Feature 2767

#800 Feature 800

#251 Feature 251

#2078 Feature 2078

#826 Feature 826

#1867 Feature 1867

#1501 Feature 1501

#634 Feature 634

#1819 Feature 1819

#1082 Feature 1082

#952 Feature 952

#2984 Feature 2984

#2012 Feature 2012

#1593 Feature 1593

#2385 Feature 2385

#1606 Feature 1606

#268 Feature 268

#2999 Feature 2999

#289 Feature 289

#286 Feature 286

#2088 Feature 2088

#699 Feature 699

#403 Feature 403

#2672 Feature 2672

#2736 Feature 2736

#643 Feature 643

#1436 Feature 1436

#1620 Feature 1620

#1460 Feature 1460

#135 Feature 135

#179 Feature 179

#679 Feature 679

#2640 Feature 2640

#357 Feature 357

#686 Feature 686

#221 Feature 221

#2696 Feature 2696

#2351 Feature 2351

#235 Feature 235

#1936 Feature 1936

#2744 Feature 2744

#597 Feature 597

#111 Feature 111

#1417 Feature 1417

#857 Feature 857

#2838 Feature 2838

#1658 Feature 1658

#1625 Feature 1625

#1753 Feature 1753

#1407 Feature 1407

#693 Feature 693

#2138 Feature 2138

#1308 Feature 1308

#1404 Feature 1404

#1431 Feature 1431

#1398 Feature 1398

#1799 Feature 1799

#503 Feature 503

#2955 Feature 2955

#2613 Feature 2613

#1913 Feature 1913

#1355 Feature 1355

#2913 Feature 2913

#2408 Feature 2408

#1225 Feature 1225

#1546 Feature 1546

#2579 Feature 2579

#3059 Feature 3059

#372 Feature 372

#1478 Feature 1478

#1649 Feature 1649

#2209 Feature 2209

#2799 Feature 2799

#1577 Feature 1577

#2907 Feature 2907

#2621 Feature 2621

#2265 Feature 2265

#882 Feature 882

#118 Feature 118

#739 Feature 739

#2683 Feature 2683

#1445 Feature 1445

#1954 Feature 1954

#158 Feature 158

#1179 Feature 1179

#383 Feature 383

#2822 Feature 2822

#1631 Feature 1631

#568 Feature 568

#462 Feature 462

#824 Feature 824

#340 Feature 340

#1540 Feature 1540

#3007 Feature 3007

#830 Feature 830

#1087 Feature 1087

#2250 Feature 2250

#1012 Feature 1012

#2870 Feature 2870

#1539 Feature 1539

#1452 Feature 1452

#2245 Feature 2245

#2759 Feature 2759

#770 Feature 770

#2128 Feature 2128

#2264 Feature 2264

#362 Feature 362

#1046 Feature 1046

#2518 Feature 2518

#2308 Feature 2308

#170 Feature 170

#341 Feature 341

#2857 Feature 2857

#563 Feature 563

#1078 Feature 1078

#1677 Feature 1677

#575 Feature 575

#890 Feature 890

#1164 Feature 1164

#191 Feature 191

#371 Feature 371

#1420 Feature 1420

#1948 Feature 1948

#2667 Feature 2667

#700 Feature 700

#2715 Feature 2715

#2437 Feature 2437

#867 Feature 867

#211 Feature 211

#1777 Feature 1777

#2779 Feature 2779

#2280 Feature 2280

#1508 Feature 1508

#1987 Feature 1987

#363 Feature 363

#1826 Feature 1826

#2928 Feature 2928

#1156 Feature 1156

#1181 Feature 1181

#2806 Feature 2806

#2619 Feature 2619

#2828 Feature 2828

#1247 Feature 1247

#1243 Feature 1243

#1017 Feature 1017

#249 Feature 249

#2010 Feature 2010

#1550 Feature 1550

#556 Feature 556

#2336 Feature 2336

#2042 Feature 2042

#2394 Feature 2394

#252 Feature 252

#302 Feature 302

#220 Feature 220

#2040 Feature 2040

#2496 Feature 2496

#558 Feature 558

#2382 Feature 2382

#527 Feature 527

#1304 Feature 1304

#930 Feature 930

#2576 Feature 2576

#1870 Feature 1870

#1518 Feature 1518

#810 Feature 810

#389 Feature 389

#2599 Feature 2599

#1218 Feature 1218

#2997 Feature 2997

#1047 Feature 1047

#297 Feature 297

#845 Feature 845

#2990 Feature 2990

#1671 Feature 1671

#1932 Feature 1932

#2769 Feature 2769

#1513 Feature 1513

#2533 Feature 2533

#1971 Feature 1971

#2816 Feature 2816

#2575 Feature 2575

#2481 Feature 2481

#2423 Feature 2423

#241 Feature 241

#190 Feature 190

#887 Feature 887

#2463 Feature 2463

#350 Feature 350

#1549 Feature 1549

#2527 Feature 2527

#701 Feature 701

#2931 Feature 2931

#2504 Feature 2504

#2101 Feature 2101

#587 Feature 587

#2413 Feature 2413

#781 Feature 781

#2491 Feature 2491

#2024 Feature 2024

#2543 Feature 2543

#2865 Feature 2865

#1067 Feature 1067

#337 Feature 337

#2930 Feature 2930

#2566 Feature 2566

#1844 Feature 1844

#802 Feature 802

#2340 Feature 2340

#2464 Feature 2464

#1336 Feature 1336

#1359 Feature 1359

#421 Feature 421

#1288 Feature 1288

#1588 Feature 1588

#1241 Feature 1241

#215 Feature 215

#541 Feature 541

#827 Feature 827

#419 Feature 419

#1538 Feature 1538

#1350 Feature 1350

#1441 Feature 1441

#3031 Feature 3031

#662 Feature 662

#1924 Feature 1924

#2742 Feature 2742

#2506 Feature 2506

#2633 Feature 2633

#2525 Feature 2525

#2188 Feature 2188

#2637 Feature 2637

#152 Feature 152

#1066 Feature 1066

#417 Feature 417

#554 Feature 554

#1121 Feature 1121

#1223 Feature 1223

#165 Feature 165

#2797 Feature 2797

#938 Feature 938

#1142 Feature 1142

#1203 Feature 1203

#2337 Feature 2337

#880 Feature 880

#2343 Feature 2343

#760 Feature 760

#1295 Feature 1295

#1268 Feature 1268

#254 Feature 254

#961 Feature 961

#2529 Feature 2529

#3017 Feature 3017

#1632 Feature 1632

#1639 Feature 1639

#2412 Feature 2412

#987 Feature 987

#2261 Feature 2261

#320 Feature 320

#766 Feature 766

#649 Feature 649

#847 Feature 847

#1376 Feature 1376

#140 Feature 140

#967 Feature 967

#2739 Feature 2739

#524 Feature 524

#889 Feature 889

#1106 Feature 1106

#2222 Feature 2222

#2945 Feature 2945

#1496 Feature 1496

#287 Feature 287

#1423 Feature 1423

#2669 Feature 2669

#1348 Feature 1348

#2027 Feature 2027

#1374 Feature 1374

#884 Feature 884

#214 Feature 214

#1829 Feature 1829

#2612 Feature 2612

#446 Feature 446

#837 Feature 837

#2635 Feature 2635

#2467 Feature 2467

#136 Feature 136

#2404 Feature 2404

#2985 Feature 2985

#2119 Feature 2119

#387 Feature 387

#1318 Feature 1318

#759 Feature 759

#1828 Feature 1828

#2878 Feature 2878

#1701 Feature 1701

#260 Feature 260

#125 Feature 125

#218 Feature 218

#1051 Feature 1051

#1686 Feature 1686

#3028 Feature 3028

#1793 Feature 1793

#1137 Feature 1137

#798 Feature 798

#1771 Feature 1771

#885 Feature 885

#1303 Feature 1303

#2332 Feature 2332

#1856 Feature 1856

#792 Feature 792

#2682 Feature 2682

#1446 Feature 1446

#2712 Feature 2712

#2918 Feature 2918

#2516 Feature 2516

#1853 Feature 1853

#831 Feature 831

#2755 Feature 2755

#941 Feature 941

#1609 Feature 1609

#1861 Feature 1861

#1630 Feature 1630

#498 Feature 498

#2957 Feature 2957

#3008 Feature 3008

#1815 Feature 1815

#2204 Feature 2204

#1840 Feature 1840

#1144 Feature 1144

#979 Feature 979

#1315 Feature 1315

#2319 Feature 2319

#413 Feature 413

#1544 Feature 1544

#675 Feature 675

#2502 Feature 2502

#2904 Feature 2904

#939 Feature 939

#1796 Feature 1796

#2029 Feature 2029

#2082 Feature 2082

#532 Feature 532

#102 Feature 102

#895 Feature 895

#2820 Feature 2820

#2368 Feature 2368

#1134 Feature 1134

#1597 Feature 1597

#1330 Feature 1330

#1693 Feature 1693

#2601 Feature 2601

#3018 Feature 3018

#2628 Feature 2628

#2253 Feature 2253

#1890 Feature 1890

#1722 Feature 1722

#1882 Feature 1882

#314 Feature 314

#2244 Feature 2244

#313 Feature 313

#2785 Feature 2785

#943 Feature 943

#2066 Feature 2066

#154 Feature 154

#2724 Feature 2724

#477 Feature 477

#2761 Feature 2761

#2939 Feature 2939

#284 Feature 284

#2498 Feature 2498

#915 Feature 915

#2770 Feature 2770

#2943 Feature 2943

#1801 Feature 1801

#205 Feature 205

#2455 Feature 2455

#1113 Feature 1113

#127 Feature 127

#424 Feature 424

#2352 Feature 2352

#2541 Feature 2541

#2665 Feature 2665

#273 Feature 273

#2716 Feature 2716

#1627 Feature 1627

#1535 Feature 1535

#665 Feature 665

#516 Feature 516

#3039 Feature 3039

#3053 Feature 3053

#2975 Feature 2975

#1730 Feature 1730

#2718 Feature 2718

#187 Feature 187

#1035 Feature 1035

#2958 Feature 2958

#1706 Feature 1706

#1794 Feature 1794

#1623 Feature 1623

#1992 Feature 1992

#1020 Feature 1020

#2083 Feature 2083

#2246 Feature 2246

#2164 Feature 2164

#1927 Feature 1927

#531 Feature 531

#667 Feature 667

#1946 Feature 1946

#2951 Feature 2951

#905 Feature 905

#1776 Feature 1776

#1758 Feature 1758

#2898 Feature 2898

#2695 Feature 2695

#148 Feature 148

#2610 Feature 2610

#1585 Feature 1585

#272 Feature 272

#1147 Feature 1147

#3070 Spiritual and Holistic Care in Healthcare

#1791 Feature 1791

#110 Feature 110

#2229 Feature 2229

#2041 Feature 2041

#240 Feature 240

#2740 Feature 2740

#2697 Feature 2697

#2004 Feature 2004

#2283 Feature 2283

#2758 Feature 2758

#3002 Feature 3002

#2976 Feature 2976

#129 Feature 129

#2311 Feature 2311

#835 Feature 835

#1744 Feature 1744

#376 Feature 376

#2438 Feature 2438

#2969 Feature 2969

#1704 Feature 1704

#545 Feature 545

#295 Feature 295

#2410 Feature 2410

#499 Feature 499

#203 Feature 203

#373 Feature 373

#2237 Feature 2237

#1002 Feature 1002

#1409 Feature 1409

#1595 Feature 1595

#1016 Feature 1016

#2345 Feature 2345

#2860 Feature 2860

#2055 Feature 2055

#1993 Feature 1993

#414 Feature 414

#2511 Feature 2511

#1916 Feature 1916

#2507 Feature 2507

#2807 Feature 2807

#2940 Feature 2940

#871 Feature 871

#1634 Feature 1634

#1373 Feature 1373

#2399 Feature 2399

#1724 Feature 1724

#2185 Feature 2185

#3055 Feature 3055

#2158 Feature 2158

#2490 Feature 2490

#1139 Feature 1139

#748 Feature 748

#2893 Feature 2893

#536 Feature 536

#1914 Feature 1914

#3022 Feature 3022

#749 Feature 749

#2232 Medical Case Reports & Cancer Research

#1167 Feature 1167

#2585 Feature 2585

#2784 Feature 2784

#2172 Feature 2172

#379 Feature 379

#1424 Feature 1424

#328 Feature 328

#2465 Feature 2465

#1264 Feature 1264

#2505 Feature 2505

#1849 Feature 1849

#1406 Feature 1406

#1129 Feature 1129

#2414 Feature 2414

#2829 Feature 2829

#1229 Feature 1229

#891 Feature 891

#2925 Feature 2925

#1925 Feature 1925

#2425 Feature 2425

#2213 Feature 2213

#746 Feature 746

#2961 Feature 2961

#2679 Feature 2679

#1743 Feature 1743

#1665 Feature 1665

#2673 Feature 2673

#325 Feature 325

#495 Feature 495

#2727 Feature 2727

#680 Feature 680

#1506 Justification/Rationale for Actions

#1052 Feature 1052

#177 Feature 177

#692 Feature 692

#1578 Feature 1578

#631 Feature 631

#1893 Feature 1893

#2882 Feature 2882

#2411 Feature 2411

#488 Feature 488

#909 Feature 909

#614 Feature 614

#969 Feature 969

#2050 Feature 2050

#735 Feature 735

#2991 Feature 2991

#1967 Feature 1967

#2190 Feature 2190

#609 Feature 609

#2168 Feature 2168

#876 Feature 876

#2106 Feature 2106

#1682 Feature 1682

#1586 Feature 1586

#1908 Feature 1908

#2002 Feature 2002

#1790 Feature 1790

#2081 Feature 2081

#2528 Feature 2528

#2977 Feature 2977

#1571 Feature 1571

#2144 Feature 2144

#2615 Feature 2615

#1624 Feature 1624

#2791 Feature 2791

#1802 Feature 1802

#1080 Feature 1080

#2704 Feature 2704

#656 Feature 656

#1364 Feature 1364

#427 Feature 427

#894 Feature 894

#1456 Feature 1456

#1786 Feature 1786

#250 Feature 250

#1322 Feature 1322

#2397 Feature 2397

#1873 Feature 1873

#2800 Feature 2800

#1895 Feature 1895

#486 Feature 486

#566 Feature 566

#892 Feature 892

#1504 Feature 1504

#1148 Feature 1148

#2582 Feature 2582

#3049 Feature 3049

#2874 Feature 2874

#832 Feature 832

#411 Feature 411

#1072 Feature 1072

#265 Feature 265

#290 Feature 290

#1389 Feature 1389

#2367 Feature 2367

#2299 Feature 2299

#228 Feature 228

#2485 Feature 2485

#1680 Feature 1680

#151 Feature 151

#509 Feature 509

#358 Feature 358

#2583 Feature 2583

#793 Feature 793

#2401 Feature 2401

#2936 Feature 2936

#1570 Feature 1570

#1439 Feature 1439

#1207 Feature 1207

#848 Feature 848

#2092 Feature 2092

#1919 Feature 1919

#1279 Feature 1279

#690 Feature 690

#126 Feature 126

#1270 Feature 1270

#1615 Feature 1615

#2383 Feature 2383

#1807 Feature 1807

#579 Feature 579

#2431 Feature 2431

#2460 Feature 2460

#2406 Feature 2406

#2064 Feature 2064

#1362 Feature 1362

#2722 Feature 2722

#584 Feature 584

#844 Feature 844

#514 Feature 514

#511 Feature 511

#2470 Feature 2470

#1698 Feature 1698

#1323 Feature 1323

#1514 Feature 1514

#2645 Feature 2645

#2003 Feature 2003

#1215 Feature 1215

#506 Feature 506

#1486 Feature 1486

#1818 Feature 1818

#1334 Feature 1334

#1646 Feature 1646

#1382 Feature 1382

#505 Feature 505

#1390 Feature 1390

#490 Feature 490

#2011 Feature 2011

#1298 Feature 1298

#646 Feature 646

#2297 Feature 2297

#850 Feature 850

#2512 Feature 2512

#1391 Feature 1391

#1490 Feature 1490

#1180 Feature 1180

#860 Feature 860

#2944 Feature 2944

#2871 Feature 2871

#2764 Feature 2764

#1645 Feature 1645

#3061 Feature 3061

#2609 Feature 2609

#2206 Feature 2206

#285 Feature 285

#1071 Feature 1071

#3023 Feature 3023

#2271 Feature 2271

#1757 Feature 1757

#2560 Feature 2560

#1061 Feature 1061

#629 Feature 629

#3011 Feature 3011

#2885 Feature 2885

#2353 Feature 2353

#2602 Feature 2602

#1584 Feature 1584

#409 Feature 409

#553 Feature 553

#2255 Feature 2255

#1520 Feature 1520

#3068 Feature 3068

#795 Feature 795

#641 Feature 641

#245 Feature 245

#2685 Feature 2685

#1263 Feature 1263

#2593 Feature 2593

#657 Feature 657

#710 Feature 710

#1327 Feature 1327

#2366 Feature 2366

#1265 Feature 1265

#1820 Feature 1820

#1328 Feature 1328

#2819 Feature 2819

#244 Feature 244

#2833 Feature 2833

#467 Feature 467

#2098 Feature 2098

#2112 Feature 2112

#2211 Feature 2211

#2866 Feature 2866

#163 Feature 163

#1765 Feature 1765

#853 Feature 853

#3040 Feature 3040

#1611 Feature 1611

#2553 Feature 2553

#238 Feature 238

#1489 Feature 1489

#2535 Feature 2535

#1005 Feature 1005

#791 Feature 791

#2846 Feature 2846

#2776 Feature 2776

#801 Feature 801

#2103 Feature 2103

#326 Feature 326

#1879 Feature 1879

#2150 Feature 2150

#1065 Feature 1065

#2611 Feature 2611

#893 Feature 893

#1354 Feature 1354

#493 Feature 493

#1541 Feature 1541

#2967 Feature 2967

#1104 Feature 1104

#1762 Feature 1762

#2062 Feature 2062

#2647 Feature 2647

#2959 Feature 2959

#114 Feature 114

#1907 Feature 1907

#825 Feature 825

#2614 Feature #2614

#1702 Feature 1702

#1558 Feature 1558

#452 Feature 452

#577 Feature 577

#1926 Feature 1926

#1311 Molecular Mechanisms and Biological Processes

#2296 Feature 2296

#1108 Feature 1108

#2890 Feature 2890

#321 Feature 321

#422 Feature 422

#2008 Feature 2008

#1780 Feature 1780

#2760 Feature 2760

#2734 Feature 2734

#1774 Feature 1774

#1885 Feature 1885

#1930 Feature 1930

#684 Feature 684

#2191 Feature 2191

#336 Feature 336

#2948 Feature 2948

#1385 Feature 1385

#578 Feature 578

#964 Feature 964

#3012 Feature 3012

#164 Feature 164

#2549 Feature 2549

#1732 Feature 1732

#1921 Feature 1921

#1458 Feature 1458

#799 Feature 799

#233 Feature 233

#1258 Feature 1258

#2441 Feature 2441

#1532 Feature 1532

#1784 Feature 1784

#1675 Feature 1675

#1547 Feature 1547

#1353 Feature 1353

#562 Feature 562

#1437 Feature 1437

#940 Feature 940

#2402 Feature 2402

#2173 Feature 2173

#2705 Feature 2705

#1551 Feature 1551

#2307 Feature 2307

#2749 Feature 2749

#2853 Feature 2853

#1386 Feature 1386

#2738 Feature 2738

#1714 Feature 1714

#2069 Feature 2069

#994 Feature 994

#2374 Feature 2374

#897 Feature 897

#2523 Feature 2523

#475 Feature 475

#3036 Feature 3036

#2631 Feature 2631

#557 Feature 557

#2326 Feature 2326

#2201 Feature 2201

#790 Feature 790

#1607 Feature 1607

#2181 Feature 2181

#1806 Feature 1806

#185 Feature 185

#2262 Feature 2262

#1418 Feature 1418

#1401 Feature 1401

#2469 Feature 2469

#2305 Feature 2305

#2189 Feature 2189

#1934 Feature 1934

#611 Feature 611

#1652 Feature 1652

#100 Feature 100

#681 Feature 681

#2752 Feature 2752

#1933 Feature 1933

#231 Feature 231

#650 Feature 650

#1572 Feature 1572

#324 Feature 324

#971 Feature 971

#1054 Feature 1054

#868 Feature 868

#1351 Feature 1351

#2643 Feature 2643

#2783 Feature 2783

#2686 Feature 2686

#2638 Feature 2638

#732 Feature 732

#1440 Feature 1440

#485 Feature 485

#2897 Feature 2897

#3005 Feature 3005

#525 Feature 525

#2023 Feature 2023

#2916 Feature 2916

#1608 Feature 1608

#542 Feature 542

#2650 Feature 2650

#2924 Feature 2924

#1184 Feature 1184

#572 Feature 572

#128 Feature 128

#1290 Feature 1290

#2178 Feature 2178

#1768 Feature 1768

#644 Feature 644

#2346 Feature 2346

#1739 Feature 1739

#2589 Feature 2589

#2488 Feature 2488

#1576 Feature 1576

#2072 Feature 2072

#1669 Feature 1669

#935 Feature 935

#1497 Feature 1497

#1293 Feature 1293

#116 Feature 116

#2071 Feature 2071

#1871 Feature 1871

#1715 Feature 1715

#1667 Feature 1667

#1400 Feature 1400

#616 Feature 616

#619 Feature 619

#1469 Feature 1469

#107 Feature 107

#2917 Feature 2917

#370 Feature 370

#1860 Feature 1860

#2135 Feature 2135

#270 Feature 270

#965 Feature 965

#2416 Feature 2416

#2179 Feature 2179

#194 Feature 194

#1333 Feature 1333

#972 Feature 972

#2153 Feature 2153

#1043 Feature 1043

#655 Feature 655

#2298 Feature 2298

#771 Feature 771

#1862 Feature 1862

#1000 Feature 1000

#2436 Feature 2436

#121 Feature 121

#1589 Feature 1589

#772 Feature 772

#2166 Feature 2166

#1836 Feature 1836

#878 Feature 878

#2996 Feature 2996

#2554 Feature 2554

#2970 Feature 2970

#806 Feature 806

#2787 Feature 2787

#2627 Feature 2627

#2104 Feature 2104

#661 Feature 661

#1226 Feature 1226

#2249 Feature 2249

#1091 Feature 1091

#2788 Feature 2788

#2329 Feature 2329

#2551 Feature 2551

#2058 Feature 2058

#369 Feature 369

#2034 Feature 2034

#982 Feature 982

#182 Feature 182

#865 Feature 865

#2325 Feature 2325

#2607 Feature 2607

#1937 Feature 1937

#2322 Feature 2322

#718 Feature 718

#1493 Feature 1493

#2338 Feature 2338

#2753 Feature 2753

#1778 Feature 1778

#124 Feature 124

#582 Feature 582

#2294 Feature 2294

#607 Feature 607

#872 Feature 872

#464 Feature 464

#1009 Feature 1009

#166 Feature 166

#1594 Feature 1594

#1959 Feature 1959

#1140 Feature 1140

#1245 Feature 1245

#398 Feature 398

#839 Feature 839

#3067 Feature 3067

#1227 Feature 1227

#2862 Feature 2862

#811 Feature 811

#2286 Feature 2286

#237 Feature 237

#702 Feature 702

#530 Feature 530

#1692 Feature 1692

#953 Feature 953

#983 Feature 983

#687 Feature 687

#1275 Feature 1275

#674 Feature 674

#2182 Feature 2182

#2301 Feature 2301

#2934 Feature 2934

#269 Feature 269

#1261 Feature 1261

#2570 Feature 2570

#1395 Feature 1395

#1233 Feature 1233

#2321 Feature 2321

#1596 Feature 1596

#2043 Feature 2043

#912 Feature 912

#1846 Feature 1846

#234 Feature 234

#236 Feature 236

#1889 Feature 1889

#1475 Feature 1475

#1013 Feature 1013

#1772 Feature 1772

#1138 Feature 1138

#1332 Feature 1332

#518 Feature 518

#2386 Feature 2386

#1734 Feature 1734

#2341 Feature 2341

#2293 Feature 2293

#2176 Feature 2176

#1120 Feature 1120

#167 Feature 167

#1998 Feature 1998

#1877 Feature 1877

#2700 Feature 2700

#2863 Feature 2863

#755 Feature 755

#1750 Feature 1750

#1684 Feature 1684

#2539 Feature 2539

#2063 Feature 2063

#186 Feature 186

#1136 Feature 1136

#2355 Feature 2355

#1521 Feature 1521

#968 Feature 968

#2714 Feature 2714

#2461 Feature 2461

#1982 Feature 1982

#1123 Feature 1123

#2684 Feature 2684

#1306 Feature 1306

#2992 Feature 2992

#2427 Feature 2427

#2079 Feature 2079

#2500 Feature 2500

#1876 Feature 1876

#489 Feature 489

#836 Feature 836

#2080 Feature 2080

#1473 Feature 1473

#1952 Feature 1952

#2449 Feature 2449

#574 Feature 574

#3006 Feature 3006

#2196 Feature 2196

#2493 Feature 2493

#1931 Feature 1931

#2998 Feature 2998

#1881 Feature 1881

#1591 Feature 1591

#1397 Feature 1397

#1747 Feature 1747

#2515 Feature 2515

#1073 Feature 1073

#1412 Feature 1412

#2972 Sensory-Motor Integration

#1559 Feature 1559

#713 Feature 713

#604 Feature 604

#2285 Feature 2285

#155 Feature 155

#2288 Feature 2288

#2312 Feature 2312

#399 Feature 399

#146 Feature 146

#258 Feature 258

#1687 Feature 1687

#1256 Feature 1256

#2315 Feature 2315

#353 Feature 353

#1960 Feature 1960

#1944 Feature 1944

#2765 Feature 2765

#1201 Feature 1201

#2798 Feature 2798

#2409 Feature 2409

#2100 Feature 2100

#2750 Feature 2750

#445 Feature 445

#642 Feature 642

#2247 Feature 2247

#1378 Feature 1378

#914 Feature 914

#1713 Feature 1713

#1940 Feature 1940

#1383 Feature 1383

#2347 Feature 2347

#480 Feature 480

#1569 Feature 1569

#1910 Feature 1910

#2826 Feature 2826

#3021 Feature 3021

#1260 Feature 1260

#1163 Feature 1163

#2979 Feature 2979

#2149 Feature 2149

#849 Feature 849

#2950 Feature 2950

#1494 Feature 1494

#1883 Feature 1883

#1338 Feature 1338

#2895 Feature 2895

#1502 Feature 1502

#1740 Feature 1740

#533 Feature 533

#1719 Feature 1719

#2205 Feature 2205

#2387 Feature 2387

#877 Feature 877

#1906 Feature 1906

#630 Feature 630

#3052 Feature 3052

#2489 Feature 2489

#1990 Feature 1990

#2096 Feature 2096

#2089 Feature 2089

#361 Feature 361

#2905 Feature 2905

#224 Feature 224

#1663 Feature 1663

#1086 Feature 1086

#2921 Feature 2921

#1185 Feature 1185

#2398 Feature 2398

#444 Feature 444

#1457 Feature 1457

#1957 Feature 1957

#3042 Feature 3042

#1530 Feature 1530

#780 Feature 780

#1107 Feature 1107

#1837 Feature 1837

#2117 Feature 2117

#2519 Feature 2519

#1188 Feature 1188

#1077 Feature 1077

#1909 Feature 1909

#1340 Feature 1340

#1419 Feature 1419

#2254 Feature 2254

#1866 Feature 1866

#1996 Feature 1996

#2963 Feature 2963

#1170 Feature 1170

#2047 Feature 2047

#763 Feature 763

#1255 Feature 1255

#2818 Feature 2818

#2577 Feature 2577

#2147 Feature 2147

#1522 Feature 1522

#2474 Feature 2474

#535 Feature 535

#1001 Feature 1001

#1393 Feature 1393

#2357 Feature 2357

#2858 Feature 2858

#2048 Feature 2048

#2726 Feature 2726

#1369 Feature 1369

#2706 Feature 2706

#543 Feature 543

#814 Feature 814

#169 Feature 169

#1125 Feature 1125

#471 Feature 471

#719 Feature 719

#440 Feature 440

#300 Feature 300

#2911 Feature 2911

#697 Feature 697

#1760 Feature 1760

#2949 Feature 2949

#2344 Feature 2344

#2199 Feature 2199

#2018 Feature 2018

#962 Feature 962

#2942 Feature 2942

#435 Feature 435

#712 Feature 712

#2146 Feature 2146

#1958 Feature 1958

#2989 Feature 2989

#1058 Feature 1058

#1252 Feature 1252

#3054 Feature 3054

#469 Feature 469

#1396 Feature 1396

#2433 Feature 2433

#2658 Feature 2658

#2544 Feature 2544

#2839 Feature 2839

#957 Feature 957

#2953 Feature 2953

#1689 Feature 1689

#1368 Feature 1368

#2275 Feature 2275

#2584 Feature 2584

#1023 Feature 1023

#2118 Feature 2118

#2702 Feature 2702

#1697 Feature 1697

#858 Feature 858

#156 Feature 156

#2978 Feature 2978

#502 Feature 502

#2110 Feature 2110

#1158 Feature 1158

#911 Feature 911

#2252 Feature 2252

#2377 Feature 2377

#1286 Feature 1286

#1464 Feature 1464

#1902 Feature 1902

#2564 Feature 2564

#344 Feature 344

#1664 Feature 1664

#298 Feature 298

#1193 Feature 1193

#255 Feature 255

#199 Feature 199

#400 Feature 400

#2856 Feature 2856

#538 Feature 538

#1360 Feature 1360

#927 Feature 927

#288 Feature 288

#743 Feature 743

#1232 Feature 1232

#2395 Feature 2395

#519 Feature 519

#2766 Feature 2766

#902 Feature 902

#2060 Feature 2060

#1599 Feature 1599

#1568 Feature 1568

#1691 Feature 1691

#2827 Feature 2827

#651 Feature 651

#230 Feature 230

#2510 Feature 2510

#2487 Feature 2487

#613 Feature 613

#1770 Feature 1770

#2468 Feature 2468

#751 Feature 751

#2995 Feature 2995

#275 Feature 275

#2861 Feature 2861

#3033 Feature 3033

#1943 Feature 1943

#482 Feature 482

#1756 Feature 1756

#1964 Feature 1964

#809 Feature 809

#2732 Feature 2732

#2981 Feature 2981

#1447 Feature 1447

#2198 Feature 2198

#360 Feature 360

#777 Feature 777

#2526 Feature 2526

#2666 Feature 2666

#171 Feature 171

#157 Feature 157

Document Content

A phase I safety and pharmacokinetic study of OGT 719 in patients with liver cancer.
OGT 719 (Oxford GlycoSciences, Abingdon, UK) is a novel nucleoside analogue with a galactose molecule attached to a fluorinated pyrimidine. OGT 719 has the capacity selectively to bind to asialoglycoprotein receptors that are found exclusively on hepatocytes and hepatocellular carcinoma (HCC) cells. The aim of this study was to establish the safety and to examine the pharmacokinetics of this novel compound in patients with liver cancer. Fourteen patients received a total of 37 cycles of OGT 719 at four dose levels ([500 mg/m2 first cycle, 1 000 mg/m2 subsequent cycles], 1000 mg/m2, 3 300 mg/m2 and 7500 mg/m2). OGT 719 was administered as a 3-h intravenous infusion in a 250 ml saline solution, daily for 5 days every 4 weeks. Pharmacokinetic parameters were studied during the first cycle of dose levels 1 and 2 (500 mg/m2. and 1 000 mg/m2, respectively). The maximum plasma concentration was attained within 5 min of completing the infusion and almost doubled, dose dependently, with a doubling of the infused dose. The plasma level declined rapidly in a monophasic manner with an elimination half-life of 2.1 and 2.5 h for dose level 1 and 2, respectively The mean area under the curve (AUC(o - infinity) area under the curve to 24 h; AUC(o - infinity), area under the curve to infinity) doubled at the higher dose level. None of the patients had a significant tumor response. Elimination half-life of OGT 719 by 3-h intravenous infusion is short and monophasic. Toxicity was minimal at the highest dose level.

Similar Documents