Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1540

MIN ACTIVATION

0.0

Details List

#1419 Feature 1419

#2978 Feature 2978

#1611 Feature 1611

#2858 Feature 2858

#2304 Feature 2304

#1903 Feature 1903

#2416 Feature 2416

#751 Feature 751

#401 Feature 401

#2806 Feature 2806

#2682 Feature 2682

#1067 Feature 1067

#1959 Feature 1959

#2374 Feature 2374

#847 Feature 847

#931 Feature 931

#1180 Feature 1180

#1229 Feature 1229

#2496 Feature 2496

#872 Feature 872

#1000 Feature 1000

#957 Feature 957

#3063 Feature 3063

#2631 Feature 2631

#2732 Feature 2732

#2956 Feature 2956

#2711 Feature 2711

#2033 Feature 2033

#2126 Feature 2126

#2297 Feature 2297

#648 Feature 648

#1859 Feature 1859

#1374 Feature 1374

#1250 Feature 1250

#2567 Feature 2567

#1289 Feature 1289

#1974 Feature 1974

#701 Feature 701

#2030 Feature 2030

#1260 Feature 1260

#1337 Feature 1337

#239 Feature 239

#2992 Feature 2992

#2587 Feature 2587

#2286 Feature 2286

#1308 Feature 1308

#1537 Feature 1537

#977 Feature 977

#391 Feature 391

#2377 Feature 2377

#1590 Feature 1590

#2294 Feature 2294

#3037 Feature 3037

#2908 Feature 2908

#1953 Feature 1953

#2976 Feature 2976

#350 Feature 350

#1921 Feature 1921

#1951 Feature 1951

#2391 Feature 2391

#2740 Feature 2740

#163 Feature 163

#1232 Feature 1232

#1417 Feature 1417

#1518 Feature 1518

#433 Feature 433

#767 Feature 767

#1628 Feature 1628

#1781 Feature 1781

#515 Feature 515

#1964 Feature 1964

#2485 Feature 2485

#1797 Feature 1797

#2475 Feature 2475

#831 Feature 831

#1386 Feature 1386

#2861 Feature 2861

#2597 Feature 2597

#1039 Feature 1039

#1364 Feature 1364

#2427 Feature 2427

#1230 Feature 1230

#1186 Feature 1186

#2874 Feature 2874

#2859 Feature 2859

#2392 Feature 2392

#3064 Surgical Complications and Physiological Stress

#1328 Feature 1328

#2140 Feature 2140

#1487 Feature 1487

#1831 Feature 1831

#1179 Feature 1179

#2175 Feature 2175

#1307 Feature 1307

#2856 Feature 2856

#1334 Feature 1334

#2355 Feature 2355

#567 Feature 567

#1549 Feature 1549

#1494 Feature 1494

#758 Feature 758

#2419 Feature 2419

#1722 Feature 1722

#2765 Feature 2765

#2022 Feature 2022

#3069 Feature 3069

#386 Feature 386

#1017 Feature 1017

#2333 Feature 2333

#552 Feature 552

#3065 Feature 3065

#938 Feature 938

#1209 Feature 1209

#2151 Feature 2151

#378 Feature 378

#2401 Feature 2401

#1012 Feature 1012

#826 Feature 826

#2005 Feature 2005

#1995 Feature 1995

#1809 Feature 1809

#159 Feature 159

#2105 Feature 2105

#2178 Feature 2178

#2589 Feature 2589

#1085 Feature 1085

#1207 Feature 1207

#224 Feature 224

#1798 Feature 1798

#3040 Feature 3040

#123 Feature 123

#289 Feature 289

#2226 Feature 2226

#2338 Feature 2338

#1445 Feature 1445

#179 Feature 179

#1988 Feature 1988

#1279 Feature 1279

#162 Feature 162

#936 Feature 936

#2781 Feature 2781

#1141 Feature 1141

#2666 Feature 2666

#2467 Feature 2467

#795 Feature 795

#1671 Feature 1671

#2507 Feature 2507

#457 Feature 457

#184 Feature 184

#916 Feature 916

#1857 Feature 1857

#1020 Feature 1020

#1466 Feature 1466

#948 Feature 948

#823 Feature 823

#743 Feature 743

#375 Feature 375

#1693 Feature 1693

#1446 Feature 1446

#2917 Feature 2917

#1210 Feature 1210

#1411 Feature 1411

#1071 Feature 1071

#435 Feature 435

#3043 Feature 3043

#2375 Feature 2375

#1034 Feature 1034

#2853 Feature 2853

#2261 Feature 2261

#251 Feature 251

#2171 Molecular and Cellular Biological Processes

#323 Feature 323

#437 Feature 437

#2973 Feature 2973

#2240 Feature 2240

#1941 Feature 1941

#2808 Feature 2808

#2197 Feature 2197

#2829 Feature 2829

#2284 Feature 2284

#1115 Feature 1115

#2319 Feature 2319

#1406 Feature 1406

#2006 Feature 2006

#901 Feature 901

#2456 Feature 2456

#1014 Feature 1014

#683 Feature 683

#581 Feature 581

#2253 Feature 2253

#1354 Feature 1354

#1221 Feature 1221

#2446 Feature 2446

#918 Feature 918

#641 Feature 641

#2192 Feature 2192

#1119 Feature 1119

#1807 Feature 1807

#2080 Feature 2080

#771 Feature 771

#2554 Feature 2554

#1475 Feature 1475

#1183 Feature 1183

#1925 Feature 1925

#2331 Feature 2331

#371 Feature 371

#1224 Feature 1224

#510 Feature 510

#2873 Feature 2873

#2818 Feature 2818

#341 Feature 341

#2081 Feature 2081

#1158 Feature 1158

#1432 Feature 1432

#548 Feature 548

#2661 Feature 2661

#2409 Feature 2409

#175 Feature 175

#506 Feature 506

#1888 Feature 1888

#345 Feature 345

#2735 Feature 2735

#1418 Feature 1418

#693 Feature 693

#1596 Feature 1596

#2366 Feature 2366

#143 Feature 143

#1414 Feature 1414

#1629 Feature 1629

#2251 Feature 2251

#2462 Feature 2462

#1994 Feature 1994

#2089 Feature 2089

#2381 Feature 2381

#534 Feature 534

#897 Feature 897

#2092 Feature 2092

#2371 Feature 2371

#2357 Feature 2357

#801 Feature 801

#875 Feature 875

#1573 Feature 1573

#2434 Feature 2434

#891 Feature 891

#2823 Feature 2823

#2704 Feature 2704

#1305 Feature 1305

#2057 Feature 2057

#1550 Feature 1550

#253 Feature 253

#629 Feature 629

#1785 Feature 1785

#824 Feature 824

#883 Feature 883

#2841 Feature 2841

#1392 Feature 1392

#803 Feature 803

#1851 Feature 1851

#150 Feature 150

#1799 Feature 1799

#2667 Feature 2667

#1660 Feature 1660

#886 Feature 886

#1617 Feature 1617

#2429 Feature 2429

#924 Feature 924

#1011 Feature 1011

#619 Feature 619

#1428 Feature 1428

#2267 Feature 2267

#2899 Feature 2899

#2000 Feature 2000

#1164 Feature 1164

#2588 Feature 2588

#1770 Feature 1770

#2848 Feature 2848

#3015 Feature 3015

#547 Feature 547

#556 Feature 556

#2298 Feature 2298

#1086 Feature 1086

#1254 Feature 1254

#1178 Feature 1178

#1592 Feature 1592

#775 Feature 775

#2521 Feature 2521

#2787 Feature 2787

#504 Feature 504

#1776 Feature 1776

#2397 Feature 2397

#997 Feature 997

#2569 Feature 2569

#463 Feature 463

#1777 Feature 1777

#523 Feature 523

#3032 Feature 3032

#2831 Feature 2831

#2326 Feature 2326

#2441 Feature 2441

#3068 Feature 3068

#1001 Feature 1001

#1516 Feature 1516

#524 Feature 524

#2784 Feature 2784

#550 Feature 550

#1860 Feature 1860

#2862 Feature 2862

#2692 Feature 2692

#1123 Feature 1123

#221 Feature 221

#2819 Feature 2819

#1755 Feature 1755

#2062 Feature 2062

#1134 Feature 1134

#848 Feature 848

#264 Feature 264

#1409 Feature 1409

#1736 Feature 1736

#2545 Feature 2545

#1404 Feature 1404

#763 Feature 763

#1653 Feature 1653

#1131 Feature 1131

#2190 Feature 2190

#594 Feature 594

#908 Feature 908

#811 Feature 811

#766 Feature 766

#2533 Feature 2533

#2669 Feature 2669

#1556 Feature 1556

#412 Feature 412

#2562 Feature 2562

#2277 Feature 2277

#1082 Feature 1082

#1113 Feature 1113

#287 Feature 287

#2950 Feature 2950

#283 Feature 283

#752 Feature 752

#2085 Feature 2085

#2613 Feature 2613

#1526 Feature 1526

#2414 Feature 2414

#2067 Feature 2067

#2880 Feature 2880

#1741 Feature 1741

#2836 Feature 2836

#2674 Feature 2674

#261 Feature 261

#358 Feature 358

#503 Feature 503

#1990 Feature 1990

#2103 Feature 2103

#1327 Feature 1327

#1689 Feature 1689

#1087 Feature 1087

#2318 Feature 2318

#844 Feature 844

#2292 Feature 2292

#1147 Feature 1147

#575 Feature 575

#1410 Feature 1410

#672 Feature 672

#2960 Feature 2960

#1976 Feature 1976

#2252 Feature 2252

#1949 Feature 1949

#2221 Feature 2221

#2713 Feature 2713

#1049 Feature 1049

#3055 Feature 3055

#2024 Feature 2024

#144 Feature 144

#1355 Feature 1355

#1730 Feature 1730

#2764 Feature 2764

#2541 Feature 2541

#2279 Feature 2279

#1690 Feature 1690

#1369 Feature 1369

#1544 Feature 1544

#494 Feature 494

#1076 Feature 1076

#2709 Feature 2709

#1243 Feature 1243

#2478 Feature 2478

#1479 Feature 1479

#2069 Feature 2069

#2474 Feature 2474

#1890 Feature 1890

#973 Feature 973

#205 Feature 205

#168 Feature 168

#2020 Feature 2020

#1079 Feature 1079

#600 Feature 600

#2590 Feature 2590

#2380 Feature 2380

#1542 Feature 1542

#1290 Feature 1290

#2498 Feature 2498

#2807 Feature 2807

#1584 Feature 1584

#2417 Feature 2417

#2638 Feature 2638

#106 Feature 106

#1257 Feature 1257

#256 Feature 256

#418 Feature 418

#2023 Feature 2023

#2001 Feature 2001

#2453 Feature 2453

#2497 Feature 2497

#1927 Feature 1927

#958 Feature 958

#1761 Feature 1761

#904 Feature 904

#1834 Feature 1834

#2878 Feature 2878

#2757 Feature 2757

#2299 Feature 2299

#1065 Feature 1065

#1461 Feature 1461

#889 Feature 889

#2746 Feature 2746

#687 Feature 687

#198 Feature 198

#1121 Feature 1121

#2766 Feature 2766

#130 Feature 130

#2804 Feature 2804

#2058 Feature 2058

#2981 Feature 2981

#1408 Feature 1408

#2920 Feature 2920

#185 Feature 185

#2111 Feature 2111

#258 Feature 258

#2607 Feature 2607

#2335 Feature 2335

#1425 Feature 1425

#712 Feature 712

#2224 Feature 2224

#1641 Feature 1641

#1997 Feature 1997

#1233 Feature 1233

#2610 Feature 2610

#2593 Feature 2593

#436 Feature 436

#2930 Feature 2930

#2215 Feature 2215

#2309 Feature 2309

#1748 Feature 1748

#498 Feature 498

#794 Feature 794

#200 Feature 200

#1196 Feature 1196

#2387 Feature 2387

#1273 Feature 1273

#1501 Feature 1501

#1613 Feature 1613

#1698 Feature 1698

#2961 Feature 2961

#734 Feature 734

#852 Feature 852

#372 Feature 372

#1338 Feature 1338

#638 Feature 638

#1701 Feature 1701

#1405 Feature 1405

#1054 Feature 1054

#921 Feature 921

#2354 Feature 2354

#2912 Feature 2912

#1820 Feature 1820

#1075 Feature 1075

#1684 Feature 1684

#559 Feature 559

#151 Feature 151

#929 Feature 929

#2686 Feature 2686

#2396 Feature 2396

#1588 Feature 1588

#598 Feature 598

#634 Feature 634

#879 Feature 879

#236 Feature 236

#2046 Feature 2046

#360 Feature 360

#1747 Feature 1747

#1051 Feature 1051

#755 Feature 755

#113 Feature 113

#2108 Feature 2108

#1376 Feature 1376

#2131 Feature 2131

#1647 Feature 1647

#2083 Feature 2083

#1697 Feature 1697

#2524 Feature 2524

#2187 Feature 2187

#898 Feature 898

#699 Feature 699

#1840 Feature 1840

#2907 Feature 2907

#1546 Feature 1546

#825 Feature 825

#1397 Feature 1397

#2410 Feature 2410

#170 Feature 170

#2034 Feature 2034

#2288 Feature 2288

#2352 Feature 2352

#2099 Feature 2099

#1148 Feature 1148

#1352 Feature 1352

#2778 Hippocampal Memory and Cognitive Function

#329 Feature 329

#2420 Feature 2420

#1794 Feature 1794

#1093 Feature 1093

#2583 Feature 2583

#2316 Feature 2316

#2650 Feature 2650

#338 Feature 338

#1101 Feature 1101

#680 Feature 680

#365 Feature 365

#1078 Feature 1078

#1854 Feature 1854

#2322 Feature 2322

#539 Feature 539

#2100 Feature 2100

#2494 Feature 2494

#2909 Feature 2909

#2365 Feature 2365

#728 Feature 728

#2188 Feature 2188

#2172 Feature 2172

#2431 Feature 2431

#285 Feature 285

#1468 Feature 1468

#1476 Feature 1476

#317 Feature 317

#1367 Feature 1367

#445 Feature 445

#387 Feature 387

#206 Feature 206

#2842 Feature 2842

#1332 Feature 1332

#1008 Feature 1008

#663 Feature 663

#1390 Feature 1390

#3021 Feature 3021

#1971 Feature 1971

#2264 Feature 2264

#984 Feature 984

#1401 Feature 1401

#1244 Feature 1244

#845 Feature 845

#1092 Feature 1092

#2690 Feature 2690

#1739 Feature 1739

#1919 Feature 1919

#1351 Feature 1351

#3018 Feature 3018

#1946 Feature 1946

#260 Feature 260

#1905 Feature 1905

#1806 Feature 1806

#819 Feature 819

#1659 Feature 1659

#1767 Feature 1767

#1398 Feature 1398

#2164 Feature 2164

#1048 Feature 1048

#3020 Feature 3020

#2801 Feature 2801

#919 Feature 919

#689 Feature 689

#1498 Feature 1498

#483 Feature 483

#1724 Feature 1724

#894 Feature 894

#405 Feature 405

#636 Feature 636

#1691 Feature 1691

#2758 Feature 2758

#1732 Feature 1732

#1948 Feature 1948

#1996 Feature 1996

#1984 Feature 1984

#1395 Feature 1395

#2232 Medical Case Reports & Cancer Research

#480 Feature 480

#431 Feature 431

#1789 Feature 1789

#2710 Feature 2710

#1415 Feature 1415

#1535 Feature 1535

#2177 Feature 2177

#2068 Feature 2068

#2048 Feature 2048

#183 Feature 183

#464 Feature 464

#533 Feature 533

#2634 Feature 2634

#2082 Feature 2082

#952 Feature 952

#1616 Feature 1616

#1255 Feature 1255

#1677 Feature 1677

#2358 Feature 2358

#1368 Feature 1368

#199 Feature 199

#2637 Feature 2637

#1970 Feature 1970

#399 Feature 399

#939 Feature 939

#263 Feature 263

#669 Feature 669

#1955 Feature 1955

#1282 Feature 1282

#1280 Feature 1280

#306 Feature 306

#1266 Feature 1266

#1499 Feature 1499

#357 Feature 357

#2945 Feature 2945

#969 Feature 969

#2890 Feature 2890

#2559 Feature 2559

#553 Feature 553

#210 Feature 210

#2695 Feature 2695

#310 Feature 310

#1934 Feature 1934

#2378 Feature 2378

#2280 Feature 2280

#2850 Feature 2850

#1303 Feature 1303

#2871 Feature 2871

#1928 Feature 1928

#2515 Feature 2515

#681 Feature 681

#2435 Feature 2435

#1548 Feature 1548

#2579 Feature 2579

#116 Feature 116

#458 Feature 458

#2119 Feature 2119

#635 Feature 635

#2107 Feature 2107

#1152 Feature 1152

#2465 Feature 2465

#2729 Feature 2729

#2050 Feature 2050

#2301 Feature 2301

#3005 Feature 3005

#2418 Feature 2418

#1427 Feature 1427

#1545 Feature 1545

#838 Feature 838

#2785 Feature 2785

#1891 Feature 1891

#632 Feature 632

#2379 Feature 2379

#2317 Feature 2317

#866 Feature 866

#2665 Feature 2665

#1822 Feature 1822

#1889 Feature 1889

#107 Feature 107

#1253 Feature 1253

#3028 Feature 3028

#2608 Feature 2608

#1579 Feature 1579

#2346 Feature 2346

#727 Feature 727

#2184 Feature 2184

#2896 Feature 2896

#334 Feature 334

#1865 Feature 1865

#492 Feature 492

#1836 Feature 1836

#1444 Feature 1444

#1435 Feature 1435

#1246 Feature 1246

#1508 Feature 1508

#2985 Feature 2985

#1191 Feature 1191

#349 Feature 349

#415 Feature 415

#761 Feature 761

#414 Feature 414

#668 Feature 668

#2997 Feature 2997

#406 Feature 406

#535 Feature 535

#181 Feature 181

#2149 Feature 2149

#2877 Feature 2877

#473 Feature 473

#991 Feature 991

#2477 Feature 2477

#2555 Feature 2555

#630 Feature 630

#2243 Feature 2243

#1980 Feature 1980

#1681 Feature 1681

#3012 Feature 3012

#217 Feature 217

#347 Feature 347

#1208 Feature 1208

#2134 Feature 2134

#402 Feature 402

#1276 Feature 1276

#2967 Feature 2967

#2925 Feature 2925

#691 Feature 691

#810 Feature 810

#2767 Feature 2767

#2323 Feature 2323

#1721 Feature 1721

#2415 Feature 2415

#1676 Feature 1676

#2336 Feature 2336

#2285 Feature 2285

#1009 Feature 1009

#197 Feature 197

#686 Feature 686

#2577 Feature 2577

#1021 Feature 1021

#1430 Feature 1430

#1593 Feature 1593

#1311 Molecular Mechanisms and Biological Processes

#2700 Feature 2700

#2490 Feature 2490

#1930 Feature 1930

#2946 Feature 2946

#2865 Feature 2865

#1044 Feature 1044

#1162 Feature 1162

#2926 Feature 2926

#2500 Feature 2500

#882 Feature 882

#148 Feature 148

#1346 Feature 1346

#2281 Feature 2281

#2231 Feature 2231

#446 Feature 446

#2098 Feature 2098

#2324 Feature 2324

#926 Feature 926

#1472 Feature 1472

#2843 Feature 2843

#1382 Feature 1382

#2370 Feature 2370

#146 Feature 146

#1615 Feature 1615

#2963 Feature 2963

#1878 Feature 1878

#1455 Feature 1455

#714 Feature 714

#1962 Feature 1962

#2118 Feature 2118

#2980 Feature 2980

#2182 Feature 2182

#657 Feature 657

#1766 Feature 1766

#1704 Feature 1704

#757 Feature 757

#1543 Feature 1543

#1456 Feature 1456

#2572 Feature 2572

#1003 Feature 1003

#396 Feature 396

#1743 Feature 1743

#2863 Feature 2863

#244 Feature 244

#2949 Feature 2949

#623 Feature 623

#1489 Feature 1489

#2300 Feature 2300

#342 Feature 342

#1503 Feature 1503

#313 Feature 313

#2552 Feature 2552

#1602 Feature 1602

#2201 Feature 2201

#2629 Feature 2629

#1074 Feature 1074

#2979 Feature 2979

#1060 Feature 1060

#1658 Feature 1658

#1894 Feature 1894

#1805 Feature 1805

#421 Feature 421

#1024 Feature 1024

#1597 Feature 1597

#469 Feature 469

#2293 Feature 2293

#1231 Feature 1231

#2112 Feature 2112

#1023 Feature 1023

#580 Feature 580

#2513 Feature 2513

#427 Feature 427

#2399 Feature 2399

#1648 Feature 1648

#124 Feature 124

#2703 Feature 2703

#2984 Feature 2984

#240 Feature 240

#122 Feature 122

#3056 Feature 3056

#2646 Feature 2646

#670 Feature 670

#1069 Feature 1069

#3017 Feature 3017

#1582 Feature 1582

#2406 Feature 2406

#2816 Feature 2816

#2894 Feature 2894

#274 Feature 274

#1645 Feature 1645

#2278 Feature 2278

#229 Feature 229

#773 Feature 773

#2591 Feature 2591

#639 Feature 639

#1339 Feature 1339

#1618 Feature 1618

#1318 Feature 1318

#2270 Feature 2270

#2236 Feature 2236

#2904 Feature 2904

#776 Feature 776

#495 Feature 495

#226 Feature 226

#389 Feature 389

#1177 Feature 1177

#1757 Feature 1757

#1304 Feature 1304

#2295 Feature 2295

#1437 Feature 1437

#570 Feature 570

#1467 Feature 1467

#778 Feature 778

#2296 Feature 2296

#1236 Feature 1236

#837 Feature 837

#1143 Feature 1143

#985 Feature 985

#320 Feature 320

#2755 Feature 2755

#772 Feature 772

#1577 Feature 1577

#1064 Feature 1064

#2663 Feature 2663

#2476 Feature 2476

#2266 Feature 2266

#319 Feature 319

#2044 Feature 2044

#1424 Feature 1424

#1184 Feature 1184

#1846 Feature 1846

#725 Feature 725

#954 Feature 954

#2257 Feature 2257

#789 Feature 789

#558 Feature 558

#2913 Feature 2913

#2789 Feature 2789

#1098 Feature 1098

#694 Feature 694

#1687 Feature 1687

#2991 Feature 2991

#1531 Feature 1531

#3003 Feature 3003

#962 Feature 962

#2994 Feature 2994

#235 Feature 235

#3058 Feature 3058

#2421 Feature 2421

#152 Feature 152

#407 Feature 407

#1510 Feature 1510

#230 Feature 230

#1103 Feature 1103

#609 Feature 609

#301 Feature 301

#1754 Feature 1754

#1294 Feature 1294

#664 Feature 664

#2884 Feature 2884

#818 Feature 818

#1703 Feature 1703

#705 Feature 705

#161 Feature 161

#1607 Feature 1607

#216 Feature 216

#2897 Feature 2897

#586 Feature 586

#2581 Feature 2581

#1160 Feature 1160

#331 Feature 331

#1124 Feature 1124

#1313 Feature 1313

#1045 Feature 1045

#1106 Feature 1106

#645 Feature 645

#2339 Feature 2339

#2847 Feature 2847

#3033 Feature 3033

#2668 Feature 2668

#827 Feature 827

#749 Feature 749

#233 Feature 233

#521 Feature 521

#1153 Feature 1153

#1601 Feature 1601

#1480 Feature 1480

#2940 Feature 2940

#1383 Feature 1383

#1238 Feature 1238

#132 Feature 132

#1261 Feature 1261

#1745 Feature 1745

#915 Feature 915

#799 Feature 799

#1758 Feature 1758

#568 Feature 568

#812 Feature 812

#1796 Feature 1796

#555 Feature 555

#3000 Feature 3000

#2902 Feature 2902

#1206 Feature 1206

#2329 Feature 2329

#280 Feature 280

#2855 Feature 2855

#1473 Feature 1473

#798 Feature 798

#2487 Feature 2487

#2241 Feature 2241

#601 Feature 601

#2230 Feature 2230

#2601 Feature 2601

#1015 Feature 1015

#3041 Feature 3041

#2014 Feature 2014

#2517 Feature 2517

#259 Feature 259

#327 Feature 327

#2910 Feature 2910

#754 Feature 754

#2708 Feature 2708

#2689 Feature 2689

#1619 Feature 1619

#368 Feature 368

#631 Feature 631

#2290 Feature 2290

#808 Feature 808

#2245 Feature 2245

#2824 Feature 2824

#1728 Feature 1728

#296 Feature 296

#2156 Feature 2156

#1187 Feature 1187

#2018 Feature 2018

#2505 Feature 2505

#1639 Feature 1639

#1778 Feature 1778

#1091 Feature 1091

#1112 Feature 1112

#1433 Feature 1433

#963 Feature 963

#1746 Feature 1746

#2393 Feature 2393

#180 Feature 180

#2262 Feature 2262

#3067 Feature 3067

#960 Feature 960

#2814 Feature 2814

#1604 Feature 1604

#584 Feature 584

#1879 Feature 1879

#710 Feature 710

#1216 Feature 1216

#1938 Feature 1938

#1867 Feature 1867

#911 Feature 911

#1066 Feature 1066

#2805 Feature 2805

#462 Feature 462

#353 Feature 353

#633 Feature 633

#2529 Feature 2529

#1908 Feature 1908

#270 Feature 270

#1792 Metastatic Cancer

#1605 Feature 1605

#2776 Feature 2776

#1632 Feature 1632

#1912 Feature 1912

#1651 Feature 1651

#688 Feature 688

#659 Feature 659

#3009 Feature 3009

#1620 Feature 1620

#679 Feature 679

#2227 Feature 2227

#538 Feature 538

#1640 Feature 1640

#1242 Feature 1242

#1381 Feature 1381

#1084 Feature 1084

#994 Feature 994

#2308 Feature 2308

#1139 Feature 1139

#1324 Feature 1324

#1388 Feature 1388

#724 Feature 724

#796 Feature 796

#2155 Feature 2155

#1991 Feature 1991

#247 Feature 247

#252 Feature 252

#944 Feature 944

#2749 Feature 2749

#981 Feature 981

#2864 Feature 2864

#2248 Feature 2248

#780 Feature 780

#644 Feature 644

#2198 Feature 2198

#2922 Feature 2922

#2440 Feature 2440

#2238 Feature 2238

#1525 Feature 1525

#2799 Feature 2799

#849 Feature 849

#793 Feature 793

#1818 Feature 1818

#328 Feature 328

#332 Feature 332

#1102 Feature 1102

#2769 Feature 2769

#2457 Feature 2457

#1490 Feature 1490

#685 Feature 685

#1830 Feature 1830

#1986 Feature 1986

#637 Feature 637

#2382 Feature 2382

#1146 Feature 1146

#489 Feature 489

#1729 Feature 1729

#1514 Feature 1514

#2782 Feature 2782

#1429 Feature 1429

#917 Feature 917

#188 Feature 188

#2531 Feature 2531

#2027 Feature 2027

#2051 Feature 2051

#1043 Feature 1043

#1773 Feature 1773

#2537 Feature 2537

#1631 Feature 1631

#377 Feature 377

#1700 Feature 1700

#1095 Feature 1095

#1823 Feature 1823

#2208 Feature 2208

#218 Feature 218

#2676 Feature 2676

#864 Feature 864

#1688 Feature 1688

#1321 Feature 1321

#700 Feature 700

#2004 Feature 2004

#1283 Feature 1283

#993 Feature 993

#1350 Feature 1350

#1315 Feature 1315

#145 Feature 145

#1268 Feature 1268

#662 Feature 662

#1551 Feature 1551

#1892 Feature 1892

#690 Feature 690

#452 Feature 452

#1920 Feature 1920

#665 Feature 665

#2222 Feature 2222

#1793 Feature 1793

#1711 Feature 1711

#271 Feature 271

#2652 Feature 2652

#1774 Feature 1774

#186 Feature 186

#1217 Feature 1217

#2341 Feature 2341

#1322 Feature 1322

#704 Feature 704

#2903 Feature 2903

#870 Feature 870

#3004 Feature 3004

#2614 Feature #2614

#215 Feature 215

#511 Feature 511

#551 Feature 551

#2609 Feature 2609

#867 Feature 867

#2954 Feature 2954

#802 Feature 802

#835 Feature 835

#1821 Feature 1821

#1885 Feature 1885

#716 Feature 716

#267 Feature 267

#3010 Feature 3010

#543 Feature 543

#207 Feature 207

#238 Feature 238

#171 Feature 171

#2095 Feature 2095

#522 Feature 522

#868 Feature 868

#2511 Feature 2511

#1193 Feature 1193

#833 Feature 833

#708 Drug Resistance Mechanisms in Cancer

#733 Feature 733

#2229 Feature 2229

#272 Feature 272

#797 Feature 797

#273 Feature 273

#961 Feature 961

#592 Feature 592

#2088 Feature 2088

#1181 Feature 1181

#2351 Feature 2351

#1036 Feature 1036

#517 Feature 517

#1182 Feature 1182

#293 Feature 293

#1050 Feature 1050

#902 Feature 902

#549 Feature 549

#432 Feature 432

#2867 Feature 2867

#2146 Feature 2146

#1488 Feature 1488

#1804 Feature 1804

#1924 Feature 1924

#1801 Feature 1801

#1833 Feature 1833

#2530 Feature 2530

#815 Feature 815

#2009 Feature 2009

#1262 Feature 1262

#1527 Feature 1527

#2180 Feature 2180

#1237 Feature 1237

#2369 Feature 2369

#1309 Feature 1309

#1813 Feature 1813

#1491 Feature 1491

#2152 Feature 2152

#1016 Feature 1016

#1666 Feature 1666

#2207 Feature 2207

#1958 Feature 1958

#764 Feature 764

#376 Feature 376

#1906 Feature 1906

#1858 Feature 1858

#2965 Feature 2965

#914 Feature 914

#1987 Feature 1987

#2728 Feature 2728

#881 Feature 881

#303 Feature 303

#1029 Feature 1029

#279 Feature 279

#1359 Feature 1359

#2282 Feature 2282

#1656 Feature 1656

#1902 Feature 1902

#1570 Feature 1570

#1870 Feature 1870

#194 Feature 194

#2471 Feature 2471

#618 Feature 618

#3007 Feature 3007

#678 Feature 678

#336 Feature 336

#1802 Feature 1802

#2084 Feature 2084

#2791 Feature 2791

#2144 Feature 2144

#989 Feature 989

#934 Feature 934

#2214 Feature 2214

#2833 Feature 2833

#713 Feature 713

#2595 Feature 2595

#514 Feature 514

#983 Feature 983

#2337 Feature 2337

#191 Feature 191

#1169 Feature 1169

#2493 Feature 2493

#903 Feature 903

#1826 Feature 1826

#257 Feature 257

#2096 Feature 2096

#2888 Feature 2888

#101 Feature 101

#2701 Feature 2701

#222 Feature 222

#1751 Feature 1751

#2779 Feature 2779

#2372 Feature 2372

#2712 Feature 2712

#1348 Feature 1348

#587 Feature 587

#966 Feature 966

#1142 Feature 1142

#2174 Feature 2174

#2102 Feature 2102

#2621 Feature 2621

#1037 Feature 1037

#843 Feature 843

#1940 Feature 1940

#2212 Feature 2212

#2932 Feature 2932

#178 Feature 178

#2970 Feature 2970

#2433 Feature 2433

#1695 Feature 1695

#2941 Feature 2941

#3014 Feature 3014

#998 Feature 998

#294 Feature 294

#726 Feature 726

#979 Feature 979

#692 Feature 692

#782 Feature 782

#174 Feature 174

#1828 Feature 1828

#343 Feature 343

#1916 Feature 1916

#578 Feature 578

#1528 Feature 1528

#2122 Feature 2122

#2606 Feature 2606

#1837 Feature 1837

#1855 Feature 1855

#1375 Feature 1375

#1378 Feature 1378

#666 Feature 666

#2138 Feature 2138

#2235 Feature 2235

#1533 Feature 1533

#1598 Feature 1598

#2837 Feature 2837

#604 Feature 604

#1168 Feature 1168

#959 Feature 959

#2602 Feature 2602

#1844 Feature 1844

#846 Feature 846

#2205 Feature 2205

#2617 Feature 2617

#1624 Feature 1624

#1705 Feature 1705

#1536 Feature 1536

#564 Feature 564

#1083 Feature 1083

#290 Feature 290

#1795 Feature 1795

#136 Feature 136

#1715 Feature 1715

#379 Feature 379

#1895 Feature 1895

#2203 Feature 2203

#2436 Feature 2436

#2139 Feature 2139

#2320 Feature 2320

#1583 Feature 1583

#1006 Feature 1006

#2924 Feature 2924

#2123 Feature 2123

#2869 Feature 2869

#2640 Feature 2640

#1302 Sensing and Detection Technologies

#2330 Feature 2330

#2015 Feature 2015

#732 Feature 732

#2424 Feature 2424

#1373 Feature 1373

#1791 Feature 1791

#2898 Feature 2898

#1248 Feature 1248

#2566 Feature 2566

#2237 Feature 2237

#2872 Feature 2872

#3036 Feature 3036

#717 Feature 717

#1881 Feature 1881

#2835 Feature 2835

#2812 Feature 2812

#1509 Feature 1509

#731 Feature 731

#2803 Feature 2803

#1441 Feature 1441

#2142 Feature 2142

#321 Feature 321

#1744 Feature 1744

#2074 Feature 2074

#1109 Feature 1109

#364 Feature 364

#1116 Feature 1116

#1627 Feature 1627

#1638 Feature 1638

#2247 Feature 2247

#1915 Feature 1915

#2468 Feature 2468

#1062 Feature 1062

#291 Feature 291

#1591 Feature 1591

#909 Feature 909

#1685 Feature 1685

#1195 Feature 1195

#544 Feature 544

#2551 Feature 2551

#241 Feature 241

#541 Feature 541

#1599 Feature 1599

#1678 Feature 1678

#2921 Feature 2921

#2133 Feature 2133

#1241 Feature 1241

#2696 Feature 2696

#531 Feature 531

#2538 Feature 2538

#698 Feature 698

#1672 Feature 1672

#1120 Feature 1120

#1407 Feature 1407

#2260 Historical Context & Development

#1753 Feature 1753

#1199 Feature 1199

#1002 Feature 1002

#520 Feature 520

#1565 Feature 1565

#2539 Feature 2539

#1512 Feature 1512

#1105 Feature 1105

#1256 Feature 1256

#1587 Feature 1587

#390 Feature 390

#1816 Feature 1816

#1954 Feature 1954

#135 Feature 135

#1096 Feature 1096

#1100 Feature 1100

#2489 Feature 2489

#2472 Feature 2472

#119 Feature 119

#640 Feature 640

#1171 Feature 1171

#2313 Feature 2313

#1839 Feature 1839

#1609 Feature 1609

#682 Feature 682

#1470 Feature 1470

#1635 Feature 1635

#1608 Feature 1608

#1013 Feature 1013

#1497 Feature 1497

#2750 Feature 2750

#2259 Feature 2259

#2064 Feature 2064

#2632 Feature 2632

#1150 Feature 1150

#417 Feature 417

#153 Feature 153

#1486 Feature 1486

#485 Feature 485

#201 Feature 201

#2359 Feature 2359

#1649 Feature 1649

#2612 Feature 2612

#703 Feature 703

#2428 Feature 2428

#2563 Feature 2563

#518 Feature 518

#874 Feature 874

#1323 Feature 1323

#574 Feature 574

#3024 Feature 3024

#2564 Feature 2564

#1911 Feature 1911

#2796 Feature 2796

#2846 Feature 2846

#1213 Feature 1213

#2771 Feature 2771

#1190 Feature 1190

#1361 Feature 1361

#1945 Feature 1945

#855 Feature 855

#1856 Feature 1856

#2969 Feature 2969

#2662 Feature 2662

#2479 Feature 2479

#1495 Feature 1495

#1901 Feature 1901

#1072 Feature 1072

#590 Feature 590

#2029 Feature 2029

#227 Feature 227

#990 Feature 990

#352 Feature 352

#591 Feature 591

#2570 Feature 2570

#1981 Feature 1981

#374 Medical Imaging and Oncology

#2090 Feature 2090

#1145 Feature 1145

#2328 Feature 2328

#284 Feature 284

#2191 Feature 2191

#1278 Feature 1278

#1507 Feature 1507

#505 Feature 505

#491 Feature 491

#380 Feature 380

#1333 Feature 1333

#1812 Feature 1812

#1900 Feature 1900

#1291 Feature 1291

#1932 Feature 1932

#1293 Feature 1293

#1898 Feature 1898

#1887 Feature 1887

#1832 Feature 1832

#2443 Feature 2443

#2368 Feature 2368

#1004 Feature 1004

#2193 Feature 2193

#118 Feature 118

#2800 Feature 2800

#3048 Feature 3048

#281 Feature 281

#3039 Feature 3039

#1174 Feature 1174

#1331 Feature 1331

#2951 Feature 2951

#2955 Feature 2955

#2659 Feature 2659

#2745 Feature 2745

#2128 Feature 2128

#129 Feature 129

#1271 Feature 1271

#2454 Feature 2454

#2303 Feature 2303

#1038 Feature 1038

#711 Feature 711

#2673 Feature 2673

#2535 Feature 2535

#2797 Feature 2797

#809 Feature 809

#946 Feature 946

#311 Feature 311

#471 Feature 471

#2325 Feature 2325

#2395 Feature 2395

#792 Feature 792

#784 Feature 784

#884 Feature 884

#1269 Feature 1269

#2927 Feature 2927

#2461 Feature 2461

#2486 Feature 2486

#660 Feature 660

Document Content

Domain structure of the large subunit of Escherichia coli carbamoyl phosphate synthetase. Location of the binding site for the allosteric inhibitor UMP in the COOH-terminal domain.
The large subunit of Escherichia coli carbamoyl phosphate synthetase (a polypeptide of 117.7 kDa that consists of two homologous halves) is responsible for carbamoyl phosphate synthesis from NH3 and for the binding of the allosteric activators ornithine and IMP and of the inhibitor UMP. Elastase, trypsin, and chymotrypsin inactivate the enzyme and cleave the large subunit at a site approximately 15 kDa from the COOH terminus (demonstrated by NH2-terminal sequencing). UMP, IMP, and ornithine prevent this cleavage and the inactivation. Upon irradiation with ultraviolet light in the presence of [14C]UMP, the large subunit is labeled selectively and specifically. The labeling is inhibited by ornithine and IMP. Cleavage of the 15-kDa COOH-terminal region by prior treatment of the enzyme with trypsin prevents the labeling on subsequent irradiation with [14C]UMP. The [14C]UMP-labeled large subunit is resistant to proteolytic cleavage, but if it is treated with SDS the resistance is lost, indicating that UMP is cross-linked to its binding site and that the protection is due to conformational factors. In the presence of SDS, the labeled large subunit is cleaved by trypsin or by V8 staphylococcal protease at a site located 15 or 25 kDa, respectively, from the COOH terminus (shown by NH2-terminal sequencing), and only the 15- or 25-kDa fragments are labeled. Similarly, upon cleavage of the aspartyl-prolyl bonds of the [14C]UMP-labeled enzyme with 70% formic acid, labeling was found only in the 18.5-kDa fragment that contains the COOH terminus of the subunit. Thus, UMP binds to the COOH-terminal domain.(ABSTRACT TRUNCATED AT 250 WORDS)

Similar Documents