Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1503

MIN ACTIVATION

0.0

Details List

#708 Drug Resistance Mechanisms in Cancer

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#2334 Feature 2334

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#374 Medical Imaging and Oncology

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#2638 Feature 2638

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#2972 Sensory-Motor Integration

#2918 Feature 2918

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#2779 Feature 2779

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#1132 Feature 1132

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#1786 Feature 1786

#1293 Feature 1293

#23 Neuronal Circuitry and Cellular Processes

#1586 Feature 1586

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#1611 Feature 1611

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#2171 Molecular and Cellular Biological Processes

#2958 Feature 2958

#1192 Feature 1192

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#3070 Spiritual and Holistic Care in Healthcare

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#1311 Molecular Mechanisms and Biological Processes

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Document Content

Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer.
Polyamines are essential for tumor growth; consequently, agents that interfere with their metabolisms have been developed as antineoplastic agents. Diethylnorspermine (DENSPM) is one such agent. A focused Phase I clinical trial in patients with advanced non-small cell lung cancer was undertaken. Twenty-nine patients were treated with DENSPM using a dosing schedule of once daily for 5 days. Doses ranged from 25 mg/m(2)/day to 231 mg/m(2)/day. The dose-limiting toxicity was determined to be gastrointestinal including asthenia, abdominal cramps, diarrhea, and nausea. The maximal tolerated dose was 185 mg/m(2)/day for 5 days. At drug dosages for which it was possible to estimate, serum half-life ranged from 0.5 to 3.7 h without apparent dose dependence. Maximal serum concentrations increased with dosage. However, the increase was greater than the proportional increase of the administered dose. There were no objective disease responses observed during the Phase I trial. The results of the Phase I clinical trial suggest that DENSPM can safely be administered to patients with minimal toxicity. Furthermore, the observed dose-limiting toxicity is unique to DENSPM, thus underscoring the potential for DENSPM to be a suitable agent for chemotherapy in combination with agents possessing different spectrums of toxicities.

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