Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1522

MIN ACTIVATION

0.0

Details List

#3052 Feature 3052

#2175 Feature 2175

#803 Feature 803

#205 Feature 205

#434 Feature 434

#490 Feature 490

#2597 Feature 2597

#1915 Feature 1915

#286 Feature 286

#977 Feature 977

#2282 Feature 2282

#1541 Feature 1541

#1430 Feature 1430

#1878 Feature 1878

#2171 Molecular and Cellular Biological Processes

#1179 Feature 1179

#1071 Feature 1071

#2812 Feature 2812

#1590 Feature 1590

#929 Feature 929

#1778 Feature 1778

#1320 Feature 1320

#491 Feature 491

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#1341 Feature 1341

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#2904 Feature 2904

#2888 Feature 2888

#2327 Feature 2327

#1660 Feature 1660

#2614 Feature #2614

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#3064 Surgical Complications and Physiological Stress

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#267 Feature 267

#2663 Feature 2663

#329 Feature 329

#2524 Feature 2524

#1402 Feature 1402

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#2027 Feature 2027

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#2851 Feature 2851

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#2144 Feature 2144

#1273 Feature 1273

#2899 Feature 2899

#629 Feature 629

#2067 Feature 2067

#180 Feature 180

#353 Feature 353

#2217 Feature 2217

#1822 Feature 1822

#2309 Feature 2309

#374 Medical Imaging and Oncology

#1003 Feature 1003

#1442 Feature 1442

#516 Feature 516

#1380 Feature 1380

#2045 Feature 2045

#1999 Feature 1999

#172 Feature 172

#601 Feature 601

#1161 Feature 1161

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#2384 Feature 2384

#2143 Feature 2143

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#2451 Feature #2451

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#2513 Feature 2513

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#3018 Feature 3018

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#547 Feature 547

#2908 Feature 2908

#2659 Feature 2659

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#1388 Feature 1388

#1410 Feature 1410

#965 Feature 965

#664 Feature 664

#563 Feature 563

#1012 Feature 1012

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#264 Feature 264

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#2022 Feature 2022

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#2976 Feature 2976

#2496 Feature 2496

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#2509 Feature 2509

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#2856 Feature 2856

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#1501 Feature 1501

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#365 Feature 365

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#1576 Feature 1576

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#2363 Feature 2363

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#2338 Feature 2338

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#1929 Feature 1929

#1776 Feature 1776

#3043 Feature 3043

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#2379 Feature 2379

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#127 Feature 127

#918 Feature 918

#417 Feature #417

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#1661 Feature 1661

#2824 Feature 2824

#2661 Feature 2661

#2920 Feature 2920

#1522 Feature 1522

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#435 Feature 435

#1095 Feature 1095

#2485 Feature 2485

#1553 Feature 1553

#1377 Feature 1377

#319 Feature 319

#2177 Feature 2177

#2475 Feature 2475

#2336 Feature 2336

#1786 Feature 1786

#608 Feature 608

#2431 Feature 2431

#1302 Sensing and Detection Technologies

#514 Feature 514

#2594 Feature 2594

#627 Feature 627

#2823 Feature 2823

#295 Feature 295

#2003 Feature 2003

#1455 Feature 1455

#1104 Feature 1104

#1702 Feature 1702

#2917 Feature 2917

#1510 Feature 1510

#2711 Feature 2711

#948 Feature 948

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#1186 Feature 1186

#1147 Feature 1147

#2804 Feature 2804

#2638 Feature 2638

#163 Feature 163

#2058 Feature 2058

#2118 Feature 2118

#1139 Feature 1139

#2616 Feature 2616

#538 Feature 538

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#306 Feature 306

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#1641 Feature 1641

#1621 Feature 1621

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#2422 Feature 2422

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#2574 Feature 2574

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#1723 Feature 1723

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#2416 Feature 2416

#2290 Feature 2290

#699 Feature 699

#2932 Feature 2932

#280 Feature 280

#1170 Feature 1170

#1924 Feature 1924

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#285 Feature 285

#454 Feature 454

#2080 Feature 2080

#1757 Feature 1757

#2321 Feature 2321

#2131 Feature 2131

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#707 Feature 707

#1926 Feature 1926

#2874 Feature 2874

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#1903 Feature 1903

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#1098 Feature 1098

#2331 Feature 2331

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#216 Feature 216

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#397 Feature 397

#2702 Feature 2702

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#2156 Feature 2156

#2235 Feature 2235

#2016 Feature 2016

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#1259 Feature 1259

#621 Feature 621

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#367 Feature 367

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#2106 Feature 2106

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#823 Feature 823

#2890 Feature 2890

#2676 Feature 2676

#2725 Feature 2725

#2865 Feature 2865

#1720 Feature 1720

#1196 Feature 1196

#1406 Feature 1406

#2515 Feature 2515

#561 Feature 561

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#1353 Feature 1353

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#410 Feature 410

#2572 Feature 2572

#2215 Feature 2215

#1930 Feature 1930

#1910 Feature 1910

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#2652 Feature 2652

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#2162 Feature 2162

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#1015 Feature 1015

#2240 Feature 2240

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#2970 Feature 2970

#2859 Feature 2859

#2117 Feature 2117

#402 Feature 402

#2070 Feature 2070

#962 Feature 962

#185 Feature 185

#890 Feature 890

#1468 Feature 1468

#826 Feature 826

#2119 Feature 2119

#1987 Feature 1987

#2798 Feature 2798

#2263 Feature 2263

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#731 Feature 731

#3033 Feature 3033

#2435 Feature 2435

#1290 Feature 1290

#659 Feature 659

#1184 Feature 1184

#2808 Feature 2808

#1343 Feature 1343

#852 Feature 852

#2356 Feature 2356

#1149 Feature 1149

#2478 Feature 2478

#2343 Feature 2343

#260 Feature 260

#1973 Feature 1973

#431 Feature 431

#3015 Feature 3015

#2769 Feature 2769

#2180 Feature 2180

#2108 Feature 2108

#443 Feature 443

#1866 Feature 1866

#1296 Feature 1296

#676 Feature 676

#995 Feature 995

#1428 Feature 1428

#1572 Feature 1572

#2056 Feature 2056

#183 Feature 183

#2861 Feature 2861

#1838 Feature 1838

#150 Feature 150

#1140 Feature 1140

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#2178 Feature 2178

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#665 Feature 665

#1405 Feature 1405

#2672 Feature 2672

#3037 Feature 3037

#2220 Feature 2220

#1724 Feature 1724

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#921 Feature 921

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#2247 Feature 2247

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#1601 Feature 1601

#2350 Feature 2350

#1939 Feature 1939

#2151 Feature 2151

#1943 Feature 1943

#2833 Feature 2833

#2556 Feature 2556

#1123 Feature 1123

#1675 Feature 1675

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#335 Feature 335

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#2104 Feature 2104

#2272 Feature 2272

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#2316 Feature #2316

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#2727 Feature 2727

#3003 Feature 3003

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#911 Feature 911

#1707 Feature 1707

#2310 Feature 2310

#522 Feature 522

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#3023 Feature 3023

#1670 Feature 1670

#2947 Feature 2947

#1153 Feature 1153

#539 Feature 539

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#541 Feature 541

#2528 Feature 2528

#2569 Feature 2569

#1913 Feature 1913

#2242 Feature 2242

#2477 Feature 2477

#1984 Feature 1984

#1818 Feature 1818

#1515 Feature 1515

#2172 Feature 2172

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#1508 Feature 1508

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#1712 Feature 1712

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#1470 Feature 1470

#1668 Feature 1668

#2919 Feature 2919

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#3001 Feature 3001

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#2337 Feature 2337

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#1114 Feature 1114

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#1099 Feature 1099

#404 Interactions and Mechanisms

#123 Feature 123

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#2731 Feature 2731

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#2148 Feature 2148

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#1701 Feature 1701

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#2232 Medical Case Reports & Cancer Research

#1263 Feature 1263

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#1240 Feature 1240

#2202 Feature 2202

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#2031 Feature 2031

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#2292 Feature 2292

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#221 Feature 221

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#2393 Feature 2393

#1693 Feature 1693

#2967 Feature 2967

#2155 Feature 2155

#2924 Feature 2924

#1267 Feature 1267

#1111 Feature 1111

#1043 Feature 1043

#2520 Feature 2520

#1770 Feature 1770

#615 Feature 615

#1119 Feature 1119

#1862 Feature 1862

#1922 Feature 1922

#400 Feature 400

#1397 Feature 1397

#1517 Feature 1517

#482 Feature 482

#1800 Feature 1800

#2402 Feature 2402

#719 Feature 719

#1768 Feature 1768

#586 Feature 586

#2437 Feature 2437

#671 Feature 671

#835 Feature 835

#531 Feature 531

#609 Feature 609

#2735 Feature 2735

#760 Feature 760

#1914 Feature 1914

#2590 Feature 2590

#2121 Feature 2121

#764 Feature 764

#1691 Feature 1691

#1242 Feature 1242

#499 Feature 499

#1085 Feature 1085

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#2736 Feature 2736

#1026 Feature 1026

#1704 Feature 1704

#2284 Feature 2284

#1845 Feature 1845

#1000 Feature 1000

#1613 Feature 1613

#2181 Feature 2181

#2810 Feature 2810

#2062 Feature 2062

#1129 Feature 1129

#2624 Feature 2624

#1131 Feature 1131

#2911 Feature 2911

#256 Feature 256

#492 Feature 492

#366 Feature 366

#3054 Feature 3054

#2546 Feature 2546

#971 Feature 971

#770 Feature 770

#737 Feature 737

#312 Feature 312

#612 Feature 612

#1212 Feature 1212

#2570 Feature 2570

#1045 Feature 1045

#3044 Feature 3044

#530 Feature 530

#662 Feature 662

#2893 Feature 2893

#1844 Feature 1844

#1214 Feature 1214

#145 Feature 145

#752 Feature 752

#1642 Feature 1642

#576 Feature 576

#2776 Feature 2776

#1073 Feature 1073

#2779 Feature 2779

#1741 Feature 1741

#895 Feature 895

#924 Feature 924

#2637 Feature 2637

#1084 Feature 1084

#174 Feature 174

#1990 Feature 1990

#1440 Feature 1440

#1269 Feature 1269

#2721 Feature 2721

#809 Feature 809

#2753 Feature 2753

#1172 Feature 1172

#1201 Feature 1201

#745 Feature 745

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Document Content

Role of serine esterase in hydrogen peroxide-mediated activation of phospholipase A2 in rabbit pulmonary arterial smooth muscle cells.
Exposure of rabbit pulmonary arterial smooth muscle cells to hydrogen peroxide cause dose-dependent stimulation of [14C] arachidonic acid (AA) release and enhancement of the cell membrane-associated phospholipase A2 activity as well as of the cell membrane-bound serine esterase activity tested against synthetic substrate p-tosyl-L-arginine methyl ester. While pretreatment of cells with serine protease inhibitors, viz. phenyl methyl sulphonyl fluoride, diisopropyl fluorophosphate and alpha-1-proteinase inhibitor, and antioxidant vitamin E prevents H2O2 stimulation of AA release and the cell membrane-bound serine esterase and PLA2 activities, that with actinomycin D and cycloheximide is devoid of any effect on H2O2 caused stimulation of AA release and the smooth muscle cell membrane associated serine esterase and PLA2 activities. Treatment of the smooth muscle cell membrane suspension with the serine protease trypsin markedly stimulates PLA2 activity. These results suggest that on exposure to H2O2 the smooth muscle cell membrane-bound serine esterase plays an important role in stimulating the cell membrane associated PLA2 activity thereby resulting in an increase in AA release.

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