Analyzer · Sparsifire

Analyze how specific documents activate the features of the SAE. Select a dataset, a run and a document to begin.

Dataset

SAE Model

Document

Active Features

1501

MIN ACTIVATION

0.0

Details List

#633 Feature 633

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#253 Feature 253

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#763 Feature 763

#1540 Feature 1540

#1822 Feature 1822

#2425 Feature 2425

#2972 Sensory-Motor Integration

#1209 Feature 1209

#941 Feature 941

#2742 Feature 2742

#931 Feature 931

#3053 Feature 3053

#2627 Feature 2627

#474 Surgical Procedures & Gastrointestinal Issues

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#2778 Hippocampal Memory and Cognitive Function

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#2220 Feature 2220

#1817 Feature 1817

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#3070 Spiritual and Holistic Care in Healthcare

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#1678 Feature 1678

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#3022 Feature 3022

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#2333 Feature 2333

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#780 Feature 780

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#1593 Feature 1593

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#687 Feature 687

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#696 Feature 696

#2582 Feature 2582

#2930 Feature 2930

#1266 Feature 1266

#2602 Feature 2602

#1200 Feature 1200

#468 Feature 468

#831 Feature 831

#1792 Metastatic Cancer

#183 Feature 183

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#2251 Feature 2251

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#1506 Justification/Rationale for Actions

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#708 Drug Resistance Mechanisms in Cancer

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#2232 Medical Case Reports & Cancer Research

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#2075 Feature 2075

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#2331 Feature 2331

#2813 Feature 2813

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#2144 Feature 2144

#1734 Feature 1734

#2603 Instructional/Educational Content

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#2097 Feature 2097

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#121 Feature 121

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#2013 Feature 2013

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Document Content

Four-year follow-up of mycophenolate mofetil for graft rescue in liver allograft recipients.
Mycophenolate mofetil (MMF) has been shown to have promise in short-term liver transplantation graft rescue studies. The purpose of this study was to evaluate the long-term efficacy and safety of MMF in liver transplant patients who had failed cyclosporine (CsA)-based conventional immunosuppression. Nineteen orthotopic liver allograft recipients were converted from azathioprine to MMF in combination with CsA and prednisone in this prospective, open-labeled, single-center, graft rescue, pilot study. Six patients were taken off CsA when MMF was initiated. A 4-year patient follow-up is reported here. Patients were considered to have failed CsA-based immunosuppression either for refractory rejection, chronic rejection, or severe CsA neurologic toxicity. Twelve patients had complete histologic resolution, two had partial resolution, and three had worsening of their rejection. Thirteen patients had a complete biochemical response; one had a partial response and four had worsening of their rejection. Two patients had no histologic and one no biochemical follow-up. Of the six patients treated with MMF and prednisone alone, four had complete resolution of rejection without recurrence. The majority of adverse reactions were gastrointestinal [nausea and/or vomiting (n=5); diarrhea (n=8); gastritis, duodenitis, or esophagitis (n=4); and ulcers (n=2)] or bone marrow suppressive [leukopenia (n=9), anemia (n=6), and thrombocytopenia (n=5)]. MMF seems to be an effective alternative immunosuppressive in patients failing CsA-based conventional therapy. MMF may be of particular benefit in patients who do not tolerate CsA or tacrolimus. The long-term safety profile is similar to that of other immunosuppressives.

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